LOCUS       NM_001037193            1401 bp    mRNA    linear   ROD 31-MAY-2024
DEFINITION  Rattus norvegicus ACD, shelterin complex subunit and telomerase
            recruitment factor (Acd), mRNA.
ACCESSION   NM_001037193 XM_226409
VERSION     NM_001037193.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1401)
  AUTHORS   Min,S., Kwon,S.M., Hong,J., Lee,Y.K., Park,T.J., Lim,S.B. and
            Yoon,G.
  TITLE     Mitoribosomal Deregulation Drives Senescence via TPP1-Mediated
            Telomere Deprotection
  JOURNAL   Cells 11 (13), 2079 (2022)
   PUBMED   35805162
  REMARK    GeneRIF: Mitoribosomal Deregulation Drives Senescence via
            TPP1-Mediated Telomere Deprotection.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1401)
  AUTHORS   Pandita,R.K., Chow,T.T., Udayakumar,D., Bain,A.L., Cubeddu,L.,
            Hunt,C.R., Shi,W., Horikoshi,N., Zhao,Y., Wright,W.E., Khanna,K.K.,
            Shay,J.W. and Pandita,T.K.
  TITLE     Single-strand DNA-binding protein SSB1 facilitates TERT recruitment
            to telomeres and maintains telomere G-overhangs
  JOURNAL   Cancer Res 75 (5), 858-869 (2015)
   PUBMED   25589350
REFERENCE   3  (bases 1 to 1401)
  AUTHORS   Zemp,I. and Lingner,J.
  TITLE     The shelterin component TPP1 is a binding partner and substrate for
            the deubiquitinating enzyme USP7
  JOURNAL   J Biol Chem 289 (41), 28595-28606 (2014)
   PUBMED   25172512
REFERENCE   4  (bases 1 to 1401)
  AUTHORS   Kappei,D., Butter,F., Benda,C., Scheibe,M., Draskovic,I.,
            Stevense,M., Novo,C.L., Basquin,C., Araki,M., Araki,K.,
            Krastev,D.B., Kittler,R., Jessberger,R., Londono-Vallejo,J.A.,
            Mann,M. and Buchholz,F.
  TITLE     HOT1 is a mammalian direct telomere repeat-binding protein
            contributing to telomerase recruitment
  JOURNAL   EMBO J 32 (12), 1681-1701 (2013)
   PUBMED   23685356
REFERENCE   5  (bases 1 to 1401)
  AUTHORS   Grolimund,L., Aeby,E., Hamelin,R., Armand,F., Chiappe,D.,
            Moniatte,M. and Lingner,J.
  TITLE     A quantitative telomeric chromatin isolation protocol identifies
            different telomeric states
  JOURNAL   Nat Commun 4, 2848 (2013)
   PUBMED   24270157
REFERENCE   6  (bases 1 to 1401)
  AUTHORS   O'Connor,M.S., Safari,A., Xin,H., Liu,D. and Songyang,Z.
  TITLE     A critical role for TPP1 and TIN2 interaction in high-order
            telomeric complex assembly
  JOURNAL   Proc Natl Acad Sci U S A 103 (32), 11874-11879 (2006)
   PUBMED   16880378
REFERENCE   7  (bases 1 to 1401)
  AUTHORS   Keegan,C.E., Hutz,J.E., Else,T., Adamska,M., Shah,S.P., Kent,A.E.,
            Howes,J.M., Beamer,W.G. and Hammer,G.D.
  TITLE     Urogenital and caudal dysgenesis in adrenocortical dysplasia (acd)
            mice is caused by a splicing mutation in a novel telomeric
            regulator
  JOURNAL   Hum Mol Genet 14 (1), 113-123 (2005)
   PUBMED   15537664
REFERENCE   8  (bases 1 to 1401)
  AUTHORS   Liu,D., O'Connor,M.S., Qin,J. and Songyang,Z.
  TITLE     Telosome, a mammalian telomere-associated complex formed by
            multiple telomeric proteins
  JOURNAL   J Biol Chem 279 (49), 51338-51342 (2004)
   PUBMED   15383534
REFERENCE   9  (bases 1 to 1401)
  AUTHORS   Houghtaling,B.R., Cuttonaro,L., Chang,W. and Smith,S.
  TITLE     A dynamic molecular link between the telomere length regulator TRF1
            and the chromosome end protector TRF2
  JOURNAL   Curr Biol 14 (18), 1621-1631 (2004)
   PUBMED   15380063
REFERENCE   10 (bases 1 to 1401)
  AUTHORS   Liu,D., Safari,A., O'Connor,M.S., Chan,D.W., Laegeler,A., Qin,J.
            and Songyang,Z.
  TITLE     PTOP interacts with POT1 and regulates its localization to
            telomeres
  JOURNAL   Nat Cell Biol 6 (7), 673-680 (2004)
   PUBMED   15181449
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC099222.1.
