LOCUS       NM_012804               3352 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus ATP binding cassette subfamily D member 3
            (Abcd3), mRNA.
ACCESSION   NM_012804 XM_346639
VERSION     NM_012804.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3352)
  AUTHORS   Ferdinandusse,S., Jimenez-Sanchez,G., Koster,J., Denis,S., Van
            Roermund,C.W., Silva-Zolezzi,I., Moser,A.B., Visser,W.F.,
            Gulluoglu,M., Durmaz,O., Demirkol,M., Waterham,H.R., Gokcay,G.,
            Wanders,R.J. and Valle,D.
  TITLE     A novel bile acid biosynthesis defect due to a deficiency of
            peroxisomal ABCD3
  JOURNAL   Hum Mol Genet 24 (2), 361-370 (2015)
   PUBMED   25168382
REFERENCE   2  (bases 1 to 3352)
  AUTHORS   Bharti,P., Schliebs,W., Schievelbusch,T., Neuhaus,A., David,C.,
            Kock,K., Herrmann,C., Meyer,H.E., Wiese,S., Warscheid,B., Theiss,C.
            and Erdmann,R.
  TITLE     PEX14 is required for microtubule-based peroxisome motility in
            human cells
  JOURNAL   J Cell Sci 124 (Pt 10), 1759-1768 (2011)
   PUBMED   21525035
REFERENCE   3  (bases 1 to 3352)
  AUTHORS   Kaczmarek,K., Studencka,M., Meinhardt,A., Wieczerzak,K., Thoms,S.,
            Engel,W. and Grzmil,P.
  TITLE     Overexpression of peroxisomal testis-specific 1 protein induces
            germ cell apoptosis and leads to infertility in male mice
  JOURNAL   Mol Biol Cell 22 (10), 1766-1779 (2011)
   PUBMED   21460186
REFERENCE   4  (bases 1 to 3352)
  AUTHORS   Day,M.E., Gaietta,G.M., Sastri,M., Koller,A., Mackey,M.R.,
            Scott,J.D., Perkins,G.A., Ellisman,M.H. and Taylor,S.S.
  TITLE     Isoform-specific targeting of PKA to multivesicular bodies
  JOURNAL   J Cell Biol 193 (2), 347-363 (2011)
   PUBMED   21502359
REFERENCE   5  (bases 1 to 3352)
  AUTHORS   Iwashita,S., Tsuchida,M., Tsukuda,M., Yamashita,Y., Emi,Y.,
            Kida,Y., Komori,M., Kashiwayama,Y., Imanaka,T. and Sakaguchi,M.
  TITLE     Multiple organelle-targeting signals in the N-terminal portion of
            peroxisomal membrane protein PMP70
  JOURNAL   J Biochem 147 (4), 581-590 (2010)
   PUBMED   20007743
REFERENCE   6  (bases 1 to 3352)
  AUTHORS   Braiterman,L.T., Zheng,S., Watkins,P.A., Geraghty,M.T., Johnson,G.,
            McGuinness,M.C., Moser,A.B. and Smith,K.D.
  TITLE     Suppression of peroxisomal membrane protein defects by peroxisomal
            ATP binding cassette (ABC) proteins
  JOURNAL   Hum Mol Genet 7 (2), 239-247 (1998)
   PUBMED   9425230
REFERENCE   7  (bases 1 to 3352)
  AUTHORS   Albet,S., Causeret,C., Bentejac,M., Mandel,J.L., Aubourg,P. and
            Maurice,B.
  TITLE     Fenofibrate differently alters expression of genes encoding
            ATP-binding transporter proteins of the peroxisomal membrane
  JOURNAL   FEBS Lett 405 (3), 394-397 (1997)
   PUBMED   9108325
REFERENCE   8  (bases 1 to 3352)
  AUTHORS   Gartner,J., Obie,C., Watkins,P. and Valle,D.
  TITLE     Restoration of peroxisome biogenesis in a peroxisome-deficient
            mammalian cell line by expression of either the 35 kDa or the 70
            kDa peroxisomal membrane proteins
  JOURNAL   J Inherit Metab Dis 17 (3), 327-329 (1994)
   PUBMED   7528830
REFERENCE   9  (bases 1 to 3352)
  AUTHORS   Gartner,J., Moser,H. and Valle,D.
  TITLE     Mutations in the 70K peroxisomal membrane protein gene in Zellweger
            syndrome
  JOURNAL   Nat Genet 1 (1), 16-23 (1992)
   PUBMED   1301993
REFERENCE   10 (bases 1 to 3352)
  AUTHORS   Kamijo,K., Taketani,S., Yokota,S., Osumi,T. and Hashimoto,T.
