LOCUS       NM_001006995            2050 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus acetyl-CoA acetyltransferase 2 (Acat2), mRNA.
ACCESSION   NM_001006995 XM_217796
VERSION     NM_001006995.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2050)
  AUTHORS   Ichigo,Y., Takeshita,A., Hibino,M., Nakagawa,T., Hayakawa,T.,
            Patel,D., Field,C.J. and Shimada,M.
  TITLE     High-Fructose Diet-Induced Hypertriglyceridemia Is Associated With
            Enhanced Hepatic Expression of ACAT2 in Rats
  JOURNAL   Physiol Res 68 (6), 1021-1026 (2019)
   PUBMED   31647302
REFERENCE   2  (bases 1 to 2050)
  AUTHORS   Zhai,S., Zhao,M., Zhou,C., Lu,F., Zhang,H., Na,L., Feng,S.,
            Qiang,X. and Du,Y.
  TITLE     The association and significance of H3K27me3 and a folate metabolic
            gene ACat2 in neural tube defects
  JOURNAL   Nutr J 15 (1), 95 (2016)
   PUBMED   27809850
  REMARK    GeneRIF: The increased H3K27me3 expression might cause a disorder
            of folate metabolic pathway by silencing ACat2 expression, leading
            to reduced proliferation and differentiation of neural stem cells,
            and ultimately the occurrence of neural tube defects.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2050)
  AUTHORS   Cote,I., Chapados,N.A. and Lavoie,J.M.
  TITLE     Impaired VLDL assembly: a novel mechanism contributing to hepatic
            lipid accumulation following ovariectomy and
            high-fat/high-cholesterol diets?
  JOURNAL   Br J Nutr 112 (10), 1592-1600 (2014)
   PUBMED   25263431
REFERENCE   4  (bases 1 to 2050)
  AUTHORS   Morris,A.A.
  TITLE     Cerebral ketone body metabolism
  JOURNAL   J Inherit Metab Dis 28 (2), 109-121 (2005)
   PUBMED   15877199
  REMARK    Review article
REFERENCE   5  (bases 1 to 2050)
  AUTHORS   McCarthy,J.J., Meyer,J., Moliterno,D.J., Newby,L.K., Rogers,W.J.
            and Topol,E.J.
  CONSRTM   GenQuest multicenter study
  TITLE     Evidence for substantial effect modification by gender in a
            large-scale genetic association study of the metabolic syndrome
            among coronary heart disease patients
  JOURNAL   Hum Genet 114 (1), 87-98 (2003)
   PUBMED   14557872
REFERENCE   6  (bases 1 to 2050)
  AUTHORS   Antonenkov,V.D., Croes,K., Waelkens,E., Van Veldhoven,P.P. and
            Mannaerts,G.P.
  TITLE     Identification, purification and characterization of an
            acetoacetyl-CoA thiolase from rat liver peroxisomes
  JOURNAL   Eur J Biochem 267 (10), 2981-2990 (2000)
   PUBMED   10806397
REFERENCE   7  (bases 1 to 2050)
  AUTHORS   Song,X.Q., Fukao,T., Yamaguchi,S., Miyazawa,S., Hashimoto,T. and
            Orii,T.
  TITLE     Molecular cloning and nucleotide sequence of complementary DNA for
            human hepatic cytosolic acetoacetyl-coenzyme A thiolase
  JOURNAL   Biochem Biophys Res Commun 201 (1), 478-485 (1994)
   PUBMED   7911016
REFERENCE   8  (bases 1 to 2050)
  AUTHORS   Middleton,B.
  TITLE     The acetoacetyl-coenzyme A thiolases of rat brain and their
            relative activities during postnatal development
  JOURNAL   Biochem J 132 (4), 731-737 (1973)
   PUBMED   4721608
REFERENCE   9  (bases 1 to 2050)
  AUTHORS   Lockwood,E.A. and Bailey,E.