            
            On Nov 18, 2005 this sequence version replaced XM_226409.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC099222.1, SRR8487230.17132.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1401
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="19"
                     /map="19q12"
     gene            1..1401
                     /gene="Acd"
                     /note="ACD, shelterin complex subunit and telomerase
                     recruitment factor"
                     /db_xref="GeneID:307798"
                     /db_xref="RGD:1565053"
     exon            1..134
                     /gene="Acd"
                     /inference="alignment:Splign:2.1.0"
     CDS             36..1289
                     /gene="Acd"
                     /note="adrenocortical dysplasia homolog"
                     /codon_start=1
                     /product="adrenocortical dysplasia protein homolog"
                     /protein_id="NP_001032270.1"
                     /db_xref="GeneID:307798"
                     /db_xref="RGD:1565053"
                     /translation="MSNSGRLVLRPWIRELILGSETLSSPQAGHLLKVLQDSETPGPS
                     SAPDTPDTGAVLLVSDGTHSVRCVVTRNAIDTSDWEEKEFGFRGTEGRLLLLQACGLR
                     IQVAQDYAPAEFYLQVDRFNLLPTEQPRVQVTGCNQDSDVQKKLNKCLEDHLSESASS
                     SAGLTLSQLLDEVKEDGDHRGALVRLAESCLVLQGPFTARPLTHWATSCSQATEEAVF
                     TVPSFLLHISENEEQILSSIDSSQKAQENPASPSLMPQEESGASVSLLSALPTSDPGQ
                     KDNSQPPPTVCSTSPRAQAPSSTPCSSTPSSPLLTCSPSLSPLRHAPTSYQACETRTQ
                     FHKLEFRELQWPIKRRQLLPRTGAQEPHSVWEPPERHRDTSAFQYKYGTPSASLHTQV
                     QTARLSPQLVAWALNIVMESELPQV"
     exon            135..271
                     /gene="Acd"
                     /inference="alignment:Splign:2.1.0"
     exon            272..365
                     /gene="Acd"
                     /inference="alignment:Splign:2.1.0"
     exon            366..442
                     /gene="Acd"
                     /inference="alignment:Splign:2.1.0"
     exon            443..487
                     /gene="Acd"
                     /inference="alignment:Splign:2.1.0"
     exon            488..522
                     /gene="Acd"
                     /inference="alignment:Splign:2.1.0"
     exon            523..674
                     /gene="Acd"
                     /inference="alignment:Splign:2.1.0"
     exon            675..771
                     /gene="Acd"
                     /inference="alignment:Splign:2.1.0"
     exon            772..1130
                     /gene="Acd"
                     /inference="alignment:Splign:2.1.0"
     exon            1131..1222
                     /gene="Acd"
                     /inference="alignment:Splign:2.1.0"
     exon            1223..1377
                     /gene="Acd"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccttcatggg ggtgtcctag ggtgccgtcg tgctaatgtc gaattcaggg aggctggtcc
       61 tgcgtccctg gattcgagag ctgatcctgg gctcagaaac actgtcaagt ccacaagccg
      121 gtcatctgct caaggtactc caggactcgg agactccggg cccatcttcc gcccctgaca
      181 cacctgacac cggggccgtg ttacttgtgt cagatggaac tcatagtgtc cgatgcgtgg
      241 tgacgcgtaa tgccatcgac acctctgact gggaggagaa ggagttcgga ttccgtggga
      301 ccgagggccg gctcctgctg ctgcaggcgt gcgggctccg cattcaggtg gctcaggact
      361 atgcgcctgc ggagttctac ctccaggtgg atcgctttaa cctgctgccc acggagcagc
      421 cccgggtaca ggtgactggt tgcaatcagg attcagatgt gcagaaaaag ctcaataaat
      481 gccttgagga ccacctctct gagtctgctt cttccagtgc aggcttaacc ctgtctcagc
      541 ttctggatga ggtgaaggaa gacggggatc atcggggagc actagtgcgt ctagctgaga
      601 gctgcctagt gctacaaggt cccttcacag caagacccct cacgcactgg gctacctctt
      661 gctcccaggc cacggaagaa gctgtgttca ccgtgcctag tttcctactg cacatctctg
      721 agaatgagga acaaattctg agttctatag actcaagtca gaaggcacag gaaaaccctg
      781 cttctcccag cctcatgcca caggaggaaa gcggtgccag tgttagcctt ctgtcagcct
      841 tgcccacatc agaccccggg cagaaggaca actcccagcc tccgccaact gtttgctcaa
      901 cctccccaag agctcaggcc cccagttcta caccctgcag ttctacaccc agctccccac
      961 tcttgacctg cagccccagt ctctcacccc ttcgacatgc ccctacttca taccaggcct
     1021 gtgagaccag aacccagttt cataagctag agttcaggga gctccagtgg cccatcaaaa
     1081 gacggcagct tctcccaaga accggagccc aggagcccca ctctgtctgg gaacccccag
     1141 agaggcatcg tgatacttct gcattccagt ataaatatgg gacaccctct gcctccctcc
     1201 atacccaggt ccaaactgcc aggctctctc ctcagcttgt agcttgggcc ttgaacatag
     1261 tgatggagtc tgagttacca caggtatgaa gaggatgtat acccatgggc ctaaggacaa
     1321 acagcattcc acgctctgtt tcattcaggt tttttaataa aataatttca tgcggcaaaa
     1381 aaaaaaaaaa aaaaaaaaaa a
//
