LOCUS       NM_001007680            2225 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Rattus norvegicus abhydrolase domain containing 6, acylglycerol
            lipase (Abhd6), mRNA.
ACCESSION   NM_001007680 XM_223871
VERSION     NM_001007680.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2225)
  AUTHORS   Noguchi,K., Kadekawa,K., Nishijima,S., Sakanashi,M.,
            Okitsu-Sakurayama,S., Higa-Nakamine,S., Yamamoto,H. and Sugaya,K.
  TITLE     Phenotypic Characterization of the Endocannabinoid-Degrading Enzyme
            Alpha/Beta-Hydrolase Domain 6 Knockout Rat
  JOURNAL   Cannabis Cannabinoid Res 7 (2), 179-187 (2022)
   PUBMED   34468198
  REMARK    GeneRIF: Phenotypic Characterization of the
            Endocannabinoid-Degrading Enzyme Alpha/Beta-Hydrolase Domain 6
            Knockout Rat.
REFERENCE   2  (bases 1 to 2225)
  AUTHORS   Zhao,S., Mugabo,Y., Ballentine,G., Attane,C., Iglesias,J.,
            Poursharifi,P., Zhang,D., Nguyen,T.A., Erb,H., Prentki,R.,
            Peyot,M.L., Joly,E., Tobin,S., Fulton,S., Brown,J.M., Madiraju,S.R.
            and Prentki,M.
  TITLE     alpha/beta-Hydrolase Domain 6 Deletion Induces Adipose Browning and
            Prevents Obesity and Type 2 Diabetes
  JOURNAL   Cell Rep 14 (12), 2872-2888 (2016)
   PUBMED   26997277
REFERENCE   3  (bases 1 to 2225)
  AUTHORS   Pribasnig,M.A., Mrak,I., Grabner,G.F., Taschler,U.,
            Knittelfelder,O., Scherz,B., Eichmann,T.O., Heier,C., Grumet,L.,
            Kowaliuk,J., Romauch,M., Holler,S., Anderl,F., Wolinski,H.,
            Lass,A., Breinbauer,R., Marsche,G., Brown,J.M. and Zimmermann,R.
  TITLE     alpha/beta Hydrolase Domain-containing 6 (ABHD6) Degrades the Late
            Endosomal/Lysosomal Lipid Bis(monoacylglycero)phosphate
  JOURNAL   J Biol Chem 290 (50), 29869-29881 (2015)
   PUBMED   26491015
REFERENCE   4  (bases 1 to 2225)
  AUTHORS   Thomas,G., Betters,J.L., Lord,C.C., Brown,A.L., Marshall,S.,
            Ferguson,D., Sawyer,J., Davis,M.A., Melchior,J.T., Blume,L.C.,
            Howlett,A.C., Ivanova,P.T., Milne,S.B., Myers,D.S., Mrak,I.,
            Leber,V., Heier,C., Taschler,U., Blankman,J.L., Cravatt,B.F.,
            Lee,R.G., Crooke,R.M., Graham,M.J., Zimmermann,R., Brown,H.A. and
            Brown,J.M.
  TITLE     The serine hydrolase ABHD6 Is a critical regulator of the metabolic
            syndrome
  JOURNAL   Cell Rep 5 (2), 508-520 (2013)
   PUBMED   24095738
REFERENCE   5  (bases 1 to 2225)
  AUTHORS   Navia-Paldanius,D., Savinainen,J.R. and Laitinen,J.T.
  TITLE     Biochemical and pharmacological characterization of human
            alpha/beta-hydrolase domain containing 6 (ABHD6) and 12 (ABHD12)
  JOURNAL   J Lipid Res 53 (11), 2413-2424 (2012)
   PUBMED   22969151
REFERENCE   6  (bases 1 to 2225)
  AUTHORS   Schwenk,J., Harmel,N., Brechet,A., Zolles,G., Berkefeld,H.,
            Muller,C.S., Bildl,W., Baehrens,D., Huber,B., Kulik,A., Klocker,N.,
            Schulte,U. and Fakler,B.
