LOCUS       NM_022512               1748 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus acyl-CoA dehydrogenase short chain (Acads), mRNA;
            nuclear gene for mitochondrial product.
ACCESSION   NM_022512
VERSION     NM_022512.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1748)
  AUTHORS   Zhong,X., Li,Z., Xu,Q., Peng,H., Su,Y., Le,K., Shu,Z., Liao,Y.,
            Ma,Z., Pan,X., Xu,S. and Zhou,S.
  TITLE     Short-chain acyl-CoA dehydrogenase is a potential target for the
            treatment of vascular remodelling
  JOURNAL   J Hypertens 41 (5), 775-793 (2023)
   PUBMED   36883465
  REMARK    GeneRIF: Short-chain acyl-CoA dehydrogenase is a potential target
            for the treatment of vascular remodelling.
REFERENCE   2  (bases 1 to 1748)
  AUTHORS   Zeng,Z., Huang,Q., Shu,Z., Liu,P., Chen,S., Pan,X., Zang,L. and
            Zhou,S.
  TITLE     Effects of short-chain acyl-CoA dehydrogenase on cardiomyocyte
            apoptosis
  JOURNAL   J Cell Mol Med 20 (7), 1381-1391 (2016)
   PUBMED   26989860
  REMARK    GeneRIF: the role of SCAD in tert-butyl hydroperoxide
            (tBHP)-induced cardiomyocyte apoptosis, is reported.
REFERENCE   3  (bases 1 to 1748)
  AUTHORS   Huang,J., Xu,L., Huang,Q., Luo,J., Liu,P., Chen,S., Yuan,X., Lu,Y.,
            Wang,P. and Zhou,S.
  TITLE     Changes in short-chain acyl-coA dehydrogenase during rat cardiac
            development and stress
  JOURNAL   J Cell Mol Med 19 (7), 1672-1688 (2015)
   PUBMED   25753319
  REMARK    GeneRIF: the down-regulated expression of SCAD in pathological
            cardiac hypertrophy may be responsible for 'the recapitulation of
            foetal energy metabolism'.
REFERENCE   4  (bases 1 to 1748)
  AUTHORS   Huang,Q., Huang,J., Zeng,Z., Luo,J., Liu,P., Chen,S., Liu,B.,
            Pan,X., Zang,L. and Zhou,S.
  TITLE     Effects of ERK1/2/PPARalpha/SCAD signal pathways on cardiomyocyte
            hypertrophy induced by insulin-like growth factor 1 and
            phenylephrine
  JOURNAL   Life Sci 124, 41-49 (2015)
   PUBMED   25636810
  REMARK    GeneRIF: the phosphorylation of ERK1/2 inhibited the expression and
            activity of SCAD through the PPARalpha signaling pathway, which
            induced the development of pathological cardiomyocyte hypertrophy.
REFERENCE   5  (bases 1 to 1748)
  AUTHORS   de Mateo,S., Castillo,J., Estanyol,J.M., Ballesca,J.L. and Oliva,R.
  TITLE     Proteomic characterization of the human sperm nucleus
  JOURNAL   Proteomics 11 (13), 2714-2726 (2011)
   PUBMED   21630459
REFERENCE   6  (bases 1 to 1748)
  AUTHORS   Matsubara,Y., Indo,Y., Naito,E., Ozasa,H., Glassberg,R.,
            Vockley,J., Ikeda,Y., Kraus,J. and Tanaka,K.
  TITLE     Molecular cloning and nucleotide sequence of cDNAs encoding the
            precursors of rat long chain acyl-coenzyme A, short chain
            acyl-coenzyme A, and isovaleryl-coenzyme A dehydrogenases. Sequence
            homology of four enzymes of the acyl-CoA dehydrogenase family
  JOURNAL   J Biol Chem 264 (27), 16321-16331 (1989)
   PUBMED   2777793
REFERENCE   7  (bases 1 to 1748)
  AUTHORS   Finocchiaro,G., Ito,M. and Tanaka,K.
  TITLE     Purification and properties of short chain acyl-CoA, medium chain
            acyl-CoA, and isovaleryl-CoA dehydrogenases from human liver
  JOURNAL   J Biol Chem 262 (17), 7982-7989 (1987)
   PUBMED   3597357
REFERENCE   8  (bases 1 to 1748)
  AUTHORS   Ikeda,Y., Keese,S.M., Fenton,W.A. and Tanaka,K.
