LOCUS       NM_130414               4829 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Rattus norvegicus ATP binding cassette subfamily G member 8
            (Abcg8), mRNA.
ACCESSION   NM_130414 XM_346758
VERSION     NM_130414.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4829)
  AUTHORS   Wang,W., Zhang,Z.Z., Wu,Y., Wang,R.Q., Chen,J.W., Chen,J.,
            Zhang,Y., Chen,Y.J., Geng,M., Xu,Z.D., Dai,M., Li,J.H. and Pan,L.L.
  TITLE     (-)-Epigallocatechin-3-Gallate Ameliorates Atherosclerosis and
            Modulates Hepatic Lipid Metabolic Gene Expression in Apolipoprotein
            E Knockout Mice: Involvement of TTC39B
  JOURNAL   Front Pharmacol 9, 195 (2018)
   PUBMED   29593532
  REMARK    Erratum:[Front Pharmacol. 2018 May 01;9:459. doi:
            10.3389/fphar.2018.00459.. PMID: 29745376]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4829)
  AUTHORS   Lee,J.Y., Kinch,L.N., Borek,D.M., Wang,J., Wang,J., Urbatsch,I.L.,
            Xie,X.S., Grishin,N.V., Cohen,J.C., Otwinowski,Z., Hobbs,H.H. and
            Rosenbaum,D.M.
  TITLE     Crystal structure of the human sterol transporter ABCG5/ABCG8
  JOURNAL   Nature 533 (7604), 561-564 (2016)
   PUBMED   27144356
REFERENCE   3  (bases 1 to 4829)
  AUTHORS   Apro,J., Beckman,L., Angelin,B. and Rudling,M.
  TITLE     Influence of dietary sugar on cholesterol and bile acid metabolism
            in the rat: Marked reduction of hepatic Abcg5/8 expression
            following sucrose ingestion
  JOURNAL   Biochem Biophys Res Commun 461 (4), 592-597 (2015)
   PUBMED   25912874
  REMARK    GeneRIF: In contrast, the marked reduction of hepatic Abcg5/8
            observed is an effect of the high sugar content of the diets.
REFERENCE   4  (bases 1 to 4829)
  AUTHORS   Cote,I., Chapados,N.A. and Lavoie,J.M.
  TITLE     Impaired VLDL assembly: a novel mechanism contributing to hepatic
            lipid accumulation following ovariectomy and
            high-fat/high-cholesterol diets?
  JOURNAL   Br J Nutr 112 (10), 1592-1600 (2014)
   PUBMED   25263431
REFERENCE   5  (bases 1 to 4829)
  AUTHORS   Cote,I., Ngo Sock,E.T., Levy,E. and Lavoie,J.M.
  TITLE     An atherogenic diet decreases liver FXR gene expression and causes
            severe hepatic steatosis and hepatic cholesterol accumulation:
            effect of endurance training
  JOURNAL   Eur J Nutr 52 (5), 1523-1532 (2013)
   PUBMED   23117815
REFERENCE   6  (bases 1 to 4829)
  AUTHORS   Kwiterovich,P.O. Jr., Chen,S.C., Virgil,D.G., Schweitzer,A.,
            Arnold,D.R. and Kratz,L.E.
  TITLE     Response of obligate heterozygotes for phytosterolemia to a low-fat
            diet and to a plant sterol ester dietary challenge
  JOURNAL   J Lipid Res 44 (6), 1143-1155 (2003)
   PUBMED   12671028
REFERENCE   7  (bases 1 to 4829)
  AUTHORS   Graf,G.A., Li,W.P., Gerard,R.D., Gelissen,I., White,A., Cohen,J.C.
            and Hobbs,H.H.
  TITLE     Coexpression of ATP-binding cassette proteins ABCG5 and ABCG8
            permits their transport to the apical surface
  JOURNAL   J Clin Invest 110 (5), 659-669 (2002)
   PUBMED   12208867
REFERENCE   8  (bases 1 to 4829)
  AUTHORS   Repa,J.J., Berge,K.E., Pomajzl,C., Richardson,J.A., Hobbs,H. and
            Mangelsdorf,D.J.
  TITLE     Regulation of ATP-binding cassette sterol transporters ABCG5 and
            ABCG8 by the liver X receptors alpha and beta
  JOURNAL   J Biol Chem 277 (21), 18793-18800 (2002)
   PUBMED   11901146
REFERENCE   9  (bases 1 to 4829)
  AUTHORS   Lu,K., Lee,M.H., Hazard,S., Brooks-Wilson,A., Hidaka,H., Kojima,H.,
            Ose,L., Stalenhoef,A.F., Mietinnen,T., Bjorkhem,I., Bruckert,E.,
            Pandya,A., Brewer,H.B. Jr., Salen,G., Dean,M., Srivastava,A. and
            Patel,S.B.