  TITLE     High-resolution proteomics unravel architecture and molecular
            diversity of native AMPA receptor complexes
  JOURNAL   Neuron 74 (4), 621-633 (2012)
   PUBMED   22632720
REFERENCE   7  (bases 1 to 2225)
  AUTHORS   Marrs,W.R., Blankman,J.L., Horne,E.A., Thomazeau,A., Lin,Y.H.,
            Coy,J., Bodor,A.L., Muccioli,G.G., Hu,S.S., Woodruff,G., Fung,S.,
            Lafourcade,M., Alexander,J.P., Long,J.Z., Li,W., Xu,C., Moller,T.,
            Mackie,K., Manzoni,O.J., Cravatt,B.F. and Stella,N.
  TITLE     The serine hydrolase ABHD6 controls the accumulation and efficacy
            of 2-AG at cannabinoid receptors
  JOURNAL   Nat Neurosci 13 (8), 951-957 (2010)
   PUBMED   20657592
REFERENCE   8  (bases 1 to 2225)
  AUTHORS   Blankman,J.L., Simon,G.M. and Cravatt,B.F.
  TITLE     A comprehensive profile of brain enzymes that hydrolyze the
            endocannabinoid 2-arachidonoylglycerol
  JOURNAL   Chem Biol 14 (12), 1347-1356 (2007)
   PUBMED   18096503
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC083826.1.
            
            On Nov 29, 2004 this sequence version replaced XM_223871.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC083826.1, SRR8487231.11565.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2225
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="15"
                     /map="15p14"
     gene            1..2225
                     /gene="Abhd6"
                     /note="abhydrolase domain containing 6, acylglycerol
                     lipase"
                     /db_xref="GeneID:305795"
                     /db_xref="RGD:1359323"
     exon            1..46
                     /gene="Abhd6"
                     /inference="alignment:Splign:2.1.0"
     exon            47..190
                     /gene="Abhd6"
                     /inference="alignment:Splign:2.1.0"
     CDS             72..1085
                     /gene="Abhd6"
                     /EC_number="3.1.1.23"
                     /note="2-arachidonoylglycerol hydrolase; abhydrolase
                     domain-containing protein 6"
                     /codon_start=1
                     /product="monoacylglycerol lipase ABHD6"
                     /protein_id="NP_001007681.1"
                     /db_xref="GeneID:305795"
                     /db_xref="RGD:1359323"
                     /translation="MDLDVVNMFVIAGGTLAIPILAFVASFLLWPSALIRIYYWYWRR
                     TLGMQVRYVHHEDYQFCYSFRGRPGHKPSVLMLHGFSAHKDMWLSVVKFLPKNLHLVC
                     VDMPGHEGTTRSSLDDLSIVGQVKRIHQFVECLKLNKKPFHLIGTSMGGNVAGVYAAY
                     YPSDVCSLSLVCPAGLQYSTDNRFVQRLKELEDSAATQKIPLIPSTPEEMSEMLQLCS
                     YVRFKVPQQILQGLVDVRIPHNSFYRKLFLEIVSEKSRYSLHENMDKIKVPTQIIWGK
                     QDQVLDVSGADILAKSITNSQVEVLENCGHSVVMERPRKTAKLVVDFLASVHNPDNNK
                     KLN"
     exon            191..347
                     /gene="Abhd6"
                     /inference="alignment:Splign:2.1.0"
     exon            348..461
                     /gene="Abhd6"
                     /inference="alignment:Splign:2.1.0"
     exon            462..594
                     /gene="Abhd6"
                     /inference="alignment:Splign:2.1.0"
     exon            595..752
