LOCUS       NM_130433               1616 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus acetyl-CoA acyltransferase 2 (Acaa2), mRNA;
            nuclear gene for mitochondrial product.
ACCESSION   NM_130433
VERSION     NM_130433.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1616)
  AUTHORS   Kiema,T.R., Harijan,R.K., Strozyk,M., Fukao,T., Alexson,S.E. and
            Wierenga,R.K.
  TITLE     The crystal structure of human mitochondrial 3-ketoacyl-CoA
            thiolase (T1): insight into the reaction mechanism of its thiolase
            and thioesterase activities
  JOURNAL   Acta Crystallogr D Biol Crystallogr 70 (Pt 12), 3212-3225 (2014)
   PUBMED   25478839
REFERENCE   2  (bases 1 to 1616)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   3  (bases 1 to 1616)
  AUTHORS   Cao,W., Liu,N., Tang,S., Bao,L., Shen,L., Yuan,H., Zhao,X. and
            Lu,H.
  TITLE     Acetyl-Coenzyme A acyltransferase 2 attenuates the apoptotic
            effects of BNIP3 in two human cell lines
  JOURNAL   Biochim Biophys Acta 1780 (6), 873-880 (2008)
   PUBMED   18371312
REFERENCE   4  (bases 1 to 1616)
  AUTHORS   Yamashita,H., Itsuki,A., Kimoto,M., Hiemori,M. and Tsuji,H.
  TITLE     Acetate generation in rat liver mitochondria; acetyl-CoA hydrolase
            activity is demonstrated by 3-ketoacyl-CoA thiolase
  JOURNAL   Biochim Biophys Acta 1761 (1), 17-23 (2006)
   PUBMED   16476568
REFERENCE   5  (bases 1 to 1616)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   6  (bases 1 to 1616)
  AUTHORS   Da Cruz,S., Xenarios,I., Langridge,J., Vilbois,F., Parone,P.A. and
            Martinou,J.C.
  TITLE     Proteomic analysis of the mouse liver mitochondrial inner membrane
  JOURNAL   J Biol Chem 278 (42), 41566-41571 (2003)
   PUBMED   12865426
REFERENCE   7  (bases 1 to 1616)
  AUTHORS   Silva,M.F., Ruiter,J.P., Overmars,H., Bootsma,A.H., van
            Gennip,A.H., Jakobs,C., Duran,M., Tavares de Almeida,I. and
            Wanders,R.J.
  TITLE     Complete beta-oxidation of valproate: cleavage of 3-oxovalproyl-CoA
            by a mitochondrial 3-oxoacyl-CoA thiolase
  JOURNAL   Biochem J 362 (Pt 3), 755-760 (2002)
   PUBMED   11879205
REFERENCE   8  (bases 1 to 1616)
  AUTHORS   Arakawa,H., Takiguchi,M., Amaya,Y., Nagata,S., Hayashi,H. and
            Mori,M.
  TITLE     cDNA-derived amino acid sequence of rat mitochondrial 3-oxoacyl-CoA
            thiolase with no transient presequence: structural relationship
            with peroxisomal isozyme
  JOURNAL   EMBO J 6 (5), 1361-1366 (1987)
   PUBMED   3038520
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000018.1.
            
            On Nov 26, 2020 this sequence version replaced NM_130433.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X05341.1, FQ216726.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-177               JAXUCZ010000018.1  70620310-70620486
            178-344             JAXUCZ010000018.1  70625721-70625887
            345-473             JAXUCZ010000018.1  70631552-70631680
            474-590             JAXUCZ010000018.1  70632466-70632582
            591-738             JAXUCZ010000018.1  70634239-70634386
            739-914             JAXUCZ010000018.1  70637624-70637799
            915-1044            JAXUCZ010000018.1  70638340-70638469
            1045-1115           JAXUCZ010000018.1  70643190-70643260
            1116-1270           JAXUCZ010000018.1  70646411-70646565
            1271-1616           JAXUCZ010000018.1  70648072-70648417
FEATURES             Location/Qualifiers
     source          1..1616
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18q12.2"
     gene            1..1616
                     /gene="Acaa2"
                     /note="acetyl-CoA acyltransferase 2"
                     /db_xref="GeneID:170465"
                     /db_xref="RGD:620482"
     exon            1..177
                     /gene="Acaa2"
                     /inference="alignment:Splign:2.1.0"
     CDS             162..1355
                     /gene="Acaa2"
                     /EC_number="2.3.1.9"
                     /EC_number="2.3.1.16"
                     /EC_number="3.1.2.2"
                     /EC_number="3.1.2.1"
