LOCUS       NM_001107943            5157 bp    mRNA    linear   ROD 22-MAR-2023
DEFINITION  Rattus norvegicus alkaline ceramidase 2 (Acer2), mRNA.
ACCESSION   NM_001107943 XM_001053269 XM_233138
VERSION     NM_001107943.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5157)
  AUTHORS   Li F, Xu R, Low BE, Lin CL, Garcia-Barros M, Schrandt J, Mileva I,
            Snider A, Luo CK, Jiang XC, Li MS, Hannun YA, Obeid LM, Wiles MV
            and Mao C.
  TITLE     Alkaline ceramidase 2 is essential for the homeostasis of plasma
            sphingoid bases and their phosphates
  JOURNAL   FASEB J 32 (6), 3058-3069 (2018)
   PUBMED   29401619
REFERENCE   2  (bases 1 to 5157)
  AUTHORS   Xu R, Garcia-Barros M, Wen S, Li F, Lin CL, Hannun YA, Obeid LM and
            Mao C.
  TITLE     Tumor suppressor p53 links ceramide metabolism to DNA damage
            response through alkaline ceramidase 2
  JOURNAL   Cell Death Differ 25 (5), 841-856 (2018)
   PUBMED   29229990
REFERENCE   3  (bases 1 to 5157)
  AUTHORS   Wang Y, Zhang C, Jin Y, Wang, He Q, Liu Z, Ai Q, Lei Y, Li Y, Song
            F and Bu Y.
  TITLE     Alkaline ceramidase 2 is a novel direct target of p53 and induces
            autophagy and apoptosis through ROS generation
  JOURNAL   Sci Rep 7, 44573 (2017)
   PUBMED   28294157
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5157)
  AUTHORS   Xu R, Wang K, Mileva I, Hannun YA, Obeid LM and Mao C.
  TITLE     Alkaline ceramidase 2 and its bioactive product sphingosine are
            novel regulators of the DNA damage response
  JOURNAL   Oncotarget 7 (14), 18440-18457 (2016)
   PUBMED   26943039
REFERENCE   5  (bases 1 to 5157)
  AUTHORS   Mao Z, Sun W, Xu R, Novgorodov S, Szulc ZM, Bielawski J, Obeid LM
            and Mao C.
  TITLE     Alkaline ceramidase 2 (ACER2) and its product dihydrosphingosine
            mediate the cytotoxicity of N-(4-hydroxyphenyl)retinamide in tumor
            cells
  JOURNAL   J Biol Chem 285 (38), 29078-29090 (2010)
   PUBMED   20628055
REFERENCE   6  (bases 1 to 5157)
  AUTHORS   Xu R, Sun W, Jin J, Obeid LM and Mao C.
  TITLE     Role of alkaline ceramidases in the generation of sphingosine and
            its phosphate in erythrocytes
  JOURNAL   FASEB J 24 (7), 2507-2515 (2010)
   PUBMED   20207939
REFERENCE   7  (bases 1 to 5157)
  AUTHORS   Sun W, Jin J, Xu R, Hu W, Szulc ZM, Bielawski J, Obeid LM and Mao
            C.
  TITLE     Substrate specificity, membrane topology, and activity regulation
            of human alkaline ceramidase 2 (ACER2)
  JOURNAL   J Biol Chem 285 (12), 8995-9007 (2010)
   PUBMED   20089856
REFERENCE   8  (bases 1 to 5157)
  AUTHORS   Sun W, Hu W, Xu R, Jin J, Szulc ZM, Zhang G, Galadari SH, Obeid LM
            and Mao C.
  TITLE     Alkaline ceramidase 2 regulates beta1 integrin maturation and cell
            adhesion
  JOURNAL   FASEB J 23 (2), 656-666 (2009)
   PUBMED   18945876
REFERENCE   9  (bases 1 to 5157)
  AUTHORS   Xu R, Jin J, Hu W, Sun W, Bielawski J, Szulc Z, Taha T, Obeid LM
            and Mao C.
  TITLE     Golgi alkaline ceramidase regulates cell proliferation and survival
            by controlling levels of sphingosine and S1P
  JOURNAL   FASEB J 20 (11), 1813-1825 (2006)
   PUBMED   16940153
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JACYVU010000162.1.
