LOCUS       NM_024397               3009 bp    mRNA    linear   ROD 26-APR-2024
DEFINITION  Rattus norvegicus abl-interactor 1 (Abi1), mRNA.
ACCESSION   NM_024397 XM_346505
VERSION     NM_024397.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3009)
  AUTHORS   Guo,Z., Neilson,L.J., Zhong,H., Murray,P.S., Zanivan,S. and
            Zaidel-Bar,R.
  TITLE     E-cadherin interactome complexity and robustness resolved by
            quantitative proteomics
  JOURNAL   Sci Signal 7 (354), rs7 (2014)
   PUBMED   25468996
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3009)
  AUTHORS   Chazeau,A., Mehidi,A., Nair,D., Gautier,J.J., Leduc,C., Chamma,I.,
            Kage,F., Kechkar,A., Thoumine,O., Rottner,K., Choquet,D.,
            Gautreau,A., Sibarita,J.B. and Giannone,G.
  TITLE     Nanoscale segregation of actin nucleation and elongation factors
            determines dendritic spine protrusion
  JOURNAL   EMBO J 33 (23), 2745-2764 (2014)
   PUBMED   25293574
REFERENCE   3  (bases 1 to 3009)
  AUTHORS   Jia,J.M., Hu,Z., Nordman,J. and Li,Z.
  TITLE     The schizophrenia susceptibility gene dysbindin regulates dendritic
            spine dynamics
  JOURNAL   J Neurosci 34 (41), 13725-13736 (2014)
   PUBMED   25297099
REFERENCE   4  (bases 1 to 3009)
  AUTHORS   Verpelli,C., Dvoretskova,E., Vicidomini,C., Rossi,F.,
            Chiappalone,M., Schoen,M., Di Stefano,B., Mantegazza,R.,
            Broccoli,V., Bockers,T.M., Dityatev,A. and Sala,C.
  TITLE     Importance of Shank3 protein in regulating metabotropic glutamate
            receptor 5 (mGluR5) expression and signaling at synapses
  JOURNAL   J Biol Chem 286 (40), 34839-34850 (2011)
   PUBMED   21795692
REFERENCE   5  (bases 1 to 3009)
  AUTHORS   Proepper,C., Steinestel,K., Schmeisser,M.J., Heinrich,J.,
            Steinestel,J., Bockmann,J., Liebau,S. and Boeckers,T.M.
  TITLE     Heterogeneous nuclear ribonucleoprotein k interacts with Abi-1 at
            postsynaptic sites and modulates dendritic spine morphology
  JOURNAL   PLoS One 6 (11), e27045 (2011)
   PUBMED   22102872
REFERENCE   6  (bases 1 to 3009)
  AUTHORS   Garcia-Garcia,M.J., Eggenschwiler,J.T., Caspary,T., Alcorn,H.L.,
            Wyler,M.R., Huangfu,D., Rakeman,A.S., Lee,J.D., Feinberg,E.H.,
            Timmer,J.R. and Anderson,K.V.
  TITLE     Analysis of mouse embryonic patterning and morphogenesis by forward
            genetics
  JOURNAL   Proc Natl Acad Sci U S A 102 (17), 5913-5919 (2005)
   PUBMED   15755804
REFERENCE   7  (bases 1 to 3009)
  AUTHORS   Tani,K., Sato,S., Sukezane,T., Kojima,H., Hirose,H., Hanafusa,H.
            and Shishido,T.
  TITLE     Abl interactor 1 promotes tyrosine 296 phosphorylation of mammalian
            enabled (Mena) by c-Abl kinase
  JOURNAL   J Biol Chem 278 (24), 21685-21692 (2003)
   PUBMED   12672821
REFERENCE   8  (bases 1 to 3009)
  AUTHORS   Stradal,T., Courtney,K.D., Rottner,K., Hahne,P., Small,J.V. and
            Pendergast,A.M.
  TITLE     The Abl interactor proteins localize to sites of actin
            polymerization at the tips of lamellipodia and filopodia
  JOURNAL   Curr Biol 11 (11), 891-895 (2001)
   PUBMED   11516653
REFERENCE   9  (bases 1 to 3009)
  AUTHORS   Courtney,K.D., Grove,M., Vandongen,H., Vandongen,A., LaMantia,A.S.
            and Pendergast,A.M.
  TITLE     Localization and phosphorylation of Abl-interactor proteins, Abi-1
            and Abi-2, in the developing nervous system
  JOURNAL   Mol Cell Neurosci 16 (3), 244-257 (2000)
   PUBMED   10995551
REFERENCE   10 (bases 1 to 3009)
  AUTHORS   Ziemnicka-Kotula,D., Xu,J., Gu,H., Potempska,A., Kim,K.S.,
            Jenkins,E.C., Trenkner,E. and Kotula,L.
