LOCUS       NM_033352               5516 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus ATP binding cassette subfamily D member 2
            (Abcd2), mRNA.
ACCESSION   NM_033352
VERSION     NM_033352.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5516)
  AUTHORS   Hartley,M.D., Kirkemo,L.L., Banerji,T. and Scanlan,T.S.
  TITLE     A Thyroid Hormone-Based Strategy for Correcting the Biochemical
            Abnormality in X-Linked Adrenoleukodystrophy
  JOURNAL   Endocrinology 158 (5), 1328-1338 (2017)
   PUBMED   28200172
REFERENCE   2  (bases 1 to 5516)
  AUTHORS   Geillon,F., Gondcaille,C., Raas,Q., Dias,A.M.M., Pecqueur,D.,
            Truntzer,C., Lucchi,G., Ducoroy,P., Falson,P., Savary,S. and
            Trompier,D.
  TITLE     Peroxisomal ATP-binding cassette transporters form mainly tetramers
  JOURNAL   J Biol Chem 292 (17), 6965-6977 (2017)
   PUBMED   28258215
  REMARK    GeneRIF: ABCD1 and its homolog ABCD2 exist mainly as homotetramers
            in the peroxisomal membrane
REFERENCE   3  (bases 1 to 5516)
  AUTHORS   Geillon,F., Gondcaille,C., Charbonnier,S., Van Roermund,C.W.,
            Lopez,T.E., Dias,A.M., Pais de Barros,J.P., Arnould,C.,
            Wanders,R.J., Trompier,D. and Savary,S.
  TITLE     Structure-function analysis of peroxisomal ATP-binding cassette
            transporters using chimeric dimers
  JOURNAL   J Biol Chem 289 (35), 24511-24520 (2014)
   PUBMED   25043761
REFERENCE   4  (bases 1 to 5516)
  AUTHORS   Archambaud,C., Nahori,M.A., Soubigou,G., Becavin,C., Laval,L.,
            Lechat,P., Smokvina,T., Langella,P., Lecuit,M. and Cossart,P.
  TITLE     Impact of lactobacilli on orally acquired listeriosis
  JOURNAL   Proc Natl Acad Sci U S A 109 (41), 16684-16689 (2012)
   PUBMED   23012479
REFERENCE   5  (bases 1 to 5516)
  AUTHORS   Genin,E.C., Geillon,F., Gondcaille,C., Athias,A., Gambert,P.,
            Trompier,D. and Savary,S.
  TITLE     Substrate specificity overlap and interaction between
            adrenoleukodystrophy protein (ALDP/ABCD1) and
            adrenoleukodystrophy-related protein (ALDRP/ABCD2)
  JOURNAL   J Biol Chem 286 (10), 8075-8084 (2011)
   PUBMED   21209459
  REMARK    GeneRIF: Substrate specificity overlap and interaction between
            adrenoleukodystrophy protein (ALDP/ABCD1) and
            adrenoleukodystrophy-related protein (ALDRP/ABCD2).
REFERENCE   6  (bases 1 to 5516)
  AUTHORS   Kikuchi,M., Hatano,N., Yokota,S., Shimozawa,N., Imanaka,T. and
            Taniguchi,H.
  TITLE     Proteomic analysis of rat liver peroxisome: presence of
            peroxisome-specific isozyme of Lon protease
  JOURNAL   J Biol Chem 279 (1), 421-428 (2004)
   PUBMED   14561759
REFERENCE   7  (bases 1 to 5516)
  AUTHORS   Albet,S., Bentejac,M., Savary,S., Gondcaille,C., Netik,A.,
            Berger,J., Szpirer,C., Troffer-Charlier,N. and Bugaut,M.
  TITLE     Rat adrenoleukodystrophy-related (ALDR) gene: full-length cDNA
            sequence and new insight in expression
  JOURNAL   Biochim Biophys Acta 1517 (2), 257-269 (2001)
   PUBMED   11342107
REFERENCE   8  (bases 1 to 5516)
  AUTHORS   Holzinger,A., Mayerhofer,P., Berger,J., Lichtner,P., Kammerer,S.
            and Roscher,A.A.
