LOCUS       NM_001024314            1949 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus abhydrolase domain containing 12,
            lysophospholipase (Abhd12), mRNA.
ACCESSION   NM_001024314 XM_575257
VERSION     NM_001024314.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1949)
  AUTHORS   Kelkar,D.S., Ravikumar,G., Mehendale,N., Singh,S., Joshi,A.,
            Sharma,A.K., Mhetre,A., Rajendran,A., Chakrapani,H. and Kamat,S.S.
  TITLE     A chemical-genetic screen identifies ABHD12 as an
            oxidized-phosphatidylserine lipase
  JOURNAL   Nat Chem Biol 15 (2), 169-178 (2019)
   PUBMED   30643283
REFERENCE   2  (bases 1 to 1949)
  AUTHORS   Joshi,A., Shaikh,M., Singh,S., Rajendran,A., Mhetre,A. and
            Kamat,S.S.
  TITLE     Biochemical characterization of the PHARC-associated serine
            hydrolase ABHD12 reveals its preference for very-long-chain lipids
  JOURNAL   J Biol Chem 293 (44), 16953-16963 (2018)
   PUBMED   30237167
REFERENCE   3  (bases 1 to 1949)
  AUTHORS   Yokoi,N., Fukata,Y., Sekiya,A., Murakami,T., Kobayashi,K. and
            Fukata,M.
  TITLE     Identification of PSD-95 Depalmitoylating Enzymes
  JOURNAL   J Neurosci 36 (24), 6431-6444 (2016)
   PUBMED   27307232
REFERENCE   4  (bases 1 to 1949)
  AUTHORS   Kamat,S.S., Camara,K., Parsons,W.H., Chen,D.H., Dix,M.M.,
            Bird,T.D., Howell,A.R. and Cravatt,B.F.
  TITLE     Immunomodulatory lysophosphatidylserines are regulated by ABHD16A
            and ABHD12 interplay
  JOURNAL   Nat Chem Biol 11 (2), 164-171 (2015)
   PUBMED   25580854
REFERENCE   5  (bases 1 to 1949)
  AUTHORS   Savinainen,J.R., Patel,J.Z., Parkkari,T., Navia-Paldanius,D.,
            Marjamaa,J.J., Laitinen,T., Nevalainen,T. and Laitinen,J.T.
  TITLE     Biochemical and pharmacological characterization of the human
            lymphocyte antigen B-associated transcript 5 (BAT5/ABHD16A)
  JOURNAL   PLoS One 9 (10), e109869 (2014)
   PUBMED   25290914
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1949)
  AUTHORS   Blankman,J.L., Long,J.Z., Trauger,S.A., Siuzdak,G. and Cravatt,B.F.
  TITLE     ABHD12 controls brain lysophosphatidylserine pathways that are
            deregulated in a murine model of the neurodegenerative disease
            PHARC
  JOURNAL   Proc Natl Acad Sci U S A 110 (4), 1500-1505 (2013)
   PUBMED   23297193
REFERENCE   7  (bases 1 to 1949)
  AUTHORS   Navia-Paldanius,D., Savinainen,J.R. and Laitinen,J.T.
  TITLE     Biochemical and pharmacological characterization of human
            alpha/beta-hydrolase domain containing 6 (ABHD6) and 12 (ABHD12)
  JOURNAL   J Lipid Res 53 (11), 2413-2424 (2012)
   PUBMED   22969151
REFERENCE   8  (bases 1 to 1949)
  AUTHORS   Schwenk,J., Harmel,N., Brechet,A., Zolles,G., Berkefeld,H.,
            Muller,C.S., Bildl,W., Baehrens,D., Huber,B., Kulik,A., Klocker,N.,
            Schulte,U. and Fakler,B.
  TITLE     High-resolution proteomics unravel architecture and molecular
            diversity of native AMPA receptor complexes
  JOURNAL   Neuron 74 (4), 621-633 (2012)
   PUBMED   22632720
REFERENCE   9  (bases 1 to 1949)
  AUTHORS   Blankman,J.L., Simon,G.M. and Cravatt,B.F.