  TITLE     The 70-kDa peroxisomal membrane protein is a member of the Mdr
            (P-glycoprotein)-related ATP-binding protein superfamily
  JOURNAL   J Biol Chem 265 (8), 4534-4540 (1990)
   PUBMED   1968461
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JACYVU010000078.1.
            
            [WARNING] On Apr 3, 2024 this sequence was replaced by NM_012804.3.
            
            On Nov 25, 2020 this sequence version replaced NM_012804.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D90038.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-172               JACYVU010000078.1  8571117-8571288     c
            173-209             JACYVU010000078.1  8553249-8553285     c
            210-308             JACYVU010000078.1  8548557-8548655     c
            309-397             JACYVU010000078.1  8547603-8547691     c
            398-467             JACYVU010000078.1  8542970-8543039     c
            468-565             JACYVU010000078.1  8541633-8541730     c
            566-689             JACYVU010000078.1  8541176-8541299     c
            690-746             JACYVU010000078.1  8539265-8539321     c
            747-889             JACYVU010000078.1  8537112-8537254     c
            890-959             JACYVU010000078.1  8534566-8534635     c
            960-1029            JACYVU010000078.1  8533395-8533464     c
            1030-1127           JACYVU010000078.1  8533212-8533309     c
            1128-1219           JACYVU010000078.1  8533027-8533118     c
            1220-1311           JACYVU010000078.1  8531838-8531929     c
            1312-1384           JACYVU010000078.1  8531684-8531756     c
            1385-1448           JACYVU010000078.1  8530295-8530358     c
            1449-1526           JACYVU010000078.1  8528236-8528313     c
            1527-1592           JACYVU010000078.1  8528076-8528141     c
            1593-1682           JACYVU010000078.1  8527891-8527980     c
            1683-1802           JACYVU010000078.1  8527343-8527462     c
            1803-1907           JACYVU010000078.1  8523717-8523821     c
            1908-1964           JACYVU010000078.1  8520436-8520492     c
            1965-3352           JACYVU010000078.1  8517695-8519082     c
FEATURES             Location/Qualifiers
     source          1..3352
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q42"
     gene            1..3352
                     /gene="Abcd3"
                     /gene_synonym="PMP70; Pxmp1"
                     /note="ATP binding cassette subfamily D member 3"
                     /db_xref="GeneID:25270"
                     /db_xref="RGD:2007"
     exon            1..172
                     /gene="Abcd3"
                     /gene_synonym="PMP70; Pxmp1"
                     /inference="alignment:Splign:2.1.0"
     CDS             63..2042
                     /gene="Abcd3"
                     /gene_synonym="PMP70; Pxmp1"
                     /note="70-kDa peroxisomal membrane protein; ATP-binding
                     cassette, sub-family D (ALD), member 3; Peroxisomal
                     membrane protein 1; ATP-binding cassette, subfamily D
                     (ALD), member 3"
                     /codon_start=1
                     /product="ATP-binding cassette sub-family D member 3"
                     /protein_id="NP_036936.1"
                     /db_xref="GeneID:25270"
                     /db_xref="RGD:2007"
                     /translation="MAAFSKYLTARNSSLAGAAFLLFCLLHKRRRALGLHGKKSGKPP
                     LQNNEKEGKKERAVVDKVFLSRLSQILKIMVPRTFCKETGYLILIAVMLVSRTYCDVW
                     MIQNGTLIESGIIGRSSKDFKRYLFNFIAAMPLISLVNNFLKYGLNELKLCFRVRLTR
                     YLYEEYLQAFTYYKMGNLDNRIANPDQLLTQDVEKFCNSVVDLYSNLSKPFLDIVLYI
                     FKLTSAIGAQGPASMMAYLLVSGLFLTRLRRPIGKMTIMEQKYEGEYRFVNSRLITNS
                     EEIAFYNGNKREKQTIHSVFRKLVEHLHNFIFFRFSMGFIDSIIAKYIATVVGYLVVS
                     RPFLDLAHPRHLHSTHSELLEDYYQSGRMLLRMSQALGRIVLAGREMTRLAGFTARIT
