LOCUS       NM_181381               2175 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Rattus norvegicus ATP binding cassette subfamily G member 2
            (Abcg2), mRNA.
ACCESSION   NM_181381
VERSION     NM_181381.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2175)
  AUTHORS   Chen,F., Wang,L., Zhai,X., Wang,N., Qin,Y., Zhu,C., Wu,S. and Lu,Y.
  TITLE     Effect of capsaicin on breast cancer resistance protein
            (BCRP/Abcg2) and pharmacokinetics of probe substrates in rats
  JOURNAL   Xenobiotica 52 (2), 209-217 (2022)
   PUBMED   35345975
  REMARK    GeneRIF: Effect of capsaicin on breast cancer resistance protein
            (BCRP/Abcg2) and pharmacokinetics of probe substrates in rats.
REFERENCE   2  (bases 1 to 2175)
  AUTHORS   Wu,T., Sheng,Y., Qin,Y.Y., Kong,W.M., Jin,M.M., Yang,H.Y.,
            Zheng,X.K., Dai,C., Liu,M., Liu,X.D. and Liu,L.
  TITLE     Bile duct ligation causes opposite impacts on the expression and
            function of BCRP and P-gp in rat brain partly via affecting
            membrane expression of ezrin/radixin/moesin proteins
  JOURNAL   Acta Pharmacol Sin 42 (11), 1942-1950 (2021)
   PUBMED   33558655
  REMARK    GeneRIF: Bile duct ligation causes opposite impacts on the
            expression and function of BCRP and P-gp in rat brain partly via
            affecting membrane expression of ezrin/radixin/moesin proteins.
REFERENCE   3  (bases 1 to 2175)
  AUTHORS   Ganguly,S., Finkelstein,D., Shaw,T.I., Michalek,R.D., Zorn,K.M.,
            Ekins,S., Yasuda,K., Fukuda,Y., Schuetz,J.D., Mukherjee,K. and
            Schuetz,E.G.
  TITLE     Metabolomic and transcriptomic analysis reveals endogenous
            substrates and metabolic adaptation in rats lacking Abcg2 and
            Abcb1a transporters
  JOURNAL   PLoS One 16 (7), e0253852 (2021)
   PUBMED   34255797
  REMARK    GeneRIF: Metabolomic and transcriptomic analysis reveals endogenous
            substrates and metabolic adaptation in rats lacking Abcg2 and
            Abcb1a transporters.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2175)
  AUTHORS   Taniguchi,T., Omura,K., Motoki,K., Sakai,M., Chikamatsu,N.,
            Ashizawa,N., Takada,T. and Iwanaga,T.
  TITLE     Hypouricemic agents reduce indoxyl sulfate excretion by inhibiting
            the renal transporters OAT1/3 and ABCG2
  JOURNAL   Sci Rep 11 (1), 7232 (2021)
   PUBMED   33790363
  REMARK    GeneRIF: Hypouricemic agents reduce indoxyl sulfate excretion by
            inhibiting the renal transporters OAT1/3 and ABCG2.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2175)
  AUTHORS   Morimoto,C., Tamura,Y., Asakawa,S., Kuribayashi-Okuma,E.,
            Nemoto,Y., Li,J., Murase,T., Nakamura,T., Hosoyamada,M., Uchida,S.
            and Shibata,S.
  TITLE     ABCG2 expression and uric acid metabolism of the intestine in
            hyperuricemia model rat
  JOURNAL   Nucleosides Nucleotides Nucleic Acids 39 (5), 744-759 (2020)
   PUBMED   31983315
  REMARK    GeneRIF: ABCG2 expression and uric acid metabolism of the intestine
            in hyperuricemia model rat.
            Erratum:[Nucleosides Nucleotides Nucleic Acids.
            2020;39(10-12):1474. doi: 10.1080/15257770.2020.1834331.. PMID:
            33231139]
REFERENCE   6  (bases 1 to 2175)
  AUTHORS   Jonker,J.W., Buitelaar,M., Wagenaar,E., Van Der Valk,M.A.,
            Scheffer,G.L., Scheper,R.J., Plosch,T., Kuipers,F., Elferink,R.P.,
            Rosing,H., Beijnen,J.H. and Schinkel,A.H.
  TITLE     The breast cancer resistance protein protects against a major
            chlorophyll-derived dietary phototoxin and protoporphyria
  JOURNAL   Proc Natl Acad Sci U S A 99 (24), 15649-15654 (2002)
   PUBMED   12429862
REFERENCE   7  (bases 1 to 2175)
  AUTHORS   Steinbach,D., Sell,W., Voigt,A., Hermann,J., Zintl,F. and
            Sauerbrey,A.
  TITLE     BCRP gene expression is associated with a poor response to
            remission induction therapy in childhood acute myeloid leukemia
  JOURNAL   Leukemia 16 (8), 1443-1447 (2002)
   PUBMED   12145683
REFERENCE   8  (bases 1 to 2175)
  AUTHORS   Sauerbrey,A., Sell,W., Steinbach,D., Voigt,A. and Zintl,F.