  TITLE     A comprehensive profile of brain enzymes that hydrolyze the
            endocannabinoid 2-arachidonoylglycerol
  JOURNAL   Chem Biol 14 (12), 1347-1356 (2007)
   PUBMED   18096503
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            On Nov 27, 2020 this sequence version replaced NM_001024314.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC078918.1, SRR26360190.854711.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760434 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-350               JAXUCZ010000003.1  160179580-160179929 c
            351-475             JAXUCZ010000003.1  160142065-160142189 c
            476-581             JAXUCZ010000003.1  160136145-160136250 c
            582-701             JAXUCZ010000003.1  160133953-160134072 c
            702-732             JAXUCZ010000003.1  160130948-160130978 c
            733-778             JAXUCZ010000003.1  160129614-160129659 c
            779-908             JAXUCZ010000003.1  160127107-160127236 c
            909-946             JAXUCZ010000003.1  160126092-160126129 c
            947-1026            JAXUCZ010000003.1  160125667-160125746 c
            1027-1109           JAXUCZ010000003.1  160124698-160124780 c
            1110-1188           JAXUCZ010000003.1  160122477-160122555 c
            1189-1316           JAXUCZ010000003.1  160121505-160121632 c
            1317-1949           JAXUCZ010000003.1  160119724-160120356 c
FEATURES             Location/Qualifiers
     source          1..1949
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q41"
     gene            1..1949
                     /gene="Abhd12"
                     /note="abhydrolase domain containing 12,
                     lysophospholipase"
                     /db_xref="GeneID:499913"
                     /db_xref="RGD:1562570"
     exon            1..350
                     /gene="Abhd12"
                     /inference="alignment:Splign:2.1.0"
     CDS             160..1356
                     /gene="Abhd12"
                     /EC_number="3.1.1.23"
                     /note="monoacylglycerol lipase ABHD12; abhydrolase
                     domain-containing protein 12; 2-arachidonoylglycerol
                     hydrolase ABHD12; oxidized phosphatidylserine lipase
                     ABHD12"
                     /codon_start=1
                     /product="lysophosphatidylserine lipase ABHD12"
                     /protein_id="NP_001019485.1"
                     /db_xref="GeneID:499913"
                     /db_xref="RGD:1562570"
                     /translation="MRKRTEPVTLEHERCAASGSSSSGSAAAALDADCSLKQNLRLAG
                     KGTAEPHSASDAGMKRALGRRKSLWFRLRKILLCVLGFYIAIPFLVKLCPGIQAKLIF
                     LNFVRVPYFIDLKKPQDQGLNHTCNYYLQPEDDVTIGVWHTIPSVWWKNAQGKDQMWY
                     EDALASNHPIILYLHGNAGTRGGDHRVELYKVLSSLGYHVVTFDYRGWGDSVGTPSER
                     GMTYDALHVFDWIKARSGDNPVYIWGHSLGTGVATNLVRRLCERETPPDALILESPFT
                     NIREEAKSHPFSVIYRYFPGFDWFFLDPITSSGIKFANDENMKHISCPLLILHAEDDP
                     VVPFHLGRKLYNIAAPSRSFRDFKVQFIPFHSDLGYRHKYIYKSPELPRILREFLGKS
                     EPERQH"
     exon            351..475
                     /gene="Abhd12"
                     /inference="alignment:Splign:2.1.0"
     exon            476..581
                     /gene="Abhd12"
                     /inference="alignment:Splign:2.1.0"
     exon            582..701
                     /gene="Abhd12"
                     /inference="alignment:Splign:2.1.0"
     exon            702..732
