LOCUS       NM_012544               4142 bp    mRNA    linear   ROD 02-APR-2024
DEFINITION  Rattus norvegicus angiotensin I converting enzyme (Ace), mRNA.
ACCESSION   NM_012544
VERSION     NM_012544.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4142)
  AUTHORS   Ferreira-Duarte,M., Oliveira,L.C.G., Quintas,C.,
            Esteves-Monteiro,M., Duarte-Araujo,M., Sousa,T., Casarini,D.E. and
            Morato,M.
  TITLE     ACE and ACE2 catalytic activity in the fecal content along the gut
  JOURNAL   Neurogastroenterol Motil 35 (9), e14598 (2023)
   PUBMED   37052403
  REMARK    GeneRIF: ACE and ACE2 catalytic activity in the fecal content along
            the gut.
REFERENCE   2  (bases 1 to 4142)
  AUTHORS   Lin,Y., Li,Y.Q., Wang,H., Wu,H.J., Bai,B.L., Ma,L.J., Zou,J.Z.,
            Zhang,Q. and Shi,L.
  TITLE     Increasing angiotensin-converting enzyme 1 regulated by histone 3
            lysine 27 hyperacetylation in high-fat diet-induced hypertensive
            rat kidney
  JOURNAL   J Hypertens 40 (10), 1969-1978 (2022)
   PUBMED   35969203
  REMARK    GeneRIF: Increasing angiotensin-converting enzyme 1 regulated by
            histone 3 lysine 27 hyperacetylation in high-fat diet-induced
            hypertensive rat kidney.
REFERENCE   3  (bases 1 to 4142)
  AUTHORS   Saadat,M.
  TITLE     No significant correlation between ACE Ins/Del genetic polymorphism
            and COVID-19 infection
  JOURNAL   Clin Chem Lab Med 58 (7), 1127-1128 (2020)
   PUBMED   32386188
REFERENCE   4  (bases 1 to 4142)
  AUTHORS   Delanghe,J.R., Speeckaert,M.M. and De Buyzere,M.L.
  TITLE     COVID-19 infections are also affected by human ACE1 D/I
            polymorphism
  JOURNAL   Clin Chem Lab Med 58 (7), 1125-1126 (2020)
   PUBMED   32286246
REFERENCE   5  (bases 1 to 4142)
  AUTHORS   Shu,Y., Cao,X.Y. and Chen,J.
  TITLE     Preparation and antagonistic effect of ACE inhibitory peptide from
            cashew
  JOURNAL   J Sci Food Agric 99 (15), 6822-6832 (2019)
   PUBMED   31385307
REFERENCE   6  (bases 1 to 4142)
  AUTHORS   Weinreb,R.N., O'Donnell,J.J., Sandman,R., Char,D.H. and Kimura,S.J.
  TITLE     Angiotensin-converting enzyme in sarcoid uveitis
  JOURNAL   Invest Ophthalmol Vis Sci 18 (12), 1285-1287 (1979)
   PUBMED   229083
REFERENCE   7  (bases 1 to 4142)
  AUTHORS   Sedov,V.A.
  TITLE     [To sanitize liv stock raising of helminthiases]
  JOURNAL   Veterinariia (12), 10-12 (1978)
   PUBMED   734899
REFERENCE   8  (bases 1 to 4142)
  AUTHORS   Zderkiewicz,E.
  TITLE     [Autoregulation of cerebral blood flow]
  JOURNAL   Pol Tyg Lek 33 (29), 1157-1159 (1978)
   PUBMED   704419
REFERENCE   9  (bases 1 to 4142)
  AUTHORS   Sancho,J., Re,R., Burton,J., Barger,A.C. and Haber,E.
  TITLE     The role of the renin-angiotensin-aldosterone system in
            cardiovascular homeostasis in normal human subjects
  JOURNAL   Circulation 53 (3), 400-405 (1976)
   PUBMED   174834
REFERENCE   10 (bases 1 to 4142)
  AUTHORS   Silverstein,E., Friedland,J., Lyons,H.A. and Gourin,A.
