LOCUS       NM_001012006            3268 bp    mRNA    linear   ROD 24-SEP-2024
DEFINITION  Rattus norvegicus angiotensin converting enzyme 2 (Ace2), mRNA.
ACCESSION   NM_001012006 XM_228924
VERSION     NM_001012006.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3268)
  AUTHORS   Tiwari,P., Mueed,S., Abdulkareem,A.O. and Hanif,K.
  TITLE     Activation of angiotensin converting enzyme 2 promotes hippocampal
            neurogenesis via activation of Wnt/beta-catenin signaling in
            hypertension
  JOURNAL   Mol Cell Neurosci 130, 103953 (2024)
   PUBMED   39013481
  REMARK    GeneRIF: Activation of angiotensin converting enzyme 2 promotes
            hippocampal neurogenesis via activation of Wnt/beta-catenin
            signaling in hypertension.
REFERENCE   2  (bases 1 to 3268)
  AUTHORS   Mendiola-Salazar,X.A., Munguia-Laguna,M.A., Franco,M.,
            Cano-Martinez,A., Santamaria Sosa,J. and Bautista-Perez,R.
  TITLE     SARS-CoV-2 Spike Protein Enhances Carboxypeptidase Activity of
            Angiotensin-Converting Enzyme 2
  JOURNAL   Int J Mol Sci 25 (11), 6276 (2024)
   PUBMED   38892464
  REMARK    GeneRIF: SARS-CoV-2 Spike Protein Enhances Carboxypeptidase
            Activity of Angiotensin-Converting Enzyme 2.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3268)
  AUTHORS   Guo,Z., Niu,Q., Mi,X., Yang,B., Cai,M. and Liang,Y.
  TITLE     Sirt1 activation prevents high glucose-induced angiotensin
            converting enzyme 2 downregulation in renal tubular cells by
            regulating the TIMP3/ADAM17 pathway
  JOURNAL   Mol Biol Rep 51 (1), 81 (2024)
   PUBMED   38183511
  REMARK    GeneRIF: Sirt1 activation prevents high glucose-induced angiotensin
            converting enzyme 2 downregulation in renal tubular cells by
            regulating the TIMP3/ADAM17 pathway.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3268)
  AUTHORS   Mei,X., Mell,B., Aryal,S., Manandhar,I., Tummala,R., Zubcevic,J.,
            Lai,K., Yang,T., Li,Q., Yeoh,B.S. and Joe,B.
  TITLE     Genetically engineered Lactobacillus paracasei rescues colonic
            angiotensin converting enzyme 2 (ACE2) and attenuates hypertension
            in female Ace2 knock out rats
  JOURNAL   Pharmacol Res 196, 106920 (2023)
   PUBMED   37716548
  REMARK    GeneRIF: Genetically engineered Lactobacillus paracasei rescues
            colonic angiotensin converting enzyme 2 (ACE2) and attenuates
            hypertension in female Ace2 knock out rats.
REFERENCE   5  (bases 1 to 3268)
  AUTHORS   Gong,J., Lu,Z., Li,R., Xu,C. and Jin,X.
  TITLE     ACE2 inhibits proliferation of smooth muscle cell through AT1R and
            its downstream signaling pathway
  JOURNAL   J Biosci 48 (2023)
   PUBMED   37539550
  REMARK    GeneRIF: ACE2 inhibits proliferation of smooth muscle cell through
            AT1R and its downstream signaling pathway.
REFERENCE   6  (bases 1 to 3268)
  AUTHORS   Tikellis,C., Johnston,C.I., Forbes,J.M., Burns,W.C., Burrell,L.M.,
            Risvanis,J. and Cooper,M.E.
  TITLE     Characterization of renal angiotensin-converting enzyme 2 in
            diabetic nephropathy
  JOURNAL   Hypertension 41 (3), 392-397 (2003)
   PUBMED   12623933
REFERENCE   7  (bases 1 to 3268)
  AUTHORS   Crackower,M.A., Sarao,R., Oudit,G.Y., Yagil,C., Kozieradzki,I.,
            Scanga,S.E., Oliveira-dos-Santos,A.J., da Costa,J., Zhang,L.,
            Pei,Y., Scholey,J., Ferrario,C.M., Manoukian,A.S., Chappell,M.C.,
            Backx,P.H., Yagil,Y. and Penninger,J.M.
  TITLE     Angiotensin-converting enzyme 2 is an essential regulator of heart
            function
  JOURNAL   Nature 417 (6891), 822-828 (2002)
   PUBMED   12075344
  REMARK    GeneRIF: Angiotensin-converting enzyme 2 (Ace2)is an essential
            regulator of heart function.
