LOCUS       NM_001106875            1125 bp    mRNA    linear   ROD 29-MAR-2024
DEFINITION  Rattus norvegicus alkaline ceramidase 1 (Acer1), mRNA.
ACCESSION   NM_001106875 XM_001059927 XM_236790
VERSION     NM_001106875.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1125)
  AUTHORS   Lin,C.L., Xu,R., Yi,J.K., Li,F., Chen,J., Jones,E.C., Slutsky,J.B.,
            Huang,L., Rigas,B., Cao,J., Zhong,X., Snider,A.J., Obeid,L.M.,
            Hannun,Y.A. and Mao,C.
  TITLE     Alkaline Ceramidase 1 Protects Mice from Premature Hair Loss by
            Maintaining the Homeostasis of Hair Follicle Stem Cells
  JOURNAL   Stem Cell Reports 9 (5), 1488-1500 (2017)
   PUBMED   29056331
REFERENCE   2  (bases 1 to 1125)
  AUTHORS   Liakath-Ali,K., Vancollie,V.E., Lelliott,C.J., Speak,A.O.,
            Lafont,D., Protheroe,H.J., Ingvorsen,C., Galli,A., Green,A.,
            Gleeson,D., Ryder,E., Glover,L., Vizcay-Barrena,G., Karp,N.A.,
            Arends,M.J., Brenn,T., Spiegel,S., Adams,D.J., Watt,F.M. and van
            der Weyden,L.
  TITLE     Alkaline ceramidase 1 is essential for mammalian skin homeostasis
            and regulating whole-body energy expenditure
  JOURNAL   J Pathol 239 (3), 374-383 (2016)
   PUBMED   27126290
REFERENCE   3  (bases 1 to 1125)
  AUTHORS   Mao,Z., Sun,W., Xu,R., Novgorodov,S., Szulc,Z.M., Bielawski,J.,
            Obeid,L.M. and Mao,C.
  TITLE     Alkaline ceramidase 2 (ACER2) and its product dihydrosphingosine
            mediate the cytotoxicity of N-(4-hydroxyphenyl)retinamide in tumor
            cells
  JOURNAL   J Biol Chem 285 (38), 29078-29090 (2010)
   PUBMED   20628055
REFERENCE   4  (bases 1 to 1125)
  AUTHORS   Xu,R., Sun,W., Jin,J., Obeid,L.M. and Mao,C.
  TITLE     Role of alkaline ceramidases in the generation of sphingosine and
            its phosphate in erythrocytes
  JOURNAL   FASEB J 24 (7), 2507-2515 (2010)
   PUBMED   20207939
REFERENCE   5  (bases 1 to 1125)
  AUTHORS   Sun,W., Xu,R., Hu,W., Jin,J., Crellin,H.A., Bielawski,J.,
            Szulc,Z.M., Thiers,B.H., Obeid,L.M. and Mao,C.
  TITLE     Upregulation of the human alkaline ceramidase 1 and acid ceramidase
            mediates calcium-induced differentiation of epidermal keratinocytes
  JOURNAL   J Invest Dermatol 128 (2), 389-397 (2008)
   PUBMED   17713573
REFERENCE   6  (bases 1 to 1125)
  AUTHORS   Houben,E., Holleran,W.M., Yaginuma,T., Mao,C., Obeid,L.M.,
            Rogiers,V., Takagi,Y., Elias,P.M. and Uchida,Y.
  TITLE     Differentiation-associated expression of ceramidase isoforms in
            cultured keratinocytes and epidermis
  JOURNAL   J Lipid Res 47 (5), 1063-1070 (2006)
   PUBMED   16477081
REFERENCE   7  (bases 1 to 1125)
  AUTHORS   Mao,C., Xu,R., Szulc,Z.M., Bielawski,J., Becker,K.P., Bielawska,A.,
            Galadari,S.H., Hu,W. and Obeid,L.M.
  TITLE     Cloning and characterization of a mouse endoplasmic reticulum
            alkaline ceramidase: an enzyme that preferentially regulates
            metabolism of very long chain ceramides
  JOURNAL   J Biol Chem 278 (33), 31184-31191 (2003)
   PUBMED   12783875
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000009.1.
