LOCUS       NM_001106307            2940 bp    mRNA    linear   ROD 29-MAR-2024
DEFINITION  Rattus norvegicus abraxas 2, BRISC complex subunit (Abraxas2),
            mRNA.
ACCESSION   NM_001106307 XM_001054804 XM_219441
VERSION     NM_001106307.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2940)
  AUTHORS   Yan,K., Li,L., Wang,X., Hong,R., Zhang,Y., Yang,H., Lin,M.,
            Zhang,S., He,Q., Zheng,D., Tang,J., Yin,Y. and Shao,G.
  TITLE     The deubiquitinating enzyme complex BRISC is required for proper
            mitotic spindle assembly in mammalian cells
  JOURNAL   J Cell Biol 210 (2), 209-224 (2015)
   PUBMED   26195665
REFERENCE   2  (bases 1 to 2940)
  AUTHORS   Zheng,H., Gupta,V., Patterson-Fortin,J., Bhattacharya,S.,
            Katlinski,K., Wu,J., Varghese,B., Carbone,C.J., Aressy,B.,
            Fuchs,S.Y. and Greenberg,R.A.
  TITLE     A BRISC-SHMT complex deubiquitinates IFNAR1 and regulates
            interferon responses
  JOURNAL   Cell Rep 5 (1), 180-193 (2013)
   PUBMED   24075985
REFERENCE   3  (bases 1 to 2940)
  AUTHORS   Ambivero,C.T., Cilenti,L. and Zervos,A.S.
  TITLE     ATF4 interacts with Abro1/KIAA0157 scaffold protein and
            participates in a cytoprotective pathway
  JOURNAL   Biochim Biophys Acta 1823 (12), 2149-2156 (2012)
   PUBMED   22974638
REFERENCE   4  (bases 1 to 2940)
  AUTHORS   Cilenti,L., Balakrishnan,M.P., Wang,X.L., Ambivero,C.,
            Sterlicchi,M., del Monte,F., Ma,X.L. and Zervos,A.S.
  TITLE     Regulation of Abro1/KIAA0157 during myocardial infarction and cell
            death reveals a novel cardioprotective mechanism for Lys63-specific
            deubiquitination
  JOURNAL   J Mol Cell Cardiol 50 (4), 652-661 (2011)
   PUBMED   21195082
REFERENCE   5  (bases 1 to 2940)
  AUTHORS   Cooper,E.M., Cutcliffe,C., Kristiansen,T.Z., Pandey,A.,
            Pickart,C.M. and Cohen,R.E.
  TITLE     K63-specific deubiquitination by two JAMM/MPN+ complexes:
            BRISC-associated Brcc36 and proteasomal Poh1
  JOURNAL   EMBO J 28 (6), 621-631 (2009)
   PUBMED   19214193
REFERENCE   6  (bases 1 to 2940)
  AUTHORS   Wang,B., Hurov,K., Hofmann,K. and Elledge,S.J.
