LOCUS       NM_001398805            2107 bp    mRNA    linear   ROD 22-SEP-2024
DEFINITION  Rattus norvegicus acyl-CoA dehydrogenase family, member 8 (Acad8),
            mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_001398805 XM_039082287
VERSION     NM_001398805.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2107)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 2107)
  AUTHORS   Liu,X., Wu,L., Deng,G., Chen,G., Li,N., Chu,X. and Li,D.
  TITLE     Comparative studies of Acyl-CoA dehydrogenases for monomethyl
            branched chain substrates in amino acid metabolism
  JOURNAL   Bioorg Chem 47, 1-8 (2013)
   PUBMED   23474214
  REMARK    GeneRIF: Isobutyryl-CoA dehydrogenase did not show the isomerase
            activity.
REFERENCE   3  (bases 1 to 2107)
  AUTHORS   Nguyen,T.V., Andresen,B.S., Corydon,T.J., Ghisla,S., Abd-El
            Razik,N., Mohsen,A.W., Cederbaum,S.D., Roe,D.S., Roe,C.R.,
            Lench,N.J. and Vockley,J.
  TITLE     Identification of isobutyryl-CoA dehydrogenase and its deficiency
            in humans
  JOURNAL   Mol Genet Metab 77 (1-2), 68-79 (2002)
   PUBMED   12359132
COMMENT     INFERRED REFSEQ: This record is predicted by genome sequence
            analysis and is not yet supported by experimental evidence. The
            reference sequence was derived from JAXUCZ010000008.1.
            
            On Dec 23, 2021 this sequence version replaced XM_039082287.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360176.58212.1,
                                           SRR21887621.1147406.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-151               JAXUCZ010000008.1  33665392-33665542   c
            152-252             JAXUCZ010000008.1  33657245-33657345   c
            253-422             JAXUCZ010000008.1  33656300-33656469   c
            423-532             JAXUCZ010000008.1  33655634-33655743   c
            533-609             JAXUCZ010000008.1  33655195-33655271   c
            610-747             JAXUCZ010000008.1  33650438-33650575   c
            748-883             JAXUCZ010000008.1  33645699-33645834   c
            884-981             JAXUCZ010000008.1  33645509-33645606   c
            982-1134            JAXUCZ010000008.1  33644366-33644518   c
            1135-1237           JAXUCZ010000008.1  33643615-33643717   c
            1238-2107           JAXUCZ010000008.1  33641420-33642289   c
FEATURES             Location/Qualifiers
     source          1..2107
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q13"
     gene            1..2107
                     /gene="Acad8"
                     /gene_synonym="RGD1564209"
                     /note="acyl-CoA dehydrogenase family, member 8"
                     /db_xref="GeneID:367196"
                     /db_xref="RGD:1564209"
     exon            1..151
                     /gene="Acad8"
                     /gene_synonym="RGD1564209"
                     /inference="alignment:Splign:2.1.0"
     CDS             55..1290
                     /gene="Acad8"
                     /gene_synonym="RGD1564209"
                     /EC_number="1.3.8.5"
                     /codon_start=1
                     /product="isobutyryl-CoA dehydrogenase, mitochondrial"
                     /protein_id="NP_001385734.1"
                     /db_xref="GeneID:367196"
                     /db_xref="RGD:1564209"
                     /translation="MLRTGSRRLGCLRAALQSLAQTDHRSITFCIDPSLGLNEEQKGF
                     QKVAFDFAAREMAPNMAEWDQKELFPVDVMRKAAQLGFGGIYVRTDVGGSGLSRLDTS
                     VIFEALATGCTSTTAYISIHNMCAWMIDSFGNEEQRHKFCPPLCTMEKFASYCLTEPG
                     SGSDAASLLTSAKRQGDHYILNGSKAFISGGGESDIYVVMCRTGGSGPKGISCIVVEK
                     GTPGLSFGKKEKKVGWNSQPTRAVIFEDCAVPVANRIGTEGQGFLIAMKGLNGGRINV
                     ASCSLGAAHASVVLTQEHLKVRKQFGAPLARSQYLQFQLADMATKLVASRLMIRTAAV
                     ALQEEREDAVALCSMAKLFVTEECFTICNQALQMHGGYGYLKDYAVQQYMRDSRVHQI
                     LEGSNEVMRMLISRSLLQD"
     exon            152..252
                     /gene="Acad8"
                     /gene_synonym="RGD1564209"
                     /inference="alignment:Splign:2.1.0"
     exon            253..422
