LOCUS       NM_012819               1453 bp    mRNA    linear   ROD 17-FEB-2024
DEFINITION  Rattus norvegicus acyl-CoA dehydrogenase, long chain (Acadl), mRNA;
            nuclear gene for mitochondrial product.
ACCESSION   NM_012819
VERSION     NM_012819.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1453)
  AUTHORS   Martin,J., Balmer,M.L., Rajendran,S., Maurhofer,O., Dufour,J.F. and
            St-Pierre,M.V.
  TITLE     Nutritional stress exacerbates hepatic steatosis induced by
            deletion of the histidine nucleotide-binding (Hint2) mitochondrial
            protein
  JOURNAL   Am J Physiol Gastrointest Liver Physiol 310 (7), G497-G509 (2016)
   PUBMED   26767982
REFERENCE   2  (bases 1 to 1453)
  AUTHORS   Exil,V.J., Silva Avila,D., Benedetto,A., Exil,E.A., Adams,M.R.,
            Au,C. and Aschner,M.
  TITLE     Stressed-induced TMEM135 protein is part of a conserved genetic
            network involved in fat storage and longevity regulation in
            Caenorhabditis elegans
  JOURNAL   PLoS One 5 (12), e14228 (2010)
   PUBMED   21151927
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1453)
  AUTHORS   Goetzman,E.S., Tian,L. and Wood,P.A.
  TITLE     Differential induction of genes in liver and brown adipose tissue
            regulated by peroxisome proliferator-activated receptor-alpha
            during fasting and cold exposure in acyl-CoA
            dehydrogenase-deficient mice
  JOURNAL   Mol Genet Metab 84 (1), 39-47 (2005)
   PUBMED   15639194
REFERENCE   4  (bases 1 to 1453)
  AUTHORS   Kwitek,A.E., Gullings-Handley,J., Yu,J., Carlos,D.C., Orlebeke,K.,
            Nie,J., Eckert,J., Lemke,A., Andrae,J.W., Bromberg,S., Pasko,D.,
            Chen,D., Scheetz,T.E., Casavant,T.L., Soares,M.B., Sheffield,V.C.,
            Tonellato,P.J. and Jacob,H.J.
  TITLE     High-density rat radiation hybrid maps containing over 24,000
            SSLPs, genes, and ESTs provide a direct link to the rat genome
            sequence
  JOURNAL   Genome Res 14 (4), 750-757 (2004)
   PUBMED   15060019
REFERENCE   5  (bases 1 to 1453)
  AUTHORS   Ghisla,S. and Thorpe,C.
  TITLE     Acyl-CoA dehydrogenases. A mechanistic overview
  JOURNAL   Eur J Biochem 271 (3), 494-508 (2004)
   PUBMED   14728676
  REMARK    Review article
REFERENCE   6  (bases 1 to 1453)
  AUTHORS   Willard,J., Vicanek,C., Battaile,K.P., Van Veldhoven,P.P.,
            Fauq,A.H., Rozen,R. and Vockley,J.
  TITLE     Cloning of a cDNA for short/branched chain acyl-Coenzyme A
            dehydrogenase from rat and characterization of its tissue
            expression and substrate specificity
  JOURNAL   Arch Biochem Biophys 331 (1), 127-133 (1996)
   PUBMED   8660691
REFERENCE   7  (bases 1 to 1453)
  AUTHORS   Hainline,B.E., Kahlenbeck,D.J., Grant,J. and Strauss,A.W.
  TITLE     Tissue specific and developmental expression of rat long-and
            medium-chain acyl-CoA dehydrogenases
  JOURNAL   Biochim Biophys Acta 1216 (3), 460-468 (1993)
   PUBMED   8268228
REFERENCE   8  (bases 1 to 1453)
  AUTHORS   Matsubara,Y., Indo,Y., Naito,E., Ozasa,H., Glassberg,R.,
            Vockley,J., Ikeda,Y., Kraus,J. and Tanaka,K.
  TITLE     Molecular cloning and nucleotide sequence of cDNAs encoding the
            precursors of rat long chain acyl-coenzyme A, short chain
            acyl-coenzyme A, and isovaleryl-coenzyme A dehydrogenases. Sequence
            homology of four enzymes of the acyl-CoA dehydrogenase family
  JOURNAL   J Biol Chem 264 (27), 16321-16331 (1989)
   PUBMED   2777793
REFERENCE   9  (bases 1 to 1453)
  AUTHORS   Ikeda,Y., Keese,S.M., Fenton,W.A. and Tanaka,K.
  TITLE     Biosynthesis of four rat liver mitochondrial acyl-CoA
            dehydrogenases: in vitro synthesis, import into mitochondria, and
            processing of their precursors in a cell-free system and in
            cultured cells
  JOURNAL   Arch Biochem Biophys 252 (2), 662-674 (1987)
   PUBMED   3813556
REFERENCE   10 (bases 1 to 1453)
  AUTHORS   Ikeda,Y., Okamura-Ikeda,K. and Tanaka,K.
  TITLE     Purification and characterization of short-chain, medium-chain, and
            long-chain acyl-CoA dehydrogenases from rat liver mitochondria.
            Isolation of the holo- and apoenzymes and conversion of the
            apoenzyme to the holoenzyme
  JOURNAL   J Biol Chem 260 (2), 1311-1325 (1985)
   PUBMED   3968063
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JACYVU010000215.1.
            
            [WARNING] On Mar 27, 2024 this sequence was replaced by
            NM_012819.3.
