LOCUS       NM_013039               4912 bp    mRNA    linear   ROD 14-FEB-2025
DEFINITION  Rattus norvegicus ATP binding cassette subfamily C member 8
            (Abcc8), transcript variant 1, mRNA.
ACCESSION   NM_013039
VERSION     NM_013039.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4912)
  AUTHORS   Li,Y., Ba,M., Du,Y., Xia,C., Tan,S., Ng,K.P. and Ma,G.
  TITLE     Abeta1-42 increases the expression of neural KATP subunits
            Kir6.2/SUR1 via the NF-kappaB, p38 MAPK and PKC signal pathways in
            rat primary cholinergic neurons
  JOURNAL   Hum Exp Toxicol 38 (6), 665-674 (2019)
   PUBMED   30868916
  REMARK    GeneRIF: Our findings suggest that the NF-kappaB, p38 MAPK, and PKC
            signal pathways are partially involved in the upregulation of KATP
            subunits Kir6.2/SUR1 expression induced by Abeta1-42 cytotoxicity
            in neurons, which supports a potential theoretical basis of
            targeting these signal pathways in the treatment of Alzheimer's
            disease.
REFERENCE   2  (bases 1 to 4912)
  AUTHORS   Zhou,X., Xu,C., Zou,Z., Shen,X., Xie,T., Zhang,R., Liao,L. and
            Dong,J.
  TITLE     aThe characteristics of glucose metabolism in the sulfonylurea
            receptor 1 knockout rat model
  JOURNAL   Mol Med 25 (1), 2 (2019)
   PUBMED   30616503
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4912)
  AUTHORS   Cooper,P.E., McClenaghan,C., Chen,X., Stary-Weinzinger,A. and
            Nichols,C.G.
  TITLE     Conserved functional consequences of disease-associated mutations
            in the slide helix of Kir6.1 and Kir6.2 subunits of the
            ATP-sensitive potassium channel
  JOURNAL   J Biol Chem 292 (42), 17387-17398 (2017)
   PUBMED   28842488
REFERENCE   4  (bases 1 to 4912)
  AUTHORS   Martin,G.M., Yoshioka,C., Rex,E.A., Fay,J.F., Xie,Q., Whorton,M.R.,
            Chen,J.Z. and Shyng,S.L.
  TITLE     Cryo-EM structure of the ATP-sensitive potassium channel
            illuminates mechanisms of assembly and gating
  JOURNAL   Elife 6, e24149 (2017)
   PUBMED   28092267
  REMARK    GeneRIF: Intricate interactions between TMD0, the loop following
            TMD0, and Kir6.2 near the proposed PIP2 binding site, and where ATP
            density is observed, suggest SUR1 may contribute to ATP and PIP2
            binding to enhance Kir6.2 sensitivity to both.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4912)
  AUTHORS   Nicholson,J.D., Guo,Y. and Bernstein,S.L.
  TITLE     SUR1-Associated Mechanisms Are Not Involved in Ischemic Optic
            Neuropathy 1 Day Post-Injury
  JOURNAL   PLoS One 11 (8), e0148855 (2016)
   PUBMED   27560494
  REMARK    GeneRIF: Despite its importance in central nervous system (CNS)
            injuries, sulfonylurea receptor 1 (SUR1) upregulation appears to
            play no part in rodent anterior ischemic optic neuropathy (rAION)
            injury.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4912)
  AUTHORS   Verkarre,V., Fournet,J.C., de Lonlay,P., Gross-Morand,M.S.,
            Devillers,M., Rahier,J., Brunelle,F., Robert,J.J.,
            Nihoul-Fekete,C., Saudubray,J.M. and Junien,C.
  TITLE     Paternal mutation of the sulfonylurea receptor (SUR1) gene and
            maternal loss of 11p15 imprinted genes lead to persistent
            hyperinsulinism in focal adenomatous hyperplasia
  JOURNAL   J Clin Invest 102 (7), 1286-1291 (1998)
   PUBMED   9769320
REFERENCE   7  (bases 1 to 4912)
  AUTHORS   Hirohashi,T., Suzuki,H., Ito,K., Ogawa,K., Kume,K., Shimizu,T. and
            Sugiyama,Y.