                     ELMQVLKDLNHGKYERTMVSQQDKGIEGAQASPLIPGAGEIINADNIIKFDHVPLATP
                     NGDILIQDLSFEVRSGANVLICGPNGCGKSSLFRVLGELWPLFGGHLTKPERGKLFYV
                     PQRPYMTLGTLRDQVIYPDGKEDQKKKGISDQVLKGYLDNVQLGHILEREGGWDSVQD
                     WMDVLSGGEKQRMAMARLFYHKPQFAILDECTSAVSVDVEDYIYSHCRKVGITLFTVS
                     HRKSLWKHHEYYLHMDGRGNYEFKKITEDTVEFGS"
     exon            173..209
                     /gene="Abcd3"
                     /gene_synonym="PMP70; Pxmp1"
                     /inference="alignment:Splign:2.1.0"
     exon            210..308
                     /gene="Abcd3"
                     /gene_synonym="PMP70; Pxmp1"
                     /inference="alignment:Splign:2.1.0"
     exon            309..397
                     /gene="Abcd3"
                     /gene_synonym="PMP70; Pxmp1"
                     /inference="alignment:Splign:2.1.0"
     exon            398..467
                     /gene="Abcd3"
                     /gene_synonym="PMP70; Pxmp1"
                     /inference="alignment:Splign:2.1.0"
     exon            468..565
                     /gene="Abcd3"
                     /gene_synonym="PMP70; Pxmp1"
                     /inference="alignment:Splign:2.1.0"
     exon            566..689
                     /gene="Abcd3"
                     /gene_synonym="PMP70; Pxmp1"
                     /inference="alignment:Splign:2.1.0"
     exon            690..746
                     /gene="Abcd3"
                     /gene_synonym="PMP70; Pxmp1"
                     /inference="alignment:Splign:2.1.0"
     exon            747..889
                     /gene="Abcd3"
                     /gene_synonym="PMP70; Pxmp1"
                     /inference="alignment:Splign:2.1.0"
     exon            890..959
                     /gene="Abcd3"
                     /gene_synonym="PMP70; Pxmp1"
                     /inference="alignment:Splign:2.1.0"
     exon            960..1029
                     /gene="Abcd3"
                     /gene_synonym="PMP70; Pxmp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1030..1127
                     /gene="Abcd3"
                     /gene_synonym="PMP70; Pxmp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1128..1219
                     /gene="Abcd3"
                     /gene_synonym="PMP70; Pxmp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1220..1311
                     /gene="Abcd3"
                     /gene_synonym="PMP70; Pxmp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1312..1384
                     /gene="Abcd3"
                     /gene_synonym="PMP70; Pxmp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1385..1448
                     /gene="Abcd3"
                     /gene_synonym="PMP70; Pxmp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1449..1526
                     /gene="Abcd3"
                     /gene_synonym="PMP70; Pxmp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1527..1592
                     /gene="Abcd3"
                     /gene_synonym="PMP70; Pxmp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1593..1682
                     /gene="Abcd3"
                     /gene_synonym="PMP70; Pxmp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1683..1802
                     /gene="Abcd3"
                     /gene_synonym="PMP70; Pxmp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1803..1907
                     /gene="Abcd3"
                     /gene_synonym="PMP70; Pxmp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1908..1964
                     /gene="Abcd3"
                     /gene_synonym="PMP70; Pxmp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1965..3352
                     /gene="Abcd3"
                     /gene_synonym="PMP70; Pxmp1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cctgcactga ggttgtcgcc ggcgcgtccc ctataccgcg gctcgctcgc cctgccggtg
       61 ccatggcggc cttcagcaag tacttgacgg cgcggaactc ctcgctggcg ggggccgcgt
      121 tcctgctgtt ctgcctgctc cacaagcggc gtcgcgccct cggcctgcac ggtaagaaaa