                     /note="beta-ketothiolase; mitochondrial 3-oxoacyl-CoA
                     thiolase; acetyl-Coenzyme A acyltransferase 2
                     (mitochondrial 3-oxoacyl-Coenzyme A thiolase); acetyl-CoA
                     acetyltransferase; acyl-CoA hydrolase, mitochondrial"
                     /codon_start=1
                     /product="3-ketoacyl-CoA thiolase, mitochondrial"
                     /protein_id="NP_569117.2"
                     /db_xref="GeneID:170465"
                     /db_xref="RGD:620482"
                     /translation="MALLRGVFIVAAKRTPFGAYGGLLKDFTATDLTEFAARAALSAG
                     KVPPETIDSVIVGNVMQSSSDAAYLARHVGLRVGVPTETGALTLNRLCGSGFQSIVSG
                     CQEICSKDAEVVLCGGTESMSQSPYSVRNVRFGTKFGLDLKLEDTLWAGLTDQHVKLP
                     MGMTAENLAAKYNISREDCDRYALQSQQRWKAANEAGYFNEEMAPIEVKTKKGKQTMQ
                     VDEHARPQTTLEQLQKLPPVFKKEGTVTAGNASGMSDGAGVVIIASEDAVKKHNFTPL
                     ARVVGYFVSGCDPAIMGIGPVPAITGALKKAGLSLKDMDLIDVNEAFAPQFLAVQKSL
                     DLDPSKTNVSGGAIALGHPLGGSGSRITAHLVHELRRRGGKYAVGSACIGGGQGISLI
                     IQNTA"
     exon            178..344
                     /gene="Acaa2"
                     /inference="alignment:Splign:2.1.0"
     exon            345..473
                     /gene="Acaa2"
                     /inference="alignment:Splign:2.1.0"
     exon            474..590
                     /gene="Acaa2"
                     /inference="alignment:Splign:2.1.0"
     exon            591..738
                     /gene="Acaa2"
                     /inference="alignment:Splign:2.1.0"
     exon            739..914
                     /gene="Acaa2"
                     /inference="alignment:Splign:2.1.0"
     exon            915..1044
                     /gene="Acaa2"
                     /inference="alignment:Splign:2.1.0"
     exon            1045..1115
                     /gene="Acaa2"
                     /inference="alignment:Splign:2.1.0"
     exon            1116..1270
                     /gene="Acaa2"
                     /inference="alignment:Splign:2.1.0"
     exon            1271..1616
                     /gene="Acaa2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 taaccttggc cccggcggcg cggggggggg ggcagggatg gaaaagtagg ggaaagggca
       61 ggggcgcggc ctctcggggc gccgcccaca ctattaaggc tgggctaggg ctggtggccg
      121 agtgaagctg tgagagaccc gtggaataac tgagcttcgt catggcgctg ctacgaggtg
      181 tgtttatcgt tgctgcgaag cgaacaccct ttggagctta tgggggtctt ctcaaggact
      241 tcactgccac tgacttaact gaatttgctg ccagggctgc cctgtctgct ggcaaagttc
      301 caccggaaac catcgatagt gtcatcgtgg gcaatgtcat gcagagctct tcagatgcgg
      361 cgtacctggc aaggcatgtg ggtttacgag tgggagtccc gacggagact ggggccctca
      421 ccctcaacag actctgtggc tctggtttcc agtccatcgt gagcggatgt caggaaatct
      481 gctcgaaaga cgctgaggtc gtcttatgtg gaggaaccga gagcatgagc cagtccccct
      541 actctgtcag aaatgtgcgc ttcggaacca aatttgggtt agatctcaag ctggaagata
      601 ctttgtgggc aggattaacg gatcaacacg tgaagctccc catggggatg actgcagaga
      661 acctggctgc aaaatacaac ataagcagag aagactgcga cagatacgcc ctgcagtccc
      721 agcagaggtg gaaagccgct aacgaggctg gctactttaa tgaggagatg gcccccattg
      781 aggtgaagac caagaagggc aaacagacca tgcaagtgga tgagcacgcc cggccccaaa
      841 cgaccctgga gcagctgcag aagctcccgc cagtgttcaa gaaagagggg acagtcacag
      901 cagggaacgc ctcgggcatg tctgacggtg ctggggtcgt catcatagcc agcgaagatg
      961 ctgtcaaaaa acataacttc acaccactgg ccagagtcgt gggctacttt gtgtctggat
     1021 gtgaccctgc tatcatgggg atcggtccag tccctgccat cactggagca ttgaagaaag
     1081 ctgggctgag ccttaaggac atggatttga tagacgtgaa tgaagcattt gctcctcagt
     1141 tcttggctgt tcagaagagc ttggatctcg accccagtaa aaccaacgtg agtggaggtg
     1201 ccatagccct gggtcacccg ctgggaggat ctggatccag aatcaccgca cacctggttc
     1261 acgagttaag gcgtcgaggt ggaaaatacg cagtgggatc agcttgcatt ggaggtggcc
     1321 aaggcatctc cctgatcatc cagaacacag cctgaaggga ttgcaagcat cctacccacc
     1381 ctcacttggc caggctacgg aacacaggcg acctttgagt cagccctgct gtgacagtaa
     1441 atgcatttga ccaagccttg atgggttctg tctacttcat acctgcctag cgtgttagaa
     1501 taaaaagacc agccatcaga ggcctttaga gatacctact ggtgtcattg tcagcagcca
     1561 ccactgtatg ccttacatgg tgaaattaca aactgaataa atgttgcctt aactcc
//