  TITLE     Hepatic expression of multidrug resistance-associated protein-like
            proteins maintained in eisai hyperbilirubinemic rats
  JOURNAL   Mol Pharmacol 53 (6), 1068-1075 (1998)
   PUBMED   9614210
REFERENCE   8  (bases 1 to 4912)
  AUTHORS   Nelson,D.A., Bryan,J., Wechsler,S., Clement,J.P. 4th and
            Aguilar-Bryan,L.
  TITLE     The high-affinity sulfonylurea receptor: distribution,
            glycosylation, purification, and immunoprecipitation of two forms
            from endocrine and neuroendocrine cell lines
  JOURNAL   Biochemistry 35 (47), 14793-14799 (1996)
   PUBMED   8942641
REFERENCE   9  (bases 1 to 4912)
  AUTHORS   Thomas,P.M., Cote,G.J., Wohllk,N., Haddad,B., Mathew,P.M., Rabl,W.,
            Aguilar-Bryan,L., Gagel,R.F. and Bryan,J.
  TITLE     Mutations in the sulfonylurea receptor gene in familial persistent
            hyperinsulinemic hypoglycemia of infancy
  JOURNAL   Science 268 (5209), 426-429 (1995)
   PUBMED   7716548
REFERENCE   10 (bases 1 to 4912)
  AUTHORS   Aguilar-Bryan,L., Nichols,C.G., Wechsler,S.W., Clement,J.P. 4th,
            Boyd,A.E. 3rd, Gonzalez,G., Herrera-Sosa,H., Nguy,K., Bryan,J. and
            Nelson,D.A.
  TITLE     Cloning of the beta cell high-affinity sulfonylurea receptor: a
            regulator of insulin secretion
  JOURNAL   Science 268 (5209), 423-426 (1995)
   PUBMED   7716547
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Sep 14, 2022 this sequence version replaced NM_013039.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X97279.1, AB052294.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-216               JAXUCZ010000001.1  105815767-105815982 c
            217-358             JAXUCZ010000001.1  105814341-105814482 c
            359-480             JAXUCZ010000001.1  105809513-105809634 c
            481-647             JAXUCZ010000001.1  105805952-105806118 c
            648-890             JAXUCZ010000001.1  105802951-105803193 c
            891-1079            JAXUCZ010000001.1  105802009-105802197 c
            1080-1244           JAXUCZ010000001.1  105787719-105787883 c
            1245-1400           JAXUCZ010000001.1  105784932-105785087 c
            1401-1535           JAXUCZ010000001.1  105781694-105781828 c
            1536-1698           JAXUCZ010000001.1  105780723-105780885 c
            1699-1739           JAXUCZ010000001.1  105770262-105770302 c
            1740-1885           JAXUCZ010000001.1  105768691-105768836 c
            1886-1991           JAXUCZ010000001.1  105767587-105767692 c
            1992-2108           JAXUCZ010000001.1  105767327-105767443 c
            2109-2184           JAXUCZ010000001.1  105766905-105766980 c
            2185-2290           JAXUCZ010000001.1  105766244-105766349 c
            2291-2323           JAXUCZ010000001.1  105757464-105757496 c
            2324-2362           JAXUCZ010000001.1  105755367-105755405 c
            2363-2461           JAXUCZ010000001.1  105754370-105754468 c
            2462-2546           JAXUCZ010000001.1  105753345-105753429 c
            2547-2627           JAXUCZ010000001.1  105752627-105752707 c
            2628-2765           JAXUCZ010000001.1  105750973-105751110 c
            2766-2891           JAXUCZ010000001.1  105749563-105749688 c
            2892-2991           JAXUCZ010000001.1  105748608-105748707 c
            2992-3233           JAXUCZ010000001.1  105747819-105748060 c
            3234-3400           JAXUCZ010000001.1  105747464-105747630 c
