LOCUS       NM_181768               2471 bp    mRNA    linear   ROD 02-APR-2024
DEFINITION  Rattus norvegicus acyl-CoA dehydrogenase family, member 9 (Acad9),
            mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_181768 XM_001059349 XM_001061665 XM_001061715 XM_574921
VERSION     NM_181768.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2471)
  AUTHORS   Zeng,J., Deng,S. and Wang,Y.
  TITLE     Identification of the Catalytic Residue of Rat Acyl-CoA
            Dehydrogenase 9 by Site-Directed Mutagenesis
  JOURNAL   Appl Biochem Biotechnol 182 (3), 1198-1207 (2017)
   PUBMED   28084602
  REMARK    GeneRIF: results suggested that Glu389 could function as the
            catalytic base that abstracted the alpha-proton of the acyl-CoA
            substrate in a proposed catalytic mechanism.
REFERENCE   2  (bases 1 to 2471)
  AUTHORS   He,M., Pei,Z., Mohsen,A.W., Watkins,P., Murdoch,G., Van
            Veldhoven,P.P., Ensenauer,R. and Vockley,J.
  TITLE     Identification and characterization of new long chain acyl-CoA
            dehydrogenases
  JOURNAL   Mol Genet Metab 102 (4), 418-429 (2011)
   PUBMED   21237683
REFERENCE   3  (bases 1 to 2471)
  AUTHORS   Nouws,J., Nijtmans,L., Houten,S.M., van den Brand,M., Huynen,M.,
            Venselaar,H., Hoefs,S., Gloerich,J., Kronick,J., Hutchin,T.,
            Willems,P., Rodenburg,R., Wanders,R., van den Heuvel,L.,
            Smeitink,J. and Vogel,R.O.
  TITLE     Acyl-CoA dehydrogenase 9 is required for the biogenesis of
            oxidative phosphorylation complex I
  JOURNAL   Cell Metab 12 (3), 283-294 (2010)
   PUBMED   20816094
REFERENCE   4  (bases 1 to 2471)
  AUTHORS   Roomets,E., Kivela,T. and Tyni,T.
  TITLE     Carnitine palmitoyltransferase I and Acyl-CoA dehydrogenase 9 in
            retina: insights of retinopathy in mitochondrial trifunctional
            protein defects
  JOURNAL   Invest Ophthalmol Vis Sci 49 (4), 1660-1664 (2008)
   PUBMED   18385088
  REMARK    GeneRIF: Accumulation of 3-hydroxylated intermediates of long-chain
            fatty acids may contribute to the pathogenesis of retinopathy in
            MTP deficiencies.
REFERENCE   5  (bases 1 to 2471)
  AUTHORS   Ensenauer,R., He,M., Willard,J.M., Goetzman,E.S., Corydon,T.J.,
            Vandahl,B.B., Mohsen,A.W., Isaya,G. and Vockley,J.
  TITLE     Human acyl-CoA dehydrogenase-9 plays a novel role in the
            mitochondrial beta-oxidation of unsaturated fatty acids
  JOURNAL   J Biol Chem 280 (37), 32309-32316 (2005)
   PUBMED   16020546
REFERENCE   6  (bases 1 to 2471)
  AUTHORS   Ghisla,S. and Thorpe,C.
  TITLE     Acyl-CoA dehydrogenases. A mechanistic overview
  JOURNAL   Eur J Biochem 271 (3), 494-508 (2004)
   PUBMED   14728676
  REMARK    Review article
REFERENCE   7  (bases 1 to 2471)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC162016.1.
