LOCUS       NM_053502               3529 bp    mRNA    linear   ROD 23-APR-2024
DEFINITION  Rattus norvegicus ATP binding cassette subfamily G member 1
            (Abcg1), mRNA.
ACCESSION   NM_053502
VERSION     NM_053502.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3529)
  AUTHORS   Kang,X., Liu,Q., Shi,Y., Wang,H., Zhang,H., Ye,T., Zhang,J., He,F.
            and Zhang,M.
  TITLE     Decreased expression of ATP-binding cassette protein G1 promotes
            abnormal adipogenesis of condylar chondrocytes in temporomandibular
            joint osteoarthritis
  JOURNAL   J Oral Rehabil 51 (5), 805-816 (2024)
   PUBMED   38146807
  REMARK    GeneRIF: Decreased expression of ATP-binding cassette protein G1
            promotes abnormal adipogenesis of condylar chondrocytes in
            temporomandibular joint osteoarthritis.
REFERENCE   2  (bases 1 to 3529)
  AUTHORS   Camargo,A.C., Constantino,F.B., Santos,S.A., Colombelli,K.T.,
            Portela,L.M., Fioretto,M.N., Barata,L.A., Valente,G.T., Moreno,C.S.
            and Justulin,L.A.
  TITLE     Deregulation of ABCG1 early in life contributes to prostate
            carcinogenesis in maternally malnourished offspring rats
  JOURNAL   Mol Cell Endocrinol 580, 112102 (2024)
   PUBMED   37972683
  REMARK    GeneRIF: Deregulation of ABCG1 early in life contributes to
            prostate carcinogenesis in maternally malnourished offspring rats.
REFERENCE   3  (bases 1 to 3529)
  AUTHORS   Jeon,S., Kim,S.H., Jeong,J., Lee,D.K., Lee,S., Kim,S., Kim,G.,
            Maruthupandy,M. and Cho,W.S.
  TITLE     ABCG1 and ABCG4 as key transporters in the development of pulmonary
            alveolar proteinosis by nanoparticles
  JOURNAL   J Hazard Mater 420, 126595 (2021)
   PUBMED   34256330
  REMARK    GeneRIF: ABCG1 and ABCG4 as key transporters in the development of
            pulmonary alveolar proteinosis by nanoparticles.
REFERENCE   4  (bases 1 to 3529)
  AUTHORS   Hussain,S.S., Harris,M.T., Kreutzberger,A.J.B., Inouye,C.M.,
            Doyle,C.A., Castle,A.M., Arvan,P. and Castle,J.D.
  TITLE     Control of insulin granule formation and function by the ABC
            transporters ABCG1 and ABCA1 and by oxysterol binding protein OSBP
  JOURNAL   Mol Biol Cell 29 (10), 1238-1257 (2018)
   PUBMED   29540530
REFERENCE   5  (bases 1 to 3529)
  AUTHORS   Xue,X.H., Shi,F.F., Chen,T., Wei,W., Zhou,X.M. and Chen,L.D.
  TITLE     Inhibition of ERK1/2 improves lipid balance in rat macrophages via
            ABCA1/G1 and CD36
  JOURNAL   Mol Med Rep 13 (2), 1533-1540 (2016)
   PUBMED   26707062
  REMARK    GeneRIF: The addition of U0126 resulted in a marked reduction of
            lipid deposition, upregulation of ABCA1/G1 expression and
            suppression of CD36 expression in Ox-LDL-stimulated macrophages.
REFERENCE   6  (bases 1 to 3529)
  AUTHORS   Wang,N., Lan,D., Chen,W., Matsuura,F. and Tall,A.R.
  TITLE     ATP-binding cassette transporters G1 and G4 mediate cellular
            cholesterol efflux to high-density lipoproteins
  JOURNAL   Proc Natl Acad Sci U S A 101 (26), 9774-9779 (2004)
   PUBMED   15210959
REFERENCE   7  (bases 1 to 3529)
  AUTHORS   Hoekstra,M., Kruijt,J.K., Van Eck,M. and Van Berkel,T.J.
  TITLE     Specific gene expression of ATP-binding cassette transporters and
            nuclear hormone receptors in rat liver parenchymal, endothelial,
            and Kupffer cells
  JOURNAL   J Biol Chem 278 (28), 25448-25453 (2003)
   PUBMED   12704191
REFERENCE   8  (bases 1 to 3529)
  AUTHORS   Kennedy,M.A., Venkateswaran,A., Tarr,P.T., Xenarios,I., Kudoh,J.,
            Shimizu,N. and Edwards,P.A.
