LOCUS       NM_053922               9106 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus acetyl-CoA carboxylase beta (Acacb), mRNA.
ACCESSION   NM_053922 XM_008769313 XM_346441
VERSION     NM_053922.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 9106)
  AUTHORS   Yan,J., Song,K., Bai,Z. and Ge,R.L.
  TITLE     WY14643 improves left ventricular myocardial mitochondrial and
            systolic functions in obese rats under chronic persistent hypoxia
            via the PPARalpha pathway
  JOURNAL   Life Sci 266, 118888 (2021)
   PUBMED   33310031
REFERENCE   2  (bases 1 to 9106)
  AUTHORS   Ritterhoff,J., Young,S., Villet,O., Shao,D., Neto,F.C.,
            Bettcher,L.F., Hsu,Y.A., Kolwicz,S.C. Jr., Raftery,D. and Tian,R.
  TITLE     Metabolic Remodeling Promotes Cardiac Hypertrophy by Directing
            Glucose to Aspartate Biosynthesis
  JOURNAL   Circ Res 126 (2), 182-196 (2020)
   PUBMED   31709908
REFERENCE   3  (bases 1 to 9106)
  AUTHORS   Sayed-Ahmed,M.M., Alrufaiq,B.I., Alrikabi,A., Abdullah,M.L.,
            Hafez,M.M. and Al-Shabanah,O.A.
  TITLE     Carnitine Supplementation Attenuates Sunitinib-Induced Inhibition
            of AMP-Activated Protein Kinase Downstream Signals in Cardiac
            Tissues
  JOURNAL   Cardiovasc Toxicol 19 (4), 344-356 (2019)
   PUBMED   30644033
REFERENCE   4  (bases 1 to 9106)
  AUTHORS   Gertz,K., Uhlemann,R., Foryst-Ludwig,A., Barrientos,R.M.,
            Kappert,K., Thone-Reineke,C., Djoufack,P., Kirschbaum,C.,
            Fink,K.B., Heinz,A., Kintscher,U., Endres,M. and Kronenberg,G.
  TITLE     The cytoskeleton in 'couch potato-ism': Insights from a murine
            model of impaired actin dynamics
  JOURNAL   Exp Neurol 306, 34-44 (2018)
   PUBMED   29684438
REFERENCE   5  (bases 1 to 9106)
  AUTHORS   Choi,Y.S., de Mattos,A.B., Shao,D., Li,T., Nabben,M., Kim,M.,
            Wang,W., Tian,R. and Kolwicz,S.C. Jr.
  TITLE     Preservation of myocardial fatty acid oxidation prevents diastolic
            dysfunction in mice subjected to angiotensin II infusion
  JOURNAL   J Mol Cell Cardiol 100, 64-71 (2016)
   PUBMED   27693463
REFERENCE   6  (bases 1 to 9106)
  AUTHORS   Abu-Elheiga,L., Almarza-Ortega,D.B., Baldini,A. and Wakil,S.J.
  TITLE     Human acetyl-CoA carboxylase 2. Molecular cloning,
            characterization, chromosomal mapping, and evidence for two
            isoforms
  JOURNAL   J Biol Chem 272 (16), 10669-10677 (1997)
   PUBMED   9099716
REFERENCE   7  (bases 1 to 9106)
  AUTHORS   Ha,J., Lee,J.K., Kim,K.S., Witters,L.A. and Kim,K.H.
  TITLE     Cloning of human acetyl-CoA carboxylase-beta and its unique
            features
  JOURNAL   Proc Natl Acad Sci U S A 93 (21), 11466-11470 (1996)
   PUBMED   8876158
REFERENCE   8  (bases 1 to 9106)
  AUTHORS   Widmer,J., Fassihi,K.S., Schlichter,S.C., Wheeler,K.S., Crute,B.E.,
            King,N., Nutile-McMenemy,N., Noll,W.W., Daniel,S., Ha,J., Kim,K.H.
            and Witters,L.A.
  TITLE     Identification of a second human acetyl-CoA carboxylase gene
  JOURNAL   Biochem J 316 (Pt 3) (Pt 3), 915-922 (1996)
   PUBMED   8670171
REFERENCE   9  (bases 1 to 9106)
  AUTHORS   Watson,J.
  TITLE     The Warble Fly Orders
  JOURNAL   Vet Rec 103 (16), 354-355 (1978)
   PUBMED   734875
REFERENCE   10 (bases 1 to 9106)
  AUTHORS   Dabrowski,Z., Gregorczyk,J., Samochowiec,L., Wojcicki,J.,
            Lawczynski,L., Antoszczyk,M., Chrzanowska-Ansilewska,K., Jurek,D.
            and Sych,Z.
  TITLE     [Effect of truncal vagotomy on the exocrine function of the
            pancreas in the dog]
  JOURNAL   Pol Tyg Lek 33 (28), 1093-1095 (1978)
   PUBMED   704405
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000012.1.
