LOCUS       NM_001105814            5229 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus ABR activator of RhoGEF and GTPase (Abr), mRNA.
ACCESSION   NM_001105814 XM_001080643 XM_220717
VERSION     NM_001105814.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5229)
  AUTHORS   Yu,M., Gong,D., Lim,M., Arutyunyan,A., Groffen,J. and
            Heisterkamp,N.
  TITLE     Lack of bcr and abr promotes hypoxia-induced pulmonary hypertension
            in mice
  JOURNAL   PLoS One 7 (11), e49756 (2012)
   PUBMED   23152932
REFERENCE   2  (bases 1 to 5229)
  AUTHORS   Oh,D., Han,S., Seo,J., Lee,J.R., Choi,J., Groffen,J., Kim,K.,
            Cho,Y.S., Choi,H.S., Shin,H., Woo,J., Won,H., Park,S.K., Kim,S.Y.,
            Jo,J., Whitcomb,D.J., Cho,K., Kim,H., Bae,Y.C., Heisterkamp,N.,
            Choi,S.Y. and Kim,E.
  TITLE     Regulation of synaptic Rac1 activity, long-term potentiation
            maintenance, and learning and memory by BCR and ABR Rac
            GTPase-activating proteins
  JOURNAL   J Neurosci 30 (42), 14134-14144 (2010)
   PUBMED   20962234
  REMARK    GeneRIF: breakpoint cluster region and ABR have novel roles in the
            regulation of synaptic Rac1 signaling, synaptic plasticity, and
            learning and memory, and that excessive Rac1 activity negatively
            affects synaptic and cognitive functions
REFERENCE   3  (bases 1 to 5229)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   4  (bases 1 to 5229)
  AUTHORS   Cunnick,J.M., Schmidhuber,S., Chen,G., Yu,M., Yi,S.J., Cho,Y.J.,
            Kaartinen,V., Minoo,P., Warburton,D., Groffen,J. and Heisterkamp,N.
  TITLE     Bcr and Abr cooperate in negatively regulating acute inflammatory
            responses
  JOURNAL   Mol Cell Biol 29 (21), 5742-5750 (2009)
   PUBMED   19703997
REFERENCE   5  (bases 1 to 5229)
  AUTHORS   Cho,Y.J., Cunnick,J.M., Yi,S.J., Kaartinen,V., Groffen,J. and
            Heisterkamp,N.
  TITLE     Abr and Bcr, two homologous Rac GTPase-activating proteins, control
            multiple cellular functions of murine macrophages
  JOURNAL   Mol Cell Biol 27 (3), 899-911 (2007)
   PUBMED   17116687
REFERENCE   6  (bases 1 to 5229)
  AUTHORS   Kaartinen,V., Nagy,A., Gonzalez-Gomez,I., Groffen,J. and
            Heisterkamp,N.
  TITLE     Vestibular dysgenesis in mice lacking Abr and Bcr Cdc42/RacGAPs
  JOURNAL   Dev Dyn 223 (4), 517-525 (2002)
   PUBMED   11921339
REFERENCE   7  (bases 1 to 5229)
  AUTHORS   Kaartinen,V., Gonzalez-Gomez,I., Voncken,J.W., Haataja,L.,
            Faure,E., Nagy,A., Groffen,J. and Heisterkamp,N.
  TITLE     Abnormal function of astroglia lacking Abr and Bcr RacGAPs
  JOURNAL   Development 128 (21), 4217-4227 (2001)
   PUBMED   11684658
REFERENCE   8  (bases 1 to 5229)
  AUTHORS   Chuang,T.H., Xu,X., Kaartinen,V., Heisterkamp,N., Groffen,J. and
            Bokoch,G.M.
  TITLE     Abr and Bcr are multifunctional regulators of the Rho GTP-binding
            protein family
  JOURNAL   Proc Natl Acad Sci U S A 92 (22), 10282-10286 (1995)
   PUBMED   7479768
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On Nov 17, 2022 this sequence version replaced NM_001105814.3.