            
            [WARNING] On Mar 27, 2024 this sequence was replaced by
            NM_001107943.3.
            
            On Nov 27, 2020 this sequence version replaced NM_001107943.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMD00132261,
                              SAMD00132263 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-196               JACYVU010000162.1  15941184-15941379
            197-311             JACYVU010000162.1  15953846-15953960
            312-453             JACYVU010000162.1  15954670-15954811
            454-591             JACYVU010000162.1  15963659-15963796
            592-729             JACYVU010000162.1  15982298-15982435
            730-5157            JACYVU010000162.1  15987486-15991913
FEATURES             Location/Qualifiers
     source          1..5157
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q32"
     gene            1..5157
                     /gene="Acer2"
                     /gene_synonym="Asah3l"
                     /note="alkaline ceramidase 2"
                     /db_xref="GeneID:313339"
                     /db_xref="RGD:1304629"
     exon            1..196
                     /gene="Acer2"
                     /gene_synonym="Asah3l"
                     /inference="alignment:Splign:2.1.0"
     CDS             89..916
                     /gene="Acer2"
                     /gene_synonym="Asah3l"
                     /EC_number="3.5.1.23"
                     /codon_start=1
                     /product="alkaline ceramidase 2"
                     /protein_id="NP_001101413.1"
                     /db_xref="GeneID:313339"
                     /db_xref="RGD:1304629"
                     /translation="MGAPHWWDQLRAGSSEVDWCEDNYTIVPAIAEFYNTISNVLFFI
                     LPPICMCLFRQYATCFNSGIYLIWTLLVVVGIGSVYFHATLSFLGQMLDELAILWVLM
                     CALAMWFPRRYLPKIFRNDRGRFKAVVCVLSAVTTCLAFVKPAINNISLMILGVPCTA
                     LLIAELKRCDNVRVFKLGLFSGLWWTLALFCWISDRAFCELLSSFHFPYLHCVWHILI
                     CLAAYLGCVCFAYFDAASEIPEQGPVIRFWPSEKWAFIGVPYVSLLCAHKKSPVKIT"
     exon            197..311
                     /gene="Acer2"
                     /gene_synonym="Asah3l"
                     /inference="alignment:Splign:2.1.0"
     exon            312..453
                     /gene="Acer2"
                     /gene_synonym="Asah3l"
                     /inference="alignment:Splign:2.1.0"
     exon            454..591
                     /gene="Acer2"
                     /gene_synonym="Asah3l"
                     /inference="alignment:Splign:2.1.0"
     exon            592..729
                     /gene="Acer2"
                     /gene_synonym="Asah3l"
                     /inference="alignment:Splign:2.1.0"
     exon            730..5157
                     /gene="Acer2"
                     /gene_synonym="Asah3l"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcaccgcata agccgcagac gcacagtgtg cccagcagcc gctcgggccg cttgcagctg
       61 ccggctgctc cgatgctcca gagcggccat gggcgccccg cactggtggg accagctgcg
      121 ggctggcagc tcggaggtgg attggtgcga ggacaactac accatcgtgc ctgccatcgc