            
            On or before Aug 29, 2008 this sequence version replaced
            XM_001061715.1, XM_001061665.1, XM_574921.2, XM_001059349.1,
            NM_181768.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC162016.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2471
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q25"
     gene            1..2471
                     /gene="Acad9"
                     /gene_synonym="ACAD-9; Nyggf2"
                     /note="acyl-CoA dehydrogenase family, member 9"
                     /db_xref="GeneID:294973"
                     /db_xref="RGD:727973"
     exon            1..201
                     /gene="Acad9"
                     /gene_synonym="ACAD-9; Nyggf2"
                     /inference="alignment:Splign:2.1.0"
     CDS             40..1917
                     /gene="Acad9"
                     /gene_synonym="ACAD-9; Nyggf2"
                     /note="acyl-CoA dehydrogenase family member 9,
                     mitochondrial; acyl-Coenzyme A dehydrogenase family,
                     member 9"
                     /codon_start=1
                     /product="complex I assembly factor ACAD9, mitochondrial"
                     /protein_id="NP_861433.2"
                     /db_xref="GeneID:294973"
                     /db_xref="RGD:727973"
                     /translation="MSGYVLFSRGATAAAAAARASRVLRVFTERRRTLHTSLQSCSFA
                     KELFLGHIQQKGVFPFPEVSQEELSEINQFVGPLEKFFNEEVDSRKIDQEGKIPADTL
                     AKLKSLGLFGIQVPEEYGGLGLSNTMYARLGEIISMDASITVTLAAHQAIGLKGIILV
                     GNEEQKAKYLPKLSSGEHIAAFCLTEPASGSDAASIQTRATLSEDKKYFVLNGSKVWI
                     TNGGLANIFTVFAKTEVVDSDGSIKDKMTAFIVERDFGGITNGKPEDKLGIRGSNTCE
                     VHFENTRVPVENVLGEVGGGFKVAMNILNSGRFSMGSAVAGMLKKLIEQTAEYACTRK
                     QFNRNLSEFGLIQEKFALMAQKAYVMESMAYLTSGMLDQPGFPDCSIEAAMVKVFSSE
                     AAWQCVSEALQILGGSGYMKDYPYERMLRDARILLIFEGTNEILRLFIALTGLQHAGR
                     ILTSRIKELKSGNVTTVMETIGRKLRDSLGRTVDLGLSSNIAVVHPSLGDSANKLEEN
                     VHYFGRTVETLLLRFGKTIVEEQLVLKRVANILINLYGMTAVLSRASRSIRIGLKNHD
                     HEILLANMFCVEAYFQNLFSLSQLDKYAPENLDEQIKKVSQQILEKRAYICAHPLDRA
                     S"
     exon            202..295
                     /gene="Acad9"
                     /gene_synonym="ACAD-9; Nyggf2"
                     /inference="alignment:Splign:2.1.0"
     exon            296..397
                     /gene="Acad9"
                     /gene_synonym="ACAD-9; Nyggf2"
                     /inference="alignment:Splign:2.1.0"
     exon            398..504
                     /gene="Acad9"
                     /gene_synonym="ACAD-9; Nyggf2"
                     /inference="alignment:Splign:2.1.0"
     exon            505..605
                     /gene="Acad9"
                     /gene_synonym="ACAD-9; Nyggf2"
                     /inference="alignment:Splign:2.1.0"
     exon            606..684
                     /gene="Acad9"
                     /gene_synonym="ACAD-9; Nyggf2"
                     /inference="alignment:Splign:2.1.0"
     exon            685..859
                     /gene="Acad9"
                     /gene_synonym="ACAD-9; Nyggf2"
                     /inference="alignment:Splign:2.1.0"
     exon            860..933
                     /gene="Acad9"
                     /gene_synonym="ACAD-9; Nyggf2"
                     /inference="alignment:Splign:2.1.0"
     exon            934..1009
                     /gene="Acad9"
                     /gene_synonym="ACAD-9; Nyggf2"
                     /inference="alignment:Splign:2.1.0"
     exon            1010..1080
                     /gene="Acad9"
                     /gene_synonym="ACAD-9; Nyggf2"
                     /inference="alignment:Splign:2.1.0"
     exon            1081..1200
                     /gene="Acad9"
                     /gene_synonym="ACAD-9; Nyggf2"
                     /inference="alignment:Splign:2.1.0"
     exon            1201..1329
                     /gene="Acad9"
                     /gene_synonym="ACAD-9; Nyggf2"
                     /inference="alignment:Splign:2.1.0"