REFERENCE   8  (bases 1 to 3268)
  AUTHORS   Vickers,C., Hales,P., Kaushik,V., Dick,L., Gavin,J., Tang,J.,
            Godbout,K., Parsons,T., Baronas,E., Hsieh,F., Acton,S., Patane,M.,
            Nichols,A. and Tummino,P.
  TITLE     Hydrolysis of biological peptides by human angiotensin-converting
            enzyme-related carboxypeptidase
  JOURNAL   J Biol Chem 277 (17), 14838-14843 (2002)
   PUBMED   11815627
REFERENCE   9  (bases 1 to 3268)
  AUTHORS   Tipnis,S.R., Hooper,N.M., Hyde,R., Karran,E., Christie,G. and
            Turner,A.J.
  TITLE     A human homolog of angiotensin-converting enzyme. Cloning and
            functional expression as a captopril-insensitive carboxypeptidase
  JOURNAL   J Biol Chem 275 (43), 33238-33243 (2000)
   PUBMED   10924499
REFERENCE   10 (bases 1 to 3268)
  AUTHORS   Donoghue,M., Hsieh,F., Baronas,E., Godbout,K., Gosselin,M.,
            Stagliano,N., Donovan,M., Woolf,B., Robison,K., Jeyaseelan,R.,
            Breitbart,R.E. and Acton,S.
  TITLE     A novel angiotensin-converting enzyme-related carboxypeptidase
            (ACE2) converts angiotensin I to angiotensin 1-9
  JOURNAL   Circ Res 87 (5), E1-E9 (2000)
   PUBMED   10969042
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000021.1.
            
            On Mar 9, 2021 this sequence version replaced NM_001012006.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: GQ262788.1, AY881244.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760393,
                                           SAMEA5760400 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-233               JAXUCZ010000021.1  33971364-33971596   c
            234-392             JAXUCZ010000021.1  33959904-33960062   c
            393-486             JAXUCZ010000021.1  33956812-33956905   c
            487-630             JAXUCZ010000021.1  33955435-33955578   c
            631-743             JAXUCZ010000021.1  33954114-33954226   c
            744-849             JAXUCZ010000021.1  33952535-33952640   c
            850-947             JAXUCZ010000021.1  33951738-33951835   c
            948-1117            JAXUCZ010000021.1  33948036-33948205   c
            1118-1344           JAXUCZ010000021.1  33945263-33945489   c
            1345-1489           JAXUCZ010000021.1  33942494-33942638   c
            1490-1588           JAXUCZ010000021.1  33940946-33941044   c
            1589-1711           JAXUCZ010000021.1  33939707-33939829   c
            1712-1884           JAXUCZ010000021.1  33939126-33939298   c
            1885-1943           JAXUCZ010000021.1  33937500-33937558   c
            1944-2044           JAXUCZ010000021.1  33934332-33934432   c
            2045-2161           JAXUCZ010000021.1  33931297-33931413   c
            2162-2356           JAXUCZ010000021.1  33928219-33928413   c
            2357-3268           JAXUCZ010000021.1  33925458-33926369   c
FEATURES             Location/Qualifiers
     source          1..3268
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="X"
                     /map="Xq14"
     gene            1..3268
                     /gene="Ace2"
                     /note="angiotensin converting enzyme 2"
                     /db_xref="GeneID:302668"
                     /db_xref="RGD:728890"
     exon            1..233
                     /gene="Ace2"
                     /inference="alignment:Splign:2.1.0"
     CDS             48..2465
                     /gene="Ace2"
                     /EC_number="3.4.17.23"
                     /note="renal angiotensin-converting enzyme 2;
                     anigotensin-converting enzyme-related carboxypeptidase;
                     ACE-related carboxypeptidase; angiotensin I converting
                     enzyme (peptidyl-dipeptidase A) 2; angiotensin I
                     converting enzyme 2"