  TITLE     Characterization of the human ABCG1 gene: liver X receptor
            activates an internal promoter that produces a novel transcript
            encoding an alternative form of the protein
  JOURNAL   J Biol Chem 276 (42), 39438-39447 (2001)
   PUBMED   11500512
  REMARK    Erratum:[J Biol Chem 2002 May 10;277(19):17375]
REFERENCE   9  (bases 1 to 3529)
  AUTHORS   Schmitz,G., Langmann,T. and Heimerl,S.
  TITLE     Role of ABCG1 and other ABCG family members in lipid metabolism
  JOURNAL   J Lipid Res 42 (10), 1513-1520 (2001)
   PUBMED   11590207
  REMARK    Review article
REFERENCE   10 (bases 1 to 3529)
  AUTHORS   Klucken,J., Buchler,C., Orso,E., Kaminski,W.E.,
            Porsch-Ozcurumez,M., Liebisch,G., Kapinsky,M., Diederich,W.,
            Drobnik,W., Dean,M., Allikmets,R. and Schmitz,G.
  TITLE     ABCG1 (ABC8), the human homolog of the Drosophila white gene, is a
            regulator of macrophage cholesterol and phospholipid transport
  JOURNAL   Proc Natl Acad Sci U S A 97 (2), 817-822 (2000)
   PUBMED   10639163
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000020.1.
            
            On Nov 26, 2020 this sequence version replaced NM_053502.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ303374.1, SRR26643299.66138.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-119               JAXUCZ010000020.1  9128056-9128174
            120-363             JAXUCZ010000020.1  9134465-9134708
            364-481             JAXUCZ010000020.1  9160612-9160729
            482-614             JAXUCZ010000020.1  9164114-9164246
            615-665             JAXUCZ010000020.1  9167879-9167929
            666-811             JAXUCZ010000020.1  9172836-9172981
            812-935             JAXUCZ010000020.1  9174453-9174576
            936-1050            JAXUCZ010000020.1  9175008-9175122
            1051-1199           JAXUCZ010000020.1  9176743-9176891
            1200-1301           JAXUCZ010000020.1  9177032-9177133
            1302-1470           JAXUCZ010000020.1  9177912-9178080
            1471-1571           JAXUCZ010000020.1  9179488-9179588
            1572-1730           JAXUCZ010000020.1  9179787-9179945
            1731-1849           JAXUCZ010000020.1  9181480-9181598
            1850-3529           JAXUCZ010000020.1  9182633-9184312
FEATURES             Location/Qualifiers
     source          1..3529
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="20"
                     /map="20p12"
     gene            1..3529
                     /gene="Abcg1"
                     /gene_synonym="Abc8"
                     /note="ATP binding cassette subfamily G member 1"
                     /db_xref="GeneID:85264"
                     /db_xref="RGD:620294"
     exon            1..119
                     /gene="Abcg1"
                     /gene_synonym="Abc8"
                     /inference="alignment:Splign:2.1.0"
     CDS             78..2078
                     /gene="Abcg1"
                     /gene_synonym="Abc8"
                     /note="ATP-binding cassette, sub-family G (WHITE), member
                     1; ATP-binding cassette, subfamily G (WHITE), member 1"
                     /codon_start=1
                     /product="ATP-binding cassette sub-family G member 1"
                     /protein_id="NP_445954.2"
                     /db_xref="GeneID:85264"
                     /db_xref="RGD:620294"
                     /translation="MACLMAAFSVGTAMNASNYSAAMTEPKSVCVSVDEVVSSNVDEL
                     ETDLLNGHLKKVDNNFTEAQRFSSLPRRAAVNIEFKDLSYSVPEGPWWRKKGYKTLLK
                     GISGKFNSGELVAIMGPSGAGKSTLMNILAGYRETGMKGAVLINGMPRDLRCFRKVSC
                     YIMQDDMLLPHLTVQEAMMVSAHLKLQEKDEGRREMVKEILTALGLLPCANTRTGSLS
