LOCUS       NM_013040               7266 bp    mRNA    linear   ROD 29-MAR-2024
DEFINITION  Rattus norvegicus ATP binding cassette subfamily C member 9
            (Abcc9), mRNA.
ACCESSION   NM_013040
VERSION     NM_013040.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 7266)
  AUTHORS   Gao,J., McClenaghan,C., Christiaans,I., Alders,M., van Duinen,K.,
            van Haelst,M.M., van Haaften,G. and Nichols,C.G.
  TITLE     Lymphedema as first clinical presentation of Cantu Syndrome:
            reversed phenotyping after identification of gain-of-function
            variant in ABCC9
  JOURNAL   Eur J Hum Genet 31 (2), 188-194 (2023)
   PUBMED   36336713
  REMARK    GeneRIF: Lymphedema as first clinical presentation of Cantu
            Syndrome: reversed phenotyping after identification of
            gain-of-function variant in ABCC9.
REFERENCE   2  (bases 1 to 7266)
  AUTHORS   Strutynskyi,R.B., Goncharov,S.V., Tumanovska,L.V., Nagibin,V.S. and
            Dosenko,V.E.
  TITLE     Cardiac dysfunction in spontaneously hypertensive old rats is
            associated with a significant decrease of SUR2 expression
  JOURNAL   Mol Cell Biochem 476 (12), 4343-4349 (2021)
   PUBMED   34455535
  REMARK    GeneRIF: Cardiac dysfunction in spontaneously hypertensive old rats
            is associated with a significant decrease of SUR2 expression.
REFERENCE   3  (bases 1 to 7266)
  AUTHORS   Wang,X. and Fitts,R.H.
  TITLE     Effects of regular exercise on ventricular myocyte biomechanics and
            KATP channel function
  JOURNAL   Am J Physiol Heart Circ Physiol 315 (4), H885-H896 (2018)
   PUBMED   30074836
  REMARK    GeneRIF: Up-regulation of the KATP channel accelerates
            repolarization and shortens action potential duration during stress
            and exercise.
REFERENCE   4  (bases 1 to 7266)
  AUTHORS   McClenaghan,C., Hanson,A., Sala-Rabanal,M., Roessler,H.I.,
            Josifova,D., Grange,D.K., van Haaften,G. and Nichols,C.G.
  TITLE     Cantu syndrome-associated SUR2 (ABCC9) mutations in distinct
            structural domains result in KATP channel gain-of-function by
            differential mechanisms
  JOURNAL   J Biol Chem 293 (6), 2041-2052 (2018)
   PUBMED   29275331
  REMARK    GeneRIF: D207E of Sue2 increases KATP channel activity by
            increasing intrinsic stability of the open state, whereas the
            cluster of Y981S/G985E/M1056I substitutions, as well as
            R1150Q/R1150W, augmented Mg-nucleotide activation.
REFERENCE   5  (bases 1 to 7266)
  AUTHORS   Cooper,P.E., McClenaghan,C., Chen,X., Stary-Weinzinger,A. and
            Nichols,C.G.
  TITLE     Conserved functional consequences of disease-associated mutations
            in the slide helix of Kir6.1 and Kir6.2 subunits of the
            ATP-sensitive potassium channel
  JOURNAL   J Biol Chem 292 (42), 17387-17398 (2017)
   PUBMED   28842488
REFERENCE   6  (bases 1 to 7266)
  AUTHORS   Konstas,A.A., Dabrowski,M., Korbmacher,C. and Tucker,S.J.
  TITLE     Intrinsic sensitivity of Kir1.1 (ROMK) to glibenclamide in the
            absence of SUR2B. Implications for the identity of the renal
            ATP-regulated secretory K+ channel
  JOURNAL   J Biol Chem 277 (24), 21346-21351 (2002)
   PUBMED   11927600
  REMARK    GeneRIF: Intrinsic sensitivity of Kir1.1 (ROMK) to glibenclamide in
            the absence of SUR2B.
REFERENCE   7  (bases 1 to 7266)
  AUTHORS   Szamosfalvi,B., Cortes,P., Alviani,R., Asano,K., Riser,B.L.,
            Zasuwa,G. and Yee,J.
