LOCUS       NM_053754               2470 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Rattus norvegicus ATP binding cassette subfamily G member 5
            (Abcg5), mRNA.
ACCESSION   NM_053754 XM_347385
VERSION     NM_053754.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2470)
  AUTHORS   Wang,W., Zhang,Z.Z., Wu,Y., Wang,R.Q., Chen,J.W., Chen,J.,
            Zhang,Y., Chen,Y.J., Geng,M., Xu,Z.D., Dai,M., Li,J.H. and Pan,L.L.
  TITLE     (-)-Epigallocatechin-3-Gallate Ameliorates Atherosclerosis and
            Modulates Hepatic Lipid Metabolic Gene Expression in Apolipoprotein
            E Knockout Mice: Involvement of TTC39B
  JOURNAL   Front Pharmacol 9, 195 (2018)
   PUBMED   29593532
  REMARK    Erratum:[Front Pharmacol. 2018 May 01;9:459. doi:
            10.3389/fphar.2018.00459.. PMID: 29745376]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2470)
  AUTHORS   Dmitrieva,R.I., Cranford,S.M. and Doris,P.A.
  TITLE     Genetic Control of Serum Marinobufagenin in the Spontaneously
            Hypertensive Rat and the Relationship to Blood Pressure
  JOURNAL   J Am Heart Assoc 6 (10), e006704 (2017)
   PUBMED   28982675
  REMARK    GeneRIF: Amino acid substitution in the sterol transport protein
            Abcg5 controls serum marinobufagenin levels in spontaneously
            hypertensive rats.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2470)
  AUTHORS   Lee,J.Y., Kinch,L.N., Borek,D.M., Wang,J., Wang,J., Urbatsch,I.L.,
            Xie,X.S., Grishin,N.V., Cohen,J.C., Otwinowski,Z., Hobbs,H.H. and
            Rosenbaum,D.M.
  TITLE     Crystal structure of the human sterol transporter ABCG5/ABCG8
  JOURNAL   Nature 533 (7604), 561-564 (2016)
   PUBMED   27144356
REFERENCE   4  (bases 1 to 2470)
  AUTHORS   Herlan,L., Schulz,A., Schulte,L., Schulz,H., Hubner,N. and
            Kreutz,R.
  TITLE     Novel candidate genes for impaired nephron development in a rat
            model with inherited nephron deficit and albuminuria
  JOURNAL   Clin Exp Pharmacol Physiol 42 (10), 1051-1058 (2015)
   PUBMED   26192016
REFERENCE   5  (bases 1 to 2470)
  AUTHORS   Apro,J., Beckman,L., Angelin,B. and Rudling,M.
  TITLE     Influence of dietary sugar on cholesterol and bile acid metabolism
            in the rat: Marked reduction of hepatic Abcg5/8 expression
            following sucrose ingestion
  JOURNAL   Biochem Biophys Res Commun 461 (4), 592-597 (2015)
   PUBMED   25912874
  REMARK    GeneRIF: In contrast, the marked reduction of hepatic Abcg5/8
            observed is an effect of the high sugar content of the diets.
REFERENCE   6  (bases 1 to 2470)
  AUTHORS   Yu,L., Hammer,R.E., Li-Hawkins,J., Von Bergmann,K., Lutjohann,D.,
            Cohen,J.C. and Hobbs,H.H.
  TITLE     Disruption of Abcg5 and Abcg8 in mice reveals their crucial role in
            biliary cholesterol secretion
  JOURNAL   Proc Natl Acad Sci U S A 99 (25), 16237-16242 (2002)
   PUBMED   12444248
REFERENCE   7  (bases 1 to 2470)
  AUTHORS   Graf,G.A., Li,W.P., Gerard,R.D., Gelissen,I., White,A., Cohen,J.C.
            and Hobbs,H.H.
  TITLE     Coexpression of ATP-binding cassette proteins ABCG5 and ABCG8
            permits their transport to the apical surface
  JOURNAL   J Clin Invest 110 (5), 659-669 (2002)
   PUBMED   12208867
REFERENCE   8  (bases 1 to 2470)
  AUTHORS   Lu,K., Lee,M.H., Hazard,S., Brooks-Wilson,A., Hidaka,H., Kojima,H.,
            Ose,L., Stalenhoef,A.F., Mietinnen,T., Bjorkhem,I., Bruckert,E.,
            Pandya,A., Brewer,H.B. Jr., Salen,G., Dean,M., Srivastava,A. and
            Patel,S.B.
  TITLE     Two genes that map to the STSL locus cause sitosterolemia: genomic
            structure and spectrum of mutations involving sterolin-1 and
            sterolin-2, encoded by ABCG5 and ABCG8, respectively
  JOURNAL   Am J Hum Genet 69 (2), 278-290 (2001)
   PUBMED   11452359
REFERENCE   9  (bases 1 to 2470)
  AUTHORS   Lee,M.H., Lu,K., Hazard,S., Yu,H., Shulenin,S., Hidaka,H.,
            Kojima,H., Allikmets,R., Sakuma,N., Pegoraro,R., Srivastava,A.K.,
            Salen,G., Dean,M. and Patel,S.B.
