LOCUS       NP_997689                351 aa            linear   ROD 01-JUN-2024
DEFINITION  1-acylglycerol-3-phosphate O-acyltransferase ABHD5 [Rattus
            norvegicus].
ACCESSION   NP_997689 XP_236775
VERSION     NP_997689.1
DBSOURCE    REFSEQ: accession NM_212524.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 351)
  AUTHORS   Ou,J., Peng,Y., Yang,W., Zhang,Y., Hao,J., Li,F., Chen,Y., Zhao,Y.,
            Xie,X., Wu,S., Zha,L., Luo,X., Xie,G., Wang,L., Sun,W., Zhou,Q.,
            Li,J. and Liang,H.
  TITLE     ABHD5 blunts the sensitivity of colorectal cancer to fluorouracil
            via promoting autophagic uracil yield
  JOURNAL   Nat Commun 10 (1), 1078 (2019)
   PUBMED   30842415
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 351)
  AUTHORS   Dettlaff-Pokora,A., Sledzinski,T. and Swierczynski,J.
  TITLE     Upregulation of Pnpla2 and Abhd5 and downregulation of G0s2 gene
            expression in mesenteric white adipose tissue as a potential reason
            for elevated concentration of circulating NEFA after removal of
            retroperitoneal, epididymal, and inguinal adipose tissue
  JOURNAL   Mol Cell Biochem 422 (1-2), 21-29 (2016)
   PUBMED   27590244
  REMARK    GeneRIF: upregulation of Pnpla2 expression and activation of ATGL
            (due to an increase in ABHD5 and decrease in G0S2 levels), as well
            as a coordinated interplay of these genes with Lipe in mesenteric
            WAT, contribute, at least in part, to an increase in the
            concentration of circulating NEFA in rats with reduced fat mass.
REFERENCE   3  (residues 1 to 351)
  AUTHORS   Chamoun,Z., Vacca,F., Parton,R.G. and Gruenberg,J.
  TITLE     PNPLA3/adiponutrin functions in lipid droplet formation
  JOURNAL   Biol Cell 105 (5), 219-233 (2013)
   PUBMED   23398201
REFERENCE   4  (residues 1 to 351)
  AUTHORS   MacPherson,R.E., Ramos,S.V., Vandenboom,R., Roy,B.D. and
            Peters,S.J.
  TITLE     Skeletal muscle PLIN proteins, ATGL and CGI-58, interactions at
            rest and following stimulated contraction
  JOURNAL   Am J Physiol Regul Integr Comp Physiol 304 (8), R644-R650 (2013)
   PUBMED   23408028
  REMARK    GeneRIF: in skeletal muscle, during contraction-induced muscle
            lipolysis, ATGL and CGI-58 strongly associate and that the PLIN
            proteins work together to regulate lipolysis
REFERENCE   5  (residues 1 to 351)
  AUTHORS   Badin,P.M., Loubiere,C., Coonen,M., Louche,K., Tavernier,G.,
            Bourlier,V., Mairal,A., Rustan,A.C., Smith,S.R., Langin,D. and
            Moro,C.
  TITLE     Regulation of skeletal muscle lipolysis and oxidative metabolism by
            the co-lipase CGI-58
  JOURNAL   J Lipid Res 53 (5), 839-848 (2012)
   PUBMED   22383684
REFERENCE   6  (residues 1 to 351)
  AUTHORS   Yamaguchi,T., Omatsu,N., Morimoto,E., Nakashima,H., Ueno,K.,
            Tanaka,T., Satouchi,K., Hirose,F. and Osumi,T.
  TITLE     CGI-58 facilitates lipolysis on lipid droplets but is not involved
            in the vesiculation of lipid droplets caused by hormonal
            stimulation
  JOURNAL   J Lipid Res 48 (5), 1078-1089 (2007)
   PUBMED   17308334
  REMARK    GeneRIF: CGI-58 facilitates lipolysis in cooperation with perilipin
            and other factors, including lipases
REFERENCE   7  (residues 1 to 351)
  AUTHORS   Schweiger,M., Schreiber,R., Haemmerle,G., Lass,A., Fledelius,C.,
            Jacobsen,P., Tornqvist,H., Zechner,R. and Zimmermann,R.