  TITLE     Two genes that map to the STSL locus cause sitosterolemia: genomic
            structure and spectrum of mutations involving sterolin-1 and
            sterolin-2, encoded by ABCG5 and ABCG8, respectively
  JOURNAL   Am J Hum Genet 69 (2), 278-290 (2001)
   PUBMED   11452359
REFERENCE   10 (bases 1 to 4829)
  AUTHORS   Berge,K.E., Tian,H., Graf,G.A., Yu,L., Grishin,N.V., Schultz,J.,
            Kwiterovich,P., Shan,B., Barnes,R. and Hobbs,H.H.
  TITLE     Accumulation of dietary cholesterol in sitosterolemia caused by
            mutations in adjacent ABC transporters
  JOURNAL   Science 290 (5497), 1771-1775 (2000)
   PUBMED   11099417
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF351785.2.
            
            On or before Dec 17, 2003 this sequence version replaced
            XM_346758.1, NM_130414.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF351785.2 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132273,
                                           SAMD00132275 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..4829
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q12"
     gene            1..4829
                     /gene="Abcg8"
                     /note="ATP binding cassette subfamily G member 8"
                     /db_xref="GeneID:155192"
                     /db_xref="RGD:620300"
     exon            1..173
                     /gene="Abcg8"
                     /inference="alignment:Splign:2.1.0"
     CDS             111..2129
                     /gene="Abcg8"
                     /note="sterolin 2; ATP-binding cassette, sub-family G
                     (WHITE), member 8; ATP-binding cassette, subfamily G
                     (WHITE), member 8"
                     /codon_start=1
                     /product="ATP-binding cassette sub-family G member 8"
                     /protein_id="NP_569098.2"
                     /db_xref="GeneID:155192"
                     /db_xref="RGD:620300"
                     /translation="MAEKTKEETQLWNGTVLQDASSLQDSVFSSESDNSLYFTYSGQS
                     NTLEVRDLTYQVDMASQVPWFEQLAQFKLPWRSRGSQDSWDLGIRNLSFKVRSGQMLA
                     IIGSAGCGRATLLDVITGRDHGGKMKSGQIWINGQPSTPQLIQKCVAHVRQQDQLLPN
                     LTVRETLTFIAQMRLPKTFSQAQRDKRVEDVIAELRLRQCANTRVGNTYVRGVSGGER
                     RRVSIGVQLLWNPGILILDEPTSGLDSFTAHNLVRTLSRLAKGNRLVLISLHQPRSDI
                     FRLFDLVLLMTSGTPIYLGVAQHMVQYFTSIGYPCPRYSNPADFYVDLTSIDRRSKEQ
                     EVATMEKARLLAALFLEKVQGFDDFLWKAEAKSLDTGTYAVSQTLTQDTNCGTAAELP
                     GMIQQFTTLIRRQISNDFRDLPTLFIHGAEACLMSLIIGFLYYGHADKPLSFMDMAAL
                     LFMIGALIPFNVILDVVSKCHSERSLLYYELEDGLYTAGPYFFAKVLGELPEHCAYVI
                     IYGMPIYWLTNLRPGPELFLLHFMLLWLVVFCCRTMALAASAMLPTFHMSSFCCNALY
                     NSFYLTAGFMINLNNLWIVPAWISKMSFLRWCFSGLMQIQFNGHIYTTQIGNLTFSVP
                     GDAMVTAMDLNSHPLYAIYLIVIGISCGFLSLYYLSLKFIKQKSIQDW"
     exon            174..275
                     /gene="Abcg8"
                     /inference="alignment:Splign:2.1.0"
     exon            276..432
                     /gene="Abcg8"
                     /inference="alignment:Splign:2.1.0"
     exon            433..671
                     /gene="Abcg8"
                     /inference="alignment:Splign:2.1.0"
     exon            672..804
                     /gene="Abcg8"
                     /inference="alignment:Splign:2.1.0"
     exon            805..1074
                     /gene="Abcg8"
