LOCUS       NM_001395748            3989 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus ArfGAP with coiled-coil, ankyrin repeat and PH
            domains 3 (Acap3), mRNA.
ACCESSION   NM_001395748 XM_006239577
VERSION     NM_001395748.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3989)
  AUTHORS   Miura,Y. and Kanaho,Y.
  TITLE     ACAP3, the GTPase-activating protein specific to the small GTPase
            Arf6, regulates neuronal migration in the developing cerebral
            cortex
  JOURNAL   Biochem Biophys Res Commun 493 (2), 1089-1094 (2017)
   PUBMED   28919417
REFERENCE   2  (bases 1 to 3989)
  AUTHORS   Miura,Y., Hongu,T., Yamauchi,Y., Funakoshi,Y., Katagiri,N.,
            Ohbayashi,N. and Kanaho,Y.
  TITLE     ACAP3 regulates neurite outgrowth through its GAP activity specific
            to Arf6 in mouse hippocampal neurons
  JOURNAL   Biochem J 473 (17), 2591-2602 (2016)
   PUBMED   27330119
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Aug 5, 2021 this sequence version replaced XM_006239577.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760383,
                              SAMEA5760433 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-201               JAXUCZ010000005.1  171783382-171783582
            202-259             JAXUCZ010000005.1  171787293-171787350
            260-379             JAXUCZ010000005.1  171787755-171787874
            380-433             JAXUCZ010000005.1  171788099-171788152
            434-492             JAXUCZ010000005.1  171789294-171789352
            493-676             JAXUCZ010000005.1  171789830-171790013
            677-721             JAXUCZ010000005.1  171790360-171790404
            722-817             JAXUCZ010000005.1  171790490-171790585
            818-892             JAXUCZ010000005.1  171790688-171790762
            893-904             JAXUCZ010000005.1  171791423-171791434
            905-1017            JAXUCZ010000005.1  171792075-171792187
            1018-1069           JAXUCZ010000005.1  171792281-171792332
            1070-1170           JAXUCZ010000005.1  171792537-171792637
            1171-1282           JAXUCZ010000005.1  171792710-171792821
            1283-1491           JAXUCZ010000005.1  171793061-171793269
            1492-1561           JAXUCZ010000005.1  171793360-171793429
            1562-1656           JAXUCZ010000005.1  171793538-171793632
            1657-1859           JAXUCZ010000005.1  171793709-171793911
            1860-1967           JAXUCZ010000005.1  171794148-171794255
            1968-2066           JAXUCZ010000005.1  171795246-171795344
            2067-2287           JAXUCZ010000005.1  171795431-171795651
            2288-2397           JAXUCZ010000005.1  171795819-171795928
            2398-2508           JAXUCZ010000005.1  171796013-171796123
            2509-3989           JAXUCZ010000005.1  171796229-171797709
FEATURES             Location/Qualifiers
     source          1..3989
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..3989
                     /gene="Acap3"
                     /gene_synonym="Centb5"
                     /note="ArfGAP with coiled-coil, ankyrin repeat and PH
                     domains 3"
                     /db_xref="GeneID:313772"
                     /db_xref="RGD:1310711"
     exon            1..201
                     /gene="Acap3"
                     /gene_synonym="Centb5"
                     /inference="alignment:Splign:2.1.0"
     CDS             155..2656