  TITLE     Expression of the BCRP gene (ABCG2/MXR/ABCP) in childhood acute
            lymphoblastic leukaemia
  JOURNAL   Br J Haematol 118 (1), 147-150 (2002)
   PUBMED   12100141
REFERENCE   9  (bases 1 to 2175)
  AUTHORS   Faneyte,I.F., Kristel,P.M., Maliepaard,M., Scheffer,G.L.,
            Scheper,R.J., Schellens,J.H. and van de Vijver,M.J.
  TITLE     Expression of the breast cancer resistance protein in breast cancer
  JOURNAL   Clin Cancer Res 8 (4), 1068-1074 (2002)
   PUBMED   11948115
REFERENCE   10 (bases 1 to 2175)
  AUTHORS   Doyle,L.A., Yang,W., Abruzzo,L.V., Krogmann,T., Gao,Y., Rishi,A.K.
            and Ross,D.D.
  TITLE     A multidrug resistance transporter from human MCF-7 breast cancer
            cells
  JOURNAL   Proc Natl Acad Sci U S A 95 (26), 15665-15670 (1998)
   PUBMED   9861027
  REMARK    Erratum:[Proc Natl Acad Sci U S A 1999 Mar 2;96(5):2569]
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AY089997.1.
            
            On Jun 3, 2003 this sequence version replaced NM_181381.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY089997.1, AB105817.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2175
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q24"
     gene            1..2175
                     /gene="Abcg2"
                     /gene_synonym="Bcrp; BCRP1"
                     /note="ATP binding cassette subfamily G member 2"
                     /db_xref="GeneID:312382"
                     /db_xref="RGD:631345"
     exon            1..62
                     /gene="Abcg2"
                     /gene_synonym="Bcrp; BCRP1"
                     /inference="alignment:Splign:2.1.0"
     exon            63..281
                     /gene="Abcg2"
                     /gene_synonym="Bcrp; BCRP1"
                     /inference="alignment:Splign:2.1.0"
     CDS             82..2055
                     /gene="Abcg2"
                     /gene_synonym="Bcrp; BCRP1"
                     /EC_number="7.6.2.2"
                     /note="ATP-binding cassette sub-family G member 2; breast
                     cancer resistance protein 1 homolog; ATP-binding cassette,
                     sub-family G (WHITE), member 2; ATP-binding cassette
                     protein G2; urate exporter; ATP binding cassette subfamily
                     G member 2 (Junior blood group); ATP-binding cassette,
                     subfamily G (WHITE), member 2"
                     /codon_start=1
                     /product="broad substrate specificity ATP-binding cassette
                     transporter ABCG2"
                     /protein_id="NP_852046.1"
                     /db_xref="GeneID:312382"
                     /db_xref="RGD:631345"
                     /translation="MSSSNDHVLVPMSQRNKNGLPGMSSRGARTLAEGDVLSFHHITY
                     RVKVKSGFLVRKTAEKEILSDINGIMKPGLNAILGPTGGGKSSLLDVLAARKDPRGLS
                     GDVLINGAPQPANFKCSSGYVVQDDVVMGTLTVRENLQFSAALRLPKAMKTHEKNERI
                     NTIIKELGLDKVADSKVGTQFTRGISGGERKRTSIGMELITDPSILFLDEPTTGLDSS
                     TANAVLLLLKRMSKQGRTIIFSIHQPRYSIFKLFDSLTLLASGKLMFHGPAQKALEYF
                     ASAGYHCEPYNNPADFFLDVINGDSSAVMLNRGEQDHEANKTEEPSKREKPIIENLAE
                     FYINSTIYGETKAELDQLPVAQKKKGSSAFREPVYVTSFCHQLRWIARRSFKNLLGNP
                     QASVAQLIVTVILGLIIGALYFGLKNDPTGMQNRAGVFFFLTTNQCFTSVSAVELFVV
                     EKKLFIHEYISGYYRVSSYFFGKLVSDLLPMRFLPSVIYTCLLYFMLGLKRTVEAFFI
                     MMFTLIMVAYTASSMALAIAAGQSVVSVATLLMTISFVFMMLFSGLLVNLRTIGPWLS
                     WLQYFSIPRYGFTALQHNEFLGQEFCPGLNVTMNSTCVNSYTICTGNDYLINQGIDLS
                     PWGLWRNHVALACMIIIFLTIAYLKLLFLKKYS"
     exon            282..341
                     /gene="Abcg2"
                     /gene_synonym="Bcrp; BCRP1"
                     /inference="alignment:Splign:2.1.0"
     exon            342..456
                     /gene="Abcg2"
                     /gene_synonym="Bcrp; BCRP1"
                     /inference="alignment:Splign:2.1.0"
     exon            457..609
                     /gene="Abcg2"
                     /gene_synonym="Bcrp; BCRP1"
                     /inference="alignment:Splign:2.1.0"
     exon            610..767
                     /gene="Abcg2"
                     /gene_synonym="Bcrp; BCRP1"
