LOCUS       NM_001108821            3411 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Rattus norvegicus ATP binding cassette subfamily D member 1
            (Abcd1), mRNA.
ACCESSION   NM_001108821 XM_001059399 XM_343840
VERSION     NM_001108821.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3411)
  AUTHORS   Geillon,F., Gondcaille,C., Raas,Q., Dias,A.M.M., Pecqueur,D.,
            Truntzer,C., Lucchi,G., Ducoroy,P., Falson,P., Savary,S. and
            Trompier,D.
  TITLE     Peroxisomal ATP-binding cassette transporters form mainly tetramers
  JOURNAL   J Biol Chem 292 (17), 6965-6977 (2017)
   PUBMED   28258215
  REMARK    GeneRIF: ABCD1 and its homolog ABCD2 exist mainly as homotetramers
            in the peroxisomal membrane
REFERENCE   2  (bases 1 to 3411)
  AUTHORS   Morita,M., Kawamichi,M., Shimura,Y., Kawaguchi,K., Watanabe,S. and
            Imanaka,T.
  TITLE     Brain microsomal fatty acid elongation is increased in
            abcd1-deficient mouse during active myelination phase
  JOURNAL   Metab Brain Dis 30 (6), 1359-1367 (2015)
   PUBMED   26108493
REFERENCE   3  (bases 1 to 3411)
  AUTHORS   Kruska,N., Schonfeld,P., Pujol,A. and Reiser,G.
  TITLE     Astrocytes and mitochondria from adrenoleukodystrophy protein
            (ABCD1)-deficient mice reveal that the
            adrenoleukodystrophy-associated very long-chain fatty acids target
            several cellular energy-dependent functions
  JOURNAL   Biochim Biophys Acta 1852 (5), 925-936 (2015)
   PUBMED   25583114
REFERENCE   4  (bases 1 to 3411)
  AUTHORS   Muneer,Z., Wiesinger,C., Voigtlander,T., Werner,H.B., Berger,J. and
            Forss-Petter,S.
  TITLE     Abcd2 is a strong modifier of the metabolic impairments in
            peritoneal macrophages of ABCD1-deficient mice
  JOURNAL   PLoS One 9 (9), e108655 (2014)
   PUBMED   25255441
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3411)
  AUTHORS   Geillon,F., Gondcaille,C., Charbonnier,S., Van Roermund,C.W.,
            Lopez,T.E., Dias,A.M., Pais de Barros,J.P., Arnould,C.,
            Wanders,R.J., Trompier,D. and Savary,S.
  TITLE     Structure-function analysis of peroxisomal ATP-binding cassette
            transporters using chimeric dimers
  JOURNAL   J Biol Chem 289 (35), 24511-24520 (2014)
   PUBMED   25043761
REFERENCE   6  (bases 1 to 3411)
  AUTHORS   Forss-Petter,S., Werner,H., Berger,J., Lassmann,H., Molzer,B.,
            Schwab,M.H., Bernheimer,H., Zimmermann,F. and Nave,K.A.
  TITLE     Targeted inactivation of the X-linked adrenoleukodystrophy gene in
            mice
  JOURNAL   J Neurosci Res 50 (5), 829-843 (1997)
   PUBMED   9418970
REFERENCE   7  (bases 1 to 3411)
  AUTHORS   Lu,J.F., Lawler,A.M., Watkins,P.A., Powers,J.M., Moser,A.B.,
            Moser,H.W. and Smith,K.D.
  TITLE     A mouse model for X-linked adrenoleukodystrophy
  JOURNAL   Proc Natl Acad Sci U S A 94 (17), 9366-9371 (1997)
   PUBMED   9256488
REFERENCE   8  (bases 1 to 3411)
  AUTHORS   Kobayashi,T., Shinnoh,N., Kondo,A. and Yamada,T.