  TITLE     Elevation of angiotensin-converting enzyme in granulomatous lymph
            nodes and serum in sarcoidosis: clinical and possible pathogenic
            significance
  JOURNAL   Ann N Y Acad Sci 278, 498-513 (1976)
   PUBMED   183595
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from U03734.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U03734.1, BC085760.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..4142
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q32.1"
     gene            1..4142
                     /gene="Ace"
                     /gene_synonym="CD143; Dcp1; StsRR92"
                     /note="angiotensin I converting enzyme"
                     /db_xref="GeneID:24310"
                     /db_xref="RGD:2493"
     exon            1..290
                     /gene="Ace"
                     /gene_synonym="CD143; Dcp1; StsRR92"
                     /inference="alignment:Splign:2.1.0"
     CDS             24..3965
                     /gene="Ace"
                     /gene_synonym="CD143; Dcp1; StsRR92"
                     /EC_number="3.4.15.1"
                     /note="kininase II; angiotensin-converting enzyme;
                     dipeptidyl carboxypeptidase I; angiotensin 1 converting
                     enzyme 1; Dipeptidyl carboxypeptidase 1 (Angiotensin
                     I-converting enzyme); angiotensin I-converting enzyme
                     (Dipeptidyl carboxypeptidase 1); angiotensin I converting
                     enzyme 1; angiotensin I converting enzyme
                     (peptidyl-dipeptidase A) 1; angiotensin-converting
                     enzyme-like"
                     /codon_start=1
                     /product="angiotensin-converting enzyme precursor"
                     /protein_id="NP_036676.1"
                     /db_xref="GeneID:24310"
                     /db_xref="RGD:2493"
                     /translation="MGAASGQRGRWPLSPPLLMLSLLLLLLLPPSPAPALDPGLQPGN
                     FSADEAGAQLFADSYNSSAEVVMFQSTAASWAHDTNITEENARLQEEAALINQEFAEV
                     WGKKAKELYESIWQNFTDQKLRRIIGSVQTLGPANLPLTQRLQYNSLLSNMSRIYSTG
                     KVCFPNKTATCWSLDPELTNILASSRNYAKVLFAWEGWHDAVGIPLKPLYQDFTALSN
                     EAYRQDGFSDTGAYWRSWYESPSFEESLEHLYHQVEPLYLNLHAFVRRALHRRYGDKY
                     INLRGPIPAHLLGDMWAQSWENIYDMVVPFPDKPNLDVTSTMVQKGWNATHMFRVAEE
                     FFTSLGLSPMPPEFWAESMLEKPADGREVVCHASAWDFYNRKDFRIKQCTRVTMDQLS
                     TVHHEMGHVQYYLQYKDLHVSLRRGANPGFHEAIGDVLALSVSTPAHLHKIGLLDRVA
                     NDIESDINYLLKMALEKIAFLPFGYLVDQWRWGVFSGRTPPSRYNYDWWYLRTKYQGI
                     CPPVARNETHFDAGAKFHIPSVTPYIRYFVSFVLQFQFHQALCKEAGHQGPLHQCDIY
                     QSTKAGAKLQQVLQAGCSRPWQEVLKDLVGSDALDASALMEYFQPVSQWLQEQNQRNG
                     EVLGWPEYQWRPPLPDNYPEGIDLETDEAKANRFVEEYDRTAKVLWNEYAEANWHYNT
                     NITIEGSKILLQKNKEVSNHTLKYGTWAKTFDVSNFQNSTIKRIIKKVQNVDRAVLPP
                     NELEEYNQILLDMETTYSVANVCYTNGTCLSLEPDLTNIMATSRKYEELLWVWKSWRD
                     KVGRAILPFFPKYVDFSNKIAKLNGYSDAGDSWRSSYESDDLEQDLEKLYQELQPLYL
                     NLHAYVRRSLHRHYGSEYINLDGPIPAHLLGNMWAQTWSNIYDLVAPFPSAPSIDATE
                     AMIKQGWTPRRIFKEADNFFTSLGLLPVPPEFWNKSMLEKPTDGREVVCHASAWDFYN
                     GKDFRIKQCTSVNMEELVIAHHEMGHIQYFMQYKDLPVTFREGANPGFHEAIGDVLAL