  TITLE     Full length cDNA cloning, promoter sequence, and genomic
            organization of the human adrenoleukodystrophy related (ALDR) gene
            functionally redundant to the gene responsible for X-linked
            adrenoleukodystrophy
  JOURNAL   Biochem Biophys Res Commun 258 (2), 436-442 (1999)
   PUBMED   10329405
REFERENCE   9  (bases 1 to 5516)
  AUTHORS   Netik,A., Forss-Petter,S., Holzinger,A., Molzer,B., Unterrainer,G.
            and Berger,J.
  TITLE     Adrenoleukodystrophy-related protein can compensate functionally
            for adrenoleukodystrophy protein deficiency (X-ALD): implications
            for therapy
  JOURNAL   Hum Mol Genet 8 (5), 907-913 (1999)
   PUBMED   10196381
REFERENCE   10 (bases 1 to 5516)
  AUTHORS   Lombard-Platet,G., Savary,S., Sarde,C.O., Mandel,J.L. and
            Chimini,G.
  TITLE     A close relative of the adrenoleukodystrophy (ALD) gene codes for a
            peroxisomal protein with a specific expression pattern
  JOURNAL   Proc Natl Acad Sci U S A 93 (3), 1265-1269 (1996)
   PUBMED   8577752
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On Dec 5, 2020 this sequence version replaced NM_033352.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF131294.1, SRR26643290.27477.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1141              JAXUCZ010000007.1  124190062-124191202 c
            1142-1322           JAXUCZ010000007.1  124188335-124188515 c
            1323-1444           JAXUCZ010000007.1  124182331-124182452 c
            1445-1610           JAXUCZ010000007.1  124178698-124178863 c
            1611-1705           JAXUCZ010000007.1  124177886-124177980 c
            1706-1851           JAXUCZ010000007.1  124174261-124174406 c
            1852-1997           JAXUCZ010000007.1  124161443-124161588 c
            1998-2082           JAXUCZ010000007.1  124155920-124156004 c
            2083-2208           JAXUCZ010000007.1  124149681-124149806 c
            2209-5516           JAXUCZ010000007.1  124142597-124145904 c
FEATURES             Location/Qualifiers
     source          1..5516
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q35"
     gene            1..5516
                     /gene="Abcd2"
                     /gene_synonym="ALDR"
                     /note="ATP binding cassette subfamily D member 2"
                     /db_xref="GeneID:84356"
                     /db_xref="RGD:69244"
     exon            1..1141
                     /gene="Abcd2"
                     /gene_synonym="ALDR"
                     /inference="alignment:Splign:2.1.0"
     CDS             203..2428
                     /gene="Abcd2"
                     /gene_synonym="ALDR"
                     /note="ATP-binding cassette, sub-family D (ALD), member 2;
                     adrenoleukodystrophy-related protein; ATP-binding
                     cassette, subfamily D (ALD), member 2"
                     /codon_start=1
                     /product="ATP-binding cassette sub-family D member 2"
                     /protein_id="NP_203503.2"
                     /db_xref="GeneID:84356"
                     /db_xref="RGD:69244"