  TITLE     Putative subunits of the rat mesangial KATP: a type 2B sulfonylurea
            receptor and an inwardly rectifying K+ channel
  JOURNAL   Kidney Int 61 (5), 1739-1749 (2002)
   PUBMED   11967023
  REMARK    GeneRIF: mesangial SUR2B as the possible first link in a chain of
            cellular events that culminates in MC contraction and altered
            extracellular matrix metabolism following exposure to
            sulfonylureas.
REFERENCE   8  (bases 1 to 7266)
  AUTHORS   Dong,K., Xu,J., Vanoye,C.G., Welch,R., MacGregor,G.G., Giebisch,G.
            and Hebert,S.C.
  TITLE     An amino acid triplet in the NH2 terminus of rat ROMK1 determines
            interaction with SUR2B
  JOURNAL   J Biol Chem 276 (47), 44347-44353 (2001)
   PUBMED   11567030
REFERENCE   9  (bases 1 to 7266)
  AUTHORS   Dorschner,H., Brekardin,E., Uhde,I., Schwanstecher,C. and
            Schwanstecher,M.
  TITLE     Stoichiometry of sulfonylurea-induced ATP-sensitive potassium
            channel closure
  JOURNAL   Mol Pharmacol 55 (6), 1060-1066 (1999)
   PUBMED   10347249
REFERENCE   10 (bases 1 to 7266)
  AUTHORS   Inagaki,N., Gonoi,T., Clement,J.P., Wang,C.Z., Aguilar-Bryan,L.,
            Bryan,J. and Seino,S.
  TITLE     A family of sulfonylurea receptors determines the pharmacological
            properties of ATP-sensitive K+ channels
  JOURNAL   Neuron 16 (5), 1011-1017 (1996)
   PUBMED   8630239
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000004.1.
            
            On Mar 25, 2021 this sequence version replaced NM_013040.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF019628.1, AF087838.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-143               JAXUCZ010000004.1  177386206-177386348 c
            144-251             JAXUCZ010000004.1  177385840-177385947 c
            252-412             JAXUCZ010000004.1  177379891-177380051 c
            413-554             JAXUCZ010000004.1  177376289-177376430 c
            555-676             JAXUCZ010000004.1  177374543-177374664 c
            677-843             JAXUCZ010000004.1  177368833-177368999 c
            844-1086            JAXUCZ010000004.1  177366470-177366712 c
            1087-1272           JAXUCZ010000004.1  177364045-177364230 c
            1273-1425           JAXUCZ010000004.1  177354847-177354999 c
            1426-1581           JAXUCZ010000004.1  177354000-177354155 c
            1582-1716           JAXUCZ010000004.1  177352072-177352206 c
            1717-1879           JAXUCZ010000004.1  177348262-177348424 c
            1880-1920           JAXUCZ010000004.1  177345448-177345488 c
            1921-2063           JAXUCZ010000004.1  177344416-177344558 c
            2064-2172           JAXUCZ010000004.1  177337608-177337716 c
            2173-2277           JAXUCZ010000004.1  177332149-177332253 c
            2278-2350           JAXUCZ010000004.1  177330180-177330252 c
            2351-2456           JAXUCZ010000004.1  177326062-177326167 c
            2457-2495           JAXUCZ010000004.1  177320485-177320523 c
            2496-2597           JAXUCZ010000004.1  177318714-177318815 c
            2598-2682           JAXUCZ010000004.1  177318338-177318422 c
            2683-2763           JAXUCZ010000004.1  177316623-177316703 c
            2764-2901           JAXUCZ010000004.1  177313027-177313164 c