            
            On or before Dec 1, 2020 this sequence version replaced
            XM_008769313.2, NM_053922.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643296.31310.1,
                                           SRR26643289.32894.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-473               JAXUCZ010000012.1  48137742-48138214   c
            474-1126            JAXUCZ010000012.1  48117559-48118211   c
            1127-1259           JAXUCZ010000012.1  48101591-48101723   c
            1260-1398           JAXUCZ010000012.1  48097889-48098027   c
            1399-1508           JAXUCZ010000012.1  48095135-48095244   c
            1509-1590           JAXUCZ010000012.1  48094886-48094967   c
            1591-1689           JAXUCZ010000012.1  48093792-48093890   c
            1690-1799           JAXUCZ010000012.1  48090914-48091023   c
            1800-1910           JAXUCZ010000012.1  48090683-48090793   c
            1911-2120           JAXUCZ010000012.1  48087116-48087325   c
            2121-2291           JAXUCZ010000012.1  48086728-48086898   c
            2292-2453           JAXUCZ010000012.1  48083140-48083301   c
            2454-2617           JAXUCZ010000012.1  48081289-48081452   c
            2618-2768           JAXUCZ010000012.1  48079262-48079412   c
            2769-2872           JAXUCZ010000012.1  48079057-48079160   c
            2873-2954           JAXUCZ010000012.1  48077558-48077639   c
            2955-3100           JAXUCZ010000012.1  48075926-48076071   c
            3101-3251           JAXUCZ010000012.1  48074631-48074781   c
            3252-3386           JAXUCZ010000012.1  48072332-48072466   c
            3387-3533           JAXUCZ010000012.1  48070573-48070719   c
            3534-3722           JAXUCZ010000012.1  48069439-48069627   c
            3723-3823           JAXUCZ010000012.1  48067848-48067948   c
            3824-3912           JAXUCZ010000012.1  48066580-48066668   c
            3913-4037           JAXUCZ010000012.1  48066190-48066314   c
            4038-4151           JAXUCZ010000012.1  48064297-48064410   c
            4152-4265           JAXUCZ010000012.1  48064095-48064208   c
            4266-4355           JAXUCZ010000012.1  48063451-48063540   c
            4356-4474           JAXUCZ010000012.1  48061169-48061287   c
            4475-4612           JAXUCZ010000012.1  48055948-48056085   c
            4613-4712           JAXUCZ010000012.1  48055604-48055703   c
            4713-4820           JAXUCZ010000012.1  48055407-48055514   c
            4821-4877           JAXUCZ010000012.1  48053953-48054009   c
            4878-4919           JAXUCZ010000012.1  48053680-48053721   c
            4920-5135           JAXUCZ010000012.1  48052190-48052405   c
            5136-5291           JAXUCZ010000012.1  48049504-48049659   c
            5292-5495           JAXUCZ010000012.1  48048273-48048476   c
            5496-5651           JAXUCZ010000012.1  48047379-48047534   c
            5652-5774           JAXUCZ010000012.1  48044890-48045012   c
            5775-6044           JAXUCZ010000012.1  48044507-48044776   c
            6045-6142           JAXUCZ010000012.1  48042416-48042513   c
            6143-6263           JAXUCZ010000012.1  48040531-48040651   c
            6264-6374           JAXUCZ010000012.1  48038465-48038575   c
            6375-6518           JAXUCZ010000012.1  48036970-48037113   c
            6519-6639           JAXUCZ010000012.1  48036173-48036293   c
            6640-6736           JAXUCZ010000012.1  48035047-48035143   c
            6737-6833           JAXUCZ010000012.1  48033782-48033878   c
            6834-6969           JAXUCZ010000012.1  48032580-48032715   c
            6970-7147           JAXUCZ010000012.1  48031812-48031989   c
            7148-7260           JAXUCZ010000012.1  48031311-48031423   c
            7261-7415           JAXUCZ010000012.1  48029347-48029501   c
            7416-7586           JAXUCZ010000012.1  48028614-48028784   c
            7587-7723           JAXUCZ010000012.1  48028357-48028493   c
