LOCUS       NM_001258237            2583 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus angiotensin I converting enzyme
            (peptidyl-dipeptidase A) 3 (Ace3), mRNA.
ACCESSION   NM_001258237 XM_001081565 XM_573208
VERSION     NM_001258237.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2583)
  AUTHORS   Yu CJ, Tang LL, Liang C, Chen X, Song SY, Ding XQ, Zhang KY, Song
            BL, Zhao D, Zhu XY, Li HL and Zhang ZR.
  TITLE     Angiotensin-Converting Enzyme 3 (ACE3) Protects Against Pressure
            Overload-Induced Cardiac Hypertrophy
  JOURNAL   J Am Heart Assoc 5 (2), e002680 (2016)
   PUBMED   26892527
  REMARK    GeneRIF: ACE3 inhibits pressure overload-induced cardiac
            hypertrophy by blocking the MEK-ERK1/2 signaling pathway.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2583)
  AUTHORS   Rella M, Elliot JL, Revett TJ, Lanfear J, Phelan A, Jackson RM,
            Turner AJ and Hooper NM.
  TITLE     Identification and characterisation of the angiotensin converting
            enzyme-3 (ACE3) gene: a novel mammalian homologue of ACE
  JOURNAL   BMC Genomics 8, 194 (2007)
   PUBMED   17597519
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC085122.1.
            
            On or before Apr 21, 2012 this sequence version replaced
            XM_573208.3, XM_001081565.2.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760383,
                              SAMEA5760389 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-818               BC085122.1         1-818
            819-2583            BC085122.1         911-2675
FEATURES             Location/Qualifiers
     source          1..2583
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q32.1"
     gene            1..2583
                     /gene="Ace3"
                     /gene_synonym="RGD1561299"
                     /note="angiotensin I converting enzyme
                     (peptidyl-dipeptidase A) 3"
                     /db_xref="GeneID:498012"
                     /db_xref="RGD:1561299"
     exon            1..98
                     /gene="Ace3"
                     /gene_synonym="RGD1561299"
                     /inference="alignment:Splign:2.1.0"
     CDS             11..2224
                     /gene="Ace3"
                     /gene_synonym="RGD1561299"
                     /EC_number="3.4.15.1"
                     /codon_start=1
                     /product="angiotensin I converting enzyme
                     (peptidyl-dipeptidase A) 3 precursor"
                     /protein_id="NP_001245166.1"
                     /db_xref="GeneID:498012"
                     /db_xref="RGD:1561299"
                     /translation="MGFPWAFLLVLLYYGQPLPWPKTVGEPSLDEFYSEAQAKMFLQF
                     YEQTARVVLNELMEATWNYVTNITKQNQENMLQKEVERSQFMLYFGTRARMFRIDHFQ
                     DLDVKRRLSKLRNIDKSALPVEDFQEFNRLLTYMKTAYGRAEVCLDEGPCMPLEPDLE
                     EIMATSRDQKELLWAWQGWRDAIGRQLRPVFEDYVHLSNKAAQYNGYKDMGALWRSKY
                     ESDTLEEDLEQLYKELQPLYLNLHAYVRRSLYRYYGPELIDLRGPIPAHLLGNMWAQS
                     WNNILDLVLPYPNKPPEDITKIMKNQHWRPEKMFEEANLFFTSMGMLPAPPAFWMKSM
                     MEKPVDGREVECHTSSWNFYRLNDFRVKKCTEVTIGDLLSIFHQMGHIQYYLQCQNLS
                     IIYQEGASPAFEEAVGSTITLSAFSHKYLLTRGLLSQQHQDSEEEVNFLLSIALEKIA
                     FIPFGYMIDLFRWKVFDGTIQKNAYNQEWWSLRLKYQGLCPPVPRSEDDFDPGAKFHI
                     PANMPYIRYFLSLVLQFQLHEVLCRASGHVGPLHRCDIYNSKVAGKILGDFLKVGSSR
                     PWQEVLKEITGKPNISTKALLTYFKPLLNWLVTENVKQGDILGWPDFSCSFEEKITKK
                     MSFLGMKIEPDQAYLGQWVLLSMSFIMLCLILALGLRLHYLERRSLDSDTVILSTPPY
                     AYFLGIAMEPRQAARKQWLLLGLCFVLMLCCIGLLIKIFIHHTRKPPWMKAEWQS"
     exon            99..235
                     /gene="Ace3"
                     /gene_synonym="RGD1561299"
                     /inference="alignment:Splign:2.1.0"
     exon            236..394
                     /gene="Ace3"
                     /gene_synonym="RGD1561299"
                     /inference="alignment:Splign:2.1.0"
     exon            395..482
                     /gene="Ace3"
                     /gene_synonym="RGD1561299"
                     /inference="alignment:Splign:2.1.0"
     exon            483..626
                     /gene="Ace3"
                     /gene_synonym="RGD1561299"
                     /inference="alignment:Splign:2.1.0"
     exon            627..818
                     /gene="Ace3"
                     /gene_synonym="RGD1561299"
                     /inference="alignment:Splign:2.1.0"
     exon            819..916
                     /gene="Ace3"
                     /gene_synonym="RGD1561299"