            
            Sequence Note:.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360194.2212117.1,
                                           SRR26360176.621723.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-365               JAXUCZ010000010.1  61903573-61903937   c
            366-550             JAXUCZ010000010.1  61852216-61852400   c
            551-649             JAXUCZ010000010.1  61830065-61830163   c
            650-835             JAXUCZ010000010.1  61822198-61822383   c
            836-943             JAXUCZ010000010.1  61815845-61815952   c
            944-1004            JAXUCZ010000010.1  61812213-61812273   c
            1005-1057           JAXUCZ010000010.1  61808013-61808065   c
            1058-1198           JAXUCZ010000010.1  61807340-61807480   c
            1199-1320           JAXUCZ010000010.1  61804918-61805039   c
            1321-1486           JAXUCZ010000010.1  61802699-61802864   c
            1487-1609           JAXUCZ010000010.1  61800371-61800493   c
            1610-1685           JAXUCZ010000010.1  61799926-61800001   c
            1686-1790           JAXUCZ010000010.1  61799393-61799497   c
            1791-1865           JAXUCZ010000010.1  61798335-61798409   c
            1866-1963           JAXUCZ010000010.1  61796236-61796333   c
            1964-2095           JAXUCZ010000010.1  61795758-61795889   c
            2096-2155           JAXUCZ010000010.1  61769268-61769327   c
            2156-2265           JAXUCZ010000010.1  61768916-61769025   c
            2266-2405           JAXUCZ010000010.1  61768015-61768154   c
            2406-2540           JAXUCZ010000010.1  61767092-61767226   c
            2541-2646           JAXUCZ010000010.1  61766267-61766372   c
            2647-2794           JAXUCZ010000010.1  61763713-61763860   c
            2795-5229           JAXUCZ010000010.1  61760743-61763177   c
FEATURES             Location/Qualifiers
     source          1..5229
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q24"
     gene            1..5229
                     /gene="Abr"
                     /note="ABR activator of RhoGEF and GTPase"
                     /db_xref="GeneID:287537"
                     /db_xref="RGD:1306279"
     exon            1..365
                     /gene="Abr"
                     /inference="alignment:Splign:2.1.0"
     CDS             305..2884
                     /gene="Abr"
                     /note="ABR, RhoGEF and GTPase activating protein; active
                     BCR-related; breakpoint cluster region protein-like"
                     /codon_start=1
                     /product="active breakpoint cluster region-related
                     protein"
                     /protein_id="NP_001099284.1"
                     /db_xref="GeneID:287537"
                     /db_xref="RGD:1306279"
                     /translation="MEPLSHRGLPRLSWIDTLYSNFSYGAEDYDAEGHEEQKGPPEGS
                     ETMPYIDESPTMSPQLSARSQGGGESISPTPPEGLAPGVEAGKGLEMRKLVLSGFLAS
                     EEIYINQLEALLLPMKPLKATATTSQPVLTIQQIETIFYKIQDIYEIHKEFYDNLCPK
                     VQQWDSQVTMGHLFQKLASQLGVYKAFVDNYKVALETAEKCSQSNNQFQKISEELKVK
                     GPKDSKDSHTSVTMEALLYKPIDRVTRSTLVLHDLLKHTPVDHPDYPLLQDALRISQN
                     FLSSINEDIDPRRTAVTTPKGETRQLVKDGFLVEMSESSRKLRHVFLFTDVLLCAKLK