                     /gene="Acad8"
                     /gene_synonym="RGD1564209"
                     /inference="alignment:Splign:2.1.0"
     exon            423..532
                     /gene="Acad8"
                     /gene_synonym="RGD1564209"
                     /inference="alignment:Splign:2.1.0"
     exon            533..609
                     /gene="Acad8"
                     /gene_synonym="RGD1564209"
                     /inference="alignment:Splign:2.1.0"
     exon            610..747
                     /gene="Acad8"
                     /gene_synonym="RGD1564209"
                     /inference="alignment:Splign:2.1.0"
     exon            748..883
                     /gene="Acad8"
                     /gene_synonym="RGD1564209"
                     /inference="alignment:Splign:2.1.0"
     exon            884..981
                     /gene="Acad8"
                     /gene_synonym="RGD1564209"
                     /inference="alignment:Splign:2.1.0"
     exon            982..1134
                     /gene="Acad8"
                     /gene_synonym="RGD1564209"
                     /inference="alignment:Splign:2.1.0"
     exon            1135..1237
                     /gene="Acad8"
                     /gene_synonym="RGD1564209"
                     /inference="alignment:Splign:2.1.0"
     exon            1238..2107
                     /gene="Acad8"
                     /gene_synonym="RGD1564209"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agttctggcc tgagctaaaa ggcccggggt ctgagattgg aagttactgt ggcgatgttg
       61 cggaccggct cccggcgcct tggctgtctg cgcgccgcgc tccagtccct ggctcagacc
      121 gaccacagga gcatcacctt ctgcatcgat ccttccttgg ggctaaatga agaacaaaaa
      181 ggatttcaga aagtggcctt tgactttgct gctcgggaaa tggctcccaa catggcagag
      241 tgggatcaga aggagctgtt ccctgtggat gtgatgcgga aggctgcaca gctgggcttt
      301 ggggggatct atgtacgaac agatgtgggt gggtctggac tgtctcgcct tgatacgtct
      361 gtcatctttg aagccttggc cacaggctgc accagcacca ctgcctatat aagcatccac
      421 aacatgtgtg cctggatgat tgatagcttt ggaaatgagg aacagaggca caaattttgc
      481 ccaccactct gtaccatgga gaagtttgcc tcctactgcc tcactgaacc aggaagtggg
      541 agtgatgctg catctctcct gacctcagct aagcgacaag gagatcatta catcctcaac
      601 ggctccaagg ccttcatcag tgggggaggt gagtcagaca tctatgtggt catgtgcaga
      661 actggtggat caggccccaa aggtatctcc tgcatagttg ttgagaaagg aacccctggc
      721 ctcagctttg gcaagaagga gaagaaggtg gggtggaact cgcagccaac ccgagcagtg
      781 atctttgaag actgtgctgt ccctgtggcc aacaggattg ggactgaggg gcagggtttt
      841 ctcatcgcca tgaaaggact gaatggtgga aggatcaatg ttgcatcctg ctctctggga
      901 gctgcacatg cttctgttgt ccttacccaa gagcacctca aggtcaggaa gcagttcgga
      961 gcacctctag ccagaagcca gtacctgcaa ttccagttgg cagacatggc caccaagctg
     1021 gttgcctccc ggttgatgat ccgcacggca gcagtggctt tgcaggagga gcgggaagat
     1081 gcagtggccc tgtgttccat ggccaagctc tttgttacag aggaatgctt tactatttgc
     1141 aaccaggctt tgcagatgca tgggggctac ggctacctga aggactatgc tgttcaacag
     1201 tatatgcggg actccagggt ccatcaaatc ctagaaggta gcaatgaagt gatgaggatg
     1261 ctgatctccc ggagcctgct tcaggactag ctccctgact ggagcctagc ctagagctcc
     1321 gagtgcagct gtaaccagtg ttgaatgctc atattggctc ttcagttgca aatgaatcat
     1381 gaagcagact gaagggccga gctcttctaa agaaacctga gctgtctgct gcagtgctgg
     1441 ctctgagaca ggaacagtgt tcttagcaga gctagaaggg ctgctccgag gagccatgcc
     1501 aaaaagcaga cctgcacact gctttcctca ctctggaagg acaaagcatc aagactgtgg
     1561 cttggatcca cagtttgtgc gttttgttga ttcttatcct tagggtctgg gtgcctcaat
     1621 gaagcttttc ctgattaaag aggtcaagac tggggaggca agggcagtgg acagaccttc
     1681 ccctttctgg tttctgttct gcactagggt catctcaggg cggtactcct gaactcagat
     1741 catgatgaaa taaatattgg ggaatctact gctacatgat gaattagggt gcacctttaa
     1801 ctcctgtaac catgaaataa atgtcaaggg ctaagactgt tttggaatat ttggattttt
     1861 aatgggattt atttcctctg gaggctcctt ctttttgtaa atgcatttaa ttagtccctt
     1921 ggtaagcgaa atctatgtct ttactgcctc cttccactat aaaccttaaa actatatttg
     1981 agattttgta tttgattaaa tatttaattg gattttggaa taattagaat tttctcctaa
     2041 ggcagtttgt ctttttaaaa ggaaatcttt tattaataat tttataaaca aagtattatt
     2101 tgtcaca
//