                     /inference="alignment:Splign:2.1.0"
     exon            768..919
                     /gene="Abcg2"
                     /gene_synonym="Bcrp; BCRP1"
                     /inference="alignment:Splign:2.1.0"
     exon            920..1024
                     /gene="Abcg2"
                     /gene_synonym="Bcrp; BCRP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1025..1275
                     /gene="Abcg2"
                     /gene_synonym="Bcrp; BCRP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1276..1358
                     /gene="Abcg2"
                     /gene_synonym="Bcrp; BCRP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1359..1448
                     /gene="Abcg2"
                     /gene_synonym="Bcrp; BCRP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1449..1573
                     /gene="Abcg2"
                     /gene_synonym="Bcrp; BCRP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1574..1728
                     /gene="Abcg2"
                     /gene_synonym="Bcrp; BCRP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1729..1818
                     /gene="Abcg2"
                     /gene_synonym="Bcrp; BCRP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1819..1907
                     /gene="Abcg2"
                     /gene_synonym="Bcrp; BCRP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1908..2175
                     /gene="Abcg2"
                     /gene_synonym="Bcrp; BCRP1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agcgtgtgta ggtcggtgtg cgagtcaggg cgcgcggctg ctgctccgcc cgggacagct
       61 agaaaggcat agatcctaaa gatgtcttct agtaatgacc acgtgttagt accgatgtca
      121 cagagaaaca agaacggcct tcctggaatg agctccagag gcgcgaggac gctcgcagag
      181 ggagatgtgc taagttttca tcacatcacc tatcgagtga aagtgaagag tggctttcta
      241 gtccggaaaa cagctgagaa agaaatacta tcagatatca atgggatcat gaaacctggt
      301 cttaatgcta ttctgggacc cacaggcgga ggcaagtctt cgttgctaga tgtcctagca
      361 gcaaggaaag acccacgggg attatctgga gatgttttga taaacggggc acctcaacct
      421 gccaatttca aatgcagttc aggttatgtg gttcaagatg acgttgtgat gggcaccctg
      481 acagtgagag aaaacttaca gttctcagca gctcttcgcc ttccaaaagc tatgaagacg
      541 catgaaaaaa atgaacggat taacacgatc attaaagagt taggcctgga caaagtagca
      601 gattccaagg ttggaactca gtttacccgt ggtatctctg gaggagaaag aaaaaggaca
      661 agcataggaa tggagctcat cactgaccct tccatcctct tcctggatga gcccacaact
      721 ggtttggact caagcacagc aaatgctgtc cttttgctcc tgaaaaggat gtctaaacag
      781 ggccggacca tcatcttctc cattcaccag cctcggtatt ccatctttaa gttgtttgac
      841 agcctcacct tactggcttc tgggaaactc atgtttcatg gcccagcaca gaaggccttg
      901 gagtactttg catcagcagg ttaccactgt gagccctaca acaaccctgc agacttcttc
      961 cttgacgtca tcaacggaga ttcttcggct gtaatgttaa acagagggga acaagaccat
     1021 gaagcaaaca agacagaaga gccttccaag agagagaagc caataataga aaatttagcc
     1081 gagttttata tcaactccac catctatgga gaaacaaaag ctgaattaga tcaacttcca
     1141 gtagctcaga aaaagaaagg atcatcagcc ttcagagagc ctgtatatgt tacctcgttc
     1201 tgtcatcagc tcagatggat tgccaggcgt tcatttaaaa acctgctcgg gaatcctcaa
     1261 gcttctgtag ctcagttaat tgttacagtc atactgggac tgattattgg tgccctttac
     1321 tttggtctga aaaatgatcc cactggaatg caaaatagag ctggggtttt ctttttcctg
     1381 actaccaacc agtgttttac cagtgtgtca gctgtggagc tcttcgtagt ggagaagaaa
     1441 ctctttatac atgagtacat cagtggatat tacagagtat cttcttactt ctttggaaag
     1501 cttgtgtctg acttactacc tatgaggttc ttgccaagtg ttatatacac ttgtttattg
     1561 tacttcatgt taggactgaa gaggacggtg gaggcttttt tcatcatgat gtttaccctt
     1621 ataatggtgg cttatacggc cagttccatg gccctggcca tagccgcagg ccaaagcgta
     1681 gtgtctgtag caacacttct catgacgatc tcttttgtgt ttatgatgct cttttctggc
     1741 ctcttggtga atctcagaac catcgggcct tggctgtcct ggcttcagta ctttagcatt
     1801 cctcgatatg gcttcacagc tttgcagcat aatgaattct tgggacaaga attttgccca
     1861 ggactcaatg taactatgaa cagcacctgt gttaacagct atacaatatg tactggtaat
     1921 gactacttga taaatcaggg catcgatctg tcaccttggg gactgtggag gaatcatgtg
     1981 gccctggctt gcatgatcat tatcttcctc acaattgcct acctgaaatt gttgtttctt
     2041 aagaagtatt cttaatttcc ccttgaaagg actattgata gtactcctat taaatatggg
     2101 cactttgatt aacatagtca gtgttctttt cttcacagtt attctgacat acaaaaatac
     2161 ctagtactga aaact
//