            3401-3470           JAXUCZ010000001.1  105746381-105746450 c
            3471-3628           JAXUCZ010000001.1  105745786-105745943 c
            3629-3721           JAXUCZ010000001.1  105743568-105743660 c
            3722-3824           JAXUCZ010000001.1  105740025-105740127 c
            3825-3938           JAXUCZ010000001.1  105739223-105739336 c
            3939-4059           JAXUCZ010000001.1  105738774-105738894 c
            4060-4190           JAXUCZ010000001.1  105738541-105738671 c
            4191-4269           JAXUCZ010000001.1  105737660-105737738 c
            4270-4378           JAXUCZ010000001.1  105737380-105737488 c
            4379-4482           JAXUCZ010000001.1  105737022-105737125 c
            4483-4616           JAXUCZ010000001.1  105736271-105736404 c
            4617-4679           JAXUCZ010000001.1  105735940-105736002 c
            4680-4912           JAXUCZ010000001.1  105734992-105735224 c
FEATURES             Location/Qualifiers
     source          1..4912
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q22"
     gene            1..4912
                     /gene="Abcc8"
                     /gene_synonym="Sur; Sur1"
                     /note="ATP binding cassette subfamily C member 8"
                     /db_xref="GeneID:25559"
                     /db_xref="RGD:3786"
     exon            1..216
                     /gene="Abcc8"
                     /gene_synonym="Sur; Sur1"
                     /inference="alignment:Splign:2.1.0"
     CDS             69..4817
                     /gene="Abcc8"
                     /gene_synonym="Sur; Sur1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     ATP-binding cassette transporter sub-family C member 8;
                     ATP-binding cassette sub-family C member 8; sulfonylurea
                     receptor 1; ATP-binding cassette, sub-family C (CFTR/MRP),
                     member 8; sulphonylurea receptor 1; ATP-binding cassette,
                     subfamily C (CFTR/MRP), member 8"
                     /codon_start=1
                     /product="ATP-binding cassette sub-family C member 8
                     isoform 1"
                     /protein_id="NP_037171.2"
                     /db_xref="GeneID:25559"
                     /db_xref="RGD:3786"
                     /translation="MPLAFCGTENHSAAYRVDQGVLNNGCFVDALNVVPHVFLLFITF
                     PILFIGWGSQSSKVHIHHSTWLHFPGHNLRWILTFILLFVLVCEIAEGILSDGVTESR
                     HLHLYMPAGMAFMAAITSVVYYHNIETSNFPKLLIALLIYWTLAFITKTIKFVKFYDH
                     AIGFSQLRFCLTGLLVILYGMLLLVEVNVIRVRRYVFFKTPREVKPPEDLQDLGVRFL
                     QPFVNLLSKGTYWWMNAFIKTAHKKPIDLRAIGKLPIAMRALTNYQRLCLAFDAQARK
                     DTQSQQGARAIWRALCHAFGRRLVLSSTFRILADLLGFAGPLCIFGIVDHLGKENHVF
                     QPKTQFLGVYFVSSQEFLGNAYVLAVLLFLALLLQRTFLQASYYVAIETGINLRGAIQ
                     TKIYNKIMHLSTSNLSMGEMTAGQICNLVAIDTNQLMWFFFLCPNLWAMPVQIIVGVI
                     LLYYILGVSALIGAAVIILLAPVQYFVATKLSQAQRSTLEYSNERLKQTNEMLRGIKL
                     LKLYAWENIFCSRVEKTRRKEMTSLRAFAVYTSISIFMNTAIPIAAVLITFVGHVSFF
                     KESDFSPSVAFASLSLFHILVTPLFLLSSVVRSTVKALVSVQKLSEFLSSAEIREEQC
                     APREPAPQGQAGKYQAVPLKVVNRKRPAREEVRDLLGPLQRLTPSTDGDADNFCVQII
                     GGFFTWTPDGIPTLSNITIRIPRGQLTMIVGQVGCGKSSLLLATLGEMQKVSGAVFWN
                     SSLPDSEGEDPSNPERETAADSDARSRGPVAYASQKPWLLNATVEENITFESPFNKQR
                     YKMVIEACSLQPDIDILPHGDQTQIGERGINLSGGQRQRISVARALYQHTNVVFLDDP
                     FSALDVHLSDHLMQAGILELLRDDKRTVVLVTHKLQYLPHADWIIAMKDGTIQREGTL