            7724-9106           JAXUCZ010000012.1  48026394-48027776   c
FEATURES             Location/Qualifiers
     source          1..9106
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12q16"
     gene            1..9106
                     /gene="Acacb"
                     /gene_synonym="Acc2"
                     /note="acetyl-CoA carboxylase beta"
                     /db_xref="GeneID:116719"
                     /db_xref="RGD:620500"
     exon            1..473
                     /gene="Acacb"
                     /gene_synonym="Acc2"
                     /inference="alignment:Splign:2.1.0"
     exon            474..1126
                     /gene="Acacb"
                     /gene_synonym="Acc2"
                     /inference="alignment:Splign:2.1.0"
     CDS             483..7850
                     /gene="Acacb"
                     /gene_synonym="Acc2"
                     /EC_number="6.4.1.2"
                     /note="acetyl-Coenzyme A carboxylase 2; acetyl-Coenzyme A
                     carboxylase beta"
                     /codon_start=1
                     /product="acetyl-CoA carboxylase 2"
                     /protein_id="NP_446374.2"
                     /db_xref="GeneID:116719"
                     /db_xref="RGD:620500"
                     /translation="MVLLLFLTCLVFSCLTISWLKIWGKMTDSKPLSNSKVDASLLSS
                     KEESFSASDQSEEHGDCSCPLTTPDQEELASHGGPVDASQQRNSVPSSHQKPPRNPLS
                     SNDTCSSPELQTNRVAAPGSEVPEANGLPFPARPQTQRTGSPTREDKKQAHIKRQLMT
                     SFILGSLDDNSSDEDPSASSFQTSSRKGSRASLGTLSQEAALNTADPESHTPTMRPSM
                     SGLHLVKRGREHKKLDLHRDFTVASPAEFVTRFGGNRVIETVLIANNGIAAVKCMRSI
                     RRWAYEMFRNERAIRFVVMVTPEDLKANAEYIKMADQYVPVPGGPNNNNYANVELIID
                     IAKRIPVQAVWAGWGHASENPKLPELLCKHEIAFLGPPSEAMWALGDKISSTIVAQTL
                     QIPTLPWSGSGLTVEWTEDSQHQGKCISVPEDVYEQGCVRDVDEGLQAAEKVGFPLMI
                     KASEGGGGKGIRRAESAEDFPMLFRQVQSEIPGSPIFLMKLAQNARHLEVQVLADQYG
                     NAVSLFGRDCSIQRRHQKIIEEAPATIAAPAVFEFMEQCAVLLAKTVGYVSAGTVEYL
                     YSQDGSFHFLELNPRLQVEHPCTEMIADVNLPAAQLQIAMGVPLHRLKDIRLLYGESP
                     WGVTPVSFETPLSPPIARGHVIAARITSENPDEGFKPSSGTVQELNFRSNKNVWGYFS
                     VAAAGGLHEFADSQFGHCFSWGENREEAISNMVVALKELSIRGDFRTTVEYLVNLLET
                     ESFQNNDIDTGWLDHLIAQRVQAEKPDIMLGVVCGALNVADAMFRTCMTEFLHSLERG
                     QVLPADSLLNIVDVELIYGGIKYVLKVARQSLTMFVLIMNGCHIEIDAHRLNDGGLLL
                     SYNGSSYTTYMKEEVDSYRITIGNKTCVFEKENDPTVLRSPSAGKLMQYTVEDGQHVE
                     VGSSYAEMEVMKMIMTLNVQESGRVKYIKRPGAVLEAGCVVAKLELDDPSKVHAAQPF
                     TGELPAQQTLPILGERLHQVFHSVLENLTNVMNGYCLPEPFFSMKLKDWVEKLMMTLR
                     HPSLPLLELQEIMTSVAGRIPVPVEKAVRRVMAQYASNITSVLCQFPSQQIATILDCH
                     AATLQRKVDREAFFMNTQSIVQLIQRYRSGTRGYMKAVVLDLLRRYLNVEHHFQQAHY
                     DKCVINLREQFKPDMTRVLDCIFSHSQVAKKNQLVTMLIDELCGPDPTLSEELTSILK
                     ELTQLSRSEHCKVALRARQVLIASHLPSYELRHNQVESIFLSAIDMYGHQFCPENLKK
                     LILSETTIFDVLPTFFYHANKVVCMASLEVYVRRGYIAYELNSLQHRELPDGTCVVEF
                     QFMLPSSHPNRMAMPINVSDPDLLRHSKELFMDSGFSPLCQRMGAMVAFRRFEEFTRN
                     FDEVISCFANVPTDTPLFSKACTSLYSEEDSKSLQEEPIHILNVAIQCADHMEDERLV
                     PVFRAFVQSKKHILVDYGLRRITFLIAQEREFPKFFTFRARDEFAEDRIYRHLEPALA
                     FQLELSRMRNFDLTAVPCANHKMHLYLGAAKVKEGLEVTDHRFFIRAIIRHSDLITKE
                     ASFEYLQNEGERLLLEAMDELEVAFNNTSVRTDCNHIFLNFVPTVIMDPLKIEESVRA
                     MVMRYGSRLWKLRVLQAEVKINIRQTTSDCAVPIRLFITNESGYYLDISLYKEVTDSR
                     SGNIMFHSFGNKQGSLHGMLINTPYVTKDLLQAKRFQAQSLGTTYVYDFPEMFRQALF
                     KLWGSPEKYPKDILTYTELVLDSQGQLVEMNRLPGCNEVGMVVFKMRFKTPEYPEGRD
                     TIVIGNDITFQIGSFGIGEDFLYLRASEMARTEGIPQIYLAANSGARMGLSEEIKQIF
                     QVAWVDPEDPYKGFRYLYLTPQDYTQISSQNSVHCKHIEDEGESRYVIVDVIGKDSSL
                     GVENLRGSGMIAGEASLAYEKNVTISMVTCRAIGIGAYLVRLGQRVIQVENSHIILTG
                     AGALNKVLGREVYTSNNQLGGVQIMHTNGVSHVTVPDDFEGVCTILEWLSYIPKDNQS
                     PVPIITPSDPIDREIEFTPTKAPYDPRWLLAGRPHPTLKGTWQSGFFDHGSFKEIMAP
