LOCUS       NM_001013100            2358 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus ATP binding cassette subfamily D member 4
            (Abcd4), mRNA.
ACCESSION   NM_001013100 XM_216760
VERSION     NM_001013100.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2358)
  AUTHORS   Kawaguchi,K., Okamoto,T., Morita,M. and Imanaka,T.
  TITLE     Translocation of the ABC transporter ABCD4 from the endoplasmic
            reticulum to lysosomes requires the escort protein LMBD1
  JOURNAL   Sci Rep 6, 30183 (2016)
   PUBMED   27456980
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2358)
  AUTHORS   Coelho,D., Kim,J.C., Miousse,I.R., Fung,S., du Moulin,M., Buers,I.,
            Suormala,T., Burda,P., Frapolli,M., Stucki,M., Nurnberg,P.,
            Thiele,H., Robenek,H., Hohne,W., Longo,N., Pasquali,M., Mengel,E.,
            Watkins,D., Shoubridge,E.A., Majewski,J., Rosenblatt,D.S.,
            Fowler,B., Rutsch,F. and Baumgartner,M.R.
  TITLE     Mutations in ABCD4 cause a new inborn error of vitamin B12
            metabolism
  JOURNAL   Nat Genet 44 (10), 1152-1155 (2012)
   PUBMED   22922874
REFERENCE   3  (bases 1 to 2358)
  AUTHORS   Tarantino,C., Paolella,G., Cozzuto,L., Minopoli,G., Pastore,L.,
            Parisi,S. and Russo,T.
  TITLE     miRNA 34a, 100, and 137 modulate differentiation of mouse embryonic
            stem cells
  JOURNAL   FASEB J 24 (9), 3255-3263 (2010)
   PUBMED   20439489
REFERENCE   4  (bases 1 to 2358)
  AUTHORS   Kashiwayama,Y., Seki,M., Yasui,A., Murasaki,Y., Morita,M.,
            Yamashita,Y., Sakaguchi,M., Tanaka,Y. and Imanaka,T.
  TITLE     70-kDa peroxisomal membrane protein related protein (P70R/ABCD4)
            localizes to endoplasmic reticulum not peroxisomes, and
            NH2-terminal hydrophobic property determines the subcellular
            localization of ABC subfamily D proteins
  JOURNAL   Exp Cell Res 315 (2), 190-205 (2009)
   PUBMED   19010322
  REMARK    GeneRIF: P70R resides in the ER but not the peroxisomal membranes,
            and the hydrophobic property of NH(2)-terminal region determines
            the subcellular localization of ABC subfamily D proteins.
REFERENCE   5  (bases 1 to 2358)
  AUTHORS   Landgraf,P., Mayerhofer,P.U., Polanetz,R., Roscher,A.A. and
            Holzinger,A.
  TITLE     Targeting of the human adrenoleukodystrophy protein to the
            peroxisomal membrane by an internal region containing a highly
            conserved motif
  JOURNAL   Eur J Cell Biol 82 (8), 401-410 (2003)
   PUBMED   14533738
REFERENCE   6  (bases 1 to 2358)
  AUTHORS   Shani,N., Jimenez-Sanchez,G., Steel,G., Dean,M. and Valle,D.
  TITLE     Identification of a fourth half ABC transporter in the human
            peroxisomal membrane
  JOURNAL   Hum Mol Genet 6 (11), 1925-1931 (1997)
   PUBMED   9302272
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000006.1.
            
            On Nov 29, 2008 this sequence version replaced NM_001013100.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643285.25345.1,
                                           SRR26643290.23565.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-89                JAXUCZ010000006.1  109991895-109991983 c
            90-208              JAXUCZ010000006.1  109990141-109990259 c
            209-336             JAXUCZ010000006.1  109989891-109990018 c
            337-476             JAXUCZ010000006.1  109988624-109988763 c
            477-593             JAXUCZ010000006.1  109987297-109987413 c
            594-719             JAXUCZ010000006.1  109986842-109986967 c
            720-770             JAXUCZ010000006.1  109986172-109986222 c
            771-865             JAXUCZ010000006.1  109983568-109983662 c
            866-987             JAXUCZ010000006.1  109983207-109983328 c
            988-1079            JAXUCZ010000006.1  109983037-109983128 c
            1080-1169           JAXUCZ010000006.1  109982804-109982893 c
            1170-1378           JAXUCZ010000006.1  109980970-109981178 c
            1379-1470           JAXUCZ010000006.1  109980745-109980836 c
            1471-1507           JAXUCZ010000006.1  109980298-109980334 c
