LOCUS       NP_001385734             411 aa            linear   ROD 22-SEP-2024
DEFINITION  isobutyryl-CoA dehydrogenase, mitochondrial [Rattus norvegicus].
ACCESSION   NP_001385734 XP_038938215
VERSION     NP_001385734.1
DBSOURCE    REFSEQ: accession NM_001398805.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 411)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (residues 1 to 411)
  AUTHORS   Liu,X., Wu,L., Deng,G., Chen,G., Li,N., Chu,X. and Li,D.
  TITLE     Comparative studies of Acyl-CoA dehydrogenases for monomethyl
            branched chain substrates in amino acid metabolism
  JOURNAL   Bioorg Chem 47, 1-8 (2013)
   PUBMED   23474214
  REMARK    GeneRIF: Isobutyryl-CoA dehydrogenase did not show the isomerase
            activity.
REFERENCE   3  (residues 1 to 411)
  AUTHORS   Nguyen,T.V., Andresen,B.S., Corydon,T.J., Ghisla,S., Abd-El
            Razik,N., Mohsen,A.W., Cederbaum,S.D., Roe,D.S., Roe,C.R.,
            Lench,N.J. and Vockley,J.
  TITLE     Identification of isobutyryl-CoA dehydrogenase and its deficiency
            in humans
  JOURNAL   Mol Genet Metab 77 (1-2), 68-79 (2002)
   PUBMED   12359132
COMMENT     INFERRED REFSEQ: This record is predicted by genome sequence
            analysis and is not yet supported by experimental evidence. The
            reference sequence was derived from JAXUCZ010000008.1.
            
            On Dec 23, 2021 this sequence version replaced XP_038938215.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360176.58212.1,
                                           SRR21887621.1147406.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..411
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q13"
     Protein         1..411
                     /product="isobutyryl-CoA dehydrogenase, mitochondrial"
                     /EC_number="1.3.8.5"
                     /calculated_mol_wt=44654
     Region          37..410
                     /region_name="IBD"
                     /note="Isobutyryl-CoA dehydrogenase; cd01162"
                     /db_xref="CDD:173851"
     Site            order(120,124,163,262,269..270,273,342,344,393..394)
                     /site_type="other"
                     /note="substrate binding pocket [chemical binding]"
                     /db_xref="CDD:173851"
     Site            order(154,156..157,162..163,187,189,231,389,396,398)
                     /site_type="other"
                     /note="FAD binding site [chemical binding]"
                     /db_xref="CDD:173851"
     Site            394
                     /site_type="active"
                     /note="catalytic base [active]"
                     /db_xref="CDD:173851"
     CDS             1..411
                     /gene="Acad8"
                     /gene_synonym="RGD1564209"
                     /coded_by="NM_001398805.1:55..1290"
                     /db_xref="GeneID:367196"
                     /db_xref="RGD:1564209"
ORIGIN      
        1 mlrtgsrrlg clraalqsla qtdhrsitfc idpslglnee qkgfqkvafd faaremapnm
       61 aewdqkelfp vdvmrkaaql gfggiyvrtd vggsglsrld tsvifealat gctsttayis
      121 ihnmcawmid sfgneeqrhk fcpplctmek fasycltepg sgsdaasllt sakrqgdhyi
      181 lngskafisg ggesdiyvvm crtggsgpkg iscivvekgt pglsfgkkek kvgwnsqptr
      241 avifedcavp vanrigtegq gfliamkgln ggrinvascs lgaahasvvl tqehlkvrkq
      301 fgaplarsqy lqfqladmat klvasrlmir taavalqeer edavalcsma klfvteecft
      361 icnqalqmhg gygylkdyav qqymrdsrvh qilegsnevm rmlisrsllq d
//