  TITLE     Identification of a gene, ABCG5, important in the regulation of
            dietary cholesterol absorption
  JOURNAL   Nat Genet 27 (1), 79-83 (2001)
   PUBMED   11138003
REFERENCE   10 (bases 1 to 2470)
  AUTHORS   Berge,K.E., Tian,H., Graf,G.A., Yu,L., Grishin,N.V., Schultz,J.,
            Kwiterovich,P., Shan,B., Barnes,R. and Hobbs,H.H.
  TITLE     Accumulation of dietary cholesterol in sitosterolemia caused by
            mutations in adjacent ABC transporters
  JOURNAL   Science 290 (5497), 1771-1775 (2000)
   PUBMED   11099417
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF312714.3.
            
            On or before Dec 17, 2003 this sequence version replaced
            XM_347385.1, NM_053754.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF312714.3 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760400
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2470
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q12"
     gene            1..2470
                     /gene="Abcg5"
                     /note="ATP binding cassette subfamily G member 5"
                     /db_xref="GeneID:114628"
                     /db_xref="RGD:620298"
     exon            1..210
                     /gene="Abcg5"
                     /inference="alignment:Splign:2.1.0"
     CDS             65..2023
                     /gene="Abcg5"
                     /note="sterolin 1; ATP-binding cassette, sub-family G
                     (WHITE), member 5 (sterolin 1); ATP-binding cassette
                     sub-family G (WHITE) member 5 (sterolin 1); ATP-binding
                     cassette, subfamily G (WHITE), member 5"
                     /codon_start=1
                     /product="ATP-binding cassette sub-family G member 5"
                     /protein_id="NP_446206.2"
                     /db_xref="GeneID:114628"
                     /db_xref="RGD:620298"
                     /translation="MSELPFLSPEGARGPHNNRGSQSSLEEGSVTGSEARHSLGVLNV
                     SFSVSNRVGPWWNIKSCQQKWDRKILKDVSLYIESGQTMCILGSSGSGKTTLLDAISG
                     RLRRTGTLEGEVFVNGCELRRDQFQDCVSYLLQSDVFLSSLTVRETLRYTAMLALRSS
                     SADFYDKKVEAVLTELSLSHVADQMIGNYNFGGISSGERRRVSIAAQLLQDPKVMMLD
                     EPTTGLDCMTANHIVLLLVELARRNRIVIVTIHQPRSELFHHFDKIAILTYGELVFCG
                     TPEEMLGFFNNCGYPCPEHSNPFDFYMDLTSVDTQSREREIETYKRVQMLESAFRQSD
                     ICHKILENIERTRHLKTLPMVPFKTKNPPGMFCKLGVLLRRVTRNLMRNKQVVIMRLV
                     QNLIMGLFLIFYLLRVQNNMLKGAVQDRVGLLYQLVGATPYTGMLNAVNLFPMLRAVS
                     DQESQDGLYQKWQMLLAYVLHALPFSIVATVIFSSVCYWTLGLYPEVARFGYFSAALL
                     APHLIGEFLTLVLLGMVQNPNIVNSIVALLSISGLLIGSGFIRNIEEMPIPLKILGYF
                     TFQKYCCEILVVNEFYGLNFTCGGSNTSVPNNPMCSMTQGIQFIEKTCPGATSRFTTN
                     FLILYSFIPTLVILGMVVFKVRDYLISR"
     exon            211..332
                     /gene="Abcg5"
                     /inference="alignment:Splign:2.1.0"
     exon            333..469
                     /gene="Abcg5"
                     /inference="alignment:Splign:2.1.0"
     exon            470..568
                     /gene="Abcg5"
                     /inference="alignment:Splign:2.1.0"
     exon            569..701
                     /gene="Abcg5"
                     /inference="alignment:Splign:2.1.0"
     exon            702..841
                     /gene="Abcg5"
                     /inference="alignment:Splign:2.1.0"
     exon            842..971
                     /gene="Abcg5"
                     /inference="alignment:Splign:2.1.0"
     exon            972..1185
                     /gene="Abcg5"
                     /inference="alignment:Splign:2.1.0"
     exon            1186..1391
