LOCUS       NM_017075               2186 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus acetyl-CoA acetyltransferase 1 (Acat1), mRNA;
            nuclear gene for mitochondrial product.
ACCESSION   NM_017075
VERSION     NM_017075.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2186)
  AUTHORS   Moslehi,A., Nabavizadeh,F., Zekri,A. and Amiri,F.
  TITLE     Naltrexone changes the expression of lipid metabolism-related
            proteins in the endoplasmic reticulum stress induced hepatic
            steatosis in mice
  JOURNAL   Clin Exp Pharmacol Physiol 44 (2), 207-212 (2017)
   PUBMED   27813192
REFERENCE   2  (bases 1 to 2186)
  AUTHORS   Tian,T., Ni,H. and Sun,B.L.
  TITLE     Neurobehavioral Deficits in a Rat Model of Recurrent Neonatal
            Seizures Are Prevented by a Ketogenic Diet and Correlate with
            Hippocampal Zinc/Lipid Transporter Signals
  JOURNAL   Biol Trace Elem Res 167 (2), 251-258 (2015)
   PUBMED   25778834
  REMARK    GeneRIF: rats treated with KD (EXP2) showed a significant
            down-regulated expression of ZnT-3, MT-3, ApoE, clusterin, and
            ACAT-1 in hippocampus
REFERENCE   3  (bases 1 to 2186)
  AUTHORS   Cho,K.H., Kim,H.J., Kamanna,V.S. and Vaziri,N.D.
  TITLE     Niacin improves renal lipid metabolism and slows progression in
            chronic kidney disease
  JOURNAL   Biochim Biophys Acta 1800 (1), 6-15 (2010)
   PUBMED   19878707
REFERENCE   4  (bases 1 to 2186)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   5  (bases 1 to 2186)
  AUTHORS   Kim,H.J. and Vaziri,N.D.
  TITLE     Sterol regulatory element-binding proteins, liver X receptor, ABCA1
            transporter, CD36, scavenger receptors A1 and B1 in nephrotic
            kidney
  JOURNAL   Am J Nephrol 29 (6), 607-614 (2009)
   PUBMED   19147991
REFERENCE   6  (bases 1 to 2186)
  AUTHORS   Schwerdt,G., Moller,U. and Huth,W.
  TITLE     Identification of the CoA-modified forms of mitochondrial
            acetyl-CoA acetyltransferase and of glutamate dehydrogenase as
            nearest-neighbour proteins
  JOURNAL   Biochem J 280 (Pt 2) (Pt 2), 353-357 (1991)
   PUBMED   1684101
REFERENCE   7  (bases 1 to 2186)
  AUTHORS   Huth,W., Worm-Breitgoff,C., Moller,U. and Wunderlich,I.
  TITLE     Evidence for an in vivo modification of mitochondrial proteins by
            coenzyme A
  JOURNAL   Biochim Biophys Acta 1077 (1), 1-10 (1991)
   PUBMED   1672610
REFERENCE   8  (bases 1 to 2186)
  AUTHORS   Fukao,T., Yamaguchi,S., Kano,M., Orii,T., Fujiki,Y., Osumi,T. and
            Hashimoto,T.
  TITLE     Molecular cloning and sequence of the complementary DNA encoding
            human mitochondrial acetoacetyl-coenzyme A thiolase and study of
            the variant enzymes in cultured fibroblasts from patients with
            3-ketothiolase deficiency
  JOURNAL   J Clin Invest 86 (6), 2086-2092 (1990)
   PUBMED   1979337
REFERENCE   9  (bases 1 to 2186)
  AUTHORS   Sokolov,Iu.N., Kaigorodtseva,R.N. and Rudykh,V.F.
  TITLE     [Various roentgenomorphological parallels in ulcers of the
            pyloro-duodenal area]
  JOURNAL   Vestn Rentgenol Radiol (6), 3-11 (1978)
   PUBMED   734884
REFERENCE   10 (bases 1 to 2186)
  AUTHORS   Bem,Z. and Birecka,A.
  TITLE     [A rare type of bone involvement in scleroderma (author's transl)]
  JOURNAL   Pol Przegl Radiol Med Nukl 42 (2), 115-117 (1978)
   PUBMED   704385
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            FM065829.1, FM071064.1, FM098848.1 and JAXUCZ010000008.1.