                     /gene="Abhd12"
                     /inference="alignment:Splign:2.1.0"
     exon            733..778
                     /gene="Abhd12"
                     /inference="alignment:Splign:2.1.0"
     exon            779..908
                     /gene="Abhd12"
                     /inference="alignment:Splign:2.1.0"
     exon            909..946
                     /gene="Abhd12"
                     /inference="alignment:Splign:2.1.0"
     exon            947..1026
                     /gene="Abhd12"
                     /inference="alignment:Splign:2.1.0"
     exon            1027..1109
                     /gene="Abhd12"
                     /inference="alignment:Splign:2.1.0"
     exon            1110..1188
                     /gene="Abhd12"
                     /inference="alignment:Splign:2.1.0"
     exon            1189..1316
                     /gene="Abhd12"
                     /inference="alignment:Splign:2.1.0"
     exon            1317..1949
                     /gene="Abhd12"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggcgctggtc catagcgggc gccgcggcct ggggctgggg atgtgaccag cagtgggctc
       61 ccagctccgg gtggtgacgg ctgtgagcga cggcgactgc ggcgcaggcg tgcggtcgaa
      121 accagggtgc ggaaagctgc cggccgacag ggccgcggga tgaggaagcg gaccgagccc
      181 gtcaccttgg agcatgagcg ctgcgccgcc tcaggctcgt cttcctccgg ctcggccgcc
      241 gcggcgctgg acgccgactg cagcttgaag cagaacctgc gtctggcggg caaggggacg
      301 gcagagccgc acagcgcatc cgacgcgggc atgaagcggg ctctgggcag acggaagagc
      361 ctgtggttcc gactaaggaa gatacttctc tgtgttttgg ggttctacat tgccattcca
      421 tttcttgtca aactgtgtcc tgggatacag gccaaactga tattcttaaa tttcgtgagg
      481 gttccctatt tcattgactt aaaaaagcca caggatcaag gtttgaatca cacctgcaat
      541 tactacctcc agcccgagga tgatgtcact attggagtct ggcacaccat tccctctgtc
      601 tggtggaaga atgcccaagg gaaggaccag atgtggtatg aggatgctct ggcttctaac
      661 caccccatca tcctgtacct gcatgggaat gcaggcacca gaggaggtga ccaccgtgtg
      721 gagctgtaca aggtgctgag ttcccttggt taccacgtgg tcaccttcga ctacagaggt
      781 tggggtgact cagtaggaac accatcagag cgaggcatga catatgatgc actccatgtt
      841 tttgactgga tcaaagcaag aagtggtgat aatcctgtgt atatctgggg ccattcgctg
      901 ggcactggag tggcaacaaa tctggtccgg cgcctttgtg agcgagagac gccaccagat
      961 gcccttatat tggagtctcc gttcacaaat attcgtgaag aagcaaagag tcatccattt
     1021 tcagtgatat acagatactt cccaggcttt gactggttct tcctcgaccc cattacaagc
     1081 agtggaatta aatttgcaaa tgacgaaaac atgaagcaca tctcctgtcc cctgctcatc
     1141 ttgcacgctg aggatgaccc agttgtaccc tttcatctcg gcaggaagct atacaatatt
     1201 gctgcgccat cccgaagttt ccgagacttc aaagtccagt tcatcccctt tcactcagac
     1261 cttggctaca gacataagta catctacaag agcccagagc ttccacggat actgagggaa
     1321 ttcctaggga agtcggaacc agagcgccag cactgagcct ggcccgtgaa ggagcatgga
     1381 gacccacctt ccttcccttc tccctgaaca gcagtctggc acccagaagc tcagagtgcc
     1441 accacctgtg gtgctcagga gcccagcgca tacctagaaa gaggactccg acacagcggg
     1501 cagaggctcc acagacggat ctatgaggaa aatacggtgg caggcaggca ggcaggcgac
     1561 cccctgaccc tctggtggcc gctgtatctg agcccttttg ggaaggctta tagacaacag
     1621 gtggagccca tacgctgggc atagggagcc tgggaagggc tcaggagctc aggaccactc
     1681 caggctctct agcaccaccg cttaaaatac aggaaaaagg ttctttctgc ccttcctggc
     1741 gtacacagaa cagattccaa gtggttcaat ttgtccccta cagctcatgt acctgcttgc
     1801 cttcctcagc tgtccctgcc tctcctggca tctgtacacc cacagtgagg ggcacctgga
     1861 cttgcacttc cattctgccc acctgtctgt cacctaacct ggccgtagac tgagcattta
     1921 tttaagaata aaatctcggt ggtggtcta
//
