LOCUS       NM_013084               1321 bp    mRNA    linear   ROD 02-APR-2024
DEFINITION  Rattus norvegicus acyl-CoA dehydrogenase, short/branched chain
            (Acadsb), mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_013084
VERSION     NM_013084.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1321)
  AUTHORS   Liu,X., Wu,L., Deng,G., Chen,G., Li,N., Chu,X. and Li,D.
  TITLE     Comparative studies of Acyl-CoA dehydrogenases for monomethyl
            branched chain substrates in amino acid metabolism
  JOURNAL   Bioorg Chem 47, 1-8 (2013)
   PUBMED   23474214
  REMARK    GeneRIF: Short/branched chain acyl-CoA dehydrogenase has its
            catalytic properties relatively similar to those of straight-chain
            acyl-CoA dehydrogenases in terms of their isomerase activity and
            enzyme inhibition.
REFERENCE   2  (bases 1 to 1321)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   3  (bases 1 to 1321)
  AUTHORS   He,M., Burghardt,T.P. and Vockley,J.
  TITLE     A novel approach to the characterization of substrate specificity
            in short/branched chain Acyl-CoA dehydrogenase
  JOURNAL   J Biol Chem 278 (39), 37974-37986 (2003)
   PUBMED   12855692
  REMARK    GeneRIF: Differences between the rat and human enzyme at positions
            383, 222, and 220 alter substrate specificity without affecting
            substrate binding.
REFERENCE   4  (bases 1 to 1321)
  AUTHORS   Pruitt,K.D. and Maglott,D.R.
  TITLE     RefSeq and LocusLink: NCBI gene-centered resources
  JOURNAL   Nucleic Acids Res 29 (1), 137-140 (2001)
   PUBMED   11125071
REFERENCE   5  (bases 1 to 1321)
  AUTHORS   Andresen,B.S., Christensen,E., Corydon,T.J., Bross,P., Pilgaard,B.,
            Wanders,R.J., Ruiter,J.P., Simonsen,H., Winter,V., Knudsen,I.,
            Schroeder,L.D., Gregersen,N. and Skovby,F.
  TITLE     Isolated 2-methylbutyrylglycinuria caused by short/branched-chain
            acyl-CoA dehydrogenase deficiency: identification of a new enzyme
            defect, resolution of its molecular basis, and evidence for
            distinct acyl-CoA dehydrogenases in isoleucine and valine
            metabolism
  JOURNAL   Am J Hum Genet 67 (5), 1095-1103 (2000)
   PUBMED   11013134
REFERENCE   6  (bases 1 to 1321)
  AUTHORS   Gibson,K.M., Burlingame,T.G., Hogema,B., Jakobs,C., Schutgens,R.B.,
            Millington,D., Roe,C.R., Roe,D.S., Sweetman,L., Steiner,R.D.,
            Linck,L., Pohowalla,P., Sacks,M., Kiss,D., Rinaldo,P. and
            Vockley,J.
  TITLE     2-Methylbutyryl-coenzyme A dehydrogenase deficiency: a new inborn
            error of L-isoleucine metabolism
  JOURNAL   Pediatr Res 47 (6), 830-833 (2000)
   PUBMED   10832746
REFERENCE   7  (bases 1 to 1321)
  AUTHORS   Willard,J., Vicanek,C., Battaile,K.P., Van Veldhoven,P.P.,
            Fauq,A.H., Rozen,R. and Vockley,J.
  TITLE     Cloning of a cDNA for short/branched chain acyl-Coenzyme A
            dehydrogenase from rat and characterization of its tissue
            expression and substrate specificity
  JOURNAL   Arch Biochem Biophys 331 (1), 127-133 (1996)
   PUBMED   8660691
REFERENCE   8  (bases 1 to 1321)
  AUTHORS   Williams,D.R., Bellhouse,R. and Davidson,C.L.
  TITLE     The prevalence of Salmonellae in healthy cattle at slaughter
  JOURNAL   Vet Rec 103 (16), 359-360 (1978)
   PUBMED   734879
REFERENCE   9  (bases 1 to 1321)
  AUTHORS   Bode,C., Martini,G.A. and Bode,J.C.
  TITLE     Effect of alcohol on microsomal cortisol 4en-5 alpha-reductase in
            the liver of rats fed on a standard or low protein diet
  JOURNAL   Horm Metab Res 10 (1), 62-64 (1978)
   PUBMED   631739
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from U64451.1.