                     WAQTVVTGRARLGGIPVGVIAVETRSVEVAVPADPANLDSEAKIIQQAGQVWFPDSAF
                     KTAQVIRDFNQEHLPLMIFANWRGFSGGMKDMYEQMLKFGAYIVDSLRLFKQPVLIYI
                     PPGAELRGGAWVVLDSSINPLCIEMYADKESRGGVLEPEGTVEIKFRKKDLVKTIRRI
                     DPVCKKLLGQLGTAQLPDKDRKELESQLKAREDLLLPIYHQVAVQFADLHDTPGHMLE
                     KGIISDVLEWKTTRTYFYWRLRRLLLEAQVKQEILRASPELSHEHTQSMLRRWFVETE
                     GAVKAYLWDSNQVVVQWLEQHWSARDNLRSTIRENINYLKRDSVLKTIQSLVQEHPEA
                     TMDCVAYLSQHLTPAEQMQVVQLLSTTESPASH"
     exon            1127..1259
                     /gene="Acacb"
                     /gene_synonym="Acc2"
                     /inference="alignment:Splign:2.1.0"
     exon            1260..1398
                     /gene="Acacb"
                     /gene_synonym="Acc2"
                     /inference="alignment:Splign:2.1.0"
     exon            1399..1508
                     /gene="Acacb"
                     /gene_synonym="Acc2"
                     /inference="alignment:Splign:2.1.0"
     exon            1509..1590
                     /gene="Acacb"
                     /gene_synonym="Acc2"
                     /inference="alignment:Splign:2.1.0"
     exon            1591..1689
                     /gene="Acacb"
                     /gene_synonym="Acc2"
                     /inference="alignment:Splign:2.1.0"
     exon            1690..1799
                     /gene="Acacb"
                     /gene_synonym="Acc2"
                     /inference="alignment:Splign:2.1.0"
     exon            1800..1910
                     /gene="Acacb"
                     /gene_synonym="Acc2"
                     /inference="alignment:Splign:2.1.0"
     exon            1911..2120
                     /gene="Acacb"
                     /gene_synonym="Acc2"
                     /inference="alignment:Splign:2.1.0"
     exon            2121..2291
                     /gene="Acacb"
                     /gene_synonym="Acc2"
                     /inference="alignment:Splign:2.1.0"
     exon            2292..2453
                     /gene="Acacb"
                     /gene_synonym="Acc2"
                     /inference="alignment:Splign:2.1.0"
     exon            2454..2617
                     /gene="Acacb"
                     /gene_synonym="Acc2"
                     /inference="alignment:Splign:2.1.0"
     exon            2618..2768
                     /gene="Acacb"
                     /gene_synonym="Acc2"
                     /inference="alignment:Splign:2.1.0"
     exon            2769..2872
                     /gene="Acacb"
                     /gene_synonym="Acc2"
                     /inference="alignment:Splign:2.1.0"
     exon            2873..2954
                     /gene="Acacb"
                     /gene_synonym="Acc2"
                     /inference="alignment:Splign:2.1.0"
     exon            2955..3100
                     /gene="Acacb"
                     /gene_synonym="Acc2"
                     /inference="alignment:Splign:2.1.0"
     exon            3101..3251
                     /gene="Acacb"
                     /gene_synonym="Acc2"
                     /inference="alignment:Splign:2.1.0"
     exon            3252..3386
                     /gene="Acacb"
                     /gene_synonym="Acc2"
                     /inference="alignment:Splign:2.1.0"
     exon            3387..3533
                     /gene="Acacb"
                     /gene_synonym="Acc2"
                     /inference="alignment:Splign:2.1.0"
     exon            3534..3722
                     /gene="Acacb"
                     /gene_synonym="Acc2"
                     /inference="alignment:Splign:2.1.0"
     exon            3723..3823
                     /gene="Acacb"
                     /gene_synonym="Acc2"
                     /inference="alignment:Splign:2.1.0"
     exon            3824..3912
                     /gene="Acacb"
                     /gene_synonym="Acc2"
                     /inference="alignment:Splign:2.1.0"
     exon            3913..4037
                     /gene="Acacb"