                     GGQRKRLAIALELVNNPPVMFFDEPTSGLDSASCFQVVSLMKGLAQGGRSIVCTIHQP
                     SAKLFELFDQLYVLSQGQCVYRGKVSNLVPYLRDLGLNCPTYHNPADFVMEVASGEYG
                     DQNSRLVRAVREGMCDSDYKRELGGDGDVNPFLWHRPAEEDSASMEGCHSFSASCLTQ
                     FCILFKRTFLSIMRDSVLTHLRITSHIGIGLLIGLLYLGIGNEAKKVLSNSGFLFFSM
                     LFLMFAALMPTVLTFPLEMSVFLREHLNYWYSLKAYYLAKTMADVPFQIMFPVAYCSI
                     VYWMTSQPSDAVRFVLFAALGTMTSLVAQSLGLLIGAASTSLQVATFVGPVTAIPVLL
                     FSGFFVSFDTIPTYLQWMSYISYVRYGFEGVILSIYGLDREDLHCDIAETCHFQKSEA
                     ILRELDVENAKLYLDFIVLGIFFISLRLIAYFVLRYKIRAER"
     exon            120..363
                     /gene="Abcg1"
                     /gene_synonym="Abc8"
                     /inference="alignment:Splign:2.1.0"
     exon            364..481
                     /gene="Abcg1"
                     /gene_synonym="Abc8"
                     /inference="alignment:Splign:2.1.0"
     exon            482..614
                     /gene="Abcg1"
                     /gene_synonym="Abc8"
                     /inference="alignment:Splign:2.1.0"
     exon            615..665
                     /gene="Abcg1"
                     /gene_synonym="Abc8"
                     /inference="alignment:Splign:2.1.0"
     exon            666..811
                     /gene="Abcg1"
                     /gene_synonym="Abc8"
                     /inference="alignment:Splign:2.1.0"
     exon            812..935
                     /gene="Abcg1"
                     /gene_synonym="Abc8"
                     /inference="alignment:Splign:2.1.0"
     exon            936..1050
                     /gene="Abcg1"
                     /gene_synonym="Abc8"
                     /inference="alignment:Splign:2.1.0"
     exon            1051..1199
                     /gene="Abcg1"
                     /gene_synonym="Abc8"
                     /inference="alignment:Splign:2.1.0"
     exon            1200..1301
                     /gene="Abcg1"
                     /gene_synonym="Abc8"
                     /inference="alignment:Splign:2.1.0"
     exon            1302..1470
                     /gene="Abcg1"
                     /gene_synonym="Abc8"
                     /inference="alignment:Splign:2.1.0"
     exon            1471..1571
                     /gene="Abcg1"
                     /gene_synonym="Abc8"
                     /inference="alignment:Splign:2.1.0"
     exon            1572..1730
                     /gene="Abcg1"
                     /gene_synonym="Abc8"
                     /inference="alignment:Splign:2.1.0"
     exon            1731..1849
                     /gene="Abcg1"
                     /gene_synonym="Abc8"
                     /inference="alignment:Splign:2.1.0"
     exon            1850..3529
                     /gene="Abcg1"
                     /gene_synonym="Abc8"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cctcgttcct gcaacctcgt ccccgccgcc cgcagcctcg tctccgccgc cgccgccgcc
       61 gccgccgccc ccggggcatg gcctgtctga tggccgcttt ctcggtcggc accgccatga
      121 atgccagcaa ctactcggcc gcaatgacgg aacccaagtc cgtgtgcgtg tcggtggacg
      181 aggtcgtgtc cagcaacgtg gatgagcttg agacagatct gcttaatggg cacctgaaga
      241 aggtggacaa caacttcacg gaggcccagc gcttttcctc cctgccgcgg agggcagccg
      301 tgaatatcga attcaaggac ctttcttact ccgtacccga gggaccctgg tggaggaaga
      361 aaggatacaa gacccttttg aaagggatct ctgggaagtt caacagtgga gagctggtgg
      421 ccatcatggg tccttctgga gctgggaagt ccacactcat gaatattctg gcgggataca
      481 gggagacggg catgaagggg gcagtcctta tcaatggtat gccccgcgac ctgcgctgct
      541 tccggaaggt ctcgtgctac atcatgcagg atgacatgct gctgcctcac ctcactgtcc
