LOCUS       NM_012489               1695 bp    mRNA    linear   ROD 27-MAR-2024
DEFINITION  Rattus norvegicus acetyl-CoA acyltransferase 1A (Acaa1a),
            transcript variant 1, mRNA.
ACCESSION   NM_012489 XM_345997
VERSION     NM_012489.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1695)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   2  (bases 1 to 1695)
  AUTHORS   Toro,A.A., Araya,C.A., Cordova,G.J., Arredondo,C.A., Cardenas,H.G.,
            Moreno,R.E., Venegas,A., Koenig,C.S., Cancino,J., Gonzalez,A. and
            Santos,M.J.
  TITLE     Pex3p-dependent peroxisomal biogenesis initiates in the endoplasmic
            reticulum of human fibroblasts
  JOURNAL   J Cell Biochem 107 (6), 1083-1096 (2009)
   PUBMED   19479899
REFERENCE   3  (bases 1 to 1695)
  AUTHORS   Nenicu,A., Luers,G.H., Kovacs,W., David,M., Zimmer,A., Bergmann,M.
            and Baumgart-Vogt,E.
  TITLE     Peroxisomes in human and mouse testis: differential expression of
            peroxisomal proteins in germ cells and distinct somatic cell types
            of the testis
  JOURNAL   Biol Reprod 77 (6), 1060-1072 (2007)
   PUBMED   17881773
  REMARK    Erratum:[Biol Reprod. 2008 Feb;78(2):378. David, M [added]; Zimmer,
            Andreas [added]]
REFERENCE   4  (bases 1 to 1695)
  AUTHORS   Onay-Besikci,A., Guner,S., Arioglu,E., Ozakca,I., Ozcelikay,A.T.
            and Altan,V.M.
  TITLE     The effects of chronic trimetazidine treatment on mechanical
            function and fatty acid oxidation in diabetic rat hearts
  JOURNAL   Can J Physiol Pharmacol 85 (5), 527-535 (2007)
   PUBMED   17632588
REFERENCE   5  (bases 1 to 1695)
  AUTHORS   Kikuchi,M., Hatano,N., Yokota,S., Shimozawa,N., Imanaka,T. and
            Taniguchi,H.
  TITLE     Proteomic analysis of rat liver peroxisome: presence of
            peroxisome-specific isozyme of Lon protease
  JOURNAL   J Biol Chem 279 (1), 421-428 (2004)
   PUBMED   14561759
REFERENCE   6  (bases 1 to 1695)
  AUTHORS   Heikoop,J.C., Ossendorp,B.C., Wanders,R.J., Wirtz,K.W. and
            Tager,J.M.
  TITLE     Subcellular localisation and processing of non-specific lipid
            transfer protein are not aberrant in Rhizomelic Chondrodysplasia
            Punctata fibroblasts
  JOURNAL   FEBS Lett 299 (2), 201-204 (1992)
   PUBMED   1347505
REFERENCE   7  (bases 1 to 1695)
  AUTHORS   Swinkels,B.W., Gould,S.J., Bodnar,A.G., Rachubinski,R.A. and
            Subramani,S.
  TITLE     A novel, cleavable peroxisomal targeting signal at the
            amino-terminus of the rat 3-ketoacyl-CoA thiolase
  JOURNAL   EMBO J 10 (11), 3255-3262 (1991)
   PUBMED   1680677
REFERENCE   8  (bases 1 to 1695)
  AUTHORS   Bodnar,A.G. and Rachubinski,R.A.
  TITLE     Cloning and sequence determination of cDNA encoding a second rat
            liver peroxisomal 3-ketoacyl-CoA thiolase
  JOURNAL   Gene 91 (2), 193-199 (1990)
   PUBMED   2210380
REFERENCE   9  (bases 1 to 1695)
  AUTHORS   Clayton,P.T., Patel,E., Lawson,A.M., Carruthers,R.A. and Collins,J.
  TITLE     Bile acid profiles in peroxisomal 3-oxoacyl-coenzyme A thiolase
            deficiency
  JOURNAL   J Clin Invest 85 (4), 1267-1273 (1990)
   PUBMED   2318981
REFERENCE   10 (bases 1 to 1695)
  AUTHORS   Hijikata,M., Wen,J.K., Osumi,T. and Hashimoto,T.