  TITLE     Adipose triglyceride lipase and hormone-sensitive lipase are the
            major enzymes in adipose tissue triacylglycerol catabolism
  JOURNAL   J Biol Chem 281 (52), 40236-40241 (2006)
   PUBMED   17074755
REFERENCE   8  (residues 1 to 351)
  AUTHORS   Lass,A., Zimmermann,R., Haemmerle,G., Riederer,M., Schoiswohl,G.,
            Schweiger,M., Kienesberger,P., Strauss,J.G., Gorkiewicz,G. and
            Zechner,R.
  TITLE     Adipose triglyceride lipase-mediated lipolysis of cellular fat
            stores is activated by CGI-58 and defective in Chanarin-Dorfman
            Syndrome
  JOURNAL   Cell Metab 3 (5), 309-319 (2006)
   PUBMED   16679289
REFERENCE   9  (residues 1 to 351)
  AUTHORS   Yamaguchi,T., Omatsu,N., Matsushita,S. and Osumi,T.
  TITLE     CGI-58 interacts with perilipin and is localized to lipid droplets.
            Possible involvement of CGI-58 mislocalization in Chanarin-Dorfman
            syndrome
  JOURNAL   J Biol Chem 279 (29), 30490-30497 (2004)
   PUBMED   15136565
  REMARK    GeneRIF: CGI-58 interacts with perilipin and is localized to lipid
            droplets
REFERENCE   10 (residues 1 to 351)
  AUTHORS   Lefevre,C., Jobard,F., Caux,F., Bouadjar,B., Karaduman,A.,
            Heilig,R., Lakhdar,H., Wollenberg,A., Verret,J.L., Weissenbach,J.,
            Ozguc,M., Lathrop,M., Prud'homme,J.F. and Fischer,J.
  TITLE     Mutations in CGI-58, the gene encoding a new protein of the
            esterase/lipase/thioesterase subfamily, in Chanarin-Dorfman
            syndrome
  JOURNAL   Am J Hum Genet 69 (5), 1002-1012 (2001)
   PUBMED   11590543
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AY550934.1.
            
            On Aug 30, 2004 this sequence version replaced XP_236775.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY550934.1, BC127470.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..351
                     /organism="Rattus norvegicus"
                     /strain="ZDF"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q32"
     Protein         1..351
                     /product="1-acylglycerol-3-phosphate O-acyltransferase
                     ABHD5"
                     /EC_number="2.3.1.51"
                     /note="lipid droplet-binding protein CGI-58; abhydrolase
                     domain-containing protein 5"
                     /calculated_mol_wt=38973
     Region          3..347
                     /region_name="PLN02894"
                     /note="hydrolase, alpha/beta fold family protein"
                     /db_xref="CDD:215484"
     Site            124
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q6QA69.1)"
     Region          329..334
                     /region_name="HXXXXD motif"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6QA69.1)"
     CDS             1..351
                     /gene="Abhd5"
                     /gene_synonym="CGI-58"
                     /coded_by="NM_212524.1:41..1096"
                     /db_xref="GeneID:316122"
                     /db_xref="RGD:1303237"
ORIGIN      
        1 mkamaaeeev dsadagggsg wltgwlptwc ptstshlkea eekmlkcvpc tykkepvris
       61 ngnsiwtlmf shnmssktpl vllhgfgggl glwalnfedl stdrpvyafd llgfgrssrp
      121 rfdsdaeeve nqfvesieew rcalrldkmi llghnlggfl aaayslkyps rvshlilvep
      181 wgfperpdla dqerpipvwi ralgaaltpf nplaglriag pfglslvqrl rpdfkrkyss
      241 mfeddtvtey iyhcnvqtps getafknmti pygwakrpml qrigglhpdi pvsvifgars
      301 cidgnsgtsi qslrpksyvk tiailgaghy vyadqpeefn qkvkeichtv d
//