                     /inference="alignment:Splign:2.1.0"
     exon            1075..1237
                     /gene="Abcg8"
                     /inference="alignment:Splign:2.1.0"
     exon            1238..1318
                     /gene="Abcg8"
                     /inference="alignment:Splign:2.1.0"
     exon            1319..1518
                     /gene="Abcg8"
                     /inference="alignment:Splign:2.1.0"
     exon            1519..1595
                     /gene="Abcg8"
                     /inference="alignment:Splign:2.1.0"
     exon            1596..1863
                     /gene="Abcg8"
                     /inference="alignment:Splign:2.1.0"
     exon            1864..1991
                     /gene="Abcg8"
                     /inference="alignment:Splign:2.1.0"
     exon            1992..4829
                     /gene="Abcg8"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aggaggactc aagtgcccta gctctaagga gcaaagacag aaagaatcct ggcctagcca
       61 acagcagggg aggcctcagg agccacacaa agggcacaac accgcaggtc atggctgaga
      121 agaccaaaga ggagacccag ctgtggaacg ggactgtact ccaggatgct tcaagcctcc
      181 aggacagcgt gttctcctct gaaagtgaca acagcctcta cttcacctac agtggtcagt
      241 ccaacactct ggaggtcaga gatctcacct accaggtgga catggcctct caggtgcctt
      301 ggtttgagca gctggctcag ttcaagttac cgtggaggtc tcgcggcagc caggactcct
      361 gggatctggg catccgaaat ctgagcttca aagtgaggag tggacagatg ctggctatca
      421 tagggagcgc aggctgcggg agagccacat tactcgacgt tatcacaggc agagaccatg
      481 gtggcaagat gaaatcagga caaatctgga taaacgggca acccagcacg cctcagctga
      541 tacagaagtg tgtggcacat gtgcgccagc aagaccagct gctccccaat ctgactgtca
      601 gagagaccct gactttcatc gcccagatgc gcctgcccaa gaccttctct caggcccagc
      661 gagacaaacg ggtggaagac gtgattgcgg agctgcggct gcggcagtgc gccaacaccc
      721 gcgtgggcaa cacatacgta cgcggggtgt ccgggggcga gcgccgaaga gtgagcatcg
      781 gggtgcagct cctgtggaac ccaggaatcc tcatcctgga tgaacccact tccggcctcg
      841 acagcttcac cgctcacaac ctggtgagaa ctttgtcccg cctggccaaa ggcaacaggc
      901 tggtgctcat ctccctccac cagcctcgct ctgacatctt caggctattt gacctggtcc
      961 ttctgatgac gtctggcacc cctatctacc tgggggtggc acagcacatg gtgcagtact
     1021 ttacatcaat tggctaccct tgtcctcgct acagcaaccc tgctgacttc tacgtggact
     1081 tgacgagcat tgacaggcgc agcaaagaac aggaggtggc caccatggag aaggctcgat
     1141 tacttgcagc cttgttccta gaaaaagtgc aaggctttga cgactttctg tggaaagctg
     1201 aggcaaagag tctcgacaca ggcacctatg cagtcagcca gaccctcaca caggacacca
     1261 actgtggaac tgctgctgag ctgcccggga tgatacagca gtttaccacc ctgatccgtc
     1321 gtcagatttc caatgacttc cgggacttgc ccaccctgtt catccatgga gcagaagcct
     1381 gcctgatgtc tctcatcatt ggcttccttt actacggcca cgcagacaag ccgctctcct
     1441 tcatggacat ggcagccctc ctgttcatga taggagcact cattcctttt aatgtcattc
     1501 tggatgtcgt ctccaaatgt cactcggagc ggtcgctgct gtactatgaa ctggaggacg
     1561 gactgtacac tgctggtcct tatttctttg ccaaggtcct cggtgagctg ccagagcact
     1621 gtgcctatgt catcatctat gggatgccca tctactggct gaccaacctg cggccagggc
     1681 ctgagctctt cctcctgcac ttcatgcttc tgtggctggt ggtgttctgc tgcaggacca
     1741 tggccctggc cgcctctgcc atgctgccca ccttccacat gtcctccttc tgctgcaacg
     1801 ctctctacaa ctccttctac cttacggctg gcttcatgat aaacttgaac aacctgtgga
     1861 tagtacctgc atggatttcc aagatgtcgt tcctccggtg gtgcttctca gggctgatgc
     1921 agattcagtt taatggacac atttacacca cgcagatcgg caacctcacc ttctccgtcc
     1981 ccggagacgc gatggtcact gccatggacc tgaactcaca tcctctttat gcgatctacc