                     KTSAGKHQQYDCKWYIPLADLVFPSPEESEASPQVHPFPDHELEDMKVKISALKSEIQ
                     KEKANKGQSRAIERLKKKMFENEFLLLLNSPTIPFRIHNRNGKSYLFLLSSDYERSEW
                     REAIQKLQKKDLQAFVLSSVELQVLTGSCFKLRTVHNIPVTSNKDDDESPGLYGFLHV
                     IVHSAKGFKQSANLYCTLEVDSFGYFVSKAKTRVFRDTTEPKWDEEFEIELEGSQSLR
                     ILCYEKCYDKTKVNKDNNEIVDKIMGKGQIQLDPQTVESKNWHTDVIEMNGIKVEFSM
                     KFTSRDMSLKRTPSKKQTGVFGVKISVVTKRERSKVPYIVRQCIEEVEKRGIEEVGIY
                     RISGVATDIQALKAVFDANNKDILLMLSDMDINAIAGTLKLYFRELPEPLLTDRLYPA
                     FMEGIALSDPAAKENCMMHLLRSLPDPNLITFLFLLEHLKRVAEKEPINKMSLHNLAT
                     VFGPTLLRPSEVESKAHLTSAADIWSHDVMAQVQVLLYYLQHPPISFAELKRNTLYFS
                     TDV"
     exon            366..550
                     /gene="Abr"
                     /inference="alignment:Splign:2.1.0"
     exon            551..649
                     /gene="Abr"
                     /inference="alignment:Splign:2.1.0"
     exon            650..835
                     /gene="Abr"
                     /inference="alignment:Splign:2.1.0"
     exon            836..943
                     /gene="Abr"
                     /inference="alignment:Splign:2.1.0"
     exon            944..1004
                     /gene="Abr"
                     /inference="alignment:Splign:2.1.0"
     exon            1005..1057
                     /gene="Abr"
                     /inference="alignment:Splign:2.1.0"
     exon            1058..1198
                     /gene="Abr"
                     /inference="alignment:Splign:2.1.0"
     exon            1199..1320
                     /gene="Abr"
                     /inference="alignment:Splign:2.1.0"
     exon            1321..1486
                     /gene="Abr"
                     /inference="alignment:Splign:2.1.0"
     exon            1487..1609
                     /gene="Abr"
                     /inference="alignment:Splign:2.1.0"
     exon            1610..1685
                     /gene="Abr"
                     /inference="alignment:Splign:2.1.0"
     exon            1686..1790
                     /gene="Abr"
                     /inference="alignment:Splign:2.1.0"
     exon            1791..1865
                     /gene="Abr"
                     /inference="alignment:Splign:2.1.0"
     exon            1866..1963
                     /gene="Abr"
                     /inference="alignment:Splign:2.1.0"
     exon            1964..2095
                     /gene="Abr"
                     /inference="alignment:Splign:2.1.0"
     exon            2096..2155
                     /gene="Abr"
                     /inference="alignment:Splign:2.1.0"
     exon            2156..2265
                     /gene="Abr"
                     /inference="alignment:Splign:2.1.0"
     exon            2266..2405
                     /gene="Abr"
                     /inference="alignment:Splign:2.1.0"
     exon            2406..2540
                     /gene="Abr"
                     /inference="alignment:Splign:2.1.0"
     exon            2541..2646
                     /gene="Abr"
                     /inference="alignment:Splign:2.1.0"
     exon            2647..2794
                     /gene="Abr"
                     /inference="alignment:Splign:2.1.0"
     exon            2795..5229
