LOCUS       NM_212524               1108 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Rattus norvegicus abhydrolase domain containing 5, lysophosphatidic
            acid acyltransferase (Abhd5), mRNA.
ACCESSION   NM_212524 XM_236775
VERSION     NM_212524.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1108)
  AUTHORS   Ou,J., Peng,Y., Yang,W., Zhang,Y., Hao,J., Li,F., Chen,Y., Zhao,Y.,
            Xie,X., Wu,S., Zha,L., Luo,X., Xie,G., Wang,L., Sun,W., Zhou,Q.,
            Li,J. and Liang,H.
  TITLE     ABHD5 blunts the sensitivity of colorectal cancer to fluorouracil
            via promoting autophagic uracil yield
  JOURNAL   Nat Commun 10 (1), 1078 (2019)
   PUBMED   30842415
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1108)
  AUTHORS   Dettlaff-Pokora,A., Sledzinski,T. and Swierczynski,J.
  TITLE     Upregulation of Pnpla2 and Abhd5 and downregulation of G0s2 gene
            expression in mesenteric white adipose tissue as a potential reason
            for elevated concentration of circulating NEFA after removal of
            retroperitoneal, epididymal, and inguinal adipose tissue
  JOURNAL   Mol Cell Biochem 422 (1-2), 21-29 (2016)
   PUBMED   27590244
  REMARK    GeneRIF: upregulation of Pnpla2 expression and activation of ATGL
            (due to an increase in ABHD5 and decrease in G0S2 levels), as well
            as a coordinated interplay of these genes with Lipe in mesenteric
            WAT, contribute, at least in part, to an increase in the
            concentration of circulating NEFA in rats with reduced fat mass.
REFERENCE   3  (bases 1 to 1108)
  AUTHORS   Chamoun,Z., Vacca,F., Parton,R.G. and Gruenberg,J.
  TITLE     PNPLA3/adiponutrin functions in lipid droplet formation
  JOURNAL   Biol Cell 105 (5), 219-233 (2013)
   PUBMED   23398201
REFERENCE   4  (bases 1 to 1108)
  AUTHORS   MacPherson,R.E., Ramos,S.V., Vandenboom,R., Roy,B.D. and
            Peters,S.J.
  TITLE     Skeletal muscle PLIN proteins, ATGL and CGI-58, interactions at
            rest and following stimulated contraction
  JOURNAL   Am J Physiol Regul Integr Comp Physiol 304 (8), R644-R650 (2013)
   PUBMED   23408028
  REMARK    GeneRIF: in skeletal muscle, during contraction-induced muscle
            lipolysis, ATGL and CGI-58 strongly associate and that the PLIN
            proteins work together to regulate lipolysis
REFERENCE   5  (bases 1 to 1108)
  AUTHORS   Badin,P.M., Loubiere,C., Coonen,M., Louche,K., Tavernier,G.,
            Bourlier,V., Mairal,A., Rustan,A.C., Smith,S.R., Langin,D. and
            Moro,C.
  TITLE     Regulation of skeletal muscle lipolysis and oxidative metabolism by
            the co-lipase CGI-58
  JOURNAL   J Lipid Res 53 (5), 839-848 (2012)
   PUBMED   22383684
REFERENCE   6  (bases 1 to 1108)
  AUTHORS   Yamaguchi,T., Omatsu,N., Morimoto,E., Nakashima,H., Ueno,K.,
            Tanaka,T., Satouchi,K., Hirose,F. and Osumi,T.
  TITLE     CGI-58 facilitates lipolysis on lipid droplets but is not involved
            in the vesiculation of lipid droplets caused by hormonal
            stimulation
  JOURNAL   J Lipid Res 48 (5), 1078-1089 (2007)
   PUBMED   17308334
  REMARK    GeneRIF: CGI-58 facilitates lipolysis in cooperation with perilipin
            and other factors, including lipases
REFERENCE   7  (bases 1 to 1108)
  AUTHORS   Schweiger,M., Schreiber,R., Haemmerle,G., Lass,A., Fledelius,C.,
            Jacobsen,P., Tornqvist,H., Zechner,R. and Zimmermann,R.
  TITLE     Adipose triglyceride lipase and hormone-sensitive lipase are the
            major enzymes in adipose tissue triacylglycerol catabolism
  JOURNAL   J Biol Chem 281 (52), 40236-40241 (2006)
   PUBMED   17074755
REFERENCE   8  (bases 1 to 1108)
  AUTHORS   Lass,A., Zimmermann,R., Haemmerle,G., Riederer,M., Schoiswohl,G.,
            Schweiger,M., Kienesberger,P., Strauss,J.G., Gorkiewicz,G. and
            Zechner,R.
  TITLE     Adipose triglyceride lipase-mediated lipolysis of cellular fat
            stores is activated by CGI-58 and defective in Chanarin-Dorfman
            Syndrome
  JOURNAL   Cell Metab 3 (5), 309-319 (2006)
   PUBMED   16679289
REFERENCE   9  (bases 1 to 1108)
  AUTHORS   Yamaguchi,T., Omatsu,N., Matsushita,S. and Osumi,T.
  TITLE     CGI-58 interacts with perilipin and is localized to lipid droplets.