                     /translation="MIHMLNAAAYRVKWTRSGAAKRAACLVAAAYALKTLYPILGRRL
                     KQPGHRKAKAEDYPPAENRERLHCTEIICKKPAPGLNADFFKQLLELRKILFPKLVTT
                     ETGWLCLHSVALISRTFLSIYVAGLDGKIVKSIVEKKPRTFIIKLVKWLMIAVPATFV
                     NSAIRYLECKLALAFRTRLVDHAYETYFANQTYYKVINMDGRLANPDQSLTEDIMMFS
                     QSVAHLYSNLTKPILDVILTSYTLIRTATSRGASPIGPTLLAGLVVYATAKVLKACSP
                     KFGTLVAEEAHRKGYLRYVHSRIIANVEEIAFYRGHKVEMKQLQKCYKALAYQMNLIL
                     SKRLWYIMIEQFLMKYVWSGCGLIMVAIPIITATGFADGDLEDGPKQAMVSDRTEAFT
                     TARNLLASGADAIERIMSSYKEITELAGYTARVYNMFWVFDEVKRGIYKRTVTQEPEN
                     NSKSRGGLELPLSDTLAIKGTVIDVDHGILCENVPIITPAGEVVASSLNFKVEEGMHL
                     LITGPNGCGKSSLFRILSGLWPVYEGVLYKPPPQHMFYIPQRPYMSLGSLRDQVIYPD
                     SVDDMHEKGYTDRDLEHILHSVHLYHIVQREGGWDAVMDWKDVLSGGEKQRMGMARMF
                     YHKPKYALLDECTSAVSIDVEGKIFQAAIGAGISLLSITHRPSLWKYHTHLLQFDGEG
                     GWRFEQLDTAIRLTLSEEKQKLESQLAGIPKMQQRLNELCKILGEDSVLKTIQTAEDT
                     S"
     exon            1142..1322
                     /gene="Abcd2"
                     /gene_synonym="ALDR"
                     /inference="alignment:Splign:2.1.0"
     exon            1323..1444
                     /gene="Abcd2"
                     /gene_synonym="ALDR"
                     /inference="alignment:Splign:2.1.0"
     exon            1445..1610
                     /gene="Abcd2"
                     /gene_synonym="ALDR"
                     /inference="alignment:Splign:2.1.0"
     exon            1611..1705
                     /gene="Abcd2"
                     /gene_synonym="ALDR"
                     /inference="alignment:Splign:2.1.0"
     exon            1706..1851
                     /gene="Abcd2"
                     /gene_synonym="ALDR"
                     /inference="alignment:Splign:2.1.0"
     exon            1852..1997
                     /gene="Abcd2"
                     /gene_synonym="ALDR"
                     /inference="alignment:Splign:2.1.0"
     exon            1998..2082
                     /gene="Abcd2"
                     /gene_synonym="ALDR"
                     /inference="alignment:Splign:2.1.0"
     exon            2083..2208
                     /gene="Abcd2"
                     /gene_synonym="ALDR"
                     /inference="alignment:Splign:2.1.0"
     exon            2209..5516
                     /gene="Abcd2"
                     /gene_synonym="ALDR"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagggactcg cccccggtgg atgcggtgga gtttgagctt tttgctgcat ccgtccctga
       61 agaacaaaat aagagtaagg gagacaagct gcagagcatg ggaggctgtg gggttttctg
      121 aaacgtttgc tgggctctcc gcggagcatg agctgttaaa aggagttctt tggagagaaa
      181 tccatttgtg ttagctggaa aaatgataca catgctaaat gcagcagcct atcgggtgaa
      241 atggaccaga tccggtgctg ctaaaagggc tgcctgcctg gtggctgcgg catatgctct
      301 gaaaaccctc tatcccatcc ttggcaggcg tttaaagcag cctggccacc ggaaggcgaa
      361 agcagaagat tacccgcctg cagagaacag agaaagactg cattgcacag agatcatctg
      421 taaaaaacct gcgccgggac taaatgcaga ttttttcaaa cagctactag aacttcggaa