                     /gene="Acap3"
                     /gene_synonym="Centb5"
                     /note="centaurin, beta 5"
                     /codon_start=1
                     /product="arf-GAP with coiled-coil, ANK repeat and PH
                     domain-containing protein 3"
                     /protein_id="NP_001382677.1"
                     /db_xref="GeneID:313772"
                     /db_xref="RGD:1310711"
                     /translation="MTVEFEECIKDSPRFRATIDEVETDVVEIEAKLDKLVKLCSGMI
                     EAGKAYVTTNRLFVSGVRDLSQQCQGDTVISECLQRFGDSLQEMVNYHTILFDQAQRS
                     VRQQLHNFVKEDVRKFKETKKQFDKVREDMELSLVRNAQAPRHRPHEVEEATGALTLT
                     RKCFRHLALDYVLQINVLQAKKKFEILDSMLSFMHAQYSFFQQGYSLLHQLDPYMKKL
                     AAELDQLVIDSAVEKREMERKHAAIQQRTLLQDFSYDEPKVEFDVDAPSGVVMEGYLF
                     KRASNAFKTWNRRWFSIQNSQLVYQKKLKDALTVVVDDLRLCSVKPCEDIERRFCFEV
                     VSPTKSCMLQADSEKLRQAWVQAVQASIASAYRESPDSCYSERLDRTASPSTSSIDST
                     TDSRERGVKGESVLQRVQSVAGNSQCGDCGQPDPRWASINLGVLLCIECSGIHRSLGV
                     HCSKVRSLTLDSWEPELLKLMCELGNNTMNQIYEAQCEGPGIRKPTASSSRQDKEAWI
                     KDKYVEKKFLRKLTSAPVREPPRRWRAQKCQRPHSSPHAPTTRRKVRLEPVLPSVAAL
                     SSAGTMERKFRRDSLFCPDELDSLFSYFDAGAAGAGPRSLSSDSGLGGSSDGSSDVLA
                     FGTGSVVDSVTEEEGAESEESSSEVDGEAEAWSLADVRELHPGLLAHQAARTRDLPAL
                     AAALAHGAEVNWADTADEGKTPLVQAVLGGSLIVCEFLLQNGADVNQRDSLGRAPLHH
                     ATLLGRTGQVCLFLKRGADQHALDQEQQDPLTIAVQAANADIVTLLRLARMAEEMREA
                     EAPPGQPGPLPGSSPTELQYRRCIQEFIGLHLEES"
     exon            202..259
                     /gene="Acap3"
                     /gene_synonym="Centb5"
                     /inference="alignment:Splign:2.1.0"
     exon            260..379
                     /gene="Acap3"
                     /gene_synonym="Centb5"
                     /inference="alignment:Splign:2.1.0"
     exon            380..433
                     /gene="Acap3"
                     /gene_synonym="Centb5"
                     /inference="alignment:Splign:2.1.0"
     exon            434..492
                     /gene="Acap3"
                     /gene_synonym="Centb5"
                     /inference="alignment:Splign:2.1.0"
     exon            493..676
                     /gene="Acap3"
                     /gene_synonym="Centb5"
                     /inference="alignment:Splign:2.1.0"
     exon            677..721
                     /gene="Acap3"
                     /gene_synonym="Centb5"
                     /inference="alignment:Splign:2.1.0"
     exon            722..817
                     /gene="Acap3"
                     /gene_synonym="Centb5"
                     /inference="alignment:Splign:2.1.0"
     exon            818..892
                     /gene="Acap3"
                     /gene_synonym="Centb5"
                     /inference="alignment:Splign:2.1.0"
     exon            893..904
                     /gene="Acap3"
                     /gene_synonym="Centb5"
                     /inference="alignment:Splign:2.1.0"
     exon            905..1017
                     /gene="Acap3"
                     /gene_synonym="Centb5"
                     /inference="alignment:Splign:2.1.0"
     exon            1018..1069
                     /gene="Acap3"
                     /gene_synonym="Centb5"
                     /inference="alignment:Splign:2.1.0"
     exon            1070..1170
                     /gene="Acap3"