  TITLE     Biosynthesis of four rat liver mitochondrial acyl-CoA
            dehydrogenases: in vitro synthesis, import into mitochondria, and
            processing of their precursors in a cell-free system and in
            cultured cells
  JOURNAL   Arch Biochem Biophys 252 (2), 662-674 (1987)
   PUBMED   3813556
REFERENCE   9  (bases 1 to 1748)
  AUTHORS   Coulson,A.
  TITLE     Treatment of metritis in cattle with prostaglandin F2 alpha
  JOURNAL   Vet Rec 103 (16), 359 (1978)
   PUBMED   734878
REFERENCE   10 (bases 1 to 1748)
  AUTHORS   Dabrowski,Z., Gregorczyk,J., Samochowiec,L., Wojcicki,J.,
            Lawczynski,L., Antoszczyk,M., Chrzanowska-Ansilewska,K., Jurek,D.
            and Sych,Z.
  TITLE     [Effect of truncal vagotomy on the exocrine function of the
            pancreas in the dog]
  JOURNAL   Pol Tyg Lek 33 (28), 1093-1095 (1978)
   PUBMED   704405
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from J05030.1.
            
            On Aug 31, 2012 this sequence version replaced NM_022512.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: J05030.1, BC072545.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on conservation,
                                                  expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1748              J05030.1           2-1749
FEATURES             Location/Qualifiers
     source          1..1748
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12q16"
     gene            1..1748
                     /gene="Acads"
                     /gene_synonym="Scad"
                     /note="acyl-CoA dehydrogenase short chain"
                     /db_xref="GeneID:64304"
                     /db_xref="RGD:620514"
     exon            1..78
                     /gene="Acads"
                     /gene_synonym="Scad"
                     /inference="alignment:Splign:2.1.0"
     CDS             27..1271
                     /gene="Acads"
                     /gene_synonym="Scad"
                     /EC_number="1.3.8.1"
                     /note="short-chain specific acyl-CoA dehydrogenase,
                     mitochondrial; butyryl-CoA dehydrogenase; short chain
                     acyl-coenzyme A dehydrogenase; acetyl-Coenzyme A
                     dehydrogenase, short chain; short-chain acyl-CoA
                     dehydrogenase; acyl-Coenzyme A dehydrogenase, short chain;
                     acyl-Coenzyme A dehydrogenase, C-2 to C-3 short chain;
                     acyl-CoA dehydrogenase, C-2 to C-3 short chain"
                     /codon_start=1
                     /product="short-chain specific acyl-CoA dehydrogenase,
                     mitochondrial precursor"
                     /protein_id="NP_071957.1"
                     /db_xref="GeneID:64304"
                     /db_xref="RGD:620514"
                     /translation="MAMAAALLARAGGSLGRALRARDWRRLHTVYQSVELPETHQMLR
                     QTCRDFAEKELVPIAAQLDKEHLFPTSQVKKMGELGLLAMDVPEELSGAGLDYLAYSI
                     ALEEISRGCASTGVIMSVNNSLYLGPILKFGSSQQKQQWITPFTNGDKIGCFALSEPG
                     NGSDAGAASTTAREEGDSWVLNGTKAWITNSWEASATVVFASTDRSRQNKGISAFLVP
                     MPTPGLTLGKKEDKLGIRASSTANLIFEDCRIPKENLLGEPGMGFKIAMQTLDMGRIG
                     IASQALGIAQASLDCAVKYAENRHAFGAPLTKLQNIQFKLADMALALESARLLTWRAA
                     MLKDNKKPFTKESAMAKLAASEAATAISHQAIQILGGMGYVTEMPAERYYRDARITEI
                     YEGTSEIQRLVIAGHLLRSYRS"
     exon            79..242
                     /gene="Acads"
                     /gene_synonym="Scad"