  TITLE     NBA1, a new player in the Brca1 A complex, is required for DNA
            damage resistance and checkpoint control
  JOURNAL   Genes Dev 23 (6), 729-739 (2009)
   PUBMED   19261749
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473953.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_001054804.1, XM_219441.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ218234.1, SRR8487230.65448.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2940
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q41"
     gene            1..2940
                     /gene="Abraxas2"
                     /gene_synonym="Fam175b; RGD1308918"
                     /note="abraxas 2, BRISC complex subunit"
                     /db_xref="GeneID:293570"
                     /db_xref="RGD:1308918"
     CDS             1..1272
                     /gene="Abraxas2"
                     /gene_synonym="Fam175b; RGD1308918"
                     /note="BRISC complex subunit Abro1; family with sequence
                     similarity 175, member B"
                     /codon_start=1
                     /product="BRISC complex subunit Abraxas 2"
                     /protein_id="NP_001099777.2"
                     /db_xref="GeneID:293570"
                     /db_xref="RGD:1308918"
                     /translation="MGEVEISIMAASISGYTFSAVCFHSANSNADHEGFLLGEVRQEE
                     TFSISDSQISNTEFLQVIEIHNHQPCSKLFSFYDYASKVNEESLDRILKDRRKKVIGW
                     YRFRRNTQQQMSYREQVIHKQLTRVLGVPDLVFLLFSFISTANNSTHALEYVLFRPNR
                     RYNQRISLAIPNLGNTSQQEYKVSSVPNTSQSYAKVIKEHGTDFFDKDGVMKDIRAIY
                     QVYNALQEKVQAVCADVEKSERVVESCQAEVNKLRRQITQKKNEKEQERRLQQALLSR
                     QMPSESLEPAFSPRMPYSGFSAEGRSTLADAEPSDPPPPYSDFHPNNQESTLSHSRIE
                     RSVFMPRPQAVGSSNYASTSAGLKFTGSGADLLPSQSAAGDSGEETDDSDYENLIDPA
                     ESPHSEYSHSKNSRPTTHPDEDPRNTQTSQI"
     exon            1..96
                     /gene="Abraxas2"
                     /gene_synonym="Fam175b; RGD1308918"
                     /inference="alignment:Splign:2.1.0"
     exon            97..187
                     /gene="Abraxas2"
                     /gene_synonym="Fam175b; RGD1308918"
                     /inference="alignment:Splign:2.1.0"
     exon            188..224
                     /gene="Abraxas2"
                     /gene_synonym="Fam175b; RGD1308918"
                     /inference="alignment:Splign:2.1.0"
     exon            225..291
                     /gene="Abraxas2"
                     /gene_synonym="Fam175b; RGD1308918"
                     /inference="alignment:Splign:2.1.0"
     exon            292..482
                     /gene="Abraxas2"
                     /gene_synonym="Fam175b; RGD1308918"
                     /inference="alignment:Splign:2.1.0"
     exon            483..602
                     /gene="Abraxas2"
                     /gene_synonym="Fam175b; RGD1308918"
                     /inference="alignment:Splign:2.1.0"
     exon            603..687
                     /gene="Abraxas2"
                     /gene_synonym="Fam175b; RGD1308918"
                     /inference="alignment:Splign:2.1.0"
     exon            688..802
                     /gene="Abraxas2"
                     /gene_synonym="Fam175b; RGD1308918"
                     /inference="alignment:Splign:2.1.0"
     exon            803..2940
                     /gene="Abraxas2"
                     /gene_synonym="Fam175b; RGD1308918"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgggggagg tggagatttc catcatggcg gcttccattt cgggctacac cttcagcgct