  TITLE     Rat peroxisomal 3-ketoacyl-CoA thiolase gene. Occurrence of two
            closely related but differentially regulated genes
  JOURNAL   J Biol Chem 265 (8), 4600-4606 (1990)
   PUBMED   2307679
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Jul 29, 2021 this sequence version replaced NM_012489.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M32801.1, SRR26643290.31237.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-327               JAXUCZ010000008.1  127957481-127957807
            328-421             JAXUCZ010000008.1  127957947-127958040
            422-479             JAXUCZ010000008.1  127958918-127958975
            480-559             JAXUCZ010000008.1  127960192-127960271
            560-602             JAXUCZ010000008.1  127960508-127960550
            603-701             JAXUCZ010000008.1  127962275-127962373
            702-782             JAXUCZ010000008.1  127963283-127963363
            783-973             JAXUCZ010000008.1  127964609-127964799
            974-1153            JAXUCZ010000008.1  127964949-127965128
            1154-1209           JAXUCZ010000008.1  127965404-127965459
            1210-1355           JAXUCZ010000008.1  127965545-127965690
            1356-1695           JAXUCZ010000008.1  127966009-127966348
FEATURES             Location/Qualifiers
     source          1..1695
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q32"
     gene            1..1695
                     /gene="Acaa1a"
                     /gene_synonym="Acaa; Acaa1; Pktaa"
                     /note="acetyl-CoA acyltransferase 1A"
                     /db_xref="GeneID:24157"
                     /db_xref="RGD:67379"
     exon            1..327
                     /gene="Acaa1a"
                     /gene_synonym="Acaa; Acaa1; Pktaa"
                     /inference="alignment:Splign:2.1.0"
     CDS             127..1431
                     /gene="Acaa1a"
                     /gene_synonym="Acaa; Acaa1; Pktaa"
                     /EC_number="2.3.1.9"
                     /EC_number="2.3.1.16"
                     /EC_number="2.3.1.155"
                     /note="isoform 1 is encoded by transcript variant 1;
                     3-ketoacyl-CoA thiolase A, peroxisomal; acetyl-Coenzyme A
                     acyltransferase 1A; acetyl-CoA acyltransferase 3-oxo
                     acyl-CoA thiolase A 1 peroxisomal; beta-ketothiolase A;
                     acetyl-CoA acyltransferase A; peroxisomal 3-oxoacyl-CoA
                     thiolase A; acetyl-CoA acyltransferase, 3-oxo acyl-CoA
                     thiolase A; Acetyl-CoA acyltransferase 3-oxo acyl-CoA
                     thiolase A peroxisomal; acetyl-CoA acyltransferase 1;
                     acetyl-Coenzyme A acyltransferase 1 (peroxisomal
                     3-oxoacyl-Coenzyme A thiolase); acetyl-CoA
                     C-myristoyltransferase"
                     /codon_start=1
                     /product="3-ketoacyl-CoA thiolase A, peroxisomal isoform
                     1"
                     /protein_id="NP_036621.2"
                     /db_xref="GeneID:24157"
                     /db_xref="RGD:67379"
                     /translation="MSESVGRTSAMHRLQVVLGHLAGRPESSSALQAAPCSASFPQAS
                     ASDVVVVHGRRTPIGRAGRGGFKDTTPDELLSAVLTAVLQDVKLKPECLGDISVGNVL
                     EPGAGAVMARIAQFLSGIPETVPLSAVNRQCSSGLQAVANIAGGIRNGSYDIGMACGV
                     ESMSLSNRGNPGNISSRLLESDKARDCLIPMGITSENVAERFGISRQKQDAFALASQQ
                     KAASAQSKGCFRAEIVPVTTTVLDDKGDRKTITVSQDEGVRPSTTMEGLAKLKPAFKD
                     GGSTTAGNSSQVSDGAAAVLLARRSKAEELGLPILGVLRSYAVVGVPPDIMGIGPAYA
                     IPAALQKAGLTVNDIDIFEINEAFASQALYCVEKLGIPAEKVNPLGGAIALGHPLGCT
                     GARQVVTLLNELKRRGRRAYGVVSMCIGTGMGAAAVFEYPGN"
     exon            328..421
                     /gene="Acaa1a"
                     /gene_synonym="Acaa; Acaa1; Pktaa"
                     /inference="alignment:Splign:2.1.0"