            
            On Aug 30, 2012 this sequence version replaced NM_013084.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U64451.1, FQ210776.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on conservation,
                                                  expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1321              U64451.1           2-1322
FEATURES             Location/Qualifiers
     source          1..1321
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q41"
     gene            1..1321
                     /gene="Acadsb"
                     /note="acyl-CoA dehydrogenase, short/branched chain"
                     /db_xref="GeneID:25618"
                     /db_xref="RGD:2013"
     exon            1..59
                     /gene="Acadsb"
                     /inference="alignment:Splign:2.1.0"
     CDS             18..1316
                     /gene="Acadsb"
                     /EC_number="1.3.8.5"
                     /note="SBCAD; 2-MEBCAD; 2-methylbutyryl-CoA dehydrogenase;
                     2-methylbutyryl-coenzyme A dehydrogenase; 2-methyl
                     branched chain acyl-CoA dehydrogenase; acyl-Coenzyme A
                     dehydrogenase, short/branched chain; Acyl-Coenzyme A
                     dehydrogenase short-branched chain"
                     /codon_start=1
                     /product="short/branched chain specific acyl-CoA
                     dehydrogenase, mitochondrial"
                     /protein_id="NP_037216.1"
                     /db_xref="GeneID:25618"
                     /db_xref="RGD:2013"
                     /translation="MAVSAFQLWRAGGLLRRNFLTHSSSWKIPPRVLKSSQPEALLSV
                     TNNALCFAPLQTFTDEDIMMQKAVKKFAQEQIAPLVSTMDENSKMEKSVIQGLFQQGM
                     MGIEVEAKYGGTEASFLCSVLVIEELAKVDASVALLCDIQNTVINKLFRKHGTEEQKA
                     TYLPKLVTEKLGSFCLSEAGAGSDSFALKTRADKSGNYYVINGSKMWISNAEHAELFL
                     VFANVDPPSGYRGITCFLVDRDTEGFQIGRRENKMGIRASSTCQLTFENVKVPETSVL
                     GKIGHGYKYAIGSLNEGRIGIAAQMLGLAQGCFDYTIPYIKERMQFGKRIFDFQGLQH
                     QVAHVATQLEAARLLTYNAARLVEAGRPFIKEASMAKYYASEVAGLTTSKCIEWMGGV
                     GYTKDYPVEKFFRDAKIGTIYEGTSNIQLNTIAKHIDAEY"
     exon            60..219
                     /gene="Acadsb"
                     /inference="alignment:Splign:2.1.0"
     exon            220..320
                     /gene="Acadsb"
                     /inference="alignment:Splign:2.1.0"
     exon            321..527
                     /gene="Acadsb"
                     /inference="alignment:Splign:2.1.0"
     exon            528..698
                     /gene="Acadsb"
                     /inference="alignment:Splign:2.1.0"
     exon            699..824
                     /gene="Acadsb"
                     /inference="alignment:Splign:2.1.0"
     exon            825..917
                     /gene="Acadsb"
                     /inference="alignment:Splign:2.1.0"
     exon            918..1007
                     /gene="Acadsb"
                     /inference="alignment:Splign:2.1.0"
     exon            1008..1145
                     /gene="Acadsb"
                     /inference="alignment:Splign:2.1.0"
     exon            1146..1245
                     /gene="Acadsb"
                     /inference="alignment:Splign:2.1.0"
     exon            1246..1321
                     /gene="Acadsb"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctccacccga aaccaggatg gcggtgtctg ccttccagct gtggcgtgcg ggcgggctgc
       61 taagaagaaa cttcctgact cactcgtctt cttggaaaat ccctcctcgt gtcctcaaat
      121 cctcacaacc agaagctcta ctcagtgtaa caaataatgc cctatgtttc gcacctctgc
      181 agacatttac tgatgaggat attatgatgc agaaggcagt caaaaaattt gcacaggaac
      241 aaattgctcc tttggtttca actatggatg aaaattcaaa aatggagaaa tcagtgatac
      301 aaggattatt ccaacaaggg atgatgggca ttgaagttga agcaaaatat ggaggaacag
      361 aagcctcctt cttgtgctct gtcctggtga tagaggaact agctaaggtg gatgcgtccg
      421 tggctctcct atgtgacatc cagaacacag tcattaacaa actgtttagg aagcacggga
      481 cagaagaaca gaaggccacc tatttgccaa agctggttac ggaaaaatta gggagttttt
      541 gcctctctga agctggagct ggtagcgact cttttgcttt gaaaacaaga gctgataaaa
      601 gtggaaatta ctacgtcatc aatggatcga agatgtggat cagcaatgct gaacatgcag
      661 agctcttcct ggtttttgca aatgtggacc ccccctctgg gtacagaggc atcacctgct
      721 tcttagtaga ccgagataca gaaggttttc aaatagggag acgagaaaac aaaatgggga
      781 tcagagcttc ttccacctgt cagttaacat ttgaaaatgt caaggttcca gaaaccagtg
      841 ttttggggaa aattgggcac ggttataaat atgccatagg aagtcttaac gaaggtagaa
      901 ttggaattgc tgcccagatg ctaggactgg cccaaggatg ttttgactac actattccat
      961 acataaaaga aaggatgcag ttcggcaaac gaatatttga ttttcagggg ctccaacacc
     1021 aagtggctca cgtggccacc cagctggaag ctgcgcggtt gctgacgtac aacgctgcta
     1081 ggcttgtaga agccgggagg ccatttataa aagaagcatc tatggccaag tattatgcat
     1141 cagaggtcgc tgggctgaca acaagcaagt gcatcgagtg gatgggaggg gtcggctaca
     1201 ccaaagatta ccctgtggag aaattcttcc gcgatgcgaa gatcggtaca atatatgaag
     1261 gaacttccaa catccagctg aacaccattg caaagcacat cgatgcagag tactgacgtc
     1321 t
//