                     /gene_synonym="Acc2"
                     /inference="alignment:Splign:2.1.0"
     exon            4038..4151
                     /gene="Acacb"
                     /gene_synonym="Acc2"
                     /inference="alignment:Splign:2.1.0"
     exon            4152..4265
                     /gene="Acacb"
                     /gene_synonym="Acc2"
                     /inference="alignment:Splign:2.1.0"
     exon            4266..4355
                     /gene="Acacb"
                     /gene_synonym="Acc2"
                     /inference="alignment:Splign:2.1.0"
     exon            4356..4474
                     /gene="Acacb"
                     /gene_synonym="Acc2"
                     /inference="alignment:Splign:2.1.0"
     exon            4475..4612
                     /gene="Acacb"
                     /gene_synonym="Acc2"
                     /inference="alignment:Splign:2.1.0"
     exon            4613..4712
                     /gene="Acacb"
                     /gene_synonym="Acc2"
                     /inference="alignment:Splign:2.1.0"
     exon            4713..4820
                     /gene="Acacb"
                     /gene_synonym="Acc2"
                     /inference="alignment:Splign:2.1.0"
     exon            4821..4877
                     /gene="Acacb"
                     /gene_synonym="Acc2"
                     /inference="alignment:Splign:2.1.0"
     exon            4878..4919
                     /gene="Acacb"
                     /gene_synonym="Acc2"
                     /inference="alignment:Splign:2.1.0"
     exon            4920..5135
                     /gene="Acacb"
                     /gene_synonym="Acc2"
                     /inference="alignment:Splign:2.1.0"
     exon            5136..5291
                     /gene="Acacb"
                     /gene_synonym="Acc2"
                     /inference="alignment:Splign:2.1.0"
     exon            5292..5495
                     /gene="Acacb"
                     /gene_synonym="Acc2"
                     /inference="alignment:Splign:2.1.0"
     exon            5496..5651
                     /gene="Acacb"
                     /gene_synonym="Acc2"
                     /inference="alignment:Splign:2.1.0"
     exon            5652..5774
                     /gene="Acacb"
                     /gene_synonym="Acc2"
                     /inference="alignment:Splign:2.1.0"
     exon            5775..6044
                     /gene="Acacb"
                     /gene_synonym="Acc2"
                     /inference="alignment:Splign:2.1.0"
     exon            6045..6142
                     /gene="Acacb"
                     /gene_synonym="Acc2"
                     /inference="alignment:Splign:2.1.0"
     exon            6143..6263
                     /gene="Acacb"
                     /gene_synonym="Acc2"
                     /inference="alignment:Splign:2.1.0"
     exon            6264..6374
                     /gene="Acacb"
                     /gene_synonym="Acc2"
                     /inference="alignment:Splign:2.1.0"
     exon            6375..6518
                     /gene="Acacb"
                     /gene_synonym="Acc2"
                     /inference="alignment:Splign:2.1.0"
     exon            6519..6639
                     /gene="Acacb"
                     /gene_synonym="Acc2"
                     /inference="alignment:Splign:2.1.0"
     exon            6640..6736
                     /gene="Acacb"
                     /gene_synonym="Acc2"
                     /inference="alignment:Splign:2.1.0"
     exon            6737..6833
                     /gene="Acacb"
                     /gene_synonym="Acc2"
                     /inference="alignment:Splign:2.1.0"
     exon            6834..6969
                     /gene="Acacb"
                     /gene_synonym="Acc2"
                     /inference="alignment:Splign:2.1.0"
     exon            6970..7147
                     /gene="Acacb"
                     /gene_synonym="Acc2"
                     /inference="alignment:Splign:2.1.0"
     exon            7148..7260