            Possible involvement of CGI-58 mislocalization in Chanarin-Dorfman
            syndrome
  JOURNAL   J Biol Chem 279 (29), 30490-30497 (2004)
   PUBMED   15136565
  REMARK    GeneRIF: CGI-58 interacts with perilipin and is localized to lipid
            droplets
REFERENCE   10 (bases 1 to 1108)
  AUTHORS   Lefevre,C., Jobard,F., Caux,F., Bouadjar,B., Karaduman,A.,
            Heilig,R., Lakhdar,H., Wollenberg,A., Verret,J.L., Weissenbach,J.,
            Ozguc,M., Lathrop,M., Prud'homme,J.F. and Fischer,J.
  TITLE     Mutations in CGI-58, the gene encoding a new protein of the
            esterase/lipase/thioesterase subfamily, in Chanarin-Dorfman
            syndrome
  JOURNAL   Am J Hum Genet 69 (5), 1002-1012 (2001)
   PUBMED   11590543
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AY550934.1.
            
            On Aug 30, 2004 this sequence version replaced XM_236775.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY550934.1, BC127470.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1108
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="ZDF"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q32"
     gene            1..1108
                     /gene="Abhd5"
                     /gene_synonym="CGI-58"
                     /note="abhydrolase domain containing 5, lysophosphatidic
                     acid acyltransferase"
                     /db_xref="GeneID:316122"
                     /db_xref="RGD:1303237"
     exon            1..93
                     /gene="Abhd5"
                     /gene_synonym="CGI-58"
                     /inference="alignment:Splign:2.1.0"
     CDS             41..1096
                     /gene="Abhd5"
                     /gene_synonym="CGI-58"
                     /EC_number="2.3.1.51"
                     /note="lipid droplet-binding protein CGI-58; abhydrolase
                     domain-containing protein 5"
                     /codon_start=1
                     /product="1-acylglycerol-3-phosphate O-acyltransferase
                     ABHD5"
                     /protein_id="NP_997689.1"
                     /db_xref="GeneID:316122"
                     /db_xref="RGD:1303237"
                     /translation="MKAMAAEEEVDSADAGGGSGWLTGWLPTWCPTSTSHLKEAEEKM
                     LKCVPCTYKKEPVRISNGNSIWTLMFSHNMSSKTPLVLLHGFGGGLGLWALNFEDLST
                     DRPVYAFDLLGFGRSSRPRFDSDAEEVENQFVESIEEWRCALRLDKMILLGHNLGGFL
                     AAAYSLKYPSRVSHLILVEPWGFPERPDLADQERPIPVWIRALGAALTPFNPLAGLRI
                     AGPFGLSLVQRLRPDFKRKYSSMFEDDTVTEYIYHCNVQTPSGETAFKNMTIPYGWAK
                     RPMLQRIGGLHPDIPVSVIFGARSCIDGNSGTSIQSLRPKSYVKTIAILGAGHYVYAD
                     QPEEFNQKVKEICHTVD"
     exon            94..179
                     /gene="Abhd5"
                     /gene_synonym="CGI-58"
                     /inference="alignment:Splign:2.1.0"
     exon            180..552
                     /gene="Abhd5"
                     /gene_synonym="CGI-58"
                     /inference="alignment:Splign:2.1.0"
     exon            553..707
                     /gene="Abhd5"
                     /gene_synonym="CGI-58"
                     /inference="alignment:Splign:2.1.0"
     exon            708..819
                     /gene="Abhd5"
                     /gene_synonym="CGI-58"
                     /inference="alignment:Splign:2.1.0"
     exon            820..1006
                     /gene="Abhd5"
                     /gene_synonym="CGI-58"
                     /inference="alignment:Splign:2.1.0"
     exon            1007..1108
                     /gene="Abhd5"
                     /gene_synonym="CGI-58"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cggcttcgag gtgccttcct gcgcttgcgc ggcggcagtg atgaaagcga tggcggcgga
       61 ggaggaggtg gactcggcag acgccggtgg agggtcagga tggctgacag ggtggcttcc
      121 tacctggtgt cccacgtcta catcacacct taaagaagct gaagagaaaa tgctaaaatg
      181 tgtcccctgc acttacaaga aagaacctgt gcgcatatcc aatggaaaca gcatatggac
      241 actgatgttc tcgcacaaca tgtctagtaa gacaccactt gtcctcctgc atggttttgg
      301 aggaggtctt ggactttggg ccctgaattt tgaagatcta agcactgata ggcctgtcta
      361 tgcctttgac ctattgggct ttggaagaag tagtagacct aggtttgaca gtgacgcgga
      421 agaagtggag aatcagtttg tggaatccat tgaagagtgg agatgtgccc tcaggttgga
      481 caaaatgatc ttgcttggac acaacctggg agggttcttg gctgctgcct actcactgaa
      541 gtacccgtca agggtcagtc acctcatttt agtagaacca tggggttttc ctgagcgacc
      601 agatcttgct gatcaagaga gaccaattcc agtttggatc agagccttag gggcagcatt
      661 gactcccttt aaccccttgg ctggcctcag gattgcagga ccttttgggt tgagtctagt
      721 gcagcgcctg aggccggact tcaagcggaa gtactcctct atgtttgaag atgacacggt
      781 gacagagtac atctaccact gtaatgtaca aaccccaagt ggtgagacag ctttcaaaaa
      841 catgacgatt ccttacgggt gggccaagcg gcccatgctc cagcgcatag gtggcttgca
      901 ccctgacatt ccagtttcag tcatcttcgg cgcccggtcc tgcatagatg gcaactctgg
      961 caccagcatc cagtcactgc gacccaagtc atacgtgaag acaattgcta tcctcggggc
     1021 agggcattat gtgtatgcag accagccaga ggagttcaac cagaaagtca aggagatctg
     1081 ccacacagta gactgagcac acggaacc
//
