LOCUS       NM_001108866            2399 bp    mRNA    linear   ROD 23-MAR-2023
DEFINITION  Rattus norvegicus abhydrolase domain containing 4, N-acyl
            phospholipase B (Abhd4), mRNA.
ACCESSION   NM_001108866 XM_001053662 XM_344403
VERSION     NM_001108866.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2399)
  AUTHORS   Lee HC, Simon GM and Cravatt BF.
  TITLE     ABHD4 regulates multiple classes of N-acyl phospholipids in the
            mammalian central nervous system
  JOURNAL   Biochemistry 54 (15), 2539-2549 (2015)
   PUBMED   25853435
REFERENCE   2  (bases 1 to 2399)
  AUTHORS   Simon GM and Cravatt BF.
  TITLE     Endocannabinoid biosynthesis proceeding through
            glycerophospho-N-acyl ethanolamine and a role for
            alpha/beta-hydrolase 4 in this pathway
  JOURNAL   J Biol Chem 281 (36), 26465-26472 (2006)
   PUBMED   16818490
  REMARK    GeneRIF: Lysophospholipase/phospholipase B (EC 3.1.1.5) specific
            for N-acyl phosphatidylethanolamine (NAPE) suggesting a role in the
            biosynthesis of N-acyl ethanolamines including the endocannabinoid
            anandamide.
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH474049.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_001053662.1, XM_344403.3.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMD00132261,
                              SAMD00132262 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2399
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="15"
                     /map="15p13"
     gene            1..2399
                     /gene="Abhd4"
                     /gene_synonym="Abh4"
                     /note="abhydrolase domain containing 4, N-acyl
                     phospholipase B"
                     /db_xref="GeneID:364380"
                     /db_xref="RGD:1311858"
     exon            1..92
                     /gene="Abhd4"
                     /gene_synonym="Abh4"
                     /inference="alignment:Splign:2.1.0"
     CDS             31..1098
                     /gene="Abhd4"
                     /gene_synonym="Abh4"
                     /note="abhydrolase domain-containing protein 4"
                     /codon_start=1
                     /product="(Lyso)-N-acylphosphatidylethanolamine lipase"
                     /protein_id="NP_001102336.1"
                     /db_xref="GeneID:364380"
                     /db_xref="RGD:1311858"
                     /translation="MGWLSSTRQGLFTMADDLEQQPQGWLSSWLPTWRPTSMSQLKNV
                     EARILQCLQNKFLARYVSLPNQNKIWTVTVSPEQKDRTPLVMVHGFGGGVGLWILNMD
                     SLSARRTLHTFDLLGFGRSSRPTFPRDPEGAEDEFVTSIETWRETMGIPTMILLGHSL
                     GGFLATSYSIKYPERVKHLILVDPWGFPLRPTDPSEIRTPPTWVKAVASVLGRSNPLA
                     VLRVAGPWGPGLVQRFRPDFKRKFADFFEDDTISEYIYHCNAQNPSGETAFKAMMESF
                     GWARRPMLERIHLIRKDVPITMIYGANTWIDTSTGKKVKLQRPDSYVRDMEIEGASHH
                     VYADQPHIFNAVVEEICNSVD"
     exon            93..181
                     /gene="Abhd4"
                     /gene_synonym="Abh4"
                     /inference="alignment:Splign:2.1.0"
     exon            182..554
                     /gene="Abhd4"
                     /gene_synonym="Abh4"
                     /inference="alignment:Splign:2.1.0"
     exon            555..709
                     /gene="Abhd4"
                     /gene_synonym="Abh4"
                     /inference="alignment:Splign:2.1.0"
     exon            710..821