      181 gtggaaaacc gccattacag aataatgaga aagaaggaaa gaaagagcga gctgtggtgg
      241 acaaagtgtt tttatcaagg ctctcacaga tcctaaaaat tatggtccct agaacatttt
      301 gtaaagagac agggtacttg atacttattg ctgttatgct ggtatctcga acatactgtg
      361 atgtttggat gattcaaaat ggcacactga ttgaaagtgg catcattggt cgtagcagta
      421 aagatttcaa gagatactta ttcaacttca tcgctgccat gcctcttatc tcgctggtta
      481 ataacttctt gaagtatggg ttaaatgagc tcaaactgtg cttccgtgtg cggctcacta
      541 gatacctcta tgaggagtat ctccaagcct tcacctacta taaaatgggc aacctggata
      601 acagaatagc aaacccagac cagctgctta cacaagacgt agaaaagttt tgtaacagtg
      661 tagttgatct ttattcgaat cttagtaagc catttttaga catagttttg tatattttca
      721 agttaacaag tgcaattgga gctcagggcc cggcaagcat gatggcctac ttgcttgttt
      781 ctgggctatt cctaactcga ctcagaagac ccatcggtaa aatgacgatt atggagcaga
      841 agtatgaagg agaatataga ttcgttaatt cacggcttat cactaatagt gaagaaattg
      901 ccttttacaa tgggaataaa cgagaaaagc agacaatcca ctctgtcttc cgaaaactgg
      961 tggaacacct acataatttc attttcttcc ggttttctat gggtttcatt gatagcatca
     1021 ttgccaaata tattgccact gtagttgggt acctggttgt cagtcgcccg ttcctagacc
     1081 tggcgcatcc gcgacacctt cacagcaccc actcagagct gctggaggat tactaccaaa
     1141 gtggaagaat gcttttgaga atgtctcaag ctttggggcg gatagttttg gctgggcgtg
     1201 aaatgactag attggctggt tttacggctc ggattacgga attaatgcaa gtactaaagg
     1261 atttaaatca tggcaaatat gaacgtacaa tggtgtcaca acaggataag ggtattgaag
     1321 gagcacaagc tagtcccttg atacctggtg ctggagaaat catcaatgca gacaacatta
     1381 taaagtttga tcatgttcct ttagcaacac caaatggaga tatcttgatc caagacctta
     1441 gttttgaagt tcgatctggg gccaacgttc tcatttgtgg tccaaatggc tgtggaaaga
     1501 gctccctctt ccgtgttctt ggtgaattat ggcctctctt tggaggacat cttactaaac
     1561 ctgagagagg aaagttattt tatgttcctc agcgacccta tatgaccctg ggaacactga
     1621 gagaccaagt aatatatcca gatggaaagg aggatcagaa gaagaagggg atatctgacc
     1681 aagtgctgaa ggggtacttg gacaatgtac agttgggcca tatccttgag cgggaaggag
     1741 gctgggacag tgttcaggac tggatggatg tactcagcgg aggagaaaaa caaagaatgg
     1801 cgatggcaag attgttttat cataaacccc agtttgccat tctggatgag tgcacaagtg
     1861 cagttagtgt ggatgtggaa gactacattt acagccactg tcggaaggtt ggcatcaccc
     1921 tcttcactgt ctcacacagg aaatcccttt ggaaacacca cgagtactac ctgcacatgg
     1981 atggcagagg caattatgaa ttcaaaaaga tcacagaaga cacagttgag ttcggatcat
     2041 agagaccatc tggagaactt cacacttcac aagagaatga atgaacagaa tgcatttgta
     2101 aacaacgtgc attgtaaaat aaagttaagc ttgttttttt taaaaaaaca aagctacaaa
     2161 ttgactagat ataggataat tgaaacatgt taaaacattt aatattgtat aggatattgc
     2221 taattgtgta tatgttggtt taattattaa ttatgtacta agaatgtcct tattcttgtg
     2281 gttaaaaaac ctgcctgaat taaattgggc ttaaatcagt gtaacctgat tcatgggatg
     2341 taaaccattt gaagtcagct aatttgactt ttatagctct gtctttttct ttaatgaaga
     2401 accctattta aaactgggtc attagctgtt tattctaaca aagtagtctt gagttccttt
     2461 ttgggttttt tttttttttt tttttttttt ttttgtgccc catggtagtg ggaaccaaac
     2521 caatcacaat gttttattgg aacatattcc atcatcacag gatagcattt attaaacagt
     2581 ggcggatttc tctagctgct acatttattc tcattcctca tacatacctt gaggtgcatt
     2641 tgattccagg agagccattt gggttttctt tacctaaata ataaatgtac ccgtctcagt
     2701 cttttggact gagtcgttct gaaggctctc gtgtggacag cagtgtgtgc agtcgtgctt
     2761 acagcccgtg cctgctccac atggtaccag tcttaccagt gcttgagagc tcagacacac
     2821 cctgctgcat gaagttggag gtctcgggag ggttttagat tttgtgacgg gaaccggaaa
     2881 ggctcgtcag agtgtggctg tgtcatggtg agcaccacgt ggctgtagag gcccgacatg
     2941 aggtaatgca ctgagcacac aacgccactg ctgctgtctg tggctgtggg ttcttaaaag
     3001 tgctggactt tgtcatgctc gtgggccaat gatatttcct aggagcggcc tctgactcct
     3061 gtgcagctgc gtctgtgtca gctctggctc cctggaacca cgagtgactt tgcacaaagg
     3121 agggctgaga gcggacttga tcagtaagtc gtcgtgaatc agtttgcttg agtgggctcg
     3181 gaatggggcc ttatcacgat ggttttgttt cttcgtaact cataatcact ggctaccagg
     3241 ataaccctga tgtattgatt ccgtgaatac atcacattca atcttaccat gtctccttag
     3301 caaacgtgtg tacttatttt ctgttcagat taaaaaaaaa atgaataacc ta
//