                     KDFQRSECQLFEHWKTLMNRQDQELEKETVMERKAPEPSQGLPRAMSSRDGLLLDEDE
                     EEEEAAESEEDDNLSSVLHQRAKIPWRACTKYLSSAGILLLSLLVFSQLLKHMVLVAI
                     DYWLAKWTDSALVLSPAARNCSLSQECALDQSVYAMVFTVLCSLGIALCLVTSVTVEW
                     TGLKVAKRLHRSLLNRIILAPMRFFETTPLGSILNRFSSDCNTIDQHIPSTLECLSRS
                     TLLCVSALAVISYVTPVFLVALLPLAVVCYFIQKYFRVASRDLQQLDDTTQLPLLSHF
                     AETVEGLTTIRAFRYEARFQQKLLEYTDSNNIASLFLTAANRWLEVRMEYIGACVVLI
                     AAATSISNSLHRELSAGLVGLGLTYALMVSNYLNWMVRNLADMEIQLGAVKRIHTLLK
                     TEAESYEGLLAPSLIPKNWPDQGKIQIQNLSVRYDSSLKPVLKHVNALISPGQKIGIC
                     GRTGSGKSSFSLAFFRMVDMFEGRIIIDGIDIAKLPLHTLRSRLSIILQDPVLFSGTI
                     RFNLDPEKKCSDSTLWEALEIAQLKLVVKALPGGLDAIITEGGENFSQGQRQLFCLAR
                     AFVRKTSIFIMDEATASIDMATENILQKVVMTAFADRTVVTIAHRVHTILSADLVMVL
                     KRGAILEFDKPEKLLSQKDSVFASFVRADK"
     exon            217..358
                     /gene="Abcc8"
                     /gene_synonym="Sur; Sur1"
                     /inference="alignment:Splign:2.1.0"
     exon            359..480
                     /gene="Abcc8"
                     /gene_synonym="Sur; Sur1"
                     /inference="alignment:Splign:2.1.0"
     exon            481..647
                     /gene="Abcc8"
                     /gene_synonym="Sur; Sur1"
                     /inference="alignment:Splign:2.1.0"
     exon            648..890
                     /gene="Abcc8"
                     /gene_synonym="Sur; Sur1"
                     /inference="alignment:Splign:2.1.0"
     exon            891..1079
                     /gene="Abcc8"
                     /gene_synonym="Sur; Sur1"
                     /inference="alignment:Splign:2.1.0"
     exon            1080..1244
                     /gene="Abcc8"
                     /gene_synonym="Sur; Sur1"
                     /inference="alignment:Splign:2.1.0"
     exon            1245..1400
                     /gene="Abcc8"
                     /gene_synonym="Sur; Sur1"
                     /inference="alignment:Splign:2.1.0"
     exon            1401..1535
                     /gene="Abcc8"
                     /gene_synonym="Sur; Sur1"
                     /inference="alignment:Splign:2.1.0"
     exon            1536..1698
                     /gene="Abcc8"
                     /gene_synonym="Sur; Sur1"
                     /inference="alignment:Splign:2.1.0"
     exon            1699..1739
                     /gene="Abcc8"
                     /gene_synonym="Sur; Sur1"
                     /inference="alignment:Splign:2.1.0"
     exon            1740..1885
                     /gene="Abcc8"
                     /gene_synonym="Sur; Sur1"
                     /inference="alignment:Splign:2.1.0"
     exon            1886..1991
                     /gene="Abcc8"
                     /gene_synonym="Sur; Sur1"
                     /inference="alignment:Splign:2.1.0"
     exon            1992..2108
                     /gene="Abcc8"
                     /gene_synonym="Sur; Sur1"
                     /inference="alignment:Splign:2.1.0"
     exon            2109..2184
                     /gene="Abcc8"
                     /gene_synonym="Sur; Sur1"
                     /inference="alignment:Splign:2.1.0"
     exon            2185..2290
                     /gene="Abcc8"
                     /gene_synonym="Sur; Sur1"
                     /inference="alignment:Splign:2.1.0"
     exon            2291..2323