      601 aggaggccat gatggtgtcc gcgcatctga agctgcaaga gaaggatgaa ggcagacggg
      661 agatggtcaa ggagatcctg acagcactgg gcttgctgcc ctgtgccaac acacgcacag
      721 ggagcctctc gggtggccag cggaagcgcc tggccattgc actagaactg gtcaacaacc
      781 ctcctgttat gttctttgat gagcccacca gtggcctgga cagtgcctct tgcttccaag
      841 tggtgtccct gatgaaaggg ctggcccagg gcggccgctc catcgtctgc accatccacc
      901 aacccagtgc caagctcttc gagctctttg accagcttta tgtcctaagt caaggacaat
      961 gtgtctaccg gggaaaggtc tcgaatctcg tgccgtacct gagggatctg ggtctgaact
     1021 gccctaccta ccacaaccct gcagactttg tcatggaagt ggcatcaggg gagtacggtg
     1081 atcagaacag ccgcctggtg agggccgttc gggagggcat gtgtgactct gactataaga
     1141 gagaactcgg gggcgacgga gacgtgaacc cgttcctctg gcaccggcct gctgaagagg
     1201 actcggcctc catggaaggt tgccacagct tctcggccag ctgcctcacc cagttctgca
     1261 tcctcttcaa gaggaccttc cttagcatca tgcgggactc ggtactgaca cacctgcgaa
     1321 tcacctcaca catcgggatc ggtctcctca ttggcctcct gtaccttggg attgggaacg
     1381 aagccaagaa ggtcctgagc aactccggct tcctgttctt ctccatgctg ttcctcatgt
     1441 tcgccgccct catgcccacc gttctgacct ttcccctcga gatgagtgtc ttcctccgag
     1501 agcacctgaa ctactggtac agtctgaagg cctactacct ggccaagacc atggctgatg
     1561 tcccctttca gatcatgttt cccgtggcct actgcagcat cgtgtactgg atgacatcac
     1621 agccgtcgga cgctgtgcgt tttgtgctgt tcgctgcact gggcaccatg acctcgttgg
     1681 tggcccagtc cttaggccta ctcattggag ctgcgtccac atccctgcag gttgcgacgt
     1741 ttgtgggtcc cgtgacagcc atccctgtct tgctcttctc cgggttcttt gtcagctttg
     1801 acaccatccc aacctacctg cagtggatgt cctacatctc ctacgtcaga tacggcttcg
     1861 agggggtcat cctgtccatc tatggcttgg accgagagga cctgcactgc gacatcgcgg
     1921 agacatgcca cttccagaag tcagaggcca tcctgcggga gctagatgtg gagaacgcga
     1981 agctatacct ggatttcatc gtcctgggca tcttcttcat ctccctgcgg ctcatcgcct
     2041 attttgtcct gagatacaaa atccgggctg agaggtaaaa cacctccaca ctggcagtga
     2101 ggcaaagcag acattgtgac caaggacact gctgggaggt agcagtgcac ctgctcctgg
     2161 tgacaaagac tctcccaacc cagcctggag gccacgcagg tcgatgatga ccagtgttga
     2221 gcgcctccgc ccgccgggtt ggaactgttc atttcctttt ctaactagga agatgtaggg
     2281 cggttggggt ttttttgaca tgtgggactc aaaacacaac tggcacagaa tgtcatcctc
     2341 tgctccagct ggggacagga gcttcctcag tagactcctc cgggagtcta ggacacactg
     2401 gccctggatg agaggagtgt tggctgagtt ggtccccaga gaggtggatg tcttggggac
     2461 tccgcctgac gactgtcttc tcttaaggtc tcagccttct aaagttcctc tcatttctga
     2521 tgaagtcact ttccgagcca aagccgataa atttcattca cttcgagaga ttgtatcttt
     2581 ttagcacttc ttgaggactt attcagggta aagatgtgtt ttgcttagaa acggaagagt
     2641 ccaacatagt caccgagtgg gggcgctcac aggcaaaacc ggagaagaag gtcaaacgca
     2701 ggctccaggt gagggagaca ccacaccagc tgcgctgggc cagcagggac tcaatgcaat
     2761 gcaacacaat gcagacagtg ctggggggag gttggcaggc tccttccaga cttcctttct
     2821 catgtgcttc ttattttaag caaactagat gggtttaaaa actcttcctg gttttccggc
     2881 tacttttatt ttgaccaaga aatcctctat ccaccctgtc aatttttaaa agaccatttt
     2941 cccctttctt cataaatcac attaactacc tccacagagc ctgggaagcc ggcctgggga
     3001 cacatggggt gcatccctca aacttggggg gggggcaata gggtgtcaag gacgggcagg
     3061 ccagctgagt ggaaggggag gtgccatgaa tgtccccatt aagaaaacgc agctgctcac
     3121 ctctgccaga gtaccaccac cctaggatca gtctcctaca aaagtctcta tttttgtggg
     3181 caggtcagtt taacccctgt gagcctcagt ttccccacct gtaagtaatt gcactggatc
     3241 ttgttttgac cggtcctgag attcctcggc tgtggccttg acgctttcgt atcttatctg
     3301 tagagagagc taagggtccg aattttcctt acggcatgga acgtgctttg gaactattta
     3361 gagattcttt ttatttttta cactcctagg tcttttttta tagagaacac gattgaaatg
     3421 cgtattacga tgtaatcttc agtttgcttg ttctatacaa acatggcctt gccttctaga
     3481 ctcagctttt aaccagggac acgattcgcc tttataaaaa gtcttcatt
//