                     /codon_start=1
                     /product="angiotensin-converting enzyme 2 precursor"
                     /protein_id="NP_001012006.1"
                     /db_xref="GeneID:302668"
                     /db_xref="RGD:728890"
                     /translation="MSSSCWLLLSLVAVATAQSLIEEKAESFLNKFNQEAEDLSYQSS
                     LASWNYNTNITEENAQKMNEAAAKWSAFYEEQSKIAQNFSLQEIQNATIKRQLKALQQ
                     SGSSALSPDKNKQLNTILNTMSTIYSTGKVCNSMNPQECFLLEPGLDEIMATSTDYNR
                     RLWAWEGWRAEVGKQLRPLYEEYVVLKNEMARANNYEDYGDYWRGDYEAEGVEGYNYN
                     RNQLIEDVENTFKEIKPLYEQLHAYVRTKLMEVYPSYISPTGCLPAHLLGDMWGRFWT
                     NLYPLTTPFLQKPNIDVTDAMVNQSWDAERIFKEAEKFFVSVGLPQMTPGFWTNSMLT
                     EPGDDRKVVCHPTAWDLGHGDFRIKMCTKVTMDNFLTAHHEMGHIQYDMAYAKQPFLL
                     RNGANEGFHEAVGEIMSLSAATPKHLKSIGLLPSNFQEDNETEINFLLKQALTIVGTL
                     PFTYMLEKWRWMVFQDKIPREQWTKKWWEMKREIVGVVEPLPHDETYCDPASLFHVSN
                     DYSFIRYYTRTIYQFQFQEALCQAAKHDGPLHKCDISNSTEAGQKLLNMLSLGNSGPW
                     TLALENVVGSRNMDVKPLLNYFQPLFVWLKEQNRNSTVGWSTDWSPYADQSIKVRISL
                     KSALGKNAYEWTDNEMYLFRSSVAYAMREYFSREKNQTVPFGEADVWVSDLKPRVSFN
                     FFVTSPKNVSDIIPRSEVEEAIRMSRGRINDIFGLNDNSLEFLGIYPTLKPPYEPPVT
                     IWLIIFGVVMGTVVVGIVILIVTGIKGRKKKNETKREENPYDSMDIGKGESNAGFQNS
                     DDAQTSF"
     exon            234..392
                     /gene="Ace2"
                     /inference="alignment:Splign:2.1.0"
     exon            393..486
                     /gene="Ace2"
                     /inference="alignment:Splign:2.1.0"
     exon            487..630
                     /gene="Ace2"
                     /inference="alignment:Splign:2.1.0"
     exon            631..743
                     /gene="Ace2"
                     /inference="alignment:Splign:2.1.0"
     exon            744..849
                     /gene="Ace2"
                     /inference="alignment:Splign:2.1.0"
     exon            850..947
                     /gene="Ace2"
                     /inference="alignment:Splign:2.1.0"
     exon            948..1117
                     /gene="Ace2"
                     /inference="alignment:Splign:2.1.0"
     exon            1118..1344
                     /gene="Ace2"
                     /inference="alignment:Splign:2.1.0"
     exon            1345..1489
                     /gene="Ace2"
                     /inference="alignment:Splign:2.1.0"
     exon            1490..1588
                     /gene="Ace2"
                     /inference="alignment:Splign:2.1.0"
     exon            1589..1711
                     /gene="Ace2"
                     /inference="alignment:Splign:2.1.0"
     exon            1712..1884
                     /gene="Ace2"
                     /inference="alignment:Splign:2.1.0"
     exon            1885..1943
                     /gene="Ace2"
                     /inference="alignment:Splign:2.1.0"
     exon            1944..2044
                     /gene="Ace2"
                     /inference="alignment:Splign:2.1.0"
     exon            2045..2161
                     /gene="Ace2"
                     /inference="alignment:Splign:2.1.0"
     exon            2162..2356
                     /gene="Ace2"
                     /inference="alignment:Splign:2.1.0"
     exon            2357..3268
                     /gene="Ace2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tctagggaaa gttgctcagt ggatgggatc ttggcgcacg gggaaagatg tcaagctcct
       61 gctggctcct tctcagcctt gttgctgttg ctactgctca gtccctcatc gaggaaaagg
      121 ccgagagctt tttaaacaag tttaaccagg aagctgaaga cctgtcttat caaagttcac
      181 ttgcttcttg gaattacaac accaacatta cggaggagaa tgcccaaaag atgaacgagg