            2902-3027           JAXUCZ010000004.1  177312769-177312894 c
            3028-3124           JAXUCZ010000004.1  177307573-177307669 c
            3125-3354           JAXUCZ010000004.1  177301562-177301791 c
            3355-3503           JAXUCZ010000004.1  177300541-177300689 c
            3504-3573           JAXUCZ010000004.1  177300270-177300339 c
            3574-3731           JAXUCZ010000004.1  177298999-177299156 c
            3732-3824           JAXUCZ010000004.1  177294245-177294337 c
            3825-3927           JAXUCZ010000004.1  177287605-177287707 c
            3928-4029           JAXUCZ010000004.1  177279618-177279719 c
            4030-4150           JAXUCZ010000004.1  177278717-177278837 c
            4151-4281           JAXUCZ010000004.1  177277082-177277212 c
            4282-4360           JAXUCZ010000004.1  177276340-177276418 c
            4361-4469           JAXUCZ010000004.1  177274601-177274709 c
            4470-4573           JAXUCZ010000004.1  177273096-177273199 c
            4574-4707           JAXUCZ010000004.1  177272160-177272293 c
            4708-4770           JAXUCZ010000004.1  177269154-177269216 c
            4771-7266           JAXUCZ010000004.1  177262848-177265343 c
FEATURES             Location/Qualifiers
     source          1..7266
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q44"
     gene            1..7266
                     /gene="Abcc9"
                     /gene_synonym="Sur2"
                     /note="ATP binding cassette subfamily C member 9"
                     /db_xref="GeneID:25560"
                     /db_xref="RGD:3787"
     exon            1..143
                     /gene="Abcc9"
                     /gene_synonym="Sur2"
                     /inference="alignment:Splign:2.1.0"
     exon            144..251
                     /gene="Abcc9"
                     /gene_synonym="Sur2"
                     /inference="alignment:Splign:2.1.0"
     exon            252..412
                     /gene="Abcc9"
                     /gene_synonym="Sur2"
                     /inference="alignment:Splign:2.1.0"
     CDS             271..4908
                     /gene="Abcc9"
                     /gene_synonym="Sur2"
                     /note="ATP-binding cassette transporter sub-family C
                     member 9; Sulfonylurea receptor 2; ATP-binding cassette,
                     sub-family C (CFTR/MRP), member 9; ATP-binding cassette,
                     subfamily C (CFTR/MRP), member 9; ATP-binding cassette,
                     sub-family C, member 9-like"
                     /codon_start=1
                     /product="ATP-binding cassette sub-family C member 9"
                     /protein_id="NP_037172.2"
                     /db_xref="GeneID:25560"
                     /db_xref="RGD:3787"
                     /translation="MSLSFCGNNISSYNIYHGVLQNPCFVDALNLVPHVFLLFITFPI
                     LFIGWGSQSSKVQIHHNTWLHFPGHNLRWILTFALLFVHVCEIAEGIVSDSQRASRHL
                     HLFMPAVMGFVATTTSIVYYHNIETSNFPKLLLALFLYWVMAFITKTIKLVKYWQLGW
                     GMSDLRFCITGVMVILNGLLMAVEINVIRVRRYVFFMNPQKVKPPEDLQDLGVRFLQP
                     FVNLLSKATYWWMNTLIISAHRKPIDLKAIGKLPIAMRAVTNYVCLKEAYEEQKKKAA
                     DHPNRTPSIWLAMYRAFGRPILLSSTFRYLADLLGFAGPLCISGIVQRVNEPKNNTTR
                     FSETLSSKEFLENAHVLAVLLFLALILQRTFLQASYYVTIETGINLRGALLAMIYNKI