            
            On Nov 27, 2020 this sequence version replaced NM_012819.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: L11276.1, BC062006.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760400, SAMN06621351
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-83                JACYVU010000215.1  1441758-1441840     c
            84-239              JACYVU010000215.1  1437106-1437261     c
            240-377             JACYVU010000215.1  1433929-1434066     c
            378-542             JACYVU010000215.1  1432304-1432468     c
            543-609             JACYVU010000215.1  1424014-1424080     c
            610-774             JACYVU010000215.1  1419836-1420000     c
            775-876             JACYVU010000215.1  1419212-1419313     c
            877-990             JACYVU010000215.1  1418168-1418281     c
            991-1118            JACYVU010000215.1  1410695-1410822     c
            1119-1205           JACYVU010000215.1  1409200-1409286     c
            1206-1453           JACYVU010000215.1  1403672-1403919     c
FEATURES             Location/Qualifiers
     source          1..1453
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q32"
     gene            1..1453
                     /gene="Acadl"
                     /gene_synonym="ACOADA; LCAD"
                     /note="acyl-CoA dehydrogenase, long chain"
                     /db_xref="GeneID:25287"
                     /db_xref="RGD:2011"
     exon            1..83
                     /gene="Acadl"
                     /gene_synonym="ACOADA; LCAD"
                     /inference="alignment:Splign:2.1.0"
     exon            84..239
                     /gene="Acadl"
                     /gene_synonym="ACOADA; LCAD"
                     /inference="alignment:Splign:2.1.0"
     exon            240..377
                     /gene="Acadl"
                     /gene_synonym="ACOADA; LCAD"
                     /inference="alignment:Splign:2.1.0"
     exon            378..542
                     /gene="Acadl"
                     /gene_synonym="ACOADA; LCAD"
                     /inference="alignment:Splign:2.1.0"
     exon            543..609
                     /gene="Acadl"
                     /gene_synonym="ACOADA; LCAD"
                     /inference="alignment:Splign:2.1.0"
     exon            610..774
                     /gene="Acadl"
                     /gene_synonym="ACOADA; LCAD"
                     /inference="alignment:Splign:2.1.0"
     exon            775..876
                     /gene="Acadl"
                     /gene_synonym="ACOADA; LCAD"
                     /inference="alignment:Splign:2.1.0"
     exon            877..990
                     /gene="Acadl"
                     /gene_synonym="ACOADA; LCAD"
                     /inference="alignment:Splign:2.1.0"
     exon            991..1118
                     /gene="Acadl"
                     /gene_synonym="ACOADA; LCAD"
                     /inference="alignment:Splign:2.1.0"
     exon            1119..1205
                     /gene="Acadl"
                     /gene_synonym="ACOADA; LCAD"
                     /inference="alignment:Splign:2.1.0"
     exon            1206..1453
                     /gene="Acadl"
                     /gene_synonym="ACOADA; LCAD"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cccgccatgg ctgcgcgcct gctcctccgc tcccttcgtg tcctgagcgc ccgctcggcg
       61 acactcccgc cgccctccgc ccgatgttct cattctggag cagaagcacg tctagaaact
      121 ccttctgcta aaaaattaac tgatattgga atcagaagaa tcttttcctc agagcatgac
      181 attttccggg agagtgtaag gaagtttttt caagaagaag tgattcccta ccacgaagaa
      241 tgggagaaag ccggagaagt gagtagagag ctctgggaaa aagctggcaa gcaaggcctg
      301 cttggcatca acattgcaga gaaacatggc ggcatcggtg gggacttgtt gtcaacagca
      361 gttacttggg aagagcaagc atactcaaat tgcacaggcc ctggtttcag cctccattca
      421 gatattgtca tgccctatat tgcaaattac ggcacaaaag aacagatcga gcagtttatc
      481 ccccagatga cggcgggcaa gtgtattggt gccatagcca tgacagagcc tggggctgga
      541 agtgacttac aaggagtaag aacaaatgcc aaaaggtctg ggagtgattg gattctcaat
      601 ggaagcaagg tgttcatcac taatggctgg ttaagtgatc tcgtgatcgt agtggccgtc
      661 accaatcgtg aagctcgatc gcccgctcat ggcattagcc tctttttggt ggagaatgga
      721 atgaaaggat ttattaaggg caagaagcta cataagatgg gaatgaaagc ccaggacaca
      781 gcagaactat tctttgaaga tgttcgattg ccagctagtg ccctacttgg ggaagagaat
      841 aaaggcttct actacctcat gcaagagctc ccacaggaaa ggcttttaat tgctgatttg
      901 gcaatttctg cctgtgagtt catgtttgaa gaaaccagga actacgtgag acaaagaaag
      961 gcttttggaa aaacagtcgc acacatccag actgtgcagc acaaactagc agaattgaag
     1021 acgaacatat gtgttaccag agcttttgtg gacagctgcc tacagctgca tgaaaccaaa
     1081 cgtctggact ccgcctccgc ttccatggcg aaatattggg catctgaatt acaaaacact
     1141 gtagcttatc agtgtgttca actccatgga ggctggggtt acatgtggga atacccgatt
     1201 gcaaaagcct acgtggatgc tcgagttcag ccgatctacg gtggtaccaa cgaaatcatg
     1261 aaagagctga tcgcaagaca gatcgtcagt gacagctaga catctgccta catcctgaaa
     1321 tcctactaca tcacagctaa tccggattca aatatacttg agataaagtg gaacctggaa
     1381 gggggggggg gtagtaaagc tggttttatg tatggttgtt acagagaaag aaataaaaga
     1441 attataaaga ttg
//