                     /gene_synonym="Centb5"
                     /inference="alignment:Splign:2.1.0"
     exon            1171..1282
                     /gene="Acap3"
                     /gene_synonym="Centb5"
                     /inference="alignment:Splign:2.1.0"
     exon            1283..1491
                     /gene="Acap3"
                     /gene_synonym="Centb5"
                     /inference="alignment:Splign:2.1.0"
     exon            1492..1561
                     /gene="Acap3"
                     /gene_synonym="Centb5"
                     /inference="alignment:Splign:2.1.0"
     exon            1562..1656
                     /gene="Acap3"
                     /gene_synonym="Centb5"
                     /inference="alignment:Splign:2.1.0"
     exon            1657..1859
                     /gene="Acap3"
                     /gene_synonym="Centb5"
                     /inference="alignment:Splign:2.1.0"
     exon            1860..1967
                     /gene="Acap3"
                     /gene_synonym="Centb5"
                     /inference="alignment:Splign:2.1.0"
     exon            1968..2066
                     /gene="Acap3"
                     /gene_synonym="Centb5"
                     /inference="alignment:Splign:2.1.0"
     exon            2067..2287
                     /gene="Acap3"
                     /gene_synonym="Centb5"
                     /inference="alignment:Splign:2.1.0"
     exon            2288..2397
                     /gene="Acap3"
                     /gene_synonym="Centb5"
                     /inference="alignment:Splign:2.1.0"
     exon            2398..2508
                     /gene="Acap3"
                     /gene_synonym="Centb5"
                     /inference="alignment:Splign:2.1.0"
     exon            2509..3989
                     /gene="Acap3"
                     /gene_synonym="Centb5"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggcggggcc gcggcgcgcc ggcctcatac cgaggcgggc aggcgggcgg gcgcggagcg
       61 cagcacagcg cgggcgcgac ggacggtcta ccggccgggg atgccgctcg acgcgccttg
      121 gtcctcggta cagtgagcac cgctcaccgc agccatgacg gtagagttcg aggaatgcat
      181 caaggactcg ccgcgcttca gggcaactat cgatgaggta gaaacagatg tggttgagat
      241 cgaggctaaa ctggacaagc tggtcaaact gtgcagtggc atgatcgaag ctggcaaagc
      301 ctacgttacc accaacaggc tctttgtgag tggtgtccga gacctgtctc agcagtgcca
      361 gggtgacacc gtcatttcgg aatgtctgca gaggtttgga gacagcctac aggagatggt
      421 caactatcac acgatcctgt ttgaccaggc ccagagatcg gtgcggcagc agctccacaa
      481 cttcgtcaaa gaggatgtgc ggaagttcaa agagacaaag aagcagtttg acaaagtgcg
      541 agaggacatg gagctgtcct tggtgaggaa tgcccaagcc ccaaggcacc ggccccatga
      601 agtagaggag gccacaggcg ccctcactct cacccggaag tgctttcgcc acttggccct
      661 ggactatgtg ctgcagatca atgtcctcca ggccaagaag aagtttgaga tcttagattc
      721 tatgctgtcc ttcatgcatg cccagtacag cttcttccag cagggataca gccttctaca
      781 tcagctggac ccctacatga agaagctggc agctgagttg gaccagcttg tgattgactc
      841 tgcagtggaa aaacgtgaga tggagcgcaa gcatgctgcc atccagcaac ggacactcct
      901 gcaggacttt tcctacgatg aaccaaaagt ggagtttgat gtggatgcac caagtggcgt
      961 ggtaatggag ggctatctct ttaagagagc cagcaatgcc ttcaagacct ggaaccgacg
     1021 atggttctcc attcagaaca gccagctggt ctaccagaaa aaactcaagg atgcactgac
     1081 tgtggtggta gatgacctac gcctatgctc tgtgaagcca tgtgaggaca tcgaacggag
     1141 gttctgcttt gaagttgtgt cacctaccaa gagctgtatg ctgcaggctg actcggagaa
     1201 gctgcgacag gcttgggttc aagctgtgca ggctagcatt gcctctgcct accgggagag