                     /gene="Abhd6"
                     /inference="alignment:Splign:2.1.0"
     exon            753..807
                     /gene="Abhd6"
                     /inference="alignment:Splign:2.1.0"
     exon            808..908
                     /gene="Abhd6"
                     /inference="alignment:Splign:2.1.0"
     exon            909..2202
                     /gene="Abhd6"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tgggactgga gggcggcgat ccggcagcag gacctcggcc actgaggtgt cgacaggcct
       61 caaggagcag gatggatctc gatgtggtta acatgtttgt gattgcgggt gggaccctgg
      121 ccattccgat cctggccttc gtagcttctt tcctcctttg gccctcggcg ctgataagaa
      181 tctattattg gtactggcgg aggacgctgg gcatgcaagt ccgctacgtg caccacgagg
      241 actatcagtt ctgttactcc ttccggggca ggccaggaca caagccgtcc gtccttatgc
      301 ttcacgggtt ctccgcacac aaggatatgt ggctcagtgt ggtcaagttc cttcccaaga
      361 atctgcactt ggtctgtgtg gacatgcctg gacatgaagg gaccacccgt tcctccctgg
      421 atgacctgtc catagttggg caagtgaaaa ggatacatca gtttgtagaa tgccttaagc
      481 tgaacaaaaa gccctttcac cttataggca cctccatggg tggcaacgtg gctggagtat
      541 acgctgctta ctatccatct gacgtctgca gcctgtctct cgtgtgccct gctggcctgc
      601 agtattcaac tgacaatcgg tttgtacaac ggctcaaaga gctggaggac tcagccgcca
      661 cgcagaagat ccctttgatc ccatccaccc cggaagagat gagcgagatg ctgcagctct
      721 gctcgtacgt ccgcttcaag gtgccccagc agatccttca aggtcttgtc gacgttcgca
      781 tccctcacaa cagcttctac cggaaattgt ttttggaaat cgtcagtgag aaatccagat
      841 actctctgca tgagaacatg gacaagatca aggtcccaac acagatcatt tggggaaaac
      901 aagaccaggt gcttgatgtg tcgggggcag acatattagc caagtccatc actaactccc
      961 aggtagaggt tctggaaaac tgtggccatt cagtggtgat ggagagaccg aggaagacag
     1021 ccaagctcgt cgtcgacttt ttagcttctg tgcacaaccc agacaacaac aagaagctga
     1081 actgaggccg ctgccacggc ctgcattgtt gcacacagcg tctgctccca tccccaaaac
     1141 ctgacacagt aaccactctc agggatcctg ccccaaatgc tgtcggagca ccaacgtccc
     1201 tgaggaaacc agttgcctat cccagtatcc ttggttccat agagcatcag gggccgcaag
     1261 gaactctcca agatcctttt tttcaaaata gaaacctaaa tagaaaaaaa gacaacaaca
     1321 aaccacacct agccatgaag cctaccagag tcttcacgcc actggcaagc cagtgctaag
     1381 cagtcacccc ggaccgttat cttcaaggac actttcttta agacattcct cacacattaa
     1441 acttgatctc tttttgttgt tgttacttca gatgtatccc ctgcatggcc agtggccttc
     1501 tctacaggag ctttagtcat tcactgaaaa ctcttattta gatgtaattc aagttttaca
     1561 tagaggccca agtgtgaatg cattaaccac aaggccatga aagagacagc gaactgtgga
     1621 agaggcttct gcctcgaggt ctaatacaca ggaggctgag gcagaaggat ccaagatcaa
     1681 ggcctgctag aggtacagag cgagttcaag gccagcctga gctactgact ggaagaagta
     1741 aagagaaaat gtttctacct tttttttaaa tgtagaaatc aatgtgaggg ggcagtgctc
     1801 cacctcagtc agccctagaa accagccaag ccgcagaaca tgcagactga tatcgagttt
     1861 ggacacccac agatcagata catctgaccg cccacaggga agagcgcctg accgggtggg
     1921 ttccctagga gtgatttaca atttattaat aggactaata aagcaataat gttctagact
     1981 tccatctgat cggacgggag gcccatcacc aagcagctca ttggcatcct ttcaatgatg
     2041 ctgttctact gaaaaccctc ggaagtaaaa taccagctcg ttaatgaatt ctgtgaattc
     2101 cgtgaaacaa tattgtgtga ttgaaagaaa aaaaatgagt ccaaacagct gtaaaagaga
     2161 ccacaataat gtgaaataaa tttactaagt ctaggctggc aaaaaaaaaa aaaaaaaaaa
     2221 aaaaa
//