      181 cgagttctac aacacgatca gcaacgtcct gtttttcatt ttaccgccca tctgcatgtg
      241 cttgttccgc cagtacgcca cgtgcttcaa cagcggcatc tatttaatat ggactctcct
      301 agttgtagtg ggaatcggat ctgtctactt ccatgcaact cttagtttcc tgggccagat
      361 gcttgatgaa cttgccattc tttgggttct gatgtgtgct ttggccatgt ggtttcccag
      421 gaggtattta ccaaagatct ttcggaatga caggggcagg ttcaaggcag tggtgtgtgt
      481 cctgtctgca gttacaacat gcctggcgtt tgtcaagcct gctatcaaca atatctctct
      541 gatgattctg ggggttccgt gcactgcgct gctcattgca gagctgaaga ggtgtgacaa
      601 tgtgcgtgtg tttaagctgg gcctcttctc tggcctttgg tggactctgg ctctcttctg
      661 ctggatcagt gaccgagcct tctgtgagct gctgtcctcc tttcactttc cctacctgca
      721 ctgcgtgtgg cacatcctca tctgccttgc cgcgtacctg ggctgcgtgt gcttcgccta
      781 cttcgatgct gcctcagaga tacccgaaca aggtccagtc atcagattct ggcccagtga
      841 gaaatgggct tttatcggtg tcccctatgt gtccctcctg tgtgcccaca agaagtcgcc
      901 agtcaagatc acgtgacggc aaggcagtga ccggcttttc tgcttacttc tattcgagtg
      961 tgctctgggc tttgtttgct agaaaagatg gccaaggggt ttgaagaatt gatgtagtgt
     1021 gggtgtttaa aattctgttc ttttgtgatc taactggacc gctgtgcctg acatccccag
     1081 ggtgggtaat ggagggctca gggacatgag tgggtcggcc tcagcgacct ttacgggcac
     1141 atgggcttgc tgtgttatat ccatgatgac attgacagag tagttatttg ggagacccag
     1201 agcagcccaa agcttcttgc tggaaaaggt ggcttgccat agcccccacc atttccaggc
     1261 tctctcatta cacaggagtc agccccctga ttctgtgata gaaggttcca gaacttttca
     1321 ttttgctggg agaaactgtc cttcaacaaa atcgagtagg caaaaaaaaa aaaaaccaaa
     1381 aaaaaacaaa aaaaacaaaa aaaaaaacaa aaaaaaaaac aaaaaaaaaa acaaaacaaa
     1441 aaaccacaca cacacacaca tggggggctg tgactaaggc cgtggcttgt cacttgcacc
     1501 tcttagcttt ctccacatgc ctgtggatcc ttccactacc tctgctgaga gacggagcct
     1561 tggcttcaga gggcaaagcc agtaacaccc tctacgccaa gagctacagt ccactttaag
     1621 cacacattaa acactgacat tatgtctgct cttccagagt gcagcagcct cagacccaca
     1681 gaggctcctt ctggtgtggc aattccacac atagccccct accgcttgcc acttgacctc
     1741 tgtgagagca aggactcatt gcactcactg aggcagctct gagggttttg attgtagagc
     1801 tcctgtgaag cttttggaaa agcttttctt attggaagct tacagtgtgt tgttacctcc
     1861 aagactctga ccccatttct ctgctgtttt caggggatgt gtgcttcctg agggatgcca
     1921 cttccctggg atgtggacct ccagccttta tttttgtaat accggtgcta actggtttct
     1981 cagagccctt tgctcttctt gatgctggcc agtcacgaca ctctgattgg ctggctaggg
     2041 ggtcacaggt aggaaggggc agactctgac ctgaatgtct ctcacctgca ccatgctgtc
     2101 ctcactgggc tatctgcagg gtatgaggtg gaattgggta tatctcaggg atgtttgtaa
     2161 ctcaggcacc ttctgctttc tgacattcca ttgttggggt gggacagcgc tcaggggact
     2221 gcagttgcta cactgttctg agtggcgtcc tgagtttgaa ggagttggcc ggttctggcc
     2281 gttccaggaa ctcttactcc gtatagaagc ttcacagggt ccaaagtgga aactggacta
     2341 ggagttttta aatgcatagg cttcattctg cttctggggc tttgaagttt tagaagtagc
     2401 ttgctaggct ctttcttgtc tgtagtcaca aatatctgta gaacccgaat gtgtgaaaga
     2461 agtcatcttt tattaagttt atagcattta ctaaatctcc caggtagcaa gcccatagtc
     2521 atttatttga ttggtgattt ataaggcaga gatacttggc tttgaatgac tgtatatgtt
     2581 attttattgc agcttaaaat atatttaaaa tgattttgag ttaaatgttt gtggcaacct
     2641 aggggggttc atggaccaga attgctgctg agtcctttgg tttttgagtc tagaattttt