                     /gene="Acacb"
                     /gene_synonym="Acc2"
                     /inference="alignment:Splign:2.1.0"
     exon            7261..7415
                     /gene="Acacb"
                     /gene_synonym="Acc2"
                     /inference="alignment:Splign:2.1.0"
     exon            7416..7586
                     /gene="Acacb"
                     /gene_synonym="Acc2"
                     /inference="alignment:Splign:2.1.0"
     exon            7587..7723
                     /gene="Acacb"
                     /gene_synonym="Acc2"
                     /inference="alignment:Splign:2.1.0"
     exon            7724..9106
                     /gene="Acacb"
                     /gene_synonym="Acc2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tcatgattcc cagagggtct cctagaaccg agttgggaag aagtgccagg ccatctttgg
       61 gggaactttc ctccctccct ccctcactat ggactcacag gccagagtga ccttcccctg
      121 ttgcttatga caccttgggc cttagacagc tcttgtttaa gtgtctagga attttgaaat
      181 aatcgagctg tggggttgag gtggaagggc tcccagggcc ccagtgcagc cccactgggc
      241 tgctgtaaga tcatttcctc ccaccctagg tcactgctgc cactcagtgc cttgaaggtt
      301 aaatgctccg ggggatattt ttaaacagca ggggctggtt aatctaaaag tgacatttac
      361 agtcacagcc gagccactgg cagcttagat ccgggcctca gccacagagg agcttgaaaa
      421 atgtcctgga tacacagctg ggaagccatg gggaaagcaa aagtgtgaac gcagttgtct
      481 gaatggtctt gcttctcttt ctgacttgcc tggttttctc ctgcctgacc atttcctggt
      541 taaaaatctg ggggaagatg acagactcga agccgctcag caacagtaag gtggatgcaa
      601 gcctcctttc gagcaaggag gagtcctttt cagcctcgga ccagtcagag gagcatggcg
      661 actgcagctg tccgttgaca actcctgacc aggaggagct ggcctcccac ggaggtcctg
      721 tagatgccag tcagcagagg aactctgtgc caagctcaca ccagaagcct ccgaggaacc
      781 cactatcttc caatgacacc tgttcctccc cagaactcca aaccaacagg gtagcagccc
      841 ctggctcaga ggttccagaa gccaacgggt tgcctttccc agccaggcct cagacccaga
      901 gaacgggatc ccccactagg gaggacaaga agcaggcaca catcaagagg cagctgatga
      961 ccagctttat cctgggctcc ctcgatgaca actcctctga cgaggaccct agtgctagct
     1021 ccttccagac ctcctctcgg aagggcagca gggctagcct gggcaccctg tcccaggagg
     1081 ctgcattgaa cacagctgat cctgagtctc acacacctac tatgaggccc agcatgtctg
     1141 gactccatct ggtgaagaga ggccgtgaac acaagaaact ggacctgcac agagatttca
     1201 ctgtagcttc cccagccgaa tttgtcaccc gctttggagg caacagggtc atcgagacgg
     1261 tgctcatcgc caataatggt atcgctgcgg tcaagtgtat gcgctccatc cgccgctggg
     1321 cctatgagat gttccgtaat gaacgcgcca tccggtttgt ggttatggtg acacccgagg
     1381 atcttaaggc caacgcagag tacatcaaga tggcggacca gtacgttccg gtcccaggag
     1441 gacccaataa taacaactac gccaacgttg agctgatcat agacattgcc aagagaatcc
     1501 ctgtgcaggc cgtgtgggct ggctggggcc acgcttcgga aaaccccaaa cttccagagc
     1561 tactgtgcaa gcacgagatt gctttcctag gtcccccgag tgaggccatg tgggccctgg
     1621 gagacaagat ctcctccacc attgtagccc agacattgca gatcccaact ctaccctgga
     1681 gcggaagcgg tctcacagtg gagtggacgg aggacagcca gcatcagggc aaatgcatca
     1741 gcgtcccgga agacgtttat gaacaaggct gtgtgagaga tgtggacgaa ggcttgcagg
     1801 cagcagaaaa agtaggattt cctctgatga tcaaagcctc tgaaggtgga ggagggaaag
     1861 gaatccgcag ggctgagagt gcagaggact tcccgatgct tttcagacag gtgcagagtg
     1921 agatcccggg ctcgcccatc tttctcatga agctggccca gaatgctcgg cacttggagg
     1981 tccaggtctt ggcagatcag tatgggaacg cagtgtccct gtttggacga gactgctcca
     2041 tccagaggcg gcaccagaag atcattgagg aggctccggc caccatcgct gctccggctg
     2101 tgtttgagtt catggaacag tgtgccgtcc tcctggccaa gactgtgggt tatgtgagcg
     2161 cgggaaccgt ggagtaccta tacagccagg atggcagctt tcacttcttg gagctgaacc
     2221 cacgcctgca ggtggaacat ccctgcactg aaatgatcgc agatgtcaac ctgcccgctg
     2281 cacagttaca gatcgccatg ggcgtgcccc tgcaccggct gaaggacata cggcttctgt
     2341 acggagagtc cccctgggga gtgacccccg tttcttttga gacccctttg agccctccca
     2401 ttgcccgagg ccatgtcatt gcagccagga tcaccagcga aaacccagac gagggcttta
     2461 agccaagctc agggacagtg caggagctga acttccgcag caacaagaac gtgtggggtt
     2521 acttcagcgt ggccgctgct gggggcttgc acgagtttgc cgattcccag tttgggcact
     2581 gcttctcctg gggcgagaac cgtgaagagg ctatttcgaa catggtggtg gctttgaaag
