LOCUS       NM_001106816            3758 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus ATP binding cassette subfamily G member 4
            (Abcg4), mRNA.
ACCESSION   NM_001106816 XM_001066633 XM_006242915 XM_236186
VERSION     NM_001106816.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3758)
  AUTHORS   Jeon,S., Kim,S.H., Jeong,J., Lee,D.K., Lee,S., Kim,S., Kim,G.,
            Maruthupandy,M. and Cho,W.S.
  TITLE     ABCG1 and ABCG4 as key transporters in the development of pulmonary
            alveolar proteinosis by nanoparticles
  JOURNAL   J Hazard Mater 420, 126595 (2021)
   PUBMED   34256330
  REMARK    GeneRIF: ABCG1 and ABCG4 as key transporters in the development of
            pulmonary alveolar proteinosis by nanoparticles.
REFERENCE   2  (bases 1 to 3758)
  AUTHORS   Tarantino,C., Paolella,G., Cozzuto,L., Minopoli,G., Pastore,L.,
            Parisi,S. and Russo,T.
  TITLE     miRNA 34a, 100, and 137 modulate differentiation of mouse embryonic
            stem cells
  JOURNAL   FASEB J 24 (9), 3255-3263 (2010)
   PUBMED   20439489
REFERENCE   3  (bases 1 to 3758)
  AUTHORS   Engel,T., Bode,G., Lueken,A., Knop,M., Kannenberg,F., Nofer,J.R.,
            Assmann,G. and Seedorf,U.
  TITLE     Expression and functional characterization of ABCG1 splice variant
            ABCG1(666)
  JOURNAL   FEBS Lett 580 (18), 4551-4559 (2006)
   PUBMED   16870176
REFERENCE   4  (bases 1 to 3758)
  AUTHORS   Wang,N., Ranalletta,M., Matsuura,F., Peng,F. and Tall,A.R.
  TITLE     LXR-induced redistribution of ABCG1 to plasma membrane in
            macrophages enhances cholesterol mass efflux to HDL
  JOURNAL   Arterioscler Thromb Vasc Biol 26 (6), 1310-1316 (2006)
   PUBMED   16556852
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On or before Jun 3, 2021 this sequence version replaced
            XM_006242915.4, NM_001106816.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643298.43769.1,
                                           SRR26643291.22694.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-317               JAXUCZ010000008.1  53523255-53523571   c
            318-567             JAXUCZ010000008.1  53522444-53522693   c
            568-685             JAXUCZ010000008.1  53517573-53517690   c
            686-818             JAXUCZ010000008.1  53517329-53517461   c
            819-869             JAXUCZ010000008.1  53517163-53517213   c
            870-1015            JAXUCZ010000008.1  53516883-53517028   c
            1016-1139           JAXUCZ010000008.1  53515386-53515509   c
            1140-1254           JAXUCZ010000008.1  53515158-53515272   c
            1255-1397           JAXUCZ010000008.1  53514820-53514962   c
            1398-1496           JAXUCZ010000008.1  53513871-53513969   c
            1497-1665           JAXUCZ010000008.1  53513465-53513633   c
            1666-1766           JAXUCZ010000008.1  53513280-53513380   c
            1767-1925           JAXUCZ010000008.1  53510118-53510276   c
            1926-2044           JAXUCZ010000008.1  53509884-53510002   c
            2045-3758           JAXUCZ010000008.1  53508005-53509718   c
FEATURES             Location/Qualifiers
     source          1..3758
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q22"
     gene            1..3758
                     /gene="Abcg4"
                     /note="ATP binding cassette subfamily G member 4"
                     /db_xref="GeneID:300664"
                     /db_xref="RGD:1305840"
     exon            1..317
                     /gene="Abcg4"
                     /inference="alignment:Splign:2.1.0"
     exon            318..567
                     /gene="Abcg4"
                     /inference="alignment:Splign:2.1.0"
     CDS             330..2270
                     /gene="Abcg4"
                     /note="ATP-binding cassette, sub-family G (WHITE), member