                     SVSTPKHLHSLNLLSSEGSGYEHDINFLMKMALDKIAFIPFSYLIDQWRWRVFDGSIT
                     KENYNQEWWSLRLKYQGLCPPVPRSQGDFDPGSKFHVPANVPYIRYFISFIIQFQFHE
                     ALCRAAGHTGPLYKCDIYQSKEAGKLLADAMKLGYSKQWPEAMKIITGQPNMSASAIM
                     NYFKPLTEWLVTENRRHGETLGWPEYTWTPNTARAEGSLPESSRVNFLGMYLEPQQAR
                     VGQWVLLFLGVALLVATVGLAHRLYNIHNHHSLRRPHRGPQFGSEVELRHS"
     exon            291..458
                     /gene="Ace"
                     /gene_synonym="CD143; Dcp1; StsRR92"
                     /inference="alignment:Splign:2.1.0"
     exon            459..552
                     /gene="Ace"
                     /gene_synonym="CD143; Dcp1; StsRR92"
                     /inference="alignment:Splign:2.1.0"
     exon            553..696
                     /gene="Ace"
                     /gene_synonym="CD143; Dcp1; StsRR92"
                     /inference="alignment:Splign:2.1.0"
     exon            697..888
                     /gene="Ace"
                     /gene_synonym="CD143; Dcp1; StsRR92"
                     /inference="alignment:Splign:2.1.0"
     exon            889..986
                     /gene="Ace"
                     /gene_synonym="CD143; Dcp1; StsRR92"
                     /inference="alignment:Splign:2.1.0"
     exon            987..1159
                     /gene="Ace"
                     /gene_synonym="CD143; Dcp1; StsRR92"
                     /inference="alignment:Splign:2.1.0"
     exon            1160..1383
                     /gene="Ace"
                     /gene_synonym="CD143; Dcp1; StsRR92"
                     /inference="alignment:Splign:2.1.0"
     exon            1384..1528
                     /gene="Ace"
                     /gene_synonym="CD143; Dcp1; StsRR92"
                     /inference="alignment:Splign:2.1.0"
     exon            1529..1627
                     /gene="Ace"
                     /gene_synonym="CD143; Dcp1; StsRR92"
                     /inference="alignment:Splign:2.1.0"
     exon            1628..1750
                     /gene="Ace"
                     /gene_synonym="CD143; Dcp1; StsRR92"
                     /inference="alignment:Splign:2.1.0"
     exon            1751..1962
                     /gene="Ace"
                     /gene_synonym="CD143; Dcp1; StsRR92"
                     /inference="alignment:Splign:2.1.0"
     exon            1963..2099
                     /gene="Ace"
                     /gene_synonym="CD143; Dcp1; StsRR92"
                     /inference="alignment:Splign:2.1.0"
     exon            2100..2258
                     /gene="Ace"
                     /gene_synonym="CD143; Dcp1; StsRR92"
                     /inference="alignment:Splign:2.1.0"
     exon            2259..2346
                     /gene="Ace"
                     /gene_synonym="CD143; Dcp1; StsRR92"
                     /inference="alignment:Splign:2.1.0"
     exon            2347..2490
                     /gene="Ace"
                     /gene_synonym="CD143; Dcp1; StsRR92"
                     /inference="alignment:Splign:2.1.0"
     exon            2491..2682
                     /gene="Ace"
                     /gene_synonym="CD143; Dcp1; StsRR92"
                     /inference="alignment:Splign:2.1.0"
     exon            2683..2780