                     /gene="Abhd4"
                     /gene_synonym="Abh4"
                     /inference="alignment:Splign:2.1.0"
     exon            822..1008
                     /gene="Abhd4"
                     /gene_synonym="Abh4"
                     /inference="alignment:Splign:2.1.0"
     exon            1009..2399
                     /gene="Abhd4"
                     /gene_synonym="Abh4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggtcagctgg ttctggcgtc aagcggaggg atgggctggc tcagctcgac ccggcagggc
       61 ttgtttacta tggctgatga tctggagcag cagccccagg gctggctgag tagctggctc
      121 cccacttggc gccccacttc catgtctcag ctgaagaatg tggaagccag gatcctccag
      181 tgtctccaga acaagttcct ggcccgttat gtatccctcc caaaccagaa caagatctgg
      241 acggtgactg tgagcccaga gcaaaaggac cgcacccctc tggtgatggt acatggcttt
      301 gggggtggcg tgggcctctg gatcctcaac atggattccc tgagtgcccg ccgcacactc
      361 catacctttg atctgcttgg ttttgggcga agctcaaggc ctacgttccc aagggaccca
      421 gaaggagctg aagatgagtt tgtgacctca atagagacat ggcgggagac aatgggaatc
      481 cctaccatga tcctcctggg gcacagtttg ggaggattcc tggccacttc ctactctatc
      541 aagtaccctg aaagagttaa acatctaatc ctggtggatc cctggggctt tcccttacga
      601 ccgactgacc ccagtgagat ccgtacacct ccaacctggg tcaaggctgt ggcatctgtc
      661 ctgggacgct ccaatccact ggctgttctt cgagtggctg ggccttgggg gcctgggctg
      721 gtgcagagat tccgtccaga cttcaagcgc aaatttgcag acttctttga agatgatacc
      781 atctcggaat acatctacca ctgcaatgca cagaatccca gtggggaaac ggcattcaaa
      841 gccatgatgg agtccttcgg ctgggcccgg cgccccatgt tggagcgaat ccacttgatt
      901 cggaaagatg tgcccatcac catgatctat ggggccaata cctggatcga caccagcaca
      961 gggaaaaagg tgaagctgca aaggccagac tcctacgtcc gagacatgga gatcgagggt
     1021 gcatcgcacc atgtctacgc tgaccagcca cacatcttca atgctgtggt ggaggagatc
     1081 tgtaactcag ttgactgaga gggagagaag gaagccggag ttgctgtcat ctctctccct
     1141 gtcttagtca gaacttctgt cctttcctca ccaactaaca tgtgccagcc aggcagagtc
     1201 tcgggctgtc cccaagacag gaccacagtg aaaaagagca cttccaaccc catgctgagg
     1261 gcaagaggca gaatccacca gaggccttga actccctact ctggggagaa acataaaggg
     1321 ctgcctagtc ctgcccgttc tctccatacc aggtggtgat tatgaggact gcgaaccatg
     1381 ccatctccct gcatagcctt ccttcctcta gacagaggag ggctcccagc acctttccag
     1441 tgtgggaatg tgtcagagag taagttccat acaggaacat cttccttctc catcactcca
     1501 cgcttccatc caacccagtt tccacttacc caggagctgc tctactcacc tgcacaaccg
     1561 ctgcctccac cttggaggcc aaatcccaag ctcttactgg cagacgaggc aagagatcag
     1621 ggcaggatat aacacatgat gggttccaac agaactgagt atagtgcagg tctgctggct
     1681 tccagcacaa gtcgaaagct ttgtgcacca aggttccatg catacaccac tgctatggag
     1741 ccaatttaaa gttaaccttg ctctgtagtc taacctgtta tgcagggaca ctgttatctt
     1801 gccctgtgtc tcaatcctct ttgcctaagt tgggacactt ggagactctt cctctcgttc
     1861 ctcccactgt gaggctctga gcctcttctg tgccttgggc ccttaaagcc ccatgtgtag
     1921 tcatagcaaa ggtggctcct gtggagaagg ggaaagaccc tcccacccta gagtcatgtc
     1981 tggattcaca aagtccacaa gtatctgtag cattttctac ctggccctag agctgagagc
     2041 ccctccccaa ggctcactga ggagctttaa gccagcagtt ctctgtcttt atcagccaca
     2101 gaaatgcttc tcactgcctg aacctctatg cctatcattg gtcaccatgg tctccaactc
     2161 actcagcttc aaaaattacc catcagcccc ctccagtgaa tctcattcca ggtcctgctc
     2221 taagcctctg ggtactaggc tgggcctggt cccagaagcc gggcagttcc tgcctcctcc
     2281 ttcactttta taaagccaac cctttcacca gaatagtgtt aactcctggt gctttgtact
     2341 actggtccag ctgcctcggg ctccttttct atattaataa agaagagtaa aaattgtcg
//