                     4; ATP-binding cassette sub-family G member 4; ATP-binding
                     cassette, subfamily G (WHITE), member 4"
                     /codon_start=1
                     /product="ATP-binding cassette subfamily G member 4"
                     /protein_id="NP_001100286.2"
                     /db_xref="GeneID:300664"
                     /db_xref="RGD:1305840"
                     /translation="MAEKALEAVGCGLGPGAVAMAVALEDGAEPPVLTTHLKKVENHI
                     TEAQRFSHLPKRSAVDIEFVELSYSVREGPCWRKRGYKTLLKCLSGKFCRRELIGIMG
                     PSGAGKSTFMNILAGYRESGMKGQILVNGRPRDLRTFRKMSCYIMQDDMLLPHLTVLE
                     AMMVSANLKLSEKQEVKKELVTEILTALGLMSCSHTRTALLSGGQRKRLAIALELVNN
                     PPVMFFDEPTSGLDSASCFQVVSLMKSLAHGGRTVICTIHQPSAKLFEMFDKLYILSQ
                     GQCIFKGVVTNLIPYLKGLGLHCPTYHNPADFIIEVASGEYGDLNPMLFRAVQNGLCT
                     MAEKKSSPEKNEVPAHCPTCPPELDPIESHTFATSTLTQFCILFRRTFLSILRDTVLT
                     HLRFMSHVLIGVLIGLLYLHIGDDASKVFNNTGFLFFSMLFLMFAALMPTVLTFPLEM
                     AVFMREHLNYWYSLKAYYLAKTMADVPFQVVCPVVYCSIVYWMTGQPAETSRFLLFSA
                     LSIATALVAQSLGLLIGAASTSLQVATFVGPVTAIPVLLFSGFFVSFKTIPTYLQWSS
                     YLSYVRYGFEGLILTIYGMERGHLTCLEDHCPFRDPQIILHELDVEEAKLYMDFLVLG
                     IFFLALRLLAYLVLRYRVKSER"
     exon            568..685
                     /gene="Abcg4"
                     /inference="alignment:Splign:2.1.0"
     exon            686..818
                     /gene="Abcg4"
                     /inference="alignment:Splign:2.1.0"
     exon            819..869
                     /gene="Abcg4"
                     /inference="alignment:Splign:2.1.0"
     exon            870..1015
                     /gene="Abcg4"
                     /inference="alignment:Splign:2.1.0"
     exon            1016..1139
                     /gene="Abcg4"
                     /inference="alignment:Splign:2.1.0"
     exon            1140..1254
                     /gene="Abcg4"
                     /inference="alignment:Splign:2.1.0"
     exon            1255..1397
                     /gene="Abcg4"
                     /inference="alignment:Splign:2.1.0"
     exon            1398..1496
                     /gene="Abcg4"
                     /inference="alignment:Splign:2.1.0"
     exon            1497..1665
                     /gene="Abcg4"
                     /inference="alignment:Splign:2.1.0"
     exon            1666..1766
                     /gene="Abcg4"
                     /inference="alignment:Splign:2.1.0"
     exon            1767..1925
                     /gene="Abcg4"
                     /inference="alignment:Splign:2.1.0"
     exon            1926..2044
                     /gene="Abcg4"
                     /inference="alignment:Splign:2.1.0"
     exon            2045..3758
                     /gene="Abcg4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gctggggacc agactacgaa aacccagcgg gttcatccaa gcagggtcgc agcgagatct
       61 caaccatcca tccctccaca accgtgtcat cctttctgac cggagccctg ccttcctcta
      121 ctgcccgccc tggcctagcc ccgccccggc ccgggctacc gggacaggga gccggggcgc
      181 cggtgccgca gccagaggca ggtgaagaga gccgggagtg tcctcctgcg ccgcaacgct
      241 gagcatctgg gtcgaacatc ctggttgagc atctctgctg agcatccttg cgtcgcggcg
      301 gccggagacg cgtcaaggcc agctgcgtga tggcggagaa ggcactggag gctgtgggct
      361 gtggactggg ccctggggct gtggccatgg ccgtggcgct ggaggacggg gcagagcccc
      421 ctgtgctgac cacgcaccta aagaaggtgg agaaccatat cacagaagca cagcggttct
      481 ctcacctgcc caagcgctct gctgtggaca tcgagttcgt ggaactatcc tattccgtgc
      541 gggaggggcc ctgctggcgc aaacggggtt ataagaccct cctcaagtgc ctgtctggta
      601 agttctgccg ccgagagctg attggcatta tgggcccctc tggggctggc aaatccacgt
      661 tcatgaacat cttggcaggg tacagggagt cggggatgaa ggggcagatc ctggttaacg