            
            On Mar 23, 2021 this sequence version replaced NM_001106875.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643295.34359.1,
                                           SRR26643294.35405.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-138               JAXUCZ010000009.1  1911302-1911439     c
            139-253             JAXUCZ010000009.1  1885966-1886080     c
            254-395             JAXUCZ010000009.1  1885739-1885880     c
            396-533             JAXUCZ010000009.1  1884964-1885101     c
            534-671             JAXUCZ010000009.1  1882059-1882196     c
            672-1125            JAXUCZ010000009.1  1881361-1881814     c
FEATURES             Location/Qualifiers
     source          1..1125
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q11"
     gene            1..1125
                     /gene="Acer1"
                     /gene_synonym="Asah3"
                     /note="alkaline ceramidase 1"
                     /db_xref="GeneID:301118"
                     /db_xref="RGD:1588582"
     exon            1..138
                     /gene="Acer1"
                     /gene_synonym="Asah3"
                     /inference="alignment:Splign:2.1.0"
     CDS             19..840
                     /gene="Acer1"
                     /gene_synonym="Asah3"
                     /EC_number="3.5.1.23"
                     /note="N-acylsphingosine amidohydrolase (alkaline
                     ceramidase) 3"
                     /codon_start=1
                     /product="alkaline ceramidase 1"
                     /protein_id="NP_001100345.1"
                     /db_xref="GeneID:301118"
                     /db_xref="RGD:1588582"
                     /translation="MYAPSTRAKMSSIFAYQSSEVDWCESNFQHSELVAEFYNTFSNV
                     FFLIFGPLMMFLMHPYAQKRSWGIYGVSVLFMVIGLFSMYFHMTLSFVGQLLDEISIL
                     WLLASGYSVWLPRCYFPKFIKGSRFYFSCLVIMTTIISTFLTFVKPTVNAYALNSIAI
                     HILYIVRKEYKKTSNRDLRHLIAVSVILWAAALTSWVSDRVLCSFWQRIQFFYLHSIW
                     HVLISITFPYGIVTMALVDAKYEMPDKTLKVHYWPRDSWLIGLPYVEIQENDKNC"
     exon            139..253
                     /gene="Acer1"
                     /gene_synonym="Asah3"
                     /inference="alignment:Splign:2.1.0"
     exon            254..395
                     /gene="Acer1"
                     /gene_synonym="Asah3"
                     /inference="alignment:Splign:2.1.0"
     exon            396..533
                     /gene="Acer1"
                     /gene_synonym="Asah3"
                     /inference="alignment:Splign:2.1.0"
     exon            534..671
                     /gene="Acer1"
                     /gene_synonym="Asah3"
                     /inference="alignment:Splign:2.1.0"
     exon            672..1125
                     /gene="Acer1"
                     /gene_synonym="Asah3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acctctgcca ggcacaggat gtatgcaccg agcaccagag caaagatgtc cagcatcttt
       61 gcctatcaga gctctgaggt ggattggtgt gagagtaatt tccagcactc ggagttggtg
      121 gccgagttct acaatacgtt cagcaatgtg ttcttcctca tctttggacc cctcatgatg
      181 ttccttatgc acccgtatgc ccagaagcgt tcctggggta tctatggagt gtcagtcctc
      241 ttcatggtca taggtctgtt ctccatgtat ttccacatga cactcagctt cgtggggcag
      301 ctgctggatg agatctccat cctgtggttg ctggccagtg gatacagcgt gtggttgccc
      361 cgttgctact tccccaagtt catcaagggg agcaggttct acttcagctg cctggtaatt
      421 atgaccacca ttatcagcac cttcttgacg ttcgtgaagc ccacagtcaa tgcctatgcc
      481 ctcaacagta tcgccataca catcctctac attgtacgca aagagtacaa gaagactagc
      541 aacagggatc ttcggcatct gattgctgtt tctgtgatct tgtgggccgc cgccctgacc
      601 agctgggtca gcgaccgtgt gctctgcagt ttctggcagc ggattcagtt cttctacctg
      661 catagcattt ggcatgtcct cataagcatc actttccctt atggtattgt gaccatggcc
      721 ctggtggacg ccaagtatga gatgccagat aaaaccctca aagtccacta ctggccccgg
      781 gacagctggc tcattgggct gccctatgtg gagatccagg agaatgacaa gaactgctga
      841 gctctgcgaa agtctctgct caccgtccga ccagccaccc agtctcctat gttctgagga
      901 cacagagcag ggcacacttg ggagccccac acccacgctt ctcgccctgt tcggttggcc
      961 caggatagac ttacttgtgg ctcagggtac ttgtggtgac tgaggggcag gggctgcctg
     1021 gtgcgtggaa tgtctggcct acttctgctt atgagaccac ggctcctcca cggccgctga
     1081 tgtggtgggt gtacgggtgt ggctgatacg gcacctgctt gaagc
//