     2641 aactgtctat ccggggtgac ttccggacca ccgtggaata tctcgtcaac cttctggaga
     2701 cggagagctt ccagaacaat gatatcgaca cagggtggct ggaccacctc atcgctcagc
     2761 gggtgcaggc agagaagccg gacatcatgc tcggggtggt gtgtggggcc ttgaacgtgg
     2821 cagacgcgat gttcagaacc tgtatgacgg aattcctgca ttccttggaa aggggtcagg
     2881 tcctcccggc tgattctctg ctgaacatcg tggacgttga gttgatttac ggaggcatca
     2941 aatatgttct caaggtggcc cggcagtccc tgaccatgtt tgtcctcatc atgaatggtt
     3001 gccacatcga gatcgatgcc caccggctga acgatggggg cctgctcctg tcctacaatg
     3061 gtagcagtta cactacatac atgaaggaag aggtggacag ttaccggatc actatcggca
     3121 ataagacatg cgtgtttgaa aaggaaaacg accccaccgt cctgagatcc ccctcggctg
     3181 ggaagctgat gcagtacacg gtggaggatg gccagcacgt ggaagtcggg agcagctatg
     3241 ctgagatgga ggtgatgaag atgatcatga ccctgaacgt gcaagagagc ggccgggtga
     3301 agtacatcaa gcgaccaggg gcggtattgg aggctggctg cgtggtggca aagctagaac
     3361 tcgatgaccc ttcaaaagtg cacgcggcac agccgttcac aggggagctc cccgcccagc
     3421 agactctgcc catcctcggg gagaggctgc atcaggtgtt ccacagcgtc ttggaaaatc
     3481 tgaccaatgt catgaatggc tactgcctgc ccgagccctt cttcagcatg aagctgaagg
     3541 actgggtgga gaagctcatg atgactctcc ggcatccctc cctacctctg ctggagctgc
     3601 aggagatcat gaccagcgtg gcaggccgca tcccggttcc ggtggagaag gcagtccgca
     3661 gggtgatggc gcagtacgcc agcaacatca cttcggtgct ctgccagttc cccagccagc
     3721 agatagccac catcctggac tgccacgccg ccaccctgca gcgtaaggtg gaccgagagg
     3781 ccttcttcat gaacacacag agcatcgtgc agctgatcca gagataccgc agtgggaccc
     3841 gtggctacat gaaggctgtg gtgctagacc tcctgaggag atatctgaac gtggagcatc
     3901 atttccagca agcccactat gacaagtgtg tgatcaacct gagggagcag ttcaagccgg
     3961 acatgactcg ggtgctggac tgcatcttct cacactcaca agtggccaag aagaaccagc
     4021 tggtgaccat gttgatagat gagctgtgtg gcccagaccc caccctgtca gaagagctga
     4081 cctccatcct caaggaactc acgcagttga gcaggagtga gcactgcaag gtggccctca
     4141 gagccaggca ggtcctgatt gcctctcacc tcccctccta cgagctgcgg cacaaccagg
     4201 tggagtccat cttcctgtca gccattgaca tgtatggcca ccagttctgc ccggaaaacc
     4261 tcaagaaact aatactttcg gaaacgacca tattcgatgt cctgcccact ttcttctatc
     4321 acgctaacaa ggtcgtctgt atggcgtccc tggaggttta tgtgaggaga ggttacatcg
     4381 cctacgagtt aaacagccta cagcaccggg agctccctga cggcacctgc gtggtggagt
     4441 tccagttcat gctgccgtct tcccacccca accggatggc catgcccatc aatgtctctg
     4501 accctgacct gctgagacac agtaaggaac tcttcatgga cagtggcttc tccccactgt
     4561 gccagcggat gggggccatg gtggccttca ggagatttga ggagttcacc aggaacttcg
     4621 atgaagtcat ctcctgcttt gccaacgtgc ctacagacac tcctctcttc agtaaggcgt
     4681 gcacttccct ctactcagag gaggacagca agagccttca agaggagccc atccacatcc
     4741 tgaatgtggc catccagtgc gccgaccaca tggaggacga gagactggtg ccggttttcc
     4801 gtgcctttgt acagtccaag aaacacatcc ttgtggatta cggactgcga agaatcacat
     4861 tccttatcgc ccaagagaga gaatttccca agttcttcac gttcagagcg agagatgagt
     4921 ttgcagaaga ccggatttac cgccacttgg agccggccct ggccttccag ctggagctga
     4981 gccggatgcg caactttgac ctgacggccg tgccctgtgc caaccataag atgcatcttt
     5041 acctgggagc cgccaaggtg aaggaagggc tggaggtgac tgaccacagg ttcttcatcc
     5101 gagccatcat aaggcactca gacctgatca ccaaggaagc ctccttcgag tacctgcaga
     5161 atgaagggga gcggctgctg ctggaagcca tggacgagct ggaggtggcg ttcaacaaca
     5221 ccagcgtgcg cactgactgc aaccacatct tcctcaactt cgtgcccacg gtcatcatgg
     5281 acccactcaa gatcgaggag tcggtgcgtg ccatggtcat gcgttacggc agtcggctgt
     5341 ggaagctccg tgtgctgcag gcagaagtta agatcaacat ccgtcagacg acctcggact
     5401 gcgccgtccc cattcgcctc ttcatcacca acgagtccgg ctactacctg gacatcagcc
     5461 tctacaaaga agtgaccgac tccagatccg gaaacatcat gtttcattcc ttcggcaaca
     5521 aacaagggag cctgcacggg atgctgatca acacgcccta cgtcaccaag gatctgctcc
     5581 aagccaagcg attccaggcg cagtccctgg ggaccaccta tgtgtacgac ttcccagaga
     5641 tgttcaggca ggctctcttt aaattgtggg gctccccaga gaagtacccc aaagatatcc
     5701 tgacatacac agagctggtg ttggactccc agggccagct ggtggagatg aaccggcttc
     5761 ctggttgtaa cgaggtgggc atggtggttt tcaaaatgag gttcaagacc ccggagtatc
     5821 cagaaggccg ggacactatc gtcatcggca acgacattac cttccaaatc ggctctttcg