            1508-1557           JAXUCZ010000006.1  109979942-109979991 c
            1558-1610           JAXUCZ010000006.1  109979290-109979342 c
            1611-1687           JAXUCZ010000006.1  109978923-109978999 c
            1688-1803           JAXUCZ010000006.1  109978273-109978388 c
            1804-2358           JAXUCZ010000006.1  109977541-109978095 c
FEATURES             Location/Qualifiers
     source          1..2358
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q31"
     gene            1..2358
                     /gene="Abcd4"
                     /gene_synonym="Pxmp1l"
                     /note="ATP binding cassette subfamily D member 4"
                     /db_xref="GeneID:299196"
                     /db_xref="RGD:1307273"
     exon            1..89
                     /gene="Abcd4"
                     /gene_synonym="Pxmp1l"
                     /inference="alignment:Splign:2.1.0"
     CDS             52..1872
                     /gene="Abcd4"
                     /gene_synonym="Pxmp1l"
                     /EC_number="7.6.2.8"
                     /note="ATP-binding cassette, sub-family D (ALD), member 4;
                     ATP-binding cassette, sub-family D, member 4; ATP-binding
                     cassette, subfamily D (ALD), member 4"
                     /codon_start=1
                     /product="lysosomal cobalamin transporter ABCD4"
                     /protein_id="NP_001013118.2"
                     /db_xref="GeneID:299196"
                     /db_xref="RGD:1307273"
                     /translation="MAVPGPTARASARPRLDLQLVQKFIRIQKVFFPSWSSQNVLMFM
                     TLLCVALLEQLVIYQVGLIPSQYYGVLGNKDLDGFKALTFLAVALIVLNSTLKSFDQF
                     TCNLLYVSWRKDLTEHLHQLYFRARVYYTLNVLRDDIDNPDQRISQDVERFCRQLSSV
                     TSKLIISPFTLAYYTYQCFQSTGWLGPVSIFGYFILGTMVNKTLMGPIVTKLVQQEKL
                     EGDFRFKHMQIRVNAEPAAFYRAGLVEHMRTDRRLQRLLQTQRELMSRELWLYIGINT
                     FDYLGSILSYVVIAIPIFRGVYGDLSPTELSTLVSKNAFVCIYLISCFTQLIDLSTTL
                     SDVAGYTHRIGELQEALLDMSRKSHDCETLGESEWDLDKAPGWPTTEPSDTAFLLDRV
                     SILAPSSDKPLIKDLSLKICEGQSLLITGNTGTGKTSLLRVLGGLWESMKGSVQMLAD
                     FGPHGVLFLPQKPFFTDGTLREQVIYPLKEIYPDSGSADDERIVRFLELAGLSSLVAR
                     TGGLDQQVDWNWYDVLSPGEMQRLSFARLFYLQPKYAVLDEATSALTEEAESELYRIG
                     QQLGMTFISVGHRPSLEKFHSWVLRLHGGGSWELTRIKMG"
     exon            90..208
                     /gene="Abcd4"
                     /gene_synonym="Pxmp1l"
                     /inference="alignment:Splign:2.1.0"
     exon            209..336
                     /gene="Abcd4"
                     /gene_synonym="Pxmp1l"
                     /inference="alignment:Splign:2.1.0"
     exon            337..476
                     /gene="Abcd4"
                     /gene_synonym="Pxmp1l"
                     /inference="alignment:Splign:2.1.0"
     exon            477..593
                     /gene="Abcd4"
                     /gene_synonym="Pxmp1l"
                     /inference="alignment:Splign:2.1.0"
     exon            594..719
                     /gene="Abcd4"
                     /gene_synonym="Pxmp1l"
                     /inference="alignment:Splign:2.1.0"
     exon            720..770
                     /gene="Abcd4"
                     /gene_synonym="Pxmp1l"
                     /inference="alignment:Splign:2.1.0"
     exon            771..865
                     /gene="Abcd4"
                     /gene_synonym="Pxmp1l"
                     /inference="alignment:Splign:2.1.0"
     exon            866..987
                     /gene="Abcd4"
                     /gene_synonym="Pxmp1l"
                     /inference="alignment:Splign:2.1.0"
     exon            988..1079
                     /gene="Abcd4"
                     /gene_synonym="Pxmp1l"
                     /inference="alignment:Splign:2.1.0"
     exon            1080..1169
                     /gene="Abcd4"
                     /gene_synonym="Pxmp1l"
                     /inference="alignment:Splign:2.1.0"
     exon            1170..1378
                     /gene="Abcd4"
                     /gene_synonym="Pxmp1l"