  TITLE     The course of ketosis and the activity of key enzymes of
            ketogenesis and ketone-body utilization during development of the
            postnatal rat
  JOURNAL   Biochem J 124 (1), 249-254 (1971)
   PUBMED   5166591
REFERENCE   10 (bases 1 to 2050)
  AUTHORS   Page,M.A., Krebs,H.A. and Williamson,D.H.
  TITLE     Activities of enzymes of ketone-body utilization in brain and other
            tissues of suckling rats
  JOURNAL   Biochem J 121 (1), 49-53 (1971)
   PUBMED   5116556
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC083872.1.
            
            On Nov 22, 2004 this sequence version replaced XM_217796.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC083872.1, FQ210374.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2050
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q11"
     gene            1..2050
                     /gene="Acat2"
                     /gene_synonym="Ab2-076; Acat3"
                     /note="acetyl-CoA acetyltransferase 2"
                     /db_xref="GeneID:308100"
                     /db_xref="RGD:1359366"
     exon            1..81
                     /gene="Acat2"
                     /gene_synonym="Ab2-076; Acat3"
                     /inference="alignment:Splign:2.1.0"
     CDS             27..1220
                     /gene="Acat2"
                     /gene_synonym="Ab2-076; Acat3"
                     /EC_number="2.3.1.9"
                     /note="cytosolic acetoacetyl-CoA thiolase; acetyl-Coenzyme
                     A acetyltransferase 2; acetyl-Coenzyme A acetyltransferase
                     3"
                     /codon_start=1
                     /product="acetyl-CoA acetyltransferase, cytosolic"
                     /protein_id="NP_001006996.1"
                     /db_xref="GeneID:308100"
                     /db_xref="RGD:1359366"
                     /translation="MNAGSDPVVIISAARTAIGSFNGALSTVPVHNLGTTVIKEVLQR
                     AKVAPEEVSEVIFGHVLTAGCGQNPTRQASVGAGIPYSVPAWSCQMICGSGLKAVCLA
                     AQSIAMGDSTIVVAGGMENMSKAPHLAHLRSGVKMGEVPLADSILCDGLTDAFHNYHM
                     GITAENVAKKWQVSREAQDKVAVVSQNRAEHAQKAGHFDKEIVPVHVSSRKGLTEVKI
                     DEFPRHGSNLEAMSKLKPYFLTDGTGTVTPANASGMNDGAAAVVLMKKTEAESRMLKP
                     LAQVVSWSQAGVEPSVMGVGPIPAIKQAVAKAGWSLEDVDVFEINEAFAAVSAAIAKE
                     LGLSPEKVNIDGGAIALGHPLGASGCRILVTLLHTLERVGGTRGVAALCIGGGMGIAM
                     CVQRG"
     exon            82..216
                     /gene="Acat2"
                     /gene_synonym="Ab2-076; Acat3"
                     /inference="alignment:Splign:2.1.0"
     exon            217..398
                     /gene="Acat2"
                     /gene_synonym="Ab2-076; Acat3"
                     /inference="alignment:Splign:2.1.0"
     exon            399..516
                     /gene="Acat2"
                     /gene_synonym="Ab2-076; Acat3"
                     /inference="alignment:Splign:2.1.0"
     exon            517..660
                     /gene="Acat2"
                     /gene_synonym="Ab2-076; Acat3"
                     /inference="alignment:Splign:2.1.0"
     exon            661..783
                     /gene="Acat2"