                     /gene="Ace"
                     /gene_synonym="CD143; Dcp1; StsRR92"
                     /inference="alignment:Splign:2.1.0"
     exon            2781..2953
                     /gene="Ace"
                     /gene_synonym="CD143; Dcp1; StsRR92"
                     /inference="alignment:Splign:2.1.0"
     exon            2954..3177
                     /gene="Ace"
                     /gene_synonym="CD143; Dcp1; StsRR92"
                     /inference="alignment:Splign:2.1.0"
     exon            3178..3322
                     /gene="Ace"
                     /gene_synonym="CD143; Dcp1; StsRR92"
                     /inference="alignment:Splign:2.1.0"
     exon            3323..3421
                     /gene="Ace"
                     /gene_synonym="CD143; Dcp1; StsRR92"
                     /inference="alignment:Splign:2.1.0"
     exon            3422..3544
                     /gene="Ace"
                     /gene_synonym="CD143; Dcp1; StsRR92"
                     /inference="alignment:Splign:2.1.0"
     exon            3545..3732
                     /gene="Ace"
                     /gene_synonym="CD143; Dcp1; StsRR92"
                     /inference="alignment:Splign:2.1.0"
     exon            3733..4142
                     /gene="Ace"
                     /gene_synonym="CD143; Dcp1; StsRR92"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgccgcaccg cgcgcaccgc gccatggggg ccgcgtccgg ccagcggggg cggtggccgt
       61 tgtcaccgcc gctcttgatg ctgtcgctgc tgctgctgct gctgctgccg ccgtcgcccg
      121 ccccggcgct tgaccctgga ttgcagccgg gcaacttttc cgcggacgag gcaggggcgc
      181 agctcttcgc tgacagctat aactcgagtg ccgaggtggt gatgttccag agcaccgcag
      241 ccagctgggc gcacgacacc aacatcacgg aggagaatgc gcggctccag gaggaagcgg
      301 ccctgatcaa ccaggagttt gcagaggtct ggggcaagaa ggccaaggag ctgtatgagt
      361 ccatctggca gaacttcact gaccaaaagc tgcgaaggat catcggatcc gtacagaccc
      421 taggacctgc caacctgccc ctgacccagc ggctgcagta caactctctg ctaagcaaca
      481 tgagcagaat ctactccacc ggcaaggtct gcttccccaa caagactgcc acctgctggt
      541 ccctggaccc agagctcacc aacatcctgg cttcctcacg aaactatgcc aaggtgctgt
      601 ttgcctggga aggctggcat gatgctgtgg gtatcccact gaagcccctc tatcaggact
      661 ttactgccct cagtaatgaa gcctacagac aagatggctt ctcagacaca ggagcctact
      721 ggcgctcctg gtatgagtcc ccctcctttg aagagagttt ggagcatctc taccaccaag
      781 tcgagcccct ctacctgaac ctccatgcct ttgtccgtcg cgcactgcac cgccgctatg
      841 gggacaaata catcaatctc agaggtccta ttcccgctca tctgctggga gacatgtggg
      901 cgcagagctg ggagaacatt tacgacatgg tagtgccttt cccggacaaa cccaacctcg
      961 atgtcaccag tacaatggta cagaagggct ggaatgccac gcacatgttc cgggtcgcag
     1021 aggaattctt tacctcgctg gggctctccc ccatgcctcc agagttctgg gcggagtcga
     1081 tgctggagaa accagctgat ggacgggagg tggtgtgcca tgcctctgcg tgggacttct
     1141 acaacaggaa ggacttcagg attaagcagt gcacgcgggt cacgatggac cagctgtcca
     1201 cagtacacca cgagatgggc cacgtgcagt actatctcca gtacaaggac ctgcacgtct
     1261 ctctgcgtcg aggtgccaac cctggcttcc acgaggccat cggggatgta ctcgctctct
     1321 ctgtctctac cccagcacat ctgcacaaaa ttggcctgct agaccgtgtt gccaatgaca
     1381 tagaaagtga catcaattac ttgctaaaga tggccctaga gaaaattgcc ttcttgccct
     1441 ttggttacct ggtggaccag tggcgctggg gggtcttcag tggacgtacc ccaccctctc
     1501 gctacaacta cgactggtgg tatcttcgaa ccaagtatca ggggatctgc ccaccagttg