                     LRLSTSNLSMGEMTLGQINNLVAIETNQLMWFLFLCPNLWAMPVQIIMGVILLYNLLG
                     SSALVGAAVIVLLAPIQYFIATKLAEAQKSTLDYSTERLKKTNEILKGIKLLKLYAWE
                     HIFCKSVEETRMKELSSLKTFALYTSLSIFMNAAIPIAAVLATFVTHAYASGNNLKPA
                     EAFASLSLFHILVTPLFLLSTVVRFAVKAIISVQKLNEFLLSDEIGEDSWRTGEGTLP
                     FESCKKHTGVQSKPINRKQPGRYHLDNYEQARRLRPAETEDVAIKVTNGYFSWGSGLA
                     TLSNIDIRIPTGQLTMIVGQVGCGKSSLLLAILGEMQTLEGKVYWNNVNESEPSFEAT
                     RSRSRYSVAYAAQKPWLLNATVEENITFGSSFNRQRYKAVTDACSLQPDIDLLPFGDQ
                     TEIGERGINLSGGQRQRICVARALYQNTNIVFLDDPFSALDIHLSDHLMQEGILKFLQ
                     DDKRTVVLVTHKLQYLTHADWIIAMKDGSVLREGTLKDIQTKDVELYEHWKTLMNRQD
                     QELEKDMEADQTTLERKTLRRAMYSREAKAQMEDEDEEEEEEEDEDDNMSTVMRLRTK
                     MPWKTCWWYLTSGGFFLLFLMIFSKLLKHSVIVAIDYWLATWTSEYSINDPGKADQTF
                     YVAGFSILCGAGIFLCLVTSLTVEWMGLTAAKNLHHNLLNKIILGPIRFFDTTPLGLI
                     LNRFSADTNIIDQHIPPTLESLTRSTLLCLSAIGMISYATPVFLIALAPLGVAFYFIQ
                     KYFRVASKDLQELDDSTQLPLLCHFSETAEGLTTIRAFRHETRFKQRMLELTDTNNIA
                     YLFLSAANRWLEVRTDYLGACIVLTASIASISGSSNSGLVGLGLLYALTITNYLNWVV
                     RNLADLEVQMGAVKKVNSFLTMESENYEGTMDPSQVPEHWPQEGEIKIHDLCVRYENN
                     LKPVLKHVKAYIKPGQKVGICGRTGSGKSSLSLAFFRMVDIFDGKIVIDGIDISKLPL
                     HTLRSRLSIILQDPILFSGSIRFNLDPECKCTDDRLWEALEIAQLKNMVKSLPGGLDA
                     TVTEGGENFSVGQRQLFCLARAFVRKSSILIMDEATASIDMATENILQKVVMTAFADR
                     TVVTIAHRVHTILTADLVIVMKRGNILEYDTPESLLAQEDGVFASFVRADM"
     exon            413..554
                     /gene="Abcc9"
                     /gene_synonym="Sur2"
                     /inference="alignment:Splign:2.1.0"
     exon            555..676
                     /gene="Abcc9"
                     /gene_synonym="Sur2"
                     /inference="alignment:Splign:2.1.0"
     exon            677..843
                     /gene="Abcc9"
                     /gene_synonym="Sur2"
                     /inference="alignment:Splign:2.1.0"
     exon            844..1086
                     /gene="Abcc9"
                     /gene_synonym="Sur2"
                     /inference="alignment:Splign:2.1.0"
     exon            1087..1272
                     /gene="Abcc9"
                     /gene_synonym="Sur2"
                     /inference="alignment:Splign:2.1.0"
     exon            1273..1425
                     /gene="Abcc9"
                     /gene_synonym="Sur2"
                     /inference="alignment:Splign:2.1.0"
     exon            1426..1581
                     /gene="Abcc9"
                     /gene_synonym="Sur2"
                     /inference="alignment:Splign:2.1.0"
     exon            1582..1716
                     /gene="Abcc9"
                     /gene_synonym="Sur2"
                     /inference="alignment:Splign:2.1.0"
     exon            1717..1879
                     /gene="Abcc9"
                     /gene_synonym="Sur2"
                     /inference="alignment:Splign:2.1.0"
     exon            1880..1920
                     /gene="Abcc9"
                     /gene_synonym="Sur2"
                     /inference="alignment:Splign:2.1.0"
     exon            1921..2063
                     /gene="Abcc9"
                     /gene_synonym="Sur2"
                     /inference="alignment:Splign:2.1.0"