                     /inference="alignment:Splign:2.1.0"
     exon            243..392
                     /gene="Acads"
                     /gene_synonym="Scad"
                     /inference="alignment:Splign:2.1.0"
     exon            393..504
                     /gene="Acads"
                     /gene_synonym="Scad"
                     /inference="alignment:Splign:2.1.0"
     exon            505..656
                     /gene="Acads"
                     /gene_synonym="Scad"
                     /inference="alignment:Splign:2.1.0"
     exon            657..827
                     /gene="Acads"
                     /gene_synonym="Scad"
                     /inference="alignment:Splign:2.1.0"
     exon            828..965
                     /gene="Acads"
                     /gene_synonym="Scad"
                     /inference="alignment:Splign:2.1.0"
     exon            966..1061
                     /gene="Acads"
                     /gene_synonym="Scad"
                     /inference="alignment:Splign:2.1.0"
     exon            1062..1118
                     /gene="Acads"
                     /gene_synonym="Scad"
                     /inference="alignment:Splign:2.1.0"
     exon            1119..1748
                     /gene="Acads"
                     /gene_synonym="Scad"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tcaggaggtc ccggaggtct gtgcccatgg ccatggccgc tgcgttgctc gcccgggccg
       61 gtggctctct cggcagagct ctccgcgctc gagattggcg aagattacat actgtttacc
      121 agtctgtgga actacctgag acacatcaga tgttgcgcca gacatgccgg gactttgctg
      181 agaaggagct ggtccccatc gctgcccagc tggacaagga acatctcttc cccacatcgc
      241 aggtgaagaa gatgggggag ctcgggctgc tggccatgga tgtgccagag gagctgagtg
      301 gtgctggcct ggattacctg gcctactcga tcgccctgga ggagatcagc cgtggctgcg
      361 cctccaccgg agtgatcatg agtgtcaaca actctctcta cttgggaccc atcctgaagt
      421 tcggatcctc acagcagaag cagcagtgga tcaccccttt caccaacggt gacaaaatcg
      481 gctgttttgc cctcagtgag ccaggcaatg gcagtgacgc gggggccgct tccaccactg
      541 cccgggaaga gggtgactcc tgggtcctca acggcaccaa agcctggatc accaactcct
      601 gggaggcttc tgccacggtg gtgtttgcta gcaccgacag gtcccggcag aacaagggta
      661 tcagcgcttt cctggttccc atgccaactc ctgggcttac gctgggcaaa aaggaagaca
      721 agctgggcat ccgggcctca tctacagcta acctcatctt tgaggactgt cgcatcccca
      781 aggagaacct gctcggcgag cctgggatgg gcttcaagat agccatgcaa accctggaca
      841 tgggccgcat tggcatcgcc tcccaggccc tgggtattgc ccaggcctcc ctggattgtg
      901 ccgtgaagta cgccgagaac cgccatgcct ttggggcacc cctcacaaag ctccaaaaca
      961 tccagttcaa gctggcagac atggccctgg ccctggagag tgcccgcctg ctgacctggc
     1021 gcgccgccat gttgaaggac aataagaagc ctttcaccaa ggagtcggcc atggccaagc
     1081 tggctgcatc agaggctgct actgccatta gccaccaggc catccagatc ctgggcggca
     1141 tggggtacgt gacagagatg ccagccgagc gctactaccg agatgcccgc atcactgaga
     1201 tctatgaagg taccagcgaa atccagagac tggtgattgc cgggcatctg ctccggagct
     1261 accggagctg agcccccgcc cttcttggga acttgccagc ctgctcagac catgaaggga
     1321 cctgcctcgg tcagcctttc tgcccctcac tgtagccccc agtcagacta ggggaaagtc
     1381 tgtctcaggg agagggaagg tcaaccgctg tgacctgtca gctcagaatg gggcggcgtg
     1441 gctacctctt taccccccac caacagtgcc tctctctttg agcgacctgc tggaggcagg
     1501 gccacagaga cctgaatgac cctggccctc ccaatgcgga tgccgttccc aagagtcctc
     1561 agaggcaaga acaggagggg cagggcgggg tgaggagggg aaggggatgg cccagtgctt
     1621 gagtccccag ggttgtcgtg ggaaggctgg ggaaccggat catagggccc tggctagagg
     1681 tcaagtggcc gcaggtggtt ctgtggctgt agagctgcct gtggtcaata aagctcacct
     1741 gtgtcctg
//