     5881 gcataggaga ggacttcctg tatctacggg catcggagat ggcccggaca gagggcatcc
     5941 cccaaatcta tctggcagcc aacagcgggg cccgtatggg cctgtccgag gagatcaagc
     6001 agatattcca agtggcatgg gtggaccctg aggatcccta caaaggattt agatacctgt
     6061 acctgacgcc ccaagactac acccagatca gctcccagaa ctccgtgcac tgcaaacaca
     6121 tcgaggacga aggcgagtcc aggtatgtca tcgttgatgt catcgggaag gacagcagcc
     6181 tgggtgtgga gaacctgcgg ggctcgggca tgattgcagg agaggcttct ctggcttacg
     6241 aaaaaaatgt caccatcagc atggtgacct gccgcgccat cggaatcggg gcttacctgg
     6301 tgaggctggg ccagcgggtg atccaggtgg aaaactccca catcatcctc acgggagccg
     6361 gtgctctcaa caaggtcctg ggaagagagg tctacacatc caacaaccaa ctgggcggtg
     6421 tgcagatcat gcacaccaac ggggtctccc acgtcacggt gccagatgac ttcgaggggg
     6481 tctgcaccat tctggaatgg ctgtcatata taccaaagga caatcaaagc ccagtcccca
     6541 tcatcactcc ttctgacccc atcgacaggg aaattgaatt caccccaacc aaagctccct
     6601 atgaccccag gtggctgctg gcagggaggc ctcacccaac tctgaagggg acctggcaga
     6661 gtggattctt cgaccatggc agtttcaagg aaatcatggc accctgggcc cagactgtgg
     6721 tgactggacg agcaaggctg gggggcatcc ctgtaggggt gattgccgtg gagactcggt
     6781 ctgtggaggt ggctgtccct gctgaccctg ccaacttgga ttctgaggcc aagatcatcc
     6841 agcaggcagg ccaggtgtgg ttcccggact ctgccttcaa gacggctcag gtcatcaggg
     6901 acttcaacca ggagcatctg cctctcatga tctttgctaa ctggagaggc ttctcgggcg
     6961 gcatgaaaga catgtacgag cagatgctga agtttggcgc ctacatcgtg gacagtctcc
     7021 gtctgttcaa gcagccagtt ctcatctata tccctcccgg tgccgaactc cgagggggcg
     7081 cctgggttgt cctcgactcc agcatcaacc ccctgtgcat agagatgtac gcagacaaag
     7141 agagcagggg gggtgtcctg gagcccgagg gcactgtgga gattaagttc cggaagaaag
     7201 atttggtgaa gaccataagg aggattgacc cagtgtgcaa gaaactcctg gggcagctgg
     7261 ggacagccca gctccctgac aaggaccgga aagagctgga gagccagctg aaggcccggg
     7321 aggacctgct gctccccatc taccaccagg tggcagtgca gttcgccgac ctgcatgaca
     7381 cgccgggcca catgctggag aagggaatca tttctgatgt gctggagtgg aagaccacac
     7441 gtacctactt ctactggagg ctgcgccggc tgctgctgga ggcacaggtg aagcaggaga
     7501 ttctgcgagc cagccctgag ctgagccatg agcacacgca gtccatgctg cgacgctggt
     7561 ttgtggagac cgagggcgcc gtcaaggcct acctgtggga cagcaaccag gtggtagtcc
     7621 agtggctgga acagcactgg tcagccaggg acaacctgcg ttccactatc cgagagaaca
     7681 tcaattatct gaagcgggac tctgtcctca agaccatcca aagcctagtt caagaacacc
     7741 cagaggcgac catggactgt gtggcatacc tgagccagca cctcacgccc gctgagcaga
     7801 tgcaggtggt tcagctgctg tctaccacgg agagcccagc ttcccactga gcaaccctgg
     7861 ccatccccag gaccctggac ggtgggaatg gccgcgcagc aggccttcgc agtacgccag
     7921 gactaatttt gggaaaactg gagctacact ccaagtgtag ctgtggttcc tgaccagtgt
     7981 cttcctagag aaaaggctcc catgttccta ctaggtgggc acagcctctc ctcacctggg
     8041 gacttcaggg tttgtcccag tgaataactg gctgcctctc tgaggcaaac tgaatggggc
     8101 atcctatgtt ccgtgttttg tttgtttgtt tgtttgtttg gcttgggatg gggatcgtgt
     8161 ctcggcgctc cctgtctgat cagaagacac atgtggttcg cactcagtcc ctggttaagc
     8221 caaagaaaac gccagatgag acccgagaaa acgtcttttt gtaatgaggc ttattagact
     8281 tctaggcatc caagcagggg caaaaatgat tccctctttt tcttttctca agagaataaa
     8341 atgacatttt gttcttcaag tggccccagt agggcaggac agccatctta tggacaggct
     8401 atctccagag gtacaggggg aatggatagg aggcttggat acgccatggc tggcagagac
     8461 caactgcctc ggactccggg gctctgtaag ccctttcttc ccaagtggag ccagcactgg
     8521 ccttcactcc atgcctcctg cagactggcc accctcatgg taccatgagt gccctactgc
     8581 ctgagctcgg agctgccccg cccccgcccc tcccaggacc acttcctcac tttgtgcctt
     8641 gataccacgg ctcctctggg ccagtgaccc aggactgtgc tgcgaacacc caggatctgc
     8701 tcacagactt ccccagcact cgcaggttcc gccgcatgag ggcctcgaat gagacattgt
     8761 tctgtgccat gacccgggct ggggaatcca tctgcgctcc tccttctggg cagtgtgtct
     8821 gaagacacca agcgtcactt caggctgagg tcccagatac tcagggaatc atctgcaaac
     8881 caggctgaaa cggaaatgtc ccgccatcag ccaaggacag ccctggtggc tgagggggcc
     8941 tggggcgagt ggagaaaagt tgctgttctg ggggatgaag agttctgggc aaggtccttt
     9001 tgctgtggag gacagcctag actgtcgctc gctgctgccc tgaccacttg ggtgcgccga
     9061 agaggctacc gggagatctg caaaataaac tatttttttg aaggac
//