     exon            2064..2172
                     /gene="Abcc9"
                     /gene_synonym="Sur2"
                     /inference="alignment:Splign:2.1.0"
     exon            2173..2277
                     /gene="Abcc9"
                     /gene_synonym="Sur2"
                     /inference="alignment:Splign:2.1.0"
     exon            2278..2350
                     /gene="Abcc9"
                     /gene_synonym="Sur2"
                     /inference="alignment:Splign:2.1.0"
     exon            2351..2456
                     /gene="Abcc9"
                     /gene_synonym="Sur2"
                     /inference="alignment:Splign:2.1.0"
     exon            2457..2495
                     /gene="Abcc9"
                     /gene_synonym="Sur2"
                     /inference="alignment:Splign:2.1.0"
     exon            2496..2597
                     /gene="Abcc9"
                     /gene_synonym="Sur2"
                     /inference="alignment:Splign:2.1.0"
     exon            2598..2682
                     /gene="Abcc9"
                     /gene_synonym="Sur2"
                     /inference="alignment:Splign:2.1.0"
     exon            2683..2763
                     /gene="Abcc9"
                     /gene_synonym="Sur2"
                     /inference="alignment:Splign:2.1.0"
     exon            2764..2901
                     /gene="Abcc9"
                     /gene_synonym="Sur2"
                     /inference="alignment:Splign:2.1.0"
     exon            2902..3027
                     /gene="Abcc9"
                     /gene_synonym="Sur2"
                     /inference="alignment:Splign:2.1.0"
     exon            3028..3124
                     /gene="Abcc9"
                     /gene_synonym="Sur2"
                     /inference="alignment:Splign:2.1.0"
     exon            3125..3354
                     /gene="Abcc9"
                     /gene_synonym="Sur2"
                     /inference="alignment:Splign:2.1.0"
     exon            3355..3503
                     /gene="Abcc9"
                     /gene_synonym="Sur2"
                     /inference="alignment:Splign:2.1.0"
     exon            3504..3573
                     /gene="Abcc9"
                     /gene_synonym="Sur2"
                     /inference="alignment:Splign:2.1.0"
     exon            3574..3731
                     /gene="Abcc9"
                     /gene_synonym="Sur2"
                     /inference="alignment:Splign:2.1.0"
     exon            3732..3824
                     /gene="Abcc9"
                     /gene_synonym="Sur2"
                     /inference="alignment:Splign:2.1.0"
     exon            3825..3927
                     /gene="Abcc9"
                     /gene_synonym="Sur2"
                     /inference="alignment:Splign:2.1.0"
     exon            3928..4029
                     /gene="Abcc9"
                     /gene_synonym="Sur2"
                     /inference="alignment:Splign:2.1.0"
     exon            4030..4150
                     /gene="Abcc9"
                     /gene_synonym="Sur2"
                     /inference="alignment:Splign:2.1.0"
     exon            4151..4281
                     /gene="Abcc9"
                     /gene_synonym="Sur2"
                     /inference="alignment:Splign:2.1.0"
     exon            4282..4360