  TITLE     Adrenoleukodystrophy protein-deficient mice represent abnormality
            of very long chain fatty acid metabolism
  JOURNAL   Biochem Biophys Res Commun 232 (3), 631-636 (1997)
   PUBMED   9126326
REFERENCE   9  (bases 1 to 3411)
  AUTHORS   Contreras,M., Sengupta,T.K., Sheikh,F., Aubourg,P. and Singh,I.
  TITLE     Topology of ATP-binding domain of adrenoleukodystrophy gene product
            in peroxisomes
  JOURNAL   Arch Biochem Biophys 334 (2), 369-379 (1996)
   PUBMED   8900413
REFERENCE   10 (bases 1 to 3411)
  AUTHORS   Kemp,S., Ligtenberg,M.J., van Geel,B.M., Barth,P.G.,
            Wolterman,R.A., Schoute,F., Sarde,C.O., Mandel,J.L., van Oost,B.A.
            and Bolhuis,P.A.
  TITLE     Identification of a two base pair deletion in five unrelated
            families with adrenoleukodystrophy: a possible hot spot for
            mutations
  JOURNAL   Biochem Biophys Res Commun 202 (2), 647-653 (1994)
   PUBMED   8048932
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH474099.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_001059399.1, XM_343840.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMD00132266,
                              SAMD00132270 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3411
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="X"
                     /map="Xq37"
     gene            1..3411
                     /gene="Abcd1"
                     /gene_synonym="ALDP; RGD1562128"
                     /note="ATP binding cassette subfamily D member 1"
                     /db_xref="GeneID:363516"
                     /db_xref="RGD:1562128"
     exon            1..1337
                     /gene="Abcd1"
                     /gene_synonym="ALDP; RGD1562128"
                     /inference="alignment:Splign:2.1.0"
     CDS             435..2648
                     /gene="Abcd1"
                     /gene_synonym="ALDP; RGD1562128"
                     /EC_number="7.6.2.4"
                     /note="ATP-binding cassette, sub-family D (ALD), member 1;
                     ATP-binding cassette, subfamily D (ALD), member 1;
                     adrenoleukodystrophy protein"
                     /codon_start=1
                     /product="ATP-binding cassette sub-family D member 1"
                     /protein_id="NP_001102291.1"
                     /db_xref="GeneID:363516"
                     /db_xref="RGD:1562128"
                     /translation="MPVLSTPSRPSRVTTLKRTAVVLALTAYGVHKIYPLVRQCLTPA
                     RGPQVPAGESTQEASGATTAKAGMNRVFLQRLLVLLRLLFPGVLCRETGLLALHSAAL
                     VSRTFLSVYVARLDGRLARCIVRKDPRAFSWQLLQWLLIALPATFINSAIRYLEGQLA
                     LSFRSRLVAHAYGLYFSQQTYYRVSNMDGRLRNPDQSLTEDMVAFAASVAHLYSNLTK
                     PLLDVAVTSYTLLRAARSRGAGTAWPSAIAGLVVFLTANVLRAFSPKFGELVAEEARR
                     KGELRYMHSRVVANSEEIAFYGGHEVELALLQHSYQDLASQINLILLERLWYVMLEQF
                     LMKYVWSASGLLMVAVPIITATGYAESDSEAMKKAALEMKEEELVSERTEAFTIARNL
                     LTAAADATERIMSSYKEVTELAGYTARVYEMFQVFEDVQHCRFKRTGDLEEAQAGPGS
                     MVHSGVHIEGPLKIQGQVVDVEQGIICENIPIITPTGEVVVASLNIRVEEGMHLLITG