      721 ggaggccacg cgatctgagg acctttcgca agatgtcctg ctacatcatg caggatgaca
      781 tgcttctgcc tcacctcacg gtgctagagg ccatgatggt ctctgccaac ctgaagctga
      841 gtgagaagca agaggtgaag aaggaactgg tgacagagat cctgacagcc ctgggactga
      901 tgtcctgctc tcacacaagg acagccctgc tctctggagg gcagaggaag cgcctggcca
      961 ttgctctgga gctggtcaac aacccgcctg tcatgttctt tgatgagcct accagcggtc
     1021 tagacagcgc ttcttgtttc caagtggtgt ccctcatgaa gtccctggcc catgggggcc
     1081 gcaccgtcat ctgcaccatc caccagccca gtgccaagct ctttgagatg tttgacaagc
     1141 tctacatcct gagccaggga cagtgcatct tcaagggcgt ggttaccaac ctgattccct
     1201 atttgaaggg gcttggcttg cactgcccca cctaccacaa ccccgctgac ttcatcattg
     1261 aggtggcctc tggagagtat ggagacctga accccatgct gttcagggct gtgcagaatg
     1321 gcctttgcac catggccgag aagaagagca gccccgagaa gaatgaggtc cctgcccact
     1381 gtcccacttg ccctccggaa ctggatccca ttgaaagcca cacgtttgcc accagcaccc
     1441 tcacccagtt ctgcatcctc ttcaggagga ctttcttgtc catcctcagg gacacggtcc
     1501 tgacccactt gcggttcatg tcacatgtgt tgatcggcgt cctcattggt ctcctctacc
     1561 tgcacatcgg cgatgatgcc agcaaggtct tcaacaacac cggcttcctc ttcttttcca
     1621 tgctcttcct catgtttgca gccctcatgc cgactgtgct cacctttccc ctagagatgg
     1681 cagtcttcat gagggagcac ctgaactact ggtacagtct caaagcatat tacctggcca
     1741 agacgatggc tgatgtaccc ttccaggttg tgtgcccagt ggtgtactgc agcattgtgt
     1801 actggatgac tggccagccg gctgagacca gccgcttcct gctcttctca gccttgtcca
     1861 tagctaccgc cttagttgcc cagtctttgg gactcttgat tggcgctgct tctacctcct
     1921 tgcaggtggc cacctttgtg ggcccagtca ctgccatccc tgtcctcttg ttctctggct
     1981 tctttgtcag tttcaagacc atccccactt acctgcaatg gagctcctac ctttcctatg
     2041 tcaggtatgg ctttgagggt ctgatcctga ccatctatgg catggagaga ggacatctga
     2101 cctgcttaga ggatcactgc ccattccggg acccacagat catcttgcat gagctggatg
     2161 tggaggaggc caagctctac atggacttcc tggtcctggg cattttcttc cttgccctgc
     2221 ggctgcttgc ataccttgtg cttcggtacc gggtcaagtc tgagagatag agcctggctc
     2281 ctacctcttc tgggcaggac gcccccagtt ccagcccttt gggactgttt taaacttgta
     2341 gacttgggtg tcggttgctg gtgcggctgc cctcctctcc ctcagctgct tcacaggccg
     2401 gctggctggc tgtgggccgt ggctcccagc ctcagcacca gaggtagggc tccagccctc
     2461 ccatcaaggc caggagtctt cccaagttga agcagtttgt agcttcctcc ctactgtctc
     2521 caacacctgc atgcaaagac tgctgggagg ctgccgccct cctctgccga aagcaccctc
     2581 ctctgttgat tacttgggag ctccatgttc tctaagcctt gacttacaag caagcaatca
     2641 gattgacccc ctctggggtc cccgccacac aagtgttggt aaactgttat catgttggag
     2701 tcccagggct gggccctgat ggggtcccca gggagtccca tcacggacat tggatggagt
     2761 aaggagggac tctggaagct tcctcctcct ccccttttct ccccacaccc actttggcta
     2821 atttggacca tctgttgaga cagaagccgg gctttctgtc tggcccacca ctcccaatcc
     2881 tggagattgg agagagcatg ggatgtccca gccccttccc taagcctttg gtcaaggtag
     2941 atctcaatgt cacctctgca ataatgtctg tgtcactctc ccatctgcca caggaactag
     3001 agaatgtact ttattctggg gaggaaggtg agccggggaa gcccccaccc tccttctttg
     3061 ctgctcctga ggctcagttc cacaggctcc tttcctctcc agagtcacat cacaggcaca
     3121 caaaggccac caggcgatct cagccctaca caggcaccac cccttatggc tcagaggaag
     3181 agtgaccatg gcagggagct gatggtggtg gcaggagggc agtcccaatg tcctcctgca
     3241 gaatcccact ttggaggcta agaacgaggc tggtgtgacc cagtgtggct ccaggctcag
     3301 caggtgtcta tctcccagtc ttccctccct cttgagccag gggtggcact ggcctcctgg
     3361 aggtcagaac ccaacaagca caagaatggg catagctggc ttcagccact gctccccatg
     3421 gccctccttt tgtgccccat gctgacactc gctctcctgc cccttctcca gctgcctgct
     3481 gctcactcaa acttctgttc acatatattc atcttccagt cagcagctgg gtcctggaca
     3541 tcagagcagc ggggcctgga tgccaggagg cagacacagc tgtgtcttct cttggtgggt
     3601 ccgggatcat cctatagctg gtttctcctc ctccaggact cttccccagt ccctgtgctc
     3661 actcctctgt atctgctcca ggttattctc atcacagaga gaccagttgt atttgtggga
     3721 tttcacccat tattaataaa acctatattt atacagta
//