     2041 tcatcgtcat tggcatcagc tgtggcttcc tgtccctgta ttatctgtcc ttgaagttca
     2101 tcaaacagaa gtcaattcaa gattggtgat gttcagcctt gcttccactg gtgggaccct
     2161 tctgcctggg ctggccgcct cctgaggagc ccgactgagg acaatgatcc cacagatctc
     2221 aagcagcatc ggcgtcttgg tgctgcagtg gcacaggtca gccacaggat ggcagtagaa
     2281 taaagacagt tgagaggttt ctgctcacag gcctgggctt gtgaaacagg tacttcgtga
     2341 acctgtaacg ttgctcattc attttatatc tctatataaa caacccagta tggaatggga
     2401 accaattatt tatgaattga gtagctaggc tatgcagaga cttgtggaac cccgagagga
     2461 tagtggtctg tagcaaaaca tttagctttc tccaccaatc tcaccctgtt aagccgctcc
     2521 cgatacagag ggtgacctaa aactgactag aaatgtcctc tcttatctct gtgtggctcc
     2581 atggacttcc agagtcggac agctgagagc taagagtatc tactccatgg tgggtgtggt
     2641 ataaagagta gtgtgtggct actgtcgttt cttcaaccca ctgatagcgg gcaccctgcc
     2701 atatcggtgc cacaccgtgg caaagactaa tccagttgtc ttagcttaca agctgctttg
     2761 tggtggaatc aaaaagacct cgaggcctct gggagttaca gagcaaaaga tcgggcctga
     2821 gatgtttcta gaaacagttt gccgtttgtg tgagctctgc ggcctcagag ttgcaccccc
     2881 tagctggggc tcaggatgag ctttgaacct tccacagtgg ctggtggatg ggctgccgca
     2941 catccaggtt gaatggttca tgcctgtgtc gaggacccac tgactcaaag cacagagctg
     3001 ggaggggctg gttcccagag gaaaacgagt ctggaactga aagaaacagc aggggtgggg
     3061 gtgtttgagg ctgggagtga tgttctccac tggttcccca ggtcctgact gcatccagtg
     3121 tagttcctgg cagcttcatg acatcactgg atgccgatga gggaggcaga atcccaggcc
     3181 tgcccagact cagggactca gtgtccgagt gtccagatta cactggtgac tagagtgcag
     3241 gccccagtgt gagcagcggc tccttagcac actgtccttt ccctgctccc tggcctcagg
     3301 aagtctacac agctctgttg ccaccatcca ttacacagat gtcactcaag agccacagaa
     3361 gcctcatcca gagcagagtc aaaagtaccc tccgattgtt tctttcggtt tggaatagtt
     3421 agctcctcag agccccctga ctttctaagg tagctttcag tttggattta tctggtgcat
     3481 ttctcaatag aatccagact gggtcccctt tgctcagaat atccagaaat ggaattggtt
     3541 tttccctgag tgcgtcctgt caggtggccc atggtttcca cttgctacac taacgacttt
     3601 gactgcctga cagaaagcag gtctgctggg cccctccacg ttcctctgtt ccctcttttt
     3661 ataattaata aagctttgga ttcctggaga ccatgccttg ctcattcctt acccaccctc
     3721 catactccct gagttggtgc tatatataaa tgacacactt gtggaatccc cttttaattt
     3781 agcaagttgc aatccgttgc tctcattagt ttcggtgctt gaattgttcc tgacttagcc
     3841 agtgggatac tcaagttggc ttctatatct tcctagtcac gttcctgtca tcactgggga
     3901 ctccgacaaa acaaagtatt tgggaatcat cccgaatttt cccagctcag ccctgggatt
     3961 gaatgcgtct ctgtagaatc tttttagtgg gaaaaagata gtttgaagcc cagatgtgac
     4021 tgagtctgct ctgctgctgt acattgctgc ttcaggactc tcagtgggca gtgagtgacc
     4081 acgtgtgcat atgtgcatgt gtgtactcag tcctaactgc atatatgctc atgtacacac
     4141 tctgtagttc acccgggtga ccacgtgtgc atatgtgcat gtgtgtactc agtcctaact
     4201 gcatatatgc tcatgtacac actctgtaca gggcctccag cccatcccgt actccctccc
     4261 cagatcctgg ctctattttg gtaacccact atctttaggc ctggatggag aagtgtggaa
     4321 gagaaggaag gttggcagcc atctgccttt gtaaattcgt cacttgtgct gtggtaccga
     4381 aacccaggca gttgctggtt cttcagtttg tccccagagc agttctccat cacatcatcg
     4441 ctggtgttga tgcaccctag actctaactc catgggttcg tttggttgaa aagtgttctt
     4501 tagagcacac aaggcctggg aagagtaaga cccaacacta ggggcaccaa tactatccag
     4561 tgctccttat tcttcgctgc aaaggagcag aattttcttg tgggttgtaa atttttgctg
     4621 ttaaggataa atattttagg ctgtcatagc catagaacct gtcagtacgc tgtgctggtg
     4681 tgaaaactgc cccaaccaca gtagaatgtg gaggatgtgg gtatgcttca ataaaacgac
     4741 ttacagaagc attcagctcc tggacttggc ctgaggctgc agcttgcaga ctcttgatcc
     4801 aaagatgaag gttttaaaat gtgcactgt
//