                     PNGCGKSSLFRILGGLWPTYSGVLYKPPPQRMFYIPQRPYMSVGSLRDQVIYPDSAED
                     MRRKGCSEQQLEAILGIVHLRHILQREGGWEAVCDWKDVLSGGEKQRIGMARMFYHRP
                     KYALLDECTSAVSIDVEGKIFQAAKDAGISLLSITHRPSLWKYHTHLLQFDGEGGWKF
                     EKLDSAARLSLTEEKQRLEQQLAGIPKMQGRLQELRQILGEAAAPVQPLVPGIPT"
     exon            1338..1518
                     /gene="Abcd1"
                     /gene_synonym="ALDP; RGD1562128"
                     /inference="alignment:Splign:2.1.0"
     exon            1519..1661
                     /gene="Abcd1"
                     /gene_synonym="ALDP; RGD1562128"
                     /inference="alignment:Splign:2.1.0"
     exon            1662..1830
                     /gene="Abcd1"
                     /gene_synonym="ALDP; RGD1562128"
                     /inference="alignment:Splign:2.1.0"
     exon            1831..1925
                     /gene="Abcd1"
                     /gene_synonym="ALDP; RGD1562128"
                     /inference="alignment:Splign:2.1.0"
     exon            1926..2071
                     /gene="Abcd1"
                     /gene_synonym="ALDP; RGD1562128"
                     /inference="alignment:Splign:2.1.0"
     exon            2072..2217
                     /gene="Abcd1"
                     /gene_synonym="ALDP; RGD1562128"
                     /inference="alignment:Splign:2.1.0"
     exon            2218..2302
                     /gene="Abcd1"
                     /gene_synonym="ALDP; RGD1562128"
                     /inference="alignment:Splign:2.1.0"
     exon            2303..2428
                     /gene="Abcd1"
                     /gene_synonym="ALDP; RGD1562128"
                     /inference="alignment:Splign:2.1.0"
     exon            2429..3411
                     /gene="Abcd1"
                     /gene_synonym="ALDP; RGD1562128"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cttggtgtag acgctgtggt tactgcccgg ctgcagagcg gacaaacacg cctagtgccc
       61 cggggagggg cgtcacgggg gggggggagg agcagtaaag aagagggagg tggaagggaa
      121 gagacaacct ctctgtttaa gacctctcga ggctctgacc tcaggggcta agggacaatc
      181 tgtggaggga agccagtttc ctccacccgg gctgcctgaa gaggccacga ccctggagga
      241 ttctaaccca accgatccag gggccccagc accaccccga gggcctaaag caacagtctc
      301 agggaccact tcaaggtttc cagttgccta gacaacgagc cctgggtcag agaaacagcc
      361 cttccaggat ctgcccgcaa ctgtagcctc gggcagcagt tccagccctc agcctgctca
      421 ccagtccagg tgacatgccg gtactctcca ctccctcccg gccctcgcgg gtgaccacgc
      481 ttaagcgcac agctgtggtc ctggccctca cagcctatgg agtccacaaa atctaccctc
      541 tagtacggca gtgtctgact cctgccagag gtcctcaggt gccagctggg gagtccacgc
      601 aagaggcctc tggggccacc acagccaagg ctggcatgaa ccgggtattc ctgcagcggc
      661 tcctggtgct cctgaggctg ctgttccccg gagtcttgtg ccgggaaaca gggctactgg
      721 ccctgcattc tgctgccctg gtaagccgaa ctttcctgtc tgtgtatgtt gcccgcctgg
      781 acggcagact ggcccgctgc attgtacgta aggacccaag ggcctttagc tggcaactgc
      841 tgcagtggct cctcatcgcc cttcctgcca ctttcatcaa cagtgccatc cgctacctag
      901 agggccagct ggctctttct ttccgaagcc gtctagtagc tcatgcctat ggcctctact