      481 aatcctcttt ccaaaacttg tgaccactga aacggggtgg ctctgcctcc actcggtggc
      541 tctaatctca cgaacgtttc tgtctatcta cgtggctggt ctggatggga aaatcgtgaa
      601 aagcatcgtg gaaaagaagc ctcggacttt catcatcaaa ctagtcaagt ggcttatgat
      661 tgccgtcccc gctacctttg tcaacagcgc tatcaggtac ctggagtgca aactggcatt
      721 ggcctttaga actcgcttag tggaccatgc ctatgagacc tattttgcaa atcagactta
      781 ttataaggtg ataaatatgg acgggaggct ggcaaaccct gaccagtctc ttactgaaga
      841 cattatgatg ttctcgcaat cggtggctca cctgtattcc aaccttacca aaccgatttt
      901 agatgtaatt ctaacctcct ataccctcat ccggacagct acatccagag gagcaagccc
      961 catcgggccc accctgttag cagggctcgt ggtgtatgcc actgctaaag tcctgaaagc
     1021 ttgctcgccc aaatttggta ctctggtggc tgaagaagct catagaaagg gctacttgcg
     1081 gtatgttcac tccagaatca tagccaatgt ggaagaaatt gccttctaca gaggacataa
     1141 ggtagaaatg aagcaactgc agaagtgtta caaggcttta gcttaccaga tgaaccttat
     1201 tctatccaaa cgtttgtggt acatcatgat agaacagttc ctgatgaagt atgtgtggag
     1261 cggctgtgga ctaattatgg tggccatacc tatcatcact gcaacaggct ttgcagatgg
     1321 tgatctggag gatggcccta agcaggctat ggttagcgat cggacagagg cctttaccac
     1381 tgctcggaat ttactggcct ctggagctga cgcgattgag aggattatgt cttcatacaa
     1441 agagatcact gaactagcgg gttatactgc cagagtgtac aacatgttct gggtcttcga
     1501 tgaagtgaag agaggcattt ataagagaac tgtcactcag gagcctgaaa acaatagcaa
     1561 gagtagaggt ggcctggagc tgcccctcag tgacaccctg gcaatcaaag ggacagtcat
     1621 tgacgtggat catggaatcc tttgtgaaaa tgttcccata atcacgccgg cgggagaagt
     1681 ggtggcttcc agtctgaact tcaaagtaga agaagggatg catcttttga taaccggccc
     1741 caatggttgt gggaaaagct ctctgttcag aatcttaagt gggctctggc ctgtgtatga
     1801 aggagtcctt tataaaccac ctccccaaca tatgttctat attccacaga ggccgtacat
     1861 gtctcttgga agtcttcggg atcaagtcat ttatcctgac tcggtggatg acatgcatga
     1921 gaaaggttat acagaccgag acctagagca tattctgcac agcgtccacc tctaccacat
     1981 agtccaaaga gaaggaggat gggatgcagt catggattgg aaagatgtcc tttcaggagg
     2041 ggagaaacag agaatgggga tggcacggat gttttaccat aaaccgaagt acgcattgct
     2101 ggacgagtgc accagtgctg tgagcattga cgtggaagga aagatatttc aggctgctat
     2161 cggggctggc atttccttac tgtctataac gcacaggcct tctctgtgga aataccacac
     2221 ccacctattg caattcgatg gcgaaggagg ttggcgcttt gaacagttgg acactgctat
     2281 ccgcttaacg ttaagcgagg agaaacagaa gttggagtcg cagctcgctg gaattcccaa
     2341 aatgcagcag agactcaatg aactgtgcaa aattttgggg gaagactcgg tgctgaaaac
     2401 gatccaaact gcagaggaca catcctaact gaccttgaca tgttttaagt taacttctag
     2461 gtgatgcctc agagactctt tctttactgc atgcagtatg ttaagctaag tgaagagaaa
     2521 gcaagccagc aaaaaaaaaa aaagtatttt gtatgatttc agcatcgagg aaatatgata
     2581 actttttcca atgaaaaaaa aagcgaacga attagttgca gttagtcatg actcaggtta
     2641 gtgccccgtg agaggctagc tcacctgtaa agtgggtttc tagattagga gagtgtgtgt
     2701 ggttcttcct aggagagaat gccccaaaac aagacagcag gggcaccagc tgggccgatg
     2761 tcaggaatta gacctttgag ggctctttca acccaggtaa cggggacaat aggtgcaaca
     2821 cctggaatct atagtcagca ttgctagggg ccaactcaaa ctgtgtacaa agtagcaggc
     2881 tgtttgatac atagtttcag tctgaaaagg gtgtatccga atgacagtgg ttgaaaacaa
     2941 gcacggctag acaagtataa agtactgtat taaatttttt cataccttga gcatcttaat