                     /gene="Abcc9"
                     /gene_synonym="Sur2"
                     /inference="alignment:Splign:2.1.0"
     exon            4361..4469
                     /gene="Abcc9"
                     /gene_synonym="Sur2"
                     /inference="alignment:Splign:2.1.0"
     exon            4470..4573
                     /gene="Abcc9"
                     /gene_synonym="Sur2"
                     /inference="alignment:Splign:2.1.0"
     exon            4574..4707
                     /gene="Abcc9"
                     /gene_synonym="Sur2"
                     /inference="alignment:Splign:2.1.0"
     exon            4708..4770
                     /gene="Abcc9"
                     /gene_synonym="Sur2"
                     /inference="alignment:Splign:2.1.0"
     exon            4771..7266
                     /gene="Abcc9"
                     /gene_synonym="Sur2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agcagctggc ctcccaccac cctaaaaata atccactcgc cgctgtctgc tgacccggga
       61 ggaaaacttg tcatcccatg gagtgtgtga gctcctcggc ttgctccaga gagatcctca
      121 accgctttga ggagtcagtg actgagttct gtgaacttgt ttgaaattta catcttcaga
      181 ctgtgcgcag gcggttggaa ggtagatcaa gtgcaccagt agggggacta agttcctgag
      241 ccaaagtcaa ggctaatcaa ctaagaagaa atgagccttt ccttctgtgg taacaacatc
      301 tcctcctaca acatctacca tggtgttctc caaaacccct gctttgtgga cgcactcaac
      361 ctggtccctc acgtcttcct gctgtttatc acctttccga tcctgttcat tggatggggg
      421 agccaaagct caaaagtgca aattcatcac aacacatggc ttcattttcc tggacacaac
      481 ctgagatgga ttctgacgtt tgcactcctg ttcgtgcatg tctgcgagat agcagaaggc
      541 attgtttcag actcgcaacg ggcgtccagg catctccacc ttttcatgcc ggctgtgatg
      601 ggatttgtcg ccaccaccac atccattgtg tattaccaca acattgaaac atcaaacttc
      661 cctaaattac ttttagcttt attcctgtac tgggtcatgg ccttcattac aaagacaata
      721 aagttggtca aatactggca gttggggtgg ggaatgtcag acctgcgctt ctgcatcacg
      781 ggagtgatgg tcatcttgaa tggactgctg atggctgtgg agatcaatgt catccgggtc
      841 cgaagatatg ttttcttcat gaatcctcag aaagtgaagc ctccagagga cctccaggac
      901 ctgggcgtga ggttcctcca gccgtttgtg aatttgctgt ccaaagctac ttactggtgg
      961 atgaacacgc ttatcatatc agctcacagg aaacctattg atctgaaggc gatcggaaag
     1021 ttgccgatag caatgagggc ggtgacgaat tatgtttgct tgaaggaggc ctatgaagag
     1081 cagaagaaaa aggctgcgga tcatccgaat cggactccct ccatatggct ggccatgtac
     1141 agggcttttg ggagaccgat cctgctgagc agcacgttcc gctacttggc tgacttgctg
     1201 ggctttgccg gccctctttg tatttccgga atcgtccagc gtgtgaatga accgaagaat
     1261 aacacgacga gattttcaga gacactctca tcgaaggagt ttctggaaaa tgcccatgtg
     1321 ctggctgtcc tgctcttcct ggccctcatc ctgcaaagga catttttgca ggcttcctac
     1381 tatgtgacca tagagaccgg catcaacctg cgtggggctc tgctggctat gatctacaac
     1441 aaaatccttc gactgtctac ttctaaccta tccatgggcg agatgaccct gggacagatc
     1501 aacaacttgg ttgccataga aaccaatcag ctcatgtggt tcttgttcct gtgtcccaat
     1561 ctgtgggcca tgcccgttca gatcataatg ggggtgatcc tgctctataa tctgcttggg
     1621 tcaagcgcac tggtaggcgc ggcggtcatc gtgctcctcg caccgattca gtacttcatc
     1681 gccacgaagc tggcggaggc tcagaagagc actctggatt attccaccga gaggctgaag
     1741 aagacaaacg agatactgaa aggcatcaag ctccttaagc tgtatgcctg ggagcacatt
     1801 ttctgcaaga gcgtggaaga gactagaatg aaggagctct ccagcctcaa aaccttcgcg
     1861 ctctacacgt cgctttccat cttcatgaac gcagccattc ccatcgcagc cgttcttgca