                     /inference="alignment:Splign:2.1.0"
     exon            917..1089
                     /gene="Ace3"
                     /gene_synonym="RGD1561299"
                     /inference="alignment:Splign:2.1.0"
     exon            1090..1313
                     /gene="Ace3"
                     /gene_synonym="RGD1561299"
                     /inference="alignment:Splign:2.1.0"
     exon            1314..1458
                     /gene="Ace3"
                     /gene_synonym="RGD1561299"
                     /inference="alignment:Splign:2.1.0"
     exon            1459..1557
                     /gene="Ace3"
                     /gene_synonym="RGD1561299"
                     /inference="alignment:Splign:2.1.0"
     exon            1558..1680
                     /gene="Ace3"
                     /gene_synonym="RGD1561299"
                     /inference="alignment:Splign:2.1.0"
     exon            1681..1865
                     /gene="Ace3"
                     /gene_synonym="RGD1561299"
                     /inference="alignment:Splign:2.1.0"
     exon            1866..2245
                     /gene="Ace3"
                     /gene_synonym="RGD1561299"
                     /inference="alignment:Splign:2.1.0"
     exon            2246..2555
                     /gene="Ace3"
                     /gene_synonym="RGD1561299"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tgggaacaag atgggctttc cctgggcctt cctacttgtg ctcctctatt acgggcagcc
       61 cttgccgtgg cccaagactg tgggagagcc aagcttagat gagttctaca gtgaagccca
      121 agcaaagatg ttcctgcagt tttatgagca aacagcccga gttgtgttga acgagctcat
      181 ggaggccact tggaactatg tcaccaatat caccaagcaa aatcaagaga acatgctgca
      241 gaaggaggtg gagaggtccc agttcatgtt gtactttggc acccgggccc gcatgtttag
      301 gatagaccat ttccaggacc tggacgtgaa gcgcaggctg agtaagctgc ggaacataga
      361 caagtcggcc ttgcccgtgg aggatttcca ggagttcaac agacttctta cctacatgaa
      421 gacagcatac ggtagagctg aggtgtgcct ggatgagggt ccatgcatgc ccctggaacc
      481 tgacctcgaa gaaatcatgg ccacctccag ggaccagaag gagctgctgt gggcctggca
      541 gggctggcgg gatgccattg gtcggcaact ccgccctgtc tttgaggact acgtacatct
      601 cagcaacaag gctgcgcagt ataatgggta caaagacatg ggggctttat ggcgatccaa
      661 gtatgagtct gataccctgg aggaagacct ggaacagctc tataaggagc tgcagccgct
      721 ctacctgaac cttcacgcct acgtgcgccg ctcactgtac cgctattacg ggcctgagct
      781 cattgacctg cgggggccca tccctgctca cctcctgggg aacatgtggg ctcagtcctg
      841 gaacaatatc ctagatctgg tcctgcccta tccaaataaa cctcctgagg atatcacaaa
      901 gatcatgaag aatcagcact ggaggcctga aaagatgttc gaagaggcta atttattctt
      961 tacctccatg ggaatgctgc ccgccccacc tgctttctgg atgaaatcta tgatggagaa
     1021 gccagttgac gggcgggaag tggagtgcca cacctcatcc tggaacttct ataggctcaa
     1081 tgacttcagg gtaaagaagt gcaccgaggt gaccatagga gacctgctct ccatcttcca
     1141 ccagatgggc cacatccagt actacttgca gtgccagaac ctctctataa tctaccaaga
     1201 aggcgccagc ccagccttcg aagaggccgt ggggtcaacc atcaccctct cagccttctc
     1261 ccacaagtac ctgctcacca gaggtctgct cagccaacag caccaggatt cagaggagga
     1321 ggtcaacttc ctgttgagca tcgccctgga gaagatcgcc ttcatcccct tcggctacat
     1381 gattgacctg tttcgttgga aggtctttga cggcactatt cagaagaacg cctacaacca
     1441 ggagtggtgg agcctcaggt tgaagtacca aggcctgtgc ccgcctgtcc cccggtcgga
     1501 agatgatttt gacccaggtg ccaagttcca catccctgcc aatatgccct acatccggta
     1561 cttcctcagc ctggtgctgc agttccaact ccatgaagta ctgtgcaggg cctcaggcca
     1621 cgtgggtcct ctgcaccggt gcgatatcta taactccaag gtcgcaggga agattctggg
     1681 ggatttcctg aaggtgggct ccagccggcc ctggcaggag gtcctaaagg agataactgg
     1741 aaagcccaac atatccacca aggccctctt gacctacttc aagccgctgc tgaactggct
     1801 ggtgactgaa aacgtgaagc aaggggacat ccttggctgg ccagacttca gctgctcttt
     1861 tgaagaaaaa atcacaaaga aaatgtcatt tctgggtatg aagatagagc ctgaccaggc
     1921 atacctgggg cagtgggtgt tgctaagcat gagttttatc atgctctgcc tcatcctggc
     1981 actgggcctc aggttgcact acttggaaag acggtcactg gacagcgaca ctgtgatact
     2041 tagcaccccg ccctatgcct acttcctggg catagcgatg gaaccccgcc aggcggcccg
     2101 aaaacagtgg ctcctactgg gcctctgctt cgtccttatg ctgtgctgta ttggcctcct
     2161 cattaagata ttcatacacc acaccaggaa gcctccatgg atgaaagctg aatggcagag
     2221 ctgagaggag ccaccatgca gactggagac cgcccttggc agccctctca tctctcagcc
     2281 actgtggccg aggtccccca ccaggtattg tgactctgcg tggcaagggc acatccagcc
     2341 caggactcca agcctctcac caggactaca gcagaagctt cactgagtct ccttggccac
     2401 ctcccttccc cctgcccccg cacttccccg gttcactttg taaagtttat atttctgcca
     2461 gagtattttc ttcaaaatgc cttcaaattt cctcccgaac atcaaacttc ttaagaactc
     2521 cactgtccat cgattaaatc tggaccttta tctagaaaaa aaaaaaaaaa aaaaaaaaaa
     2581 aaa
//