      961 tctcccagca gacttactac cgagtaagca acatggatgg acggcttcga aaccctgacc
     1021 agtctctgac agaggatatg gtagcctttg ctgcttctgt agcccacctt tattccaacc
     1081 tgaccaagcc actcctggat gtggctgtga cctcctacac tcttcttcga gctgcccgat
     1141 cccgaggagc tggtacagcc tggccctcag ccatcgctgg cctggtggtg ttcctcacag
     1201 ccaacgtgct tcgagccttc tctcccaagt ttggggagct agtggcagag gaggcacggc
     1261 gaaaggggga actgcgctac atgcactctc gagtggtggc caactcagag gaaattgcct
     1321 tctacggggg ccatgaggta gagctggcac tactacaaca ctcctatcaa gacctggctt
     1381 cacagatcaa cctcatcctc ctagaacgcc tgtggtatgt catgctagaa cagttcctca
     1441 tgaaatatgt gtggagtgca tctggcctgc tcatggtagc tgtccccatc atcacagcca
     1501 ctggctatgc agagtcagac tcagaagcca tgaaaaaggc agccttagaa atgaaggaag
     1561 aggagctggt tagtgaacgt acagaagcct tcaccattgc ccgaaacctc ctcacagctg
     1621 ctgcagatgc cactgagagg atcatgtcat cctacaagga ggtgacagag ctggctggct
     1681 acacagccag ggtgtacgag atgttccagg tatttgaaga tgtccaacac tgtcgtttta
     1741 agaggacagg agatctagag gaggctcagg ctgggcctgg gtccatggtg cattctggtg
     1801 ttcatataga agggcccctg aagatccaag gccaggtggt ggatgtggag caggggatca
     1861 tctgtgagaa catccctatc atcacaccca ctggagaggt ggtggtggcc agcctcaaca
     1921 tcagggtgga ggaaggcatg cacctgctca tcacaggccc caatggctgc ggcaagagtt
     1981 ctctgttccg aatcctaggt ggactctggc caacatacag tggggtactc tataagcccc
     2041 caccccagcg catgttctat atccctcaga ggccctacat gtccgtgggc tccttgcgtg
     2101 accaagtgat ctatcctgac tctgcggaag acatgcggag gaagggctgc tcggagcagc
     2161 agctggaagc catcctgggc atcgtgcatc tccgacacat cctgcaacgg gagggaggtt
     2221 gggaggctgt gtgtgactgg aaggacgtcc tttctggtgg tgagaagcag aggattggta
     2281 tggcgcgcat gttctatcac aggcccaagt acgccctcct ggatgagtgc actagtgccg
     2341 tgagcattga tgtggaaggc aagatcttcc aagcagccaa agatgctggt atctcactgc
     2401 tgtccatcac ccatcgaccc tccctatgga agtaccacac acacttgctg cagtttgatg
     2461 gggagggagg ctggaagttt gagaagctgg attctgctgc ccgcctgagc ctgactgaag
     2521 agaagcagcg cctggagcag caactggcag gcatccctaa gatgcagggg cgccttcagg
     2581 agctccgcca gatccttggc gaagctgcag ccccagttca acctctggtc ccaggcatcc
     2641 ccacttgact ggggacctta tccctagctc ccacccttct ccaagctctc ggatcacatg
     2701 aaggaagctg cagctcctat cctcccctta ctgccctgca tgccttcccc tcccaagcct
     2761 cctagccaat tacctgcttt ccctgaagac cccactctgg agcaagtaga tatgaatggg
     2821 gacactctgc attccacctt cactctgggg tctgctccag aaactgtgcc ctgttcggga
     2881 caatgtgtcc tttacttttc tctgaggagg gatggagggt ttggaaggcc ccagtcctga
     2941 ctctatacca gtatggctga gtcataggaa gtaagcagga gctgccctct tactgccagc
     3001 agccagaatg tgtgaagcct ggtggttgtg gatcacatcc ctcttaaaac ccaaaccctc
     3061 gtcattgctt tgatccatcc ctttgttgcc atcccctagg gtggccaacc aatgcccctg
     3121 tcctatagga cactcctgcc atgaaaacag cctaatggag cccaggatta gatggggccc
     3181 aaagcgtgcc cttccccatg gttaccccca gaatggcatg gttacctcct gagccatgag
     3241 aagaatgtag ccctggccct cccactcctc cacctctaca acctaattta ttggactccc
     3301 agtttatagg tgtctaaatt gccaacatga gtaccctgcc agcacaggag gtgactgggt
     3361 ggtcccttta atctacctag tctctggtgc caaacctggc ccctcactag c
//
