LOCUS       NM_175844               1282 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Rattus norvegicus actin-binding Rho activating protein (Abra),
            mRNA.
ACCESSION   NM_175844
VERSION     NM_175844.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1282)
  AUTHORS   Zaleska,M., Fogl,C., Kho,A.L., Ababou,A., Ehler,E. and Pfuhl,M.
  TITLE     The Cardiac Stress Response Factor Ms1 Can Bind to DNA and Has a
            Function in the Nucleus
  JOURNAL   PLoS One 10 (12), e0144614 (2015)
   PUBMED   26656831
  REMARK    GeneRIF: In rat cardiomyocytes Ms1 is exclusively found in
            sarcomere. A nuclear localisation site in the N-terminus is
            required for nuclear localisation. Ms1 has the potential to act
            directly in the nucleus through specific interaction with DNA in
            development
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1282)
  AUTHORS   Fogl,C., Puckey,L., Hinssen,U., Zaleska,M., El-Mezgueldi,M.,
            Croasdale,R., Bowman,A., Matsukawa,A., Samani,N.J., Savva,R. and
            Pfuhl,M.
  TITLE     A structural and functional dissection of the cardiac stress
            response factor MS1
  JOURNAL   Proteins 80 (2), 398-409 (2012)
   PUBMED   22081479
  REMARK    GeneRIF: The C-terminal half of the MS1 protein contains two
            independent F-actin binding domains.
REFERENCE   3  (bases 1 to 1282)
  AUTHORS   Koekemoer,A.L., Chong,N.W., Goodall,A.H. and Samani,N.J.
  TITLE     Myocyte stress 1 plays an important role in cellular hypertrophy
            and protection against apoptosis
  JOURNAL   FEBS Lett 583 (17), 2964-2967 (2009)
   PUBMED   19686740
  REMARK    GeneRIF: Results suggest the involvement of MS1 in cellular
            hypertrophy and protection against apoptosis.
REFERENCE   4  (bases 1 to 1282)
  AUTHORS   Barrientos,T., Frank,D., Kuwahara,K., Bezprozvannaya,S.,
            Pipes,G.C., Bassel-Duby,R., Richardson,J.A., Katus,H.A., Olson,E.N.
            and Frey,N.
  TITLE     Two novel members of the ABLIM protein family, ABLIM-2 and -3,
            associate with STARS and directly bind F-actin
  JOURNAL   J Biol Chem 282 (11), 8393-8403 (2007)
   PUBMED   17194709
REFERENCE   5  (bases 1 to 1282)
  AUTHORS   Kuwahara,K., Barrientos,T., Pipes,G.C., Li,S. and Olson,E.N.
  TITLE     Muscle-specific signaling mechanism that links actin dynamics to
            serum response factor
  JOURNAL   Mol Cell Biol 25 (8), 3173-3181 (2005)
   PUBMED   15798203
REFERENCE   6  (bases 1 to 1282)
  AUTHORS   Arai,A., Spencer,J.A. and Olson,E.N.
  TITLE     STARS, a striated muscle activator of Rho signaling and serum
            response factor-dependent transcription
  JOURNAL   J Biol Chem 277 (27), 24453-24459 (2002)
   PUBMED   11983702
REFERENCE   7  (bases 1 to 1282)
  AUTHORS   Mahadeva,H., Brooks,G., Lodwick,D., Chong,N.W. and Samani,N.J.
  TITLE     ms1, a novel stress-responsive, muscle-specific gene that is
            up-regulated in the early stages of pressure overload-induced left
            ventricular hypertrophy
  JOURNAL   FEBS Lett 521 (1-3), 100-104 (2002)
   PUBMED   12067735
  REMARK    Erratum:[FEBS Lett 2002 Sep 25;528(1-3):283]
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF336113.1.