     1921 acatttgtga cccatgccta tgccagtggc aacaacctga aacccgcaga ggcctttgcc
     1981 tctctgtctc tcttccacat cctcgtcaca ccgctcttcc tgctgtccac ggtggtcaga
     2041 ttcgcagtga aagccatcat cagcgttcag aagctgaatg agtttctctt gagcgatgag
     2101 attggcgagg acagctggag gactggggag gggacgctgc cttttgagtc ctgtaagaag
     2161 cacaccggag tgcaatcaaa accgataaac aggaagcagc ctggaaggta ccacctggac
     2221 aactacgagc aggcgcggcg tcttcggcct gctgagactg aagatgttgc cataaaggtg
     2281 acgaacggat acttctcatg gggcagtggt ttagccacat tatccaatat tgacattcga
     2341 attccaacag gtcagctaac catgattgtg ggtcaggtgg gttgtggcaa atcgtctctc
     2401 ctccttgcca tccttggtga gatgcagacc ctggaaggaa aagtttactg gaacaatgta
     2461 aatgaatctg agccttcttt tgaagcaacc cgaagcagaa gcaggtactc tgtggcttat
     2521 gctgcccaga agccttggct cctcaatgct acggtcgagg aaaacatcac ttttggaagt
     2581 tctttcaaca gacagaggta caaggctgtc accgatgcct gctctctgca gccagacatt
     2641 gatttgttac cctttggaga ccaaactgaa attggagaga ggggtatcaa cctgagtggg
     2701 ggtcagaggc agagaatctg cgtggcccgg gcactctacc agaacaccaa tattgtcttc
     2761 ttggacgatc cattctccgc tctggacatc cacctgagcg accacttgat gcaggaaggg
     2821 atcctgaagt ttctccagga cgacaagagg acggtcgtcc ttgtgactca caaactacag
     2881 tacctgacgc acgcggactg gatcatagcc atgaaggatg ggagtgtgtt aagggaaggg
     2941 actttgaaag acatccagac caaagacgtg gagctctatg aacactggaa aaccctcatg
     3001 aatcggcaag atcaggaatt agaaaaggac atggaagccg accaaacaac gctggagagg
     3061 aagactctcc gaagagctat gtactcaagg gaggccaaag cacagatgga ggatgaagat
     3121 gaagaggagg aggaggagga agatgaggac gacaacatgt caactgtaat gaggctcagg
     3181 acgaagatgc cctggaagac ctgttggtgg tacctcactt caggagggtt tttcctgctc
     3241 ttcctcatga tcttctctaa gcttttgaag cactctgtga tcgtggccat cgactactgg
     3301 ctagctacgt ggacctccga gtacagtata aacgacccag ggaaagctga ccagaccttc
     3361 tatgtggctg ggttcagcat cctctgtgga gcgggcattt tcctttgcct cgtcacctcc
     3421 ctcactgtag aatggatggg tctcaccgcc gccaagaacc tccaccacaa tctcctcaat
     3481 aagataattc tgggcccaat aaggttcttt gataccacgc ccctgggact gatcctcaat
     3541 cggttttctg ctgataccaa catcatcgac caacatatcc ctccgacctt ggagtcgctg
     3601 acccgctcta ccctgctctg cctgtcggct attgggatga tctcctatgc tacacccgtg
     3661 tttctcatcg ctcttgcgcc cctgggcgtc gccttttatt tcatccagaa atacttccgg
     3721 gttgcctcta aggatctcca ggaactcgat gacagcaccc agctccccct gctttgtcac
     3781 ttctcagaaa cagctgaagg gcttaccact atccgggcct tcaggcatga aaccagattc
     3841 aagcaacgca tgctggagct gacagacaca aacaacattg cctacttatt tctctccgca
     3901 gccaacagat ggctggaggt caggacggac tacctgggag cttgcattgt tctgacggcc
     3961 tccattgcat ccatcagtgg ctcttccaac tctggactag tgggcttggg ccttctgtat
     4021 gccctcacga taaccaatta cctgaattgg gttgtaagga acttggccga cctcgaagtc
     4081 cagatgggcg cagtgaagaa agtgaacagt ttcttaacta tggagtctga gaactatgaa
     4141 ggcaccatgg atccttctca agtcccagag cattggccac aggaaggtga gatcaagatt
     4201 cacgatctat gcgtcagata tgaaaataac ctgaagcccg ttctgaaaca tgtcaaggct
     4261 tacatcaagc ctgggcagaa ggtgggcatc tgtggtcgca ccggtagtgg gaagtcctct
     4321 ctatctctgg ctttcttcag aatggtcgac atatttgatg gaaagatagt cattgatgga
     4381 atagacattt ccaagctgcc cttgcacacg ctccgctcta gactgtccat cattctccag
     4441 gacccaatcc tgttcagcgg ctctatcaga tttaacttgg atcctgaatg caagtgcaca
     4501 gacgacaggc tctgggaggc tctggaaatt gctcagttga agaatatggt caaatctctg
     4561 ccaggaggcc tagacgccac tgtcaccgaa ggtggtgaga acttcagcgt tggacagaga