     1561 ctcggaatga aacccatttt gacgctgggg ccaagtttca catcccaagc gtgacaccat
     1621 acatcaggta ctttgtgagt ttcgtgctac agttccagtt ccatcaagcg ctgtgcaagg
     1681 aggcaggcca ccagggtcca ctacaccagt gtgacatcta ccagtccacc aaggcagggg
     1741 ccaagctcca acaggtgctg caggctggct gctccaggcc ctggcaggag gtgctgaagg
     1801 acctggtggg ttcagatgcg ctggatgcca gtgcgctaat ggagtacttc caaccagtaa
     1861 gccagtggct gcaggagcag aatcagcgga atggcgaggt cctaggctgg ccggagtatc
     1921 agtggcgtcc accgttacca gacaactatc cagagggaat tgacctagag actgatgaag
     1981 ccaaggctaa caggttcgtg gaggagtatg accggacagc caaggtgttg tggaacgaat
     2041 acgcagaggc caactggcat tataacacca acattaccat agagggcagc aagatcctgc
     2101 ttcagaaaaa caaggaagtg tccaaccata ccttgaaata tggcacctgg gccaagacat
     2161 ttgacgtgag caacttccag aactctacca tcaagcggat cataaagaag gttcagaacg
     2221 tggaccgggc agtgctgcct cccaacgagt tagaagagta caaccagatc ctgctagaca
     2281 tggagacgac ttacagtgta gccaatgttt gctacacaaa tggcacttgt ctgtcactgg
     2341 agcctgatct gacaaatata atggccacgt cccggaaata cgaagaattg ctttgggtgt
     2401 ggaagagctg gcgagacaag gtggggagag ccatccttcc ctttttccca aagtacgtgg
     2461 acttctccaa caagatcgcc aagctcaacg gctactctga tgcaggggat tcctggagat
     2521 cctcatatga gtccgacgac ttggagcaag acctggaaaa actataccag gagctgcagc
     2581 cgctctacct gaacctgcat gcctatgtgc gccgctccct gcaccgccat tatgggtctg
     2641 agtacatcaa cctggatggt cccattcctg ctcacctgct agggaacatg tgggcacaga
     2701 cttggtccaa catctatgac ttggtggcac ccttcccttc cgcccccagt atagatgcca
     2761 cggaggccat gataaagcag ggatggacac ccagaaggat atttaaggaa gctgacaatt
     2821 tttttacctc cctggggctg ttacctgtgc cccctgagtt ctggaacaag tcaatgttag
     2881 agaagccaac cgatgggagg gaggtggtgt gccatgcctc agcctgggac ttctacaacg
     2941 gcaaggactt caggatcaag cagtgtacct ctgtgaacat ggaggaattg gtgatagccc
     3001 accacgaaat gggccacatc cagtatttca tgcagtacaa agacttgcct gtgacctttc
     3061 gggagggcgc caaccccggt tttcatgagg ctattggaga tgttttggct ctgtctgtgt
     3121 ctacacccaa gcatctacac agtctcaacc tgctcagcag tgagggcagt ggctacgagc
     3181 atgacatcaa ctttctaatg aagatggccc ttgacaagat cgccttcatc cccttcagct
     3241 acctcattga ccagtggcgc tggagggtct ttgacggaag catcaccaag gagaactaca
     3301 accaggagtg gtggagtctc agactgaagt accagggtct ctgccctcca gtgcctagat
     3361 cccaaggtga ctttgaccca gggtccaagt tccacgttcc tgcgaatgtg ccatacatca
     3421 ggtactttat cagcttcatc atccagttcc agttccacga ggcactatgt cgcgcagccg
     3481 ggcacaccgg ccccctgtac aagtgtgata tctaccaatc caaggaagca gggaagctgc
     3541 tggcagatgc catgaagttg ggctacagta agcagtggcc agaagccatg aagataatca
     3601 caggccaacc taacatgtca gcctctgcca ttatgaatta cttcaagcca ctgactgaat
     3661 ggctcgtcac agagaacagg agacatggag agacactggg ctggccggag tacacctgga
     3721 caccaaacac ggctcgtgca gaaggctccc tcccagagtc cagtcgcgtc aacttcctgg
     3781 gtatgtacct ggaaccacag caggcccgtg tgggccagtg ggtgctgctc ttcctaggcg
     3841 tcgccctgct ggtggccacc gtgggtctcg cccaccgact ctacaacatc cataaccatc
     3901 acagcctccg ccggccccac cgtgggcccc agtttgggtc cgaggtggag ctcagacact
     3961 cctgaggtga ccctgccgtc aaggccaaca gaggagtgtc ccattaaaaa aaaattagat
     4021 gggggacatg gtgtttgagt ggaacatacc caagctgggc cttcttcctt tgctgttccc
     4081 atccactctg ccccccagcc cagcccccat tctctagata cccagcatct aacctggaat
     4141 tc
//