  TITLE     Identification of a candidate human spectrin Src homology 3
            domain-binding protein suggests a general mechanism of association
            of tyrosine kinases with the spectrin-based membrane skeleton
  JOURNAL   J Biol Chem 273 (22), 13681-13692 (1998)
   PUBMED   9593709
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CB725283.1 and BC129092.1.
            
            On Mar 8, 2007 this sequence version replaced NM_024397.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC129092.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-44                CB725283.1         2-45
            45-3009             BC129092.1         1-2965
FEATURES             Location/Qualifiers
     source          1..3009
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="17"
                     /map="17q12.3"
     gene            1..3009
                     /gene="Abi1"
                     /gene_synonym="E3b1"
                     /note="abl-interactor 1"
                     /db_xref="GeneID:79249"
                     /db_xref="RGD:621008"
     exon            1..181
                     /gene="Abi1"
                     /gene_synonym="E3b1"
                     /inference="alignment:Splign:2.1.0"
     CDS             65..1510
                     /gene="Abi1"
                     /gene_synonym="E3b1"
                     /note="abi-1; abelson interactor 1; eps8-binding protein;
                     eps8 SH3 domain-binding protein; eps8 binding protein
                     (e3B1), alternatively spliced"
                     /codon_start=1
                     /product="abl interactor 1"
                     /protein_id="NP_077373.2"
                     /db_xref="GeneID:79249"
                     /db_xref="RGD:621008"
                     /translation="MAELQMLLEEEIPSGKRALIESYQNLTRVADYCENNYIQATDKR
                     KALEETKAYTTQSLASVAYQINALANNVLQLLDIQASQLRRMESSINHISQTVDIHKE
                     KVARREIGILTTNKNTSRTHKIIAPANMERPVRYIRKPIDYTVLDDVGHGVKWLKAKH
                     GNNQPARTGTLSRTNPPTQKPPSPPVSGRGTLGRNTPYKTLEPVKPPTVPNDYMTSPA
                     RLGSQHSPGRTASLNQRPRTHSGSSGGSGSRENSGSSSIGIPIAVPTPSPPTAGPAAP
                     GAAPGSQYGTMTRQISRHNSTTSSTSSGGYRRTPSVTAQFSAQPHVNGGPLYSQNSIS
                     IAPPPPPMPQLTPQIPLTGFVARVQENIADSPTPPPPPPPDDIPMFDDSPPPPPPPPV
                     DYEDEEAAVVQYSDPYADGDPAWAPKNYIEKVVAIYDYTKDKDDELSFKEGAIIYVIK
                     KNDDGWFEGVCNRVTGLFPGNYVESIMHYTD"
     exon            182..349
                     /gene="Abi1"
                     /gene_synonym="E3b1"
                     /inference="alignment:Splign:2.1.0"
     exon            350..526
                     /gene="Abi1"
                     /gene_synonym="E3b1"
                     /inference="alignment:Splign:2.1.0"
     exon            527..541
                     /gene="Abi1"
                     /gene_synonym="E3b1"
                     /inference="alignment:Splign:2.1.0"
     exon            542..642
                     /gene="Abi1"
                     /gene_synonym="E3b1"
                     /inference="alignment:Splign:2.1.0"
     exon            643..783
                     /gene="Abi1"
                     /gene_synonym="E3b1"
                     /inference="alignment:Splign:2.1.0"
     exon            784..884
                     /gene="Abi1"
                     /gene_synonym="E3b1"
                     /inference="alignment:Splign:2.1.0"
     exon            885..1061
                     /gene="Abi1"
                     /gene_synonym="E3b1"
                     /inference="alignment:Splign:2.1.0"
     exon            1062..1148
                     /gene="Abi1"
                     /gene_synonym="E3b1"
                     /inference="alignment:Splign:2.1.0"
     exon            1149..1334
                     /gene="Abi1"
                     /gene_synonym="E3b1"
                     /inference="alignment:Splign:2.1.0"
     exon            1335..3009