                     /gene="Abr"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agttggcgcg cgggctgcgg ggccgcggct cccagatccg cagcgggttc gccgagactg
       61 ccacagctca gcactgagct ctcgggggcg ctcccctgtc ctcaccttgg cagctccggc
      121 ttgctcctcc ctactacctg tttccctggc tctcccgcct ccaccctgag ctccacaact
      181 tcgacctccg agtctggccg cccctcccgg caccccgccc gccggcgccc tccctccttt
      241 gttgtgcgat gagggtcggg tttcccatct gaccaaggag cctctgccgc acggagccgc
      301 gggcatggag ccgcttagcc accggggcct gccgcgcctc tcttggatcg acaccctcta
      361 cagcaacttc agctacggtg cagaggacta cgacgcagag gggcatgagg agcagaaggg
      421 gccccccgag ggctcggaga ccatgccata catcgacgag tcacccacca tgtcgcccca
      481 gctcagcgct cgcagccagg gcggtgggga gagcatctca cccaccccac ctgaggggtt
      541 ggcacctggg gtggaggcag ggaagggcct ggagatgagg aagctagttc tctctgggtt
      601 tctggccagt gaagagatct acattaacca gttggaagct ctgttactgc ccatgaagcc
      661 cctgaaggcc acagccacca cctcccagcc tgtgctcacc atccagcaga tcgagaccat
      721 cttctacaag atccaggaca tctacgagat ccacaaggag ttctacgaca acctctgccc
      781 caaggtgcag cagtgggaca gccaggtcac catgggccat cttttccaga aactggccag
      841 tcagcttggc gtgtacaaag catttgtgga caactataaa gtcgccctgg agacagctga
      901 gaagtgcagc cagtccaaca accagttcca gaagatctct gaggaactca aagtgaaagg
      961 acccaaggac tctaaggaca gccacacatc agtcaccatg gaagctctgc tgtataagcc
     1021 tattgaccga gtcactcgga gtaccctggt cctgcacgat ctgttgaagc acacacctgt
     1081 ggaccacccc gactacccac tgcttcagga tgcccttcga atctcccaga attttctatc
     1141 tagcattaat gaggatattg atcctcgccg gactgcagtc acaaccccca agggggagac
     1201 tcggcagctg gtgaaggacg gcttcctggt ggaaatgtct gagagctccc ggaagctgcg
     1261 gcacgtcttt ctcttcacag atgttctact gtgtgccaag ctaaagaaga cctctgcagg
     1321 aaaacatcag cagtatgact gtaagtggta catccccctg gctgacttag tgttcccatc
     1381 ccctgaggag tccgaggcca gtccccaggt acaccccttc ccagaccacg agctagagga
     1441 catgaaagtg aagatctctg ccctcaagag tgagatccag aaggagaaag ccaacaaagg
     1501 acagagccga gccattgagc gcctcaaaaa gaagatgttt gagaatgagt tcttactgct
     1561 gctcaattcc ccaacgatcc cattccggat acacaatcgg aatggaaaga gttacctgtt
     1621 tcttctgtct tctgactatg agaggtcgga gtggagagaa gcgattcaga aactacagaa
     1681 gaaggatctc caggcctttg tcctgagctc tgtggagctc caggtgctca cgggatcctg
     1741 tttcaagctt aggactgtgc acaacattcc tgtcaccagc aataaagatg acgatgagtc
     1801 tccaggactg tacggcttcc ttcatgtcat cgtccactct gccaagggct ttaaacaatc
     1861 agccaatctt tactgtactc tggaggtgga ttcctttggc tattttgtca gcaaagccaa
     1921 aaccagggtg tttcgggaca cgacagagcc caagtgggat gaggagtttg agattgagct
     1981 ggagggctcc cagtccctga ggatcctgtg ctatgagaaa tgctatgaca agaccaaggt
     2041 caacaaggac aacaatgaga ttgtggacaa gatcatgggc aaggggcaga tccagctgga
     2101 tccacagaca gtagaaagca agaactggca tacggatgtg attgaaatga atgggatcaa
     2161 agtggaattc tccatgaaat ttaccagccg tgacatgagc ctgaagagga ctccatccaa
     2221 aaagcagaca ggtgtcttcg gagtgaagat cagtgtggtg accaagcggg agcgctccaa
     2281 ggtgccctac atagtccggc agtgcataga agaggtggag aagaggggca tcgaggaggt
     2341 tggcatctac aggatatcag gggtggccac ggacatccag gccctgaagg ctgtctttga
     2401 tgccaataac aaggatatcc tactgatgct gagtgacatg gacatcaacg ctattgctgg
     2461 taccctcaag ctctactttc gggagctgcc tgagcccctc cttacagacc gactctaccc
     2521 agccttcatg gagggcattg ccctgtcaga tcctgctgcc aaggagaact gcatgatgca