            
            On Aug 16, 2012 this sequence version replaced NM_017075.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ217320.1, D13921.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN12840110 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-658               FM065829.1         1-658
            659-827             FM071064.1         447-615
            828-1261            FM098848.1         210-643
            1262-2186           JAXUCZ010000008.1  62876003-62876927   c
FEATURES             Location/Qualifiers
     source          1..2186
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q24"
     gene            1..2186
                     /gene="Acat1"
                     /gene_synonym="RATACAL"
                     /note="acetyl-CoA acetyltransferase 1"
                     /db_xref="GeneID:25014"
                     /db_xref="RGD:2016"
     exon            1..151
                     /gene="Acat1"
                     /gene_synonym="RATACAL"
                     /inference="alignment:Splign:2.1.0"
     CDS             89..1363
                     /gene="Acat1"
                     /gene_synonym="RATACAL"
                     /EC_number="2.3.1.9"
                     /note="acetyl-CoA acetyltransferase, mitochondrial;
                     acetyl-Co A acetyltransferase 1 mitochondrial;
                     acetoacetyl-CoA thiolase; acetyl-coenzyme A
                     acetyltransferase 1"
                     /codon_start=1
                     /product="acetyl-CoA acetyltransferase, mitochondrial
                     precursor"
                     /protein_id="NP_058771.2"
                     /db_xref="GeneID:25014"
                     /db_xref="RGD:2016"
                     /translation="MAALAVLHGVVRRPLLRGLLQEVRCLGRSYASKPTLNDVVIVSA
                     TRTPIGSFLGSLASQPATKLGTIAIQGAIEKAGIPKEEVKEVYMGNVIQGGEGQAPTR
                     QATLGAGLPIATPCTTVNKVCASGMKAIMMASQSLMCGHQDVMVAGGMESMSNVPYVM
                     SRGATPYGGVKLEDLIVKDGLTDVYNKIHMGNCAENTAKKLSISREEQDKYAIGSYTR
                     SKEAWDAGKFANEITPITISVKGKPDVVVKEDEEYKRVDFSKVPKLKTVFQKENGTVT
                     AANASTLNDGAAAVVLMTAEAAQRLKVKPLARIAAFADAAVDPIDFPLAPAYAVPKVL
                     KYAGLKKEDIAMWEVNEAFSVVVLANIKMLEIDPQKVNVHGGAVSLGHPIGMSGARIV
                     VHLAHALKQGEFGLASICNGGGGASAVLIEKL"
     exon            152..199
                     /gene="Acat1"
                     /gene_synonym="RATACAL"
                     /inference="alignment:Splign:2.1.0"
     exon            200..317
                     /gene="Acat1"
                     /gene_synonym="RATACAL"
                     /inference="alignment:Splign:2.1.0"
     exon            318..413
                     /gene="Acat1"
                     /gene_synonym="RATACAL"
                     /inference="alignment:Splign:2.1.0"
     exon            414..514
                     /gene="Acat1"
                     /gene_synonym="RATACAL"
                     /inference="alignment:Splign:2.1.0"
     exon            515..658
                     /gene="Acat1"
                     /gene_synonym="RATACAL"
                     /inference="alignment:Splign:2.1.0"
     exon            659..809
                     /gene="Acat1"
                     /gene_synonym="RATACAL"
                     /inference="alignment:Splign:2.1.0"
     exon            810..905
                     /gene="Acat1"
                     /gene_synonym="RATACAL"