     2701 cagactagcc ttgcttccag ctcatctcac caggcacagg ggctgctctt atatattcta
     2761 cacgatatac acatcctgag gatgacgccg agctgccttt gtctgaaagg gcccgagctg
     2821 tctggggctg gagagctggt tcagccgata aaaacacatg ttgccctccc agaggaccca
     2881 ggtttgattc ccagcatctt ataaagctga caacctgtag ctccagtccc aggggatcca
     2941 gtgccctctt ctgacctcca agggcacaga gcatgcatgt ggtacaccta tgcatacagg
     3001 caggcaagtc attcgtacat gtaaagtaat gagtaagtta ataagccggc ggagggaaag
     3061 gttttttttt tttttttttt tttttttttt tttttttttt tgttcttttt ttttttcgga
     3121 gctggggacc gaacccaggg ccttgcgctt cctaggtaag cgctctacca ctgagctaaa
     3181 tccccagccc cgggaaaggg tttttagatg caaggtttag tttgtcctgg gggcccttcc
     3241 atgacagtgg gggtgtcctc agagtcaggg aagaaccact tctttttatc aggaaaaagg
     3301 acttatttcc cagggcctct gctaacaccc ctaggtatag gtatagggat aagatattaa
     3361 tgggtgtgct tgaacgattg ggtgaaagga gatgagaacc tgactcgact cagtgggcct
     3421 cttccccagg tgtgtgagcc accatagctg gcttggtagg gagtgtgttt gggggcaagc
     3481 cctacccccc ctctgagaca aagctctgat ctttttcatg tctcaggctg tattcactgt
     3541 atagttcagg ctagcctcaa actgacggtg agaccccaag tgctaggtat acttatagga
     3601 gcaaggtacc acacccactt taaaacagaa atctctcctg cttgctagca tgggcctgac
     3661 taatcaaggg agtagataca tatgaatcta actttgagct gggctttgag cattgatcac
     3721 ttttttatta aagctttaca cgatcactcc atgggacact acagaagagc ggcagaagaa
     3781 aaagttactc atacctctct tgccttagag cctccgtcac caatttggct ttggggcgtg
     3841 tttccttcct ctcctttctg ctctcctaca gttataatga gatttcattt agaccgcttt
     3901 cccttgagtg gaatatgcat ggcagcgttt tcatggagag ctaactttct ctcctatgct
     3961 gacggctgga cgctgagctc accactgaag ctgcctttcc catgaagtcc gacttgagag
     4021 gctcctaaga catgaactga ttttggcttt gcgatgtaac aattcacatt tgggtctctg
     4081 agttgtggag agccgctgtt aaagctctga cttcatggct cctactgtgt tgagagtggt
     4141 gacaagaagc agagcaggct aactgatgtg cactccagaa tctgctccct tctggtagag
     4201 atgacctcag tgagtgatgt catggccact gttcccagca tgggcgtcag gttctgctct
     4261 gttccgaatc tgcctgggat ctcaggacag aggaagccat gaaggttacc aagtggtcat
     4321 gtctgtcagt gagttcactg ttttgatcca ttgttgattt tcaggagagg aattcttctc
     4381 tctttagtgc cctgtgatgc caaagccagc tcttcagaag tgttttttct gtctgcttcc
     4441 atttgtaatg tgatccacgt gggggaaatg ggtgtcattc tgctgaaaag tgcctaaacc
     4501 agtcacgggt caacagcatt gtgtggagga tcaaacgtgg ctctgtagaa atactgccac
     4561 ccattctatt ggttggactt ctcaggtgtc tgaaacttcc ctcacgaatc ctcttctcct
     4621 aaccgcctcc cagatccact gggatttgaa ccttcaaatc ctgcctctct tcttccttca
     4681 ggtctgacca ctaacggtct ctggggacac ctaactaggg cctcccccag ctccttcctc
     4741 cagccgaact tggattcttc ccaaccaggg cttgacctgg gtgctgttgg tcccactgcc
     4801 caatgacaca tctttgacca gattgggatt ctcaatagat tttatagaca ttattctccc
     4861 acagacttta aaaaacatgg cgtgtgtctt ttcctacaca agtcagattt aaaactattt
     4921 tataactaca ataattcaac caagcaaata gagtattttc agatatatgc cattttatac
     4981 tttatgtaga gtgtgctatg tacaggtggc atgtaccctg gctgaggtaa cattagtcat
     5041 tgctctgggg gatttacaga tcttttgcac tttatgcttt ttttgtgaac tctgataacc
     5101 atgttcaata ttaaagccat taacaggcat tttctgtgaa taaacattta tgtatct
//