     2581 cctactccgt tccctgcccg accccaacct catcaccttc cttttcctgc tggaacactt
     2641 gaaaagggtt gccgagaagg agcccatcaa caagatgtca cttcacaacc ttgccacagt
     2701 gtttggcccc acgttactga gaccctcaga agtggagagc aaagcacatc tcacatcagc
     2761 tgcagacatc tggtcccatg atgtcatggc ccaggtccag gtcctactct actacctgca
     2821 gcatcccccc atttccttcg cagaactgaa gcggaacaca ctgtacttct ccacagacgt
     2881 gtagcctggg gtgggcagct gtgggggtgg ccagcgccag ccctccagcc ggggcccaac
     2941 atagacttga aagactgcaa cagaaactcc ccagcctagc actccagagt ccgggggaag
     3001 ccaccttcca agaactggaa cacgtgcatc ttttgtgcca ccttgtacaa agccagctga
     3061 ccagcccccg cctcctcacc acaccccagc tccttccctc cgtacctgag tgtgtctgat
     3121 gctccgtgct gtccaggaat tgttttatgt atatttgtca ttgcagaaaa ggtagtggcc
     3181 gagctggtgt gggcacagac agcttgcttt gttctttcat ttctcccaac tcttctttct
     3241 gcctgagtcc agtccaagga cttttacttt gcgctgtgta actgctgcca gcttctcctc
     3301 tcctggccct gctcccagat tgcagcctcc ctgcagtgtc tgccctctcc acctcccagc
     3361 ctgctgcatg catgtgcagc atgggctttt gctccatcac tgcaaagttc tgcaggggcc
     3421 ctgggcagtg ctggcctgtc tgatgtgctg cccctggcct ccttgctctc cacatgtgga
     3481 agcacatctg ctttccttgc tgtctgtgca aatgttgaac aaggagacag acacacacta
     3541 atcctcagca cagagctgga gagctcattt ctggaatgtt ctatttgaga attgccattt
     3601 ctggggtttg tctgttctat ctcctgccta ccagtacggc atcttcagct gtttcttcta
     3661 tggctgaatt ttctgttcct tttccctggt gttctatttt ctttgagtgt aatgacctac
     3721 aagtgtcctg ccatcataga ggtcaggatt gcacctgaag ggtatggtgg gcacccaggc
     3781 tgtgaaggaa caagatgggt ggagcagcca gcagtggcaa gtcaagggaa gccagtcttc
     3841 acactaagga ccggcagagg ctatcctagt ggagtacagc ctcctggagg gcagcttctg
     3901 tggctgaatc aggtgtccag gtgaaaacag gaacctggaa ccacacatac ctcgtggtat
     3961 ttttgcctta gattttacac tctcaacagc caagcactgc cacggggcag ccacattgcc
     4021 atgcgtgctc cagagcctag gaacagcaga tagaacccag tggaatgctt ctaccctggc
     4081 ttctgaatcc aggcctgtgg gtaatcccaa gcatacagaa gttgtggagt aggaagcctc
     4141 tcttgtcaat gagttctgct ggggctgtag ggcatcaggt cagcaggtgt cattcccagc
     4201 tgtgacccat tgcttggtac taaaaaggag ttttactccc aaagtaaggt ttccagcctg
     4261 agcaggagct accagcctgt ggcaattagc acggaaagaa aggtgctcct gtcatagggg
     4321 cttgagctac catacagctt cctgtttctt ctatatggca gagttctttc attcttggcc
     4381 ctcaggattg gggagaccag ctctcattgt gtgtgctcag ggctaagtct aaacaagggt
     4441 ttgctggccc ccaagctgtt gtttgctagg tgaggttagg tagggctctc ctggtcctgt
     4501 tcatacctat tgcctttgac agaacggtac agtttgttca tgcaggagga aggaatgcca
     4561 acttcccagc tgcctattag cagtttaaca aggagccttg ctgtctcaaa caggtgaaag
     4621 aaaatgctgt gtgtaaagat cacatctgcc actatcttgg cgctcaggtg tgggtatgtg
     4681 gtgttcttgc ttcaaaggat tgatggtaac aaattatcaa agcttgactg gagctggctg
     4741 cagctcaaaa cagtgccccc tgcctctgta gagcaaagat gtgggccctg catcagctgc
     4801 tacagccaca gcttatttag gcagtgacag cagggaggcc agaggagctg aggactgtta
     4861 aacgttccca ttatttataa attccaccca aagtggacag tcaggtgcca gatctgaagt
     4921 gcaccaagga agtacctggt ggttctccgg agacgggcca tgcagcccag aacccccgca
     4981 ccgtcagcag ggcaccagga gacagggtcc aggaatccgg gtatgcctgt acttgcttgt
     5041 gcaacgactg agggctgcca gcttttgctg atgaggtagg atgggactcc caataagttg
     5101 gtatggatat attttttttt tgtctctgtt ctgtttaaac ttatgtagat tattataaat
     5161 tgatgtaaac cacgtgagag ggaaatgtta ataaaaaaat gcaaagcctc aacatttgca
     5221 caaaactca
//