     exon            1330..1409
                     /gene="Acad9"
                     /gene_synonym="ACAD-9; Nyggf2"
                     /inference="alignment:Splign:2.1.0"
     exon            1410..1536
                     /gene="Acad9"
                     /gene_synonym="ACAD-9; Nyggf2"
                     /inference="alignment:Splign:2.1.0"
     exon            1537..1614
                     /gene="Acad9"
                     /gene_synonym="ACAD-9; Nyggf2"
                     /inference="alignment:Splign:2.1.0"
     exon            1615..1743
                     /gene="Acad9"
                     /gene_synonym="ACAD-9; Nyggf2"
                     /inference="alignment:Splign:2.1.0"
     exon            1744..1816
                     /gene="Acad9"
                     /gene_synonym="ACAD-9; Nyggf2"
                     /inference="alignment:Splign:2.1.0"
     exon            1817..2443
                     /gene="Acad9"
                     /gene_synonym="ACAD-9; Nyggf2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cttccagtga cttgaagtct gaagtcaaga atagcaagca tgtctggcta tgtactgttc
       61 tcgcgtgggg cgactgcggc ggcagctgcg gcgcgagctt cccgcgtgct gagggtcttc
      121 acggagaggc gccgcacatt gcacaccagt ctgcagagct gctcgttcgc caaggagctc
      181 ttcctgggtc acatccagca gaaaggagtt ttcccatttc cagaggttag tcaagaagag
      241 cttagtgaaa tcaatcagtt tgtgggaccg ttggaaaaat tctttaatga agaagtggac
      301 tctcgaaaaa ttgaccagga gggaaaaatc ccagctgaca ccttagcgaa gttgaagagc
      361 ctgggacttt ttggcattca ggtcccagaa gaatatggtg gcctgggcct ctccaacacc
      421 atgtatgccc ggcttgggga gatcatcagc atggatgcgt ccatcacagt gaccctggca
      481 gcacaccaag ctatcggcct caaggggatt atcctggtcg gcaatgagga gcagaaggcc
      541 aagtatctgc ccaaactgtc gtctggggaa cacatcgcag ccttctgcct aacggagcca
      601 gccagtggga gtgatgctgc ctccatccag accagagcta cgttaagtga agataagaag
      661 tactttgttc tcaatggctc caaggtttgg atcactaatg gaggactggc caatattttt
      721 actgtgtttg caaaaactga ggtggttgat tctgatggtt cgataaaaga caaaatgacc
      781 gcattcatag tagaacgaga ctttggtgga atcactaatg ggaaacctga agataaatta
      841 ggcattcgag gctccaacac atgtgaagtc cattttgaaa ataccagagt gccggtggag
      901 aatgtccttg gagaagttgg gggtggcttt aaggtggcca tgaacatcct caacagtgga
      961 cgattcagca tgggcagtgc tgtggccggg atgctcaaga aactgattga acagactgct
     1021 gagtatgcct gtacgaggaa acagttcaat aggaatctca gtgaatttgg gctgattcag
     1081 gaaaagtttg cgctcatggc tcagaaggcg tatgtaatgg agagtatggc ttacctcact
     1141 tcagggatgc tggaccaacc gggatttccc gactgctcta tcgaggcagc catggtgaag
     1201 gtgtttagct ctgaggctgc ctggcagtgt gtgagcgagg ctctgcagat ccttgggggc
     1261 tcaggctaca tgaaggacta cccttatgag cgcatgctac gtgatgcccg cattctccta
     1321 atttttgagg gaaccaatga gattcttcgg ttgttcattg ccctgacagg cctgcagcat
     1381 gctggacgca tcctgacctc gaggatcaaa gagctcaaaa gtggcaatgt gaccacagtc
     1441 atggagacga ttggtcggaa gcttcgggac tcgctgggcc gaactgtaga cctggggctg
     1501 tcgagcaata ttgctgttgt ccaccccagt cttggagaca gtgccaacaa gctggaagaa
     1561 aatgtgcatt actttggccg gactgttgag accctgttac tccgatttgg aaagaccatt
     1621 gtagaggaac agctggtgtt gaagcgggta gccaacatcc tcatcaacct gtatggcatg
     1681 accgctgtgc tgtcaagggc cagccgctcc atcagaattg ggctcaagaa tcacgaccat
     1741 gagattctgt tggccaacat gttctgcgtg gaagcttatt tccagaatct cttcagcctg
     1801 tctcagctgg acaagtatgc tccagagaac ctggatgaac agattaagaa ggtgtctcag
     1861 cagatccttg agaagcgagc ctacatctgt gcccaccctc tggacagagc atcctgaggc
     1921 tggaaccctg tacccaccta gcccaggtta acataatcca gcctcttcag aagacagaaa
     1981 cgtggggtca tctgtgtgca ctgtatgtcg tttgcataca ctaccccttt cttctctgag
     2041 gaaaagcaat acttaggtgt tgacctgtag gccttgtatc tagagggatc ccttctcctg
     2101 caaggaagga agtaccgacc aaattgttga agaaagaaag aaaaacaatc aatgctgatg
     2161 gctcctgtgt gtgactgcag ggatacatct cagtggacat gggcccactt ttaagataca
     2221 aggctcacag tgaactaaga tttgagcagc cattccttct caatcatgtg ttgaagaaag
     2281 ccggagaagt tgagtctata ccactcactt gagactgttt ccaatctgtg tcaggaatca
     2341 cttaaggaat acacaggatc acctttattt ctcatgtaga ctgttcttca gtccatgact
     2401 gtgaggggtg caacattgta acaataaagt ttcttcttgg gtaaaaaaaa aaaaaaaaaa
     2461 aaaaaaaaaa a
//