     exon            422..479
                     /gene="Acaa1a"
                     /gene_synonym="Acaa; Acaa1; Pktaa"
                     /inference="alignment:Splign:2.1.0"
     exon            480..559
                     /gene="Acaa1a"
                     /gene_synonym="Acaa; Acaa1; Pktaa"
                     /inference="alignment:Splign:2.1.0"
     exon            560..602
                     /gene="Acaa1a"
                     /gene_synonym="Acaa; Acaa1; Pktaa"
                     /inference="alignment:Splign:2.1.0"
     exon            603..701
                     /gene="Acaa1a"
                     /gene_synonym="Acaa; Acaa1; Pktaa"
                     /inference="alignment:Splign:2.1.0"
     exon            702..782
                     /gene="Acaa1a"
                     /gene_synonym="Acaa; Acaa1; Pktaa"
                     /inference="alignment:Splign:2.1.0"
     exon            783..973
                     /gene="Acaa1a"
                     /gene_synonym="Acaa; Acaa1; Pktaa"
                     /inference="alignment:Splign:2.1.0"
     exon            974..1153
                     /gene="Acaa1a"
                     /gene_synonym="Acaa; Acaa1; Pktaa"
                     /inference="alignment:Splign:2.1.0"
     exon            1154..1209
                     /gene="Acaa1a"
                     /gene_synonym="Acaa; Acaa1; Pktaa"
                     /inference="alignment:Splign:2.1.0"
     exon            1210..1355
                     /gene="Acaa1a"
                     /gene_synonym="Acaa; Acaa1; Pktaa"
                     /inference="alignment:Splign:2.1.0"
     exon            1356..1695
                     /gene="Acaa1a"
                     /gene_synonym="Acaa; Acaa1; Pktaa"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agaccccatc gcaccactct cagcattatc ctacccgagc tctgatccac tttcaggcct
       61 cgtgaggtag agggctggcc tgcgcctgcg cctgccatca ttttggtttg ttaagcaagg
      121 cagagcatga gcgagtcggt gggacgcacc tccgcgatgc atcggctgca ggtagtgctg
      181 ggccacctgg ccggccgacc cgagtcgagc tccgcgctgc aagccgcgcc ctgctccgct
      241 agcttcccgc aggcttcggc ctccgacgtg gtggtggtgc acggacggcg cacccccatc
      301 ggccgcgcgg gccgcggcgg cttcaaggac accacccccg acgagcttct gtcggccgtg
      361 ttgaccgcgg ttctccagga cgtgaagcta aagcctgagt gtttgggaga catctctgtg
      421 ggtaacgtac ttgagccagg agccggagca gtcatggcgc gcattgccca atttctgagt
      481 ggcatcccag agaccgtgcc tctgtcagca gtcaacagac agtgttcatc gggactgcag
      541 gcagtggcca acattgctgg tggcatcaga aatgggtctt acgacattgg catggcctgt
      601 ggggtggagt ccatgtccct gtctaacaga gggaaccctg ggaatatttc ctcccgcctg
      661 ctggagagtg acaaagccag agactgcctg attcctatgg ggataacctc ggagaatgtg
      721 gctgagcggt ttggcatctc acggcagaag caagatgcct tcgcgctggc ctctcagcag
      781 aaggcagcaa gtgcccagag caaaggctgc ttccgtgctg agatcgtacc tgtgacaacc
      841 actgtcctcg atgacaaggg tgacaggaaa accatcaccg tgtctcagga tgagggtgtc
      901 cgccccagca ccaccatgga gggcctggcc aagctgaagc ctgccttcaa ggatggaggc
      961 tctaccacgg ctggaaactc cagtcaggtg agtgatggag cagccgccgt cctgctggcc
     1021 cggaggtcca aggctgaaga actgggcctc cccatccttg gcgtcctgag gtcctatgca
     1081 gtggtcgggg tccctcctga catcatgggc atcggacctg cctatgccat ccctgcggcc
     1141 ttgcagaaag cagggctgac tgtgaatgac atagacatct ttgagatcaa tgaggccttt
     1201 gcaagtcagg ccctctactg tgtggagaag ctgggaattc ctgcagagaa ggtgaacccc
     1261 ctggggggtg caatagccct gggccacccc ctgggctgca ccggagcaag gcaggtggtc
     1321 acgctgctca atgagctgaa gcgccgaggc agacgggctt atggcgtggt gtccatgtgc
     1381 attgggactg ggatgggagc cgctgctgtc tttgaatacc ctgggaactg aggccctgac
     1441 tgcaggcact acccagagag tcctatagta gtgtctggag agggatggta cagaagccat
     1501 cttcgtggga cactcagcag tggagggatt tgtcacagca cttcaattca gaagatgtag
     1561 tcgatgttgg aacaggaggt ggaactgccc tgtcaagtac cccaagccat gctaaagtga
     1621 gcatgggaca cccaggttgc aaagccatct gtacctctga cggatgggtg tagtaaatgt
     1681 gtgctgtctc atttt
//