                     /gene="Abi1"
                     /gene_synonym="E3b1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccccgtcgga ctcagctgcc tctgtctctt taacgcgaga ggaagcgatg cggaggggtg
       61 gaaaatggca gagctgcaga tgttactaga ggaggagatc ccgtctggca agagggcgct
      121 gatagagagt taccagaacc tgacccgggt ggcggactac tgtgaaaaca actacataca
      181 ggctacagac aagaggaaag ctctagaaga gaccaaagca tatacaactc aatctctagc
      241 tagtgttgct tatcaaataa atgcattggc caacaatgtg ctccagctgc tggatatcca
      301 ggcctctcag ctgcggagga tggagtcgtc catcaatcac atctcacaga ctgtggatat
      361 tcataaagaa aaagtggctc gaagagagat tggtattttg acaacaaata agaatacatc
      421 aagaactcat aaaataatcg cacctgcaaa tatggagcgt cctgtcaggt atattcggaa
      481 acctattgac tacacagttc tggatgatgt gggccatgga gttaagtggc taaaagccaa
      541 gcacggaaat aaccagcctg caagaactgg cacattgtcg agaacaaatc ctcccacgca
      601 gaaaccacca agccctcctg tgtcaggccg aggaactttg gggcggaata ccccttacaa
      661 aaccctagag cctgttaagc ctcccacagt tcctaatgac tacatgacta gtcctgcgag
      721 gcttggaagc cagcatagtc caggcaggac ggcttcttta aatcagagac caaggacgca
      781 tagtgggagt agtggaggaa gcggaagccg ggaaaacagt gggagcagca gcattggtat
      841 tcccattgct gtgcccacac cctccccgcc cactgcgggc ccagcagccc ctggcgcagc
      901 tcctggttcc cagtatggca caatgaccag gcagatttct cgacacaact ctaccacttc
      961 ttcgacatct tctggtggat atagacgaac tccctctgtg actgcgcaat tctctgctca
     1021 gcctcatgtt aatggaggtc cactttattc tcaaaattca atttctattg ccccccctcc
     1081 tccccccatg cctcagttga ctccacagat acctctcaca ggcttcgtgg ccagggtgca
     1141 ggaaaacatt gctgatagcc caactccacc accacctcct ccaccagatg acattcccat
     1201 gttcgatgac tctccacctc ccccaccacc tcctcctgtg gactacgaag acgaagaagc
     1261 tgcagtagtt cagtatagtg acccatatgc agatggggac cctgcatggg ctcccaagaa
     1321 ctatattgag aaagttgttg caatatatga ttatacaaaa gacaaggatg atgagctgtc
     1381 ctttaaagag ggtgcaatca tctatgtcat aaagaagaac gatgatggct ggttcgaagg
     1441 agtttgcaat cgagtaactg gactcttccc tgggaactat gttgaatcaa tcatgcacta
     1501 tactgattag tttttctttc gttttctttt catgtaggtt attactctgt catactgtgg
     1561 gactatatgg ttaacaattg ttttaatgtt taaaatgtgc ccatattttc aggacatgtt
     1621 ttattggtat atttggatgt ctacctgtaa gcttaaaatt tggaggcagt tcaaacgttg
     1681 ctgaacagca attgctgtca gactgcctgt aattgatcat gcatatgtac tcacaccttg
     1741 atacgtttat gaccagccta aaaattctgg ggatgtgggt tattatgttt aacaaatcat
     1801 ggttcagaat gcaccattac atgtttcagt gcagcatggt cactaacatt gtgtcagact
     1861 aataggaaaa aaaaaaaaca gaaacttcaa tgctggtgct ggtcatactt ttggtttcaa
     1921 ttctcatttt taaaaaagta ctgtgtttaa agcatgcata aatttttatg tattgaaata
     1981 tacttagcaa ttcaagaagc ttccaatttg tgtaagcgtt atctggagca ctactcatac
     2041 ctgagtctcc taagttctcc acgtgaaatg aaagactagc tgtatgctgt aatttgtatc
     2101 taagtttttt aatgagtgag atttgcatta taaatttttc cattcataaa tacataagta
     2161 aaccaaagga tttttgtcct ctcctttact ggtttgcttt aatcatgtgt gctcatgcat
     2221 atgcatgcac acccccagcc ccttaaaaaa gatttattgc agaattatgg ttctattttc
     2281 tcaatgcatc agtttgaaaa tatttttagc ttaatcttaa tgtgtccaaa cagcaatgcg
     2341 acagaatttt gcagattttg gagctagact gtgtcagagt aagcacatga tattctgggg
     2401 gtaacatctg aaggaatgct acacttgacc ttttatattt taatgaaact gaatttacac
     2461 tgactcagtg aaaggaaaat cttttacata ttgtaaagat ggatgcagtt agtttgtgga
     2521 taggcatatt taatccattg cctgccacta gaaacaaaat ttttacaata attgggaaag
     2581 aaactaggcc atgtaataag caggtttgta ttgtaactta aatgcaacac atgcactttg
     2641 tgtgtctcct tgatttaagg gagggtttga gggatacttc tcttgtatat aagactgtac
     2701 tgcttaggat attaaagtag atcacacaag tgtgggtttc tatgtattga gggttacaga
     2761 ttatgacagc atagtaagtg atgagagcag tgcaaaatat ttctgaaaat taaagaccat
     2821 tgttcctacc aaatcaacta ttccatatat atttcacctt tgttattttt gaagtactat
     2881 gtcattagtg atcagatagc tatattatgc tttctttttg aagcagaatg ttttcttcat
     2941 ttgtaaataa cctgttgtct aaattttatc tacagtcttt tataataaac tatgctccta
     3001 tacaaaaaa
//