                     /gene="Abcg5"
                     /inference="alignment:Splign:2.1.0"
     exon            1392..1530
                     /gene="Abcg5"
                     /inference="alignment:Splign:2.1.0"
     exon            1531..1716
                     /gene="Abcg5"
                     /inference="alignment:Splign:2.1.0"
     exon            1717..1829
                     /gene="Abcg5"
                     /inference="alignment:Splign:2.1.0"
     exon            1830..2470
                     /gene="Abcg5"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ttaaagttgc tctgaagcca gacaggacac cagaggattc actcacattt gcttcccgct
       61 ggccatgagt gagctgccct ttctgagtcc agagggagcc agagggcctc acaacaacag
      121 agggtctcag agctccctgg aggaaggctc agttacaggc tcagaggctc ggcacagctt
      181 aggtgtcctg aatgtgtcct tcagcgtcag caaccgtgtc gggccctggt ggaacatcaa
      241 atcatgccag cagaagtggg acaggaaaat cctcaaagat gtctccttgt acatcgagag
      301 tggccagacc atgtgcatct taggtagctc aggctcaggg aaaaccacgc tgctggacgc
      361 catctctggg aggctgcggc gcacagggac cttggaaggg gaagtgtttg tgaacggctg
      421 cgagctgcgc agggaccagt tccaagactg cgtctcctac ctcctgcaga gcgatgtctt
      481 tctgagcagc ctcacggtgc gggagacgct gagatacacg gcgatgctgg ctctccgcag
      541 cagctccgcg gacttctacg acaagaaggt agaggcagtc ctgacagagc tgagtctgag
      601 ccacgtggca gaccaaatga tcggcaacta taattttggg gggatttcca gtggcgagcg
      661 gcgccgagtg tccatcgcag cccaactcct tcaggacccc aaggtcatga tgcttgacga
      721 gccaaccaca ggactggact gcatgactgc aaatcatatc gtcctcctct tggtcgagct
      781 ggctcgcagg aaccgcattg taattgtcac catccaccag cctcgctctg agctcttcca
      841 ccacttcgac aaaattgcca ttctgactta cggagagttg gtgttctgtg gcacgccaga
      901 ggagatgctc ggcttcttca ataactgtgg ttacccctgt cctgaacatt ccaatccctt
      961 tgatttctac atggacttga catcggtgga cacccaaagc agagagcgag agatagagac
     1021 gtacaagcga gtccagatgc tggaatctgc cttcaggcaa tcggacatct gtcacaaaat
     1081 cctggagaac attgaaagaa caagacacct gaaaacccta cccatggttc ctttcaaaac
     1141 gaaaaatcct cccggaatgt tctgcaagct cggcgttctc ctgaggagag taacgagaaa
     1201 cctaatgagg aataagcagg tggtgattat gcgtcttgtt cagaatctga tcatgggtct
     1261 gttcctcatt ttctaccttc tccgagtcca gaacaacatg ctgaagggcg ctgttcagga
     1321 ccgcgtaggg ctgttgtacc agcttgtggg tgccaccccg tacaccggca tgctcaacgc
     1381 tgtgaacctc tttcccatgc tgagagctgt cagcgaccag gagagtcagg atggcctgta
     1441 ccagaagtgg cagatgctgc tcgcctatgt gctgcatgct ctccccttca gcatcgttgc
     1501 cacggtgatt ttcagcagcg tgtgttactg gactctgggc ttgtatcccg aggtcgccag
     1561 atttggatac ttctctgccg ctctgttggc ccctcactta attggagaat ttctgacact
     1621 tgtgctgctt ggtatggtcc aaaaccccaa tattgtcaac agcatagtgg ctctgctgag
     1681 tatttctggg ttgctcattg gatctggatt tatcagaaac atagaagaaa tgcccattcc
     1741 tttaaaaatc ctgggttact ttaccttcca aaagtactgt tgtgagattc ttgtggtcaa
     1801 tgagttctat ggcctgaact tcacttgtgg tggctccaac acttctgtgc caaataaccc
     1861 aatgtgttcc atgacccaag ggatccaatt cattgagaaa acctgcccag gggccacgtc
     1921 cagattcacg acaaacttcc tgatcttgta ctcgttcatc ccgactcttg tcatcctggg
     1981 gatggtggtc tttaaagtcc gggactacct gattagcaga taggtaagat ggcaggcagg
     2041 aaagggttaa tgggcaggct cgcccgctgt ggagtacaga gaaatactgt cttctaatca
     2101 tcatggttcc atctgtgacc ctggcatcta tgcagagcct caagggctcc gagaactcac
     2161 cgtcctttgc tagtccagct tatggggcag tgtggtgcat ggacattgtg actgaactgg
     2221 tccaatgatg taaataatac taataataat tcagaaacca aaggacatta gagcttcact
     2281 atgcgctttt tctagacaca gaaaaaataa gcctgtttga aaaaattatg tttacatttg
     2341 ataaagaatt tgataaaagt acaataaatg tgtatgatta ctgactgttc tgggtttgac
     2401 tgagaaagcc tcctacagaa gagggtaagg agcttccact gctgcttacc acccctcccc
     2461 cacccctgcc
//