                     /gene_synonym="Ab2-076; Acat3"
                     /inference="alignment:Splign:2.1.0"
     exon            784..938
                     /gene="Acat2"
                     /gene_synonym="Ab2-076; Acat3"
                     /inference="alignment:Splign:2.1.0"
     exon            939..1049
                     /gene="Acat2"
                     /gene_synonym="Ab2-076; Acat3"
                     /inference="alignment:Splign:2.1.0"
     exon            1050..2011
                     /gene="Acat2"
                     /gene_synonym="Ab2-076; Acat3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagctagcag acctcggagc tacaggatga atgcaggctc ggaccccgtc gtcatcatct
       61 cagcggcgcg gaccgccata ggttccttca atggtgccct gtccaccgtg cctgtccaca
      121 acctggggac aactgttatc aaagaagtcc ttcagagagc caaagtggct ccagaagagg
      181 tgtccgaggt catatttgga cacgttttga ctgcaggctg tgggcagaat cctactcgac
      241 aagccagtgt gggtgcgggg atcccctact cggtgccagc atggagctgc cagatgatct
      301 gtggctcggg cctaaaagcc gtgtgccttg cagctcagtc catagccatg ggtgactcca
      361 ccatcgtggt tgctggaggc atggagaaca tgagcaaggc ccctcacttg gctcacctga
      421 gatcaggagt gaagatgggt gaggtgccac tcgccgacag catcctctgt gatggcctca
      481 cagatgcgtt tcacaactac cacatgggca tcacagctga aaacgtagcc aaaaaatggc
      541 aagtgagcag agaggcccag gacaaggttg ctgttgtgtc ccagaatagg gcggagcatg
      601 cgcagaaagc tggccacttt gacaaggaga ttgtgccagt gcacgtgtct tctagaaaag
      661 gtcttactga agtgaaaatc gatgagtttc ctcgtcatgg gagtaacctt gaagccatga
      721 gcaagctgaa gccttacttt cttactgatg ggactggaac ggtcacccca gcgaatgcat
      781 caggaatgaa cgatggtgct gctgctgtgg ttcttatgaa gaagacggaa gctgagagtc
      841 ggatgctgaa acctttagca caagtggtct cctggtcaca agccggtgtg gagccttctg
      901 tcatgggagt aggaccgatt ccagccataa agcaagctgt tgcaaaggca ggctggtccc
      961 tggaggatgt tgacgtgttt gaaatcaatg aagcctttgc agcagtgtct gcagcaatag
     1021 ctaaagaact tggattaagc cccgagaagg tgaacatcga tggaggagcc attgccttgg
     1081 gacatcctct gggagcatct ggctgtagga ttctagtgac cttgttacac accctggaga
     1141 gagtgggtgg gactcgtggt gttgcagccc tgtgcattgg gggtggtatg gggatcgcaa
     1201 tgtgtgttca gagagggtga gccaccaccc ttacagttct cattaaaaca ctaaacagaa
     1261 tgtgagacca gaggaccaac ctgaggacag gaacccaggt cgacagcttg ctgtacttta
     1321 gtgtgagaca cccaaggcta agacgttgag acattgcact tgacactgtt ataaaacagg
     1381 gaaatccagt cagtcatcaa gggctccaga gtgaacgaca gtttcataat ttccatgttt
     1441 attgtctttg ctttctgggt ataattttct ctgatcattg atttgtttgt ttgtttgttt
     1501 ttgagtcagg gtctcaccat atagcctgaa aatcgttttg tagatgagct tggcttcaat
     1561 tcccagagat ccacctttct gtgcctcctg agtacttgaa ttaaagacat gcaccgttat
     1621 gcacggcccc caatatgatc cattcaagga atggggatgt ggcttctggt ttgaacttca
     1681 ggctcttcgc tcaaacaccc ctgcttgctt gttgtcttgt ggtttcccat tgatcaaatc
     1741 aagaccaatc ctgtaatgga aattggattc agtgacctct tctaagctga ggtggtgggg
     1801 taggtattct agctattcta gtcagaagat tggccgttcc aacaagtgtg cctctgggtt
     1861 gttagaaagt gagcagcaag cgccttcagt gcatttattt ctctgcttga ccagacagga
     1921 tggtacttgc ttcaaacgtc taccttgact tccccaaaat gatgaactgt aactggaatt
     1981 gaaagccaaa taaactcttc cctcccttgc aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     2041 aaaaaaaaaa
//