      241 ctgcggccaa atggtctgcc ttttatgaag aacagtccaa gatcgcccaa aatttctcac
      301 tacaagaaat tcagaatgcg accatcaagc gtcaactgaa ggcccttcag cagagcgggt
      361 cttcagcgct gtcaccagac aagaacaaac agttgaacac aattctaaac accatgagca
      421 ccatttacag tactggaaaa gtttgcaact caatgaatcc acaagaatgt tttttacttg
      481 aaccaggatt ggacgaaata atggcaacaa gcacagacta caatcgtagg ctctgggctt
      541 gggagggctg gagggctgag gtcggcaagc agctgaggcc gttatatgaa gagtatgtgg
      601 tcctgaaaaa tgagatggca agagcaaaca attatgaaga ctatggggat tattggcgag
      661 gggattatga agcagaggga gtagaaggtt acaactacaa ccgaaaccag ttgatcgaag
      721 acgtagaaaa taccttcaaa gagatcaaac cgttgtatga gcaacttcat gcctatgtga
      781 gaacgaagtt gatggaagtg tacccttctt acatcagccc tactggatgc ctccctgctc
      841 atttgcttgg tgatatgtgg ggtaggtttt ggacaaatct gtaccctttg actactccct
      901 ttcttcagaa accaaacata gatgttactg atgcaatggt gaatcagagc tgggatgcag
      961 aaagaatatt taaagaggca gagaagttct tcgtttctgt tggccttcct caaatgactc
     1021 cgggattctg gacaaactcc atgctgactg agccaggaga tgaccggaaa gttgtctgcc
     1081 accccacagc ttgggatctg ggacatggag acttcagaat caagatgtgc acaaaggtca
     1141 caatggacaa cttcttgaca gcccatcatg agatgggaca catccaatat gacatggcat
     1201 atgccaagca acctttcctg ctaagaaacg gagccaatga agggttccat gaagccgttg
     1261 gagaaatcat gtcactttct gcagctaccc ccaaacattt gaaatctatt ggtcttctgc
     1321 catccaattt tcaagaagac aatgaaacag aaataaactt cctactcaaa caggcattga
     1381 caattgttgg aacgctgcca tttacttaca tgttagagaa gtggaggtgg atggtctttc
     1441 aggataaaat tcccagagaa cagtggacca aaaagtggtg ggagatgaag cgggagatcg
     1501 ttggtgtggt ggagcctctg cctcatgatg aaacatactg tgaccctgca tctctgttcc
     1561 atgtctctaa tgattactca ttcattcgat attacacaag gaccatttat caattccagt
     1621 ttcaagaagc tctttgtcaa gcagctaaac atgatggccc actacacaaa tgtgacatct
     1681 caaattccac tgaagctggg cagaagttgc tcaatatgct gagtcttgga aactcagggc
     1741 cctggaccct agccttggaa aatgtggtag gatcaaggaa tatggatgta aaaccactgc
     1801 tcaattactt ccaaccattg tttgtctggc tgaaagagca gaacaggaat tcgactgtgg
     1861 ggtggagcac tgactggagc ccatatgccg accaaagcat taaagtgagg ataagcctaa
     1921 aatcagctct tgggaaaaat gcgtatgaat ggaccgacaa cgaaatgtac ctattccgat
     1981 catctgttgc ctatgccatg agagagtatt tttcaaggga aaagaaccag acagttcctt
     2041 ttggggaggc agacgtatgg gtgagtgatt tgaaaccaag agtctccttc aacttctttg
     2101 tcacttcacc caaaaatgtg tctgacatca ttcccagaag tgaagttgaa gaggccatca
     2161 ggatgtctcg gggccgtatc aatgatattt ttggtctgaa tgataacagc ctggagtttc
     2221 tggggatcta cccaacactt aagccacctt acgagcctcc tgtcaccata tggctgatta
     2281 tttttggtgt cgtgatggga acggtagtgg ttggcattgt tatcctgatc gtcactggga
     2341 tcaaaggtcg aaagaagaaa aatgaaacaa aaagagaaga gaatccttat gactccatgg
     2401 acattggcaa aggagaaagt aacgcaggat tccaaaacag tgatgatgct caaacttcat
     2461 tctagaaaag cactcgtcat tttactgtat gcaaatgcta acttcatagt acccaaaata
     2521 tgagattata tccatgtcct tagccatcaa aactatgatc tgttcagtaa agttgtccaa
     2581 agagcatcag acttgagtgg acatcttcac tgacattgct ttcagtattt atttctacct
     2641 taggacttga catctcttct gtttattaat agggatgttt atcttagagt aaaagaggga
     2701 aatgtgcctt tggcctcaca gtccgtccag ggagatactg tcaggcaact ggatttagaa
     2761 gatgaaatga tgtatcttgg gaggaggtgt tggcatctgg cgtgtgaact ggtgggactg
     2821 ctgaggttga gaatggtgct cgctgttcac ttgactccaa gtgtgacatc acgctctgtg
     2881 gcttctgcat taattcactt caaatactgt aggaatctgt agacagttat acttgaaatg
     2941 gactgtccct tctttggagg tacagcttca aaggagaaag aagtcggaca tcaggtagat
     3001 aacatgacct ttttctcttt caaactgctt gaacaacatc tctctaacag gacacagcta
     3061 gcacaggaaa ctccatgaac ccagagcatg cctgacagaa acttgcttcc attattctct
     3121 cactgtggag taagggaaaa ttccagctga atgctcaccc tgtgaaatgg gagcccagtc
     3181 tctgaaattg tttgtttctc tcacagggtc tgaggcaatg gtgaacacaa agcagacctc
     3241 aataaatact tattagattt gtactctc
//