       61 gtgtgtttcc acagcgccaa cagcaacgcc gaccacgaag gatttttgct gggagaggta
      121 agacaagagg aaacgtttag catcagtgac tcacaaatca gcaacacaga gtttctacaa
      181 gtaattgaaa tccataacca tcaaccctgt tcaaaactct ttagttttta tgattatgca
      241 agcaaagtga atgaagagag tttggacaga attcttaaag atcggaggaa gaaagtcatc
      301 ggatggtaca gattccggag aaacacccag cagcagatgt cctacagaga gcaagtcatc
      361 cacaagcagc tcacccgcgt cctcggcgtg ccagacctgg ttttccttct cttcagcttc
      421 atctctaccg ccaacaactc tactcatgcg ttagaatatg ttctctttcg accaaatcgc
      481 aggtataatc aaaggatatc acttgctatt cccaatctag gcaatactag ccagcaagag
      541 tacaaagtgt cttcagtgcc aaacacatct cagagttatg ccaaagttat taaagagcat
      601 ggtactgact tttttgacaa ggatggagtc atgaaggaca tcagggcaat ttatcaggtt
      661 tataatgcac ttcaggagaa agtacaggca gtgtgtgcag atgtagaaaa gagtgagcga
      721 gttgttgaat cttgtcaggc agaagtgaac aaattgagaa gacaaatcac tcagaagaaa
      781 aatgaaaagg aacaagaaag aagactgcag caggccctgt taagcagaca gatgccatct
      841 gaaagcctgg agccagcatt cagccctcgg atgccatatt ctgggttttc agccgaaggg
      901 agaagtactc tagcagatgc cgagccctct gatcctccac ctccttactc cgatttccac
      961 ccaaacaatc aagaaagtac tctgagccat tctcgcatag aaaggagtgt cttcatgccc
     1021 cggcctcagg ctgtgggctc ttccaactat gcttccacca gtgccggact gaagttcact
     1081 ggaagtggag cagatcttct tccttcccag agtgcagctg gagacagcgg ggaggagaca
     1141 gatgacagtg attatgaaaa tttgattgac cctgcagagt cccctcatag tgaatactca
     1201 cattcaaaga attcacggcc cacgacacat cctgacgagg accccaggaa cactcagacc
     1261 tcccagattt aagtaaacaa atgacactct ccacttggca ctacttttct taatggctta
     1321 ttgagtgttg ttgaggactt aatctgtggg gagacctgct ttctcagatg ccgtggctcc
     1381 tgagtggagc atcctgtgca tagaactccc agaatcctct gtccactggt cctcacctct
     1441 gggtacagtg cacaggttca caacaaaatc attatgataa tcaaattgtc ctaattctgg
     1501 tgcgattcat ggatgtacta gtaaatttag gcagagtgaa actcctcagt gtagtctgtt
     1561 ctttaagata aatcagagat cagagactaa gcacaattag tctataaata ctctctaagt
     1621 cagaaactta cctctgcact atcatgcctt gaaatttgct ttttcaaagg gaaacgaatt
     1681 tagcagcagc cttcaaagac ctttctatga tgagccaaat tcatctttgc cagaaaagaa
     1741 attttgttaa ttccaagaag cctaattgga acaagtcaga cattccttct cctgtctgca
     1801 tggttttgta agatgggaag agagggcttt gtttcaactt ttttctacta gcctgatacg
     1861 tattgtcact taaaatggtt gcctttttcc aaatgtagga atactaattc ccagtgagta
     1921 ctcatccaga tcagtgtcct gaagtcagtt ccttgtcttt tggtacagca gcgactgctg
     1981 ggctgcacca gcacagttgg cctctgttct ggagtcttag aggaaggcca cacacccgtg
     2041 gatggcagaa gggagaagcc aggctgagtc tgtagtgacc agatcccaga cacagtggat
     2101 ttaactaagt tcctgtgtaa aggatgtagt gtacttaggt gtggcaggtc ccagctagag
     2161 ttgtggagga aagacatttt taagaaaata tccaggaatc ttgaggactg cagagatcca
     2221 cgtcaagtat gaataaccat actttttctc ttttcctaaa gttgccattt aggagataac
     2281 tgcaaatgtg tggagaccat tgggatgcac ttacgctttt atttaagtac tgcttgtttt
     2341 ctagttttgc ccagaatgtg tgaaaccact aaaaaccagt tttgagtatg ttgggccact
     2401 gaattggaaa cggcaagacc taccatttat ggcaatcaat cagcccatga tgcttggcac
     2461 tgaacagcct ttccttggac tagttaaaac ctgtaaggat gtagacacca ttaaaaggct
     2521 taaaatctgg ttccaaacga ttgattttgt tttatagtga tatttactca tgagctccag
     2581 ctcccagtct cagacagtgg atacaggctt agaaatgaga tgctggactg ccctgcttgg
     2641 gttgtgcccc agggtctgca ttgtaactgc tgtcctcgtt tttctgggct caaaccactt
     2701 ccatttgatt tggatgtcgg gggtcacttt gtctgcagtg cgctccagcc tttctcagct
     2761 accttactta ctagcagctt cagcacggtc tgaatcccag tttgttcaag tgccatcgcc
     2821 atctcctctg ttcagatttt gacattcagg aaaatattct tatttttatg ccatactgaa
     2881 atatacagtg tatatctgac aaagcagtta aatgtgacaa taaaaactta tttaatcatg
//