     1261 tccagatagc tgctacagtg agaggctgga ccgcacagca tcaccatcaa caagcagcat
     1321 tgattccacc acggactctc gggagcgtgg agtcaagggc gagagcgtgc tgcagcgagt
     1381 gcagagtgtg gctggtaaca gccagtgtgg cgactgtggc cagccagatc cccgctgggc
     1441 cagcatcaac ctgggtgtgc tgctctgtat tgagtgctca ggcatccaca ggagcttggg
     1501 tgtccactgc tctaaggtac gatcgcttac actggattcc tgggagccag agctgctaaa
     1561 gctgatgtgt gagcttggaa ataacaccat gaaccagatc tatgaggccc agtgtgaggg
     1621 cccaggcatt agaaaaccca cagccagtag ttccaggcag gacaaagagg cgtggatcaa
     1681 ggacaaatac gttgaaaaga agttcctccg gaagttgact tctgcaccag tccgggaacc
     1741 cccaagacgc tggagggcac agaagtgcca gcgccctcac agctcccccc acgcccccac
     1801 cacccgccgc aaggtccggc ttgagcccgt cttgccctcc gtcgctgctt tgtcctcagc
     1861 tggcactatg gagcgcaagt tccgccgaga ctccctcttc tgccctgatg agctggactc
     1921 cctcttctcc tattttgatg caggggctgc tggggctggt ccacgcagtc taagcagcga
     1981 cagtggtcta ggaggtagct ctgatggcag ttcggatgtt cttgccttcg ggacaggctc
     2041 tgtggtggac agtgtcaccg aggaagaggg tgctgagtcc gaggagtcca gcagtgaggt
     2101 agatggagaa gcggaggcct ggagcttggc agatgtacgt gagctgcatc ccgggctact
     2161 ggcacatcaa gcagcacgta cccgtgatct gccggcactg gctgcagcac tggcccatgg
     2221 agctgaagtc aactgggctg acacggcaga tgagggcaag acaccactgg tgcaggctgt
     2281 actagggggt tccttgattg tctgtgagtt cctcctgcaa aatggagctg atgtgaacca
     2341 aagagacagc cttggccggg caccattgca ccatgctaca ctcttgggcc gtactggcca
     2401 ggtctgtcta ttcctgaagc ggggggctga ccagcatgcc ctggaccagg agcagcagga
     2461 cccactgacc atcgcagttc aagcagcgaa tgctgacatt gtcacactgc ttcgcctggc
     2521 ccgcatggct gaggagatga gagaagctga ggcaccccct ggtcagccag gccccctgcc
     2581 aggcagcagt cctaccgagc tgcagtaccg caggtgcatc caggagttca ttggcctcca
     2641 cctggaggaa agctaggacc tgacaggccg ggcagctgag ggatcccttt cccgacccca
     2701 gcctacccgg cccagaaatc ttgcatgtcc ctgaagaccc tagccccttc tctagccaca
     2761 gccctgcctg tgacaactgt gggcccatcc cagcagccca gtaccctggt gttcctggag
     2821 tcctcactct cttgcttttc cctccttctg gctgctcgga tgctcagcca gaggacagga
     2881 acccaagcac tacatcttta agacccacat ttgtgggtgc tgcatcgtct ggtgcccctc
     2941 attttacctg ggggaaacct gtcttcaggt ggtccttcct tcagggacct gggctgttca
     3001 tggcacaaac cactcttgag gtccatgtca ccctgtgccc cactgccctc agggcctatt
     3061 tcaacttgtg cccctatgtt tactgcccca aacactggcc tgctagctag gtccttccta
     3121 catactccca gagcccttcc tccagccgag ggctggtggc cggccaccag caccttccct
     3181 ggcaggagtg gcagcccacc cagggaatca ccctgagtac cttgctcagt gaccccagca
     3241 tctgggttgg gctttgatgg tgctgggagg tggagctttg gcccaggtct tccacccagc
     3301 ctggacgctg gcgtcccaaa gcctcgtggc tggccacttg ggaccttgtg cctgagggct
     3361 caaatccatc cctgcctcct ccaggggcac tgtcgggttt acctgggcca gagccagtac
     3421 ctaaagcaac tggtactttc caccctgtgc ccaatgttct ttgttactga gaggattttc
     3481 tacaacaacc tcattctgac tttgtgtgcg tcttttttct gtggacgctc aaggaccatc
     3541 ctgatcccag ctctgcctgc tgctgcggag gcccacgtag atttcctccc tgccctgccc
     3601 ccaagcttca ctccttgggc tgggcctctg ataggtccag tggtcccgta tgtggggggc
     3661 ccaccaatgc cttcaatttc cctttttctg gaggagtccc aggatagagg ctgggcccct
     3721 ctgcatacta tggggtcctt ggtttggtca agggcactca gctggtcact atgcaaacac
     3781 tgccctggaa gcatccatgg acagtgacgt aggcactgga tcagggcctc tgactccctt
     3841 gcttgatggc tgtggcccta aagagcagaa tcagcttttt cctcctgctt gagctctgcc
     3901 caccacctac cctgccactt tttggggtga caggacccca ctccttcctg ctatgatcac
     3961 actcacttaa taaatctctg ccgctcgca
//