     4621 cagctgttct gcctggccag ggcctttgtt cgaaagagca gcatactcat tatggatgag
     4681 gccacggcct ccatcgacat ggccacggaa aacattttgc agaaagtagt catgacagcc
     4741 tttgcggatc gcacggttgt aaccatagct catcgggttc acaccattct gactgctgac
     4801 ctggtcattg tgatgaagag aggaaacatt ttggaatacg acaccccgga aagcctcttg
     4861 gcccaggagg atggagtgtt cgcctcgttc gttcgtgcgg acatgtgaca ggattacatc
     4921 acaacagcac ctgtgtctcg atgcctaccg tcgcccacca gagggatccc ccaactttgc
     4981 ctcggaaggg tggcgccgga aacttcgaca gacttctgta tggaaagtag agatttctgt
     5041 ttcctgtttt ggtctgaggg acactccctg taggttcatc gtgggtgttg tactgtgatc
     5101 aggccacact ggaaaggtag cctatgctaa aacatgccag cgaccttaag gggtaaatct
     5161 gtcgatgtct gtcaagcact ggagctgaaa tgagtcgtct gtgctaccac actctcatta
     5221 ggaagactag cactgccctg ctgttgatga agaaaattca ttttctaaca aaatactcac
     5281 gttcatgatc cataggagag tcttttctgt gcatttaaca ttgttgatat ttttttttaa
     5341 cttttcccct tttaaatcat ttcctgtcac cacgaagcta tcatatttag tacctctata
     5401 aagccgaccc ctcacaagag aaagatcatg aaaagagatt gaatatttga aaatattatt
     5461 tgtttccatt tgcctccatc caataaggag gaagttcaag ttagcttcag tccttcagca
     5521 atgggccacc taaactaagc tttctagagt ttaattcttt atcagccaaa caatggctct
     5581 gaaccctgaa atgctatatt atctagggcc caaaagaata tagatgaatg gccttatctg
     5641 tcacacacac agacacacac acacacacac acacacacac atatacatac acatcttcat
     5701 gccatatctt ggctgtatgc taatcttggc atgtgcacat tcctcgaagg ttccagatat
     5761 cccctaccct acatctctgt gggaagatag aaatagttcc cactctgaat ctacacaggt
     5821 agcaagtgtt tattttcact tgggcaaatt tcagtggcag acattgatgt cacacatgtg
     5881 gccattggtc ctgttctaat ttatagagtg taccagaagt ctatatgata ttagtgtcac
     5941 atttcattta actgcccatt aataaagcca aactgactga agttcacttc cctgttatcc
     6001 cagcttccac agtttctgta acctttaacc atcagatata agcactgctc aattccatat
     6061 gagggtctcc acagaaaata gatgccccat ccccaccgtt cctgtagtca tattgcgttc
     6121 tttattctgt gtcaagactt atagttcttg tgcatcgaga tatttcaagg tgcctttatg
     6181 gatatagaac gtaatataag aaaaacgttc atagagatag acagaaacgg cccaggttac
     6241 ttagcctaat tagtcacctt ttcttccata tcaaaaactt cattagaaaa aaataatagt
     6301 attatttgca gaaagctagt aggtcacagc tattagcaat gagttcaacc tcaaaagtac
     6361 ttcataagag aatcgactaa tctactaaaa tattgctggt gtgagaaggt tctgctgggg
     6421 ctggataccc atgacgtttg ttgtcagtca gtgtctcctt ctctcctaga aatggcattc
     6481 atctacagaa gtagctccct cgctgtagcc cactacgcca tcctgtgcaa aagtgacttt
     6541 cgtttcctcg aaacttttac ttacttgatt tgcaaaaaac aaacaaacaa aaaaaaaaac
     6601 aaacaaacaa aacacctacc aaacgaagtc tggtgacatc tcagtcagtc gatcaggaat
     6661 tgcgttgtct gggtgacctg caatgacaga aaggagcttt tactgtagtt aagactgtaa
     6721 gaaaagaaaa tcgcctccac agagttaaat tttacatcga tataaccaaa tcgaattcac
     6781 acagattgat cctatcctgt ctgtgaaaag caagaagtgc agatgtgttc atgataaaat
     6841 gacagggttg ttggggtcgc cctgtgtata aggatcgctt tcctcaaagg ttgtggcgca
     6901 cacaccctgc cactactcct catgactctt ctagatgtag gttagacact gaaagatctt
     6961 tctaagcatc tggtgtgatc aggaccttat cttgtccatc ttcctgtgcc cttggcacta
     7021 aaacaagtgc atggctccaa ataaataaag tggtttctcc ccggacttct tcttttattt
     7081 ttcttttaac ttctcgtcat gtggctataa ctgtgggctc ctcttgactt cctctttact
     7141 acgcttatcc tatttattct cagtatatgg aattcattta ttatgcgcac tgtatgtttt
     7201 ctctctgtag tacatgagag cttattggct taccttatat aataaattaa ccctttgttt
     7261 acccaa
//