                     /inference="alignment:Splign:2.1.0"
     exon            1379..1470
                     /gene="Abcd4"
                     /gene_synonym="Pxmp1l"
                     /inference="alignment:Splign:2.1.0"
     exon            1471..1507
                     /gene="Abcd4"
                     /gene_synonym="Pxmp1l"
                     /inference="alignment:Splign:2.1.0"
     exon            1508..1557
                     /gene="Abcd4"
                     /gene_synonym="Pxmp1l"
                     /inference="alignment:Splign:2.1.0"
     exon            1558..1610
                     /gene="Abcd4"
                     /gene_synonym="Pxmp1l"
                     /inference="alignment:Splign:2.1.0"
     exon            1611..1687
                     /gene="Abcd4"
                     /gene_synonym="Pxmp1l"
                     /inference="alignment:Splign:2.1.0"
     exon            1688..1803
                     /gene="Abcd4"
                     /gene_synonym="Pxmp1l"
                     /inference="alignment:Splign:2.1.0"
     exon            1804..2358
                     /gene="Abcd4"
                     /gene_synonym="Pxmp1l"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cggggaggac accgggcttt ctcggttgtc ttgttgctca catcccaggt catggcggtc
       61 ccgggaccca cggcccgagc tagtgccagg cccagattag atctgcaact tgtccagaag
      121 ttcataagga tacagaaggt tttctttcct tcttggtcat cacagaatgt cttaatgttc
      181 atgacactct tgtgtgtggc cctcctggag caactggtga tctaccaagt tggcttgatc
      241 cccagtcagt attatggtgt cttgggaaac aaagacctgg atggatttaa ggcactgacc
      301 ttcctggccg tggcactcat tgttctcaac tccaccctga agagttttga ccagttcacc
      361 tgcaacctgc tgtatgtgag ctggaggaaa gacctcacag agcacctgca ccagctctac
      421 ttccgggccc gcgtgtacta caccctcaac gtgctgcggg acgacatcga taatccggac
      481 cagcggatca gccaggacgt ggagcggttc tgccggcagc tcagcagcgt gaccagcaag
      541 ctcatcatct cccccttcac tctcgcctac tatacctacc agtgcttcca aagcacaggc
      601 tggcttgggc ctgtgagcat ctttggatat ttcatcctgg gtaccatggt gaacaaaact
      661 ttgatggggc ccatcgtgac gaagctggtg cagcaggaga agctggaggg ggattttagg
      721 ttcaagcata tgcagattcg agtgaacgct gagcctgcag ctttctacag agctgggctc
      781 gtagagcaca tgaggacgga ccgcaggctg cagagactcc ttcagaccca gagagagctg
      841 atgtccaggg agctctggct ctacattggc atcaacacct ttgactacct gggcagcatt
      901 ctgagttacg tcgtcatcgc catccccatt ttcagggggg tctacggaga cttgagcccc
      961 acagagctca gcaccctggt cagcaagaat gcctttgtgt gcatctacct catcagctgc
     1021 ttcacccagc tcattgacct gtccaccacg ctctcggatg tcgccggtta cacgcacagg
     1081 attggagagc ttcaggaggc cctgctggac atgtcccgaa aatcacacga ctgtgagacc
     1141 ctaggcgaga gcgagtggga tttggacaag gccccagggt ggccgacaac agagccatca
     1201 gacactgctt ttctgcttga tcgggtctcc atcttggccc cttcctccga caagcccctg
     1261 atcaaggact tgagcctgaa gatctgtgag gggcagagtc tgctcattac gggcaacaca
     1321 ggcactggca agacctccct gctgcgggtg ctgggaggcc tgtgggagag catgaaaggc
     1381 tcagtgcaga tgctggctga ttttgggccc cacggggtgc tgttcctgcc tcagaagccg
     1441 ttcttcactg atgggacact tcgggagcag gtgatatatc ccctgaagga gatctaccct
     1501 gactcaggtt ctgccgatga tgagaggatc gtgaggttct tggagttggc aggcctgtcc
     1561 agcttggtgg caagaacagg aggtctggac cagcaggtgg attggaactg gtatgatgtc
     1621 ctgtccccag gggagatgca aagactgtcc ttcgcccgcc tcttctacct gcagcctaag
     1681 tatgcagtgc ttgatgaagc caccagtgcc ctgacagagg aagcggagag tgagctctac
     1741 cgaattggcc agcaactggg gatgacattt atcagcgtgg gacatcggcc cagccttgag
     1801 aagtttcact cctgggttct gagactccat ggaggaggaa gctgggaact gactagaatc
     1861 aaaatgggat gaagccaagc aggttcatcg gagcagaggg gctctggggc ctgcagtgcc
     1921 cacagacaag gaagcctgat gagccaggaa ggagccacag gttcacctca ggtcctacat
     1981 aggacatcct agcacccctg ggccctgccc atgggtggcc cattggggaa cactgaggtc
     2041 cccccagcgc tgctcccacg agttcttttt taattttttt ttttttttcg gagctgggga
     2101 ccgaatccag ggccttgcgc ttcctaggca agcgctctac cactgagcta aatccccaac
     2161 cccctgctcc cacgagttct tacagattac ttcagatgat gtttgctgcc gaaaaactga
     2221 atgaactgta agacatgaag tctgttcacc tcaagaaagc tggttacatt tcacagtgat
     2281 agacttttta aaaaaacttt aattaaccat ttacatttta taaagttttt taaaaaaaga
     2341 ataaatatta aaaatata
//