            
            On Feb 21, 2013 this sequence version replaced NM_175844.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF336113.1, BC158575.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760384, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1282              AF336113.1         1-1282
FEATURES             Location/Qualifiers
     source          1..1282
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="WKY"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q31"
     gene            1..1282
                     /gene="Abra"
                     /gene_synonym="Ms1; Stars"
                     /note="actin-binding Rho activating protein"
                     /db_xref="GeneID:286965"
                     /db_xref="RGD:708493"
     exon            1..703
                     /gene="Abra"
                     /gene_synonym="Ms1; Stars"
                     /inference="alignment:Splign:2.1.0"
     CDS             54..1181
                     /gene="Abra"
                     /gene_synonym="Ms1; Stars"
                     /note="striated muscle activator of Rho-dependent
                     signaling"
                     /codon_start=1
                     /product="actin-binding Rho-activating protein"
                     /protein_id="NP_787038.1"
                     /db_xref="GeneID:286965"
                     /db_xref="RGD:708493"
                     /translation="MAPGETVREAGPAKSALQKVRRATLVINLARGWQQWANENSTRQ
                     AQEPAGWLPGATQDLPHTPKEPGPRQHAPKPPSPKPDGDREGRGSEEATEVSHIKRKE
                     VTRTVVSKAYERGGDVNYLSHRYEHDGGVSEAVQPDNDIDRILLSHDSPTRRRKCTNL
                     VSKLTKGWKVMEQEEPKWKSDSIDTEDSGYGGDMEERPEQDVAQVAAARIKRPLHSQA
                     NRYSETLNCKAHRKYSQVDNLKGRWQQWADEHIQSQKLNPFSDEFDYDLAMSTRLHKG
                     DEGYGRPKEGSKTAERAKRAEEHIYREIMELCFVIRTMARHRRDGKIQVTFGELFDRY
                     VRISDKVVGILMRARKHGLVHFEGEMLWQGKDDHVVITLLE"
     exon            704..1282
                     /gene="Abra"
                     /gene_synonym="Ms1; Stars"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acattccctc tttagccagt gcctaggctg tcagcagaga agaaacaggt agcatggctc
       61 ctggagaaac tgtaagggag gcggggccgg ccaagagtgc cctccagaag gtccgcagag
      121 caaccctggt gatcaacttg gcccgaggat ggcagcagtg ggcgaatgag aacagtacca
      181 gacaggccca ggagcctgca ggctggctgc caggagcaac tcaagaccta cctcacactc
      241 ctaaagaacc gggtcctcgc cagcatgccc ccaaacctcc gtctccaaag ccagatggag
      301 acagagaggg acgaggctct gaggaagcca cggaggtctc ccatatcaaa aggaaagagg
      361 tgaccagaac ggttgtcagt aaggcgtatg agagaggagg agatgtgaac tacctgagcc
      421 acaggtacga gcatgatggc ggcgtgtctg aagcggtcca gccagacaat gacattgaca
      481 gaatcctcct cagtcacgac tcgccaacgc ggagaagaaa atgcaccaac ttggtatcta
      541 agctgaccaa aggctggaaa gtgatggaac aggaggagcc caagtggaag agtgacagca
      601 tagacacaga ggacagtggc tacggagggg acatggagga gaggcctgag caagatgtag
      661 cgcaggtggc tgctgccagg attaaacgcc ccttgcactc ccaggcaaac agatactcag
      721 agacactcaa ctgtaaggcc catcggaaat acagccaagt ggacaacttg aaaggcaggt
      781 ggcagcagtg ggccgatgaa cacatacagt cacagaagct caaccccttc agtgatgaat
      841 ttgactatga cctagccatg tccactcgac tccacaaggg agacgaggga tatggccgcc
      901 caaaagaggg aagcaagaca gctgaaaggg ccaagagagc cgaggagcac atctatcggg
      961 aaattatgga attgtgcttt gttatccgca caatggctcg ccatagacga gatggcaaga
     1021 tccaggttac tttcggagaa ctctttgata gatatgttcg aatttcagat aaagtggtgg
     1081 gcatcctcat gcgtgccagg aaacacggac tggtgcactt tgaaggggag atgctatggc
     1141 aaggcaaaga tgaccatgtt gtgattactc tccttgagta agccctcaat aaatcaacct
     1201 gccattgttt tactattaaa tgataatgta ttataagttc aaaggcaaac tgctctggaa
     1261 tgttatcaat attaaatgat tt
//