                     /inference="alignment:Splign:2.1.0"
     exon            906..1019
                     /gene="Acat1"
                     /gene_synonym="RATACAL"
                     /inference="alignment:Splign:2.1.0"
     exon            1020..1084
                     /gene="Acat1"
                     /gene_synonym="RATACAL"
                     /inference="alignment:Splign:2.1.0"
     exon            1085..1242
                     /gene="Acat1"
                     /gene_synonym="RATACAL"
                     /inference="alignment:Splign:2.1.0"
     exon            1243..2186
                     /gene="Acat1"
                     /gene_synonym="RATACAL"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cggtgcccgc cacgacgtcg tggggtctgc tgtgggaagt ggaagcagct gcgcgtctct
       61 ctgcccttga caagcttttc cggtctccat ggctgccctg gcggttctac acggcgtcgt
      121 ccgcaggcct ctgctccgcg ggctgctgca ggaagtaaga tgcctgggac gaagttatgc
      181 atccaaaccc actttgaatg atgtggttat agtgagtgct acacgaactc ccattggatc
      241 cttcctgggc agccttgcct ctcagccagc caccaagctt ggtactattg caattcaggg
      301 agccattgaa aaggcaggga ttccaaaaga agaagtgaag gaggtctaca tgggcaacgt
      361 catccaaggg ggagaaggac aggccccgac caggcaagct acactgggtg caggtctacc
      421 cattgccact ccgtgcacca cagtaaacaa ggtgtgtgcc tcaggaatga aagccatcat
      481 gatggcctct caaagtctta tgtgtggaca ccaggatgtg atggtggcag gcggaatgga
      541 gagcatgtca aatgtcccgt acgtaatgag cagaggagca acaccatacg gtggggtaaa
      601 acttgaagac ctgattgtga aagacgggct aaccgatgtc tacaataaaa ttcatatggg
      661 caattgtgct gagaacaccg cgaagaagct gagtatctcg cgggaggagc aggataagta
      721 cgccatcggc tcttacaccc gaagtaaaga ggcgtgggat gcagggaagt ttgcaaatga
      781 gattacgccc atcaccatct cagtgaaagg taaaccagac gtggtggtga aggaagatga
      841 agagtacaag cgagttgact tcagtaaagt gccaaagctc aagacagtgt tccagaaaga
      901 aaacggcaca gtaacagctg ctaacgccag cacactgaac gatggagcag ctgctgtggt
      961 tctcatgact gcagaggcag cccagaggct caaggttaag ccactggcac gaatcgcagc
     1021 atttgctgat gctgctgtag accccattga tttcccactc gcacctgcat atgctgtacc
     1081 taaggttctt aaatatgcag gactgaaaaa agaagacatt gccatgtggg aagtaaatga
     1141 agcattcagt gtggttgtac tagccaacat taaaatgctg gagattgacc ctcaaaaagt
     1201 aaatgtccat ggaggagctg tttctctggg ccatccaatc gggatgtctg gagctcggat
     1261 tgttgttcac ttggctcatg ccttgaagca aggagaattc ggtctggcta gtatttgcaa
     1321 tggaggagga ggggcttccg ccgtgctgat tgagaagctg tagacatctt gttttaggag
     1381 acagttccac gtgacccgct gaagtgaact accccttggg ccagattata ttcaggataa
     1441 gctatttcat tttttattat tttctactaa aaatttttaa aaatcacatc caaaaaccca
     1501 ttgaaattgc aaataaaaat ttctcctcct ttaatatttt ttggtaaaca gtcggatact
     1561 ctactatttg aaatacactg taggtactag aggcatggct cagccgttaa gagcacttgt
     1621 tgctacctgt gtggtgcatg gctttaatcc cagcacttgg agacagaggc aagtgcatct
     1681 ttctgagttt aaagttagcc tggtccacag agctagtgcc ctgacagcca agactacaca
     1741 gagtagtaga aactctgggg ggaaaaaaaa acaaataaaa aaaaaagagc atttgattcc
     1801 aggacccata gagggtgacg tacagcaggg aggacttgca cactgtacta cgaacagaaa
     1861 tcggagaagt gaaataccac gctttcttcc ccctccactt gcaagtaaag gaagccatcc
     1921 tcggagagag tttgaaacag gttctctcct gatgacggca gagtaaaagt tccagcattt
     1981 tatgtgtaaa tacaccaaag atcatcacaa cagcagcaac aaagcctgac tctctcaagc
     2041 ccccaaataa cctaacatcc acggacttct gtctgccacc agagcgcaca ctggatgttt
     2101 atgttctgtt tggttttgaa ctttaatcct tggacagtca aaattggttt caaataaagt
     2161 tatgtgaata gaaatgaaaa tttaaa
//