     3001 acagatacag aaattaacat taataaaaat tgtgtgtatg tgtttaaaaa aaaaaccctt
     3061 ttatgtttta aaaagagaat tgcccataca gaagaggacg gtctgaacga tacttgttct
     3121 ggctaccgct tgactctgca gtcctattta gtacggtttc tgtccagaaa tactgtctgt
     3181 ctggtgccca aaatggcatt ttagaaactt gattgctgcc ctaaatatgg atcctggaaa
     3241 tcacagttat gttcctacat tcattttacc ttactccatc ttttaagaca tacaagtttt
     3301 tgttcctttt tcttctgaaa cgcgcgcgcg cgcacacaca cacacacaca cacacacaca
     3361 cacacagatt tactttaatc acatgattta ttttggaaga gctgtagcga tcatgaaggt
     3421 ctccctcccc cacacaccag acccagtgct gtcatcacta atggccctta aatttaactg
     3481 ggatataatg tcggttttaa aacgatgtgg accaggcaga tggccagaaa tggttgtagg
     3541 caaagcaggg cataagggaa aaaaattaaa gcagataaat aaatattatt caggcataga
     3601 agagtgacag ttgcttctct tgtaggggac ctgagttcca ttgccaacat ccacatggtg
     3661 gctcaaacgt gtgtctaatt ccagctccag gggatctgac atacatgtag actccaggga
     3721 tcctgcatac atgtagtcct catacacaca tacatgcaga caaaacattc atagcattaa
     3781 aaatcaataa atctgaaaga tagtaaggat attgaaagct ggcaatgttg atgttaccat
     3841 cacttaatta ctgtttgtga gaagtgaaaa ttgagtgaga aatgcaatgg gcgttggtca
     3901 acgcagctcg gctgtgcaca cccacctgat gccgaagtgt ctgcagtgcc agcgctcagg
     3961 agggcagtac attgcacttc cggtaagctt cacgctgctg aagatgacag agaccctcac
     4021 atcatatgaa atacagtgca tctggagtac aaaaccacga ctaatgcttt aatctcatcc
     4081 tctctcagac atgacgaggt atgtgaaaac ccgagatgaa cagttttagg ggcttaaggt
     4141 tttgtttctg tattcagaca gcgctttagc agacactaac tctcgataac agacggtttg
     4201 gaagacagac cccctagaag tcattcacaa tgatggtcgt gagaaattgc agcatttcca
     4261 cattttcaat tccgcaaaaa tctacacaat ttgaattacc aatcactgtg accaccttac
     4321 acaaaacaat acaaggtcat aatcagtacc tttgtatttg tctgttactg ctacttctta
     4381 ctaataatgt gggacactaa tgaaatattt ggtttagcaa aagtataaaa ccagaaattg
     4441 acactgaatt aaaaaaaaaa aaaacacaat tcactaatct cttaacaacc gtgctagcag
     4501 ttacccaggt tatagtgcta aaggagaatc atttgaagca agggtcttat attagctctg
     4561 acaagcacaa gaggaaaatt gaaagttcac atttgaaatt ataccatttc agacttaaaa
     4621 taaaccatgt aagacctgat atcctacatt ttcaagcttt gcgaaagatg ccaacatcaa
     4681 tgctacattc ggaactagac cttatttagt agatgttacc agcgagctgg atcgaaataa
     4741 ataagactcg ttacacagtg gatgggggtt caacgatgtt tggaattcgg tactaaaact
     4801 ctagtcacga aatttaaacg ttaaggtttc agaactaact gtttcccagt agccttttgg
     4861 taactactga tttaatgctg gatatctttt ttttttttct tttttttttt tccagagctg
     4921 gggaccgaac ccagggcctt gcgcttccta ggcaagcgct ctaccactga gttaaatccc
     4981 caaccccact actgattttc tgaactgcct cttctgagcc agagtaccct ccttcttaga
     5041 gggagaaccc gatgtggatc tgtgttgtgt ataatctgac tctttccaaa gtgctcccac
     5101 gggagaccag agctgatact ctgacaggca tacttgtgaa aacacaaaga ccactgagac
     5161 ctcttctttg actaggacaa agaataataa ggaagacgaa ggatagcttc atctgtcaaa
     5221 ctactttttt tttccttaga aaaggcataa atgtatggag ttcgattatt tcggggaata
     5281 actcaaaacc tgcattgtga catccgatct ctggagcatg ctatggtatg ccaagcaccc
     5341 aagcacactg tgttcactct tacagacgag ataattgcta aaatcctctt gagtcacaag
     5401 gtcggtgatc gtacttgaaa accagcccag ttcaccctat gtttacacgg gaagagtttt
     5461 cctttgatag caatttgact tttgacccaa attttggcgt gtcaataaag gtataa
//