                     /gene="Abcc8"
                     /gene_synonym="Sur; Sur1"
                     /inference="alignment:Splign:2.1.0"
     exon            2324..2362
                     /gene="Abcc8"
                     /gene_synonym="Sur; Sur1"
                     /inference="alignment:Splign:2.1.0"
     exon            2363..2461
                     /gene="Abcc8"
                     /gene_synonym="Sur; Sur1"
                     /inference="alignment:Splign:2.1.0"
     exon            2462..2546
                     /gene="Abcc8"
                     /gene_synonym="Sur; Sur1"
                     /inference="alignment:Splign:2.1.0"
     exon            2547..2627
                     /gene="Abcc8"
                     /gene_synonym="Sur; Sur1"
                     /inference="alignment:Splign:2.1.0"
     exon            2628..2765
                     /gene="Abcc8"
                     /gene_synonym="Sur; Sur1"
                     /inference="alignment:Splign:2.1.0"
     exon            2766..2891
                     /gene="Abcc8"
                     /gene_synonym="Sur; Sur1"
                     /inference="alignment:Splign:2.1.0"
     exon            2892..2991
                     /gene="Abcc8"
                     /gene_synonym="Sur; Sur1"
                     /inference="alignment:Splign:2.1.0"
     exon            2992..3233
                     /gene="Abcc8"
                     /gene_synonym="Sur; Sur1"
                     /inference="alignment:Splign:2.1.0"
     exon            3234..3400
                     /gene="Abcc8"
                     /gene_synonym="Sur; Sur1"
                     /inference="alignment:Splign:2.1.0"
     exon            3401..3470
                     /gene="Abcc8"
                     /gene_synonym="Sur; Sur1"
                     /inference="alignment:Splign:2.1.0"
     exon            3471..3628
                     /gene="Abcc8"
                     /gene_synonym="Sur; Sur1"
                     /inference="alignment:Splign:2.1.0"
     exon            3629..3721
                     /gene="Abcc8"
                     /gene_synonym="Sur; Sur1"
                     /inference="alignment:Splign:2.1.0"
     exon            3722..3824
                     /gene="Abcc8"
                     /gene_synonym="Sur; Sur1"
                     /inference="alignment:Splign:2.1.0"
     exon            3825..3938
                     /gene="Abcc8"
                     /gene_synonym="Sur; Sur1"
                     /inference="alignment:Splign:2.1.0"
     exon            3939..4059
                     /gene="Abcc8"
                     /gene_synonym="Sur; Sur1"
                     /inference="alignment:Splign:2.1.0"
     exon            4060..4190
                     /gene="Abcc8"
                     /gene_synonym="Sur; Sur1"
                     /inference="alignment:Splign:2.1.0"
     exon            4191..4269
                     /gene="Abcc8"
                     /gene_synonym="Sur; Sur1"
                     /inference="alignment:Splign:2.1.0"
     exon            4270..4378
                     /gene="Abcc8"
                     /gene_synonym="Sur; Sur1"
                     /inference="alignment:Splign:2.1.0"
     exon            4379..4482
                     /gene="Abcc8"
                     /gene_synonym="Sur; Sur1"
                     /inference="alignment:Splign:2.1.0"
     exon            4483..4616
                     /gene="Abcc8"
                     /gene_synonym="Sur; Sur1"
                     /inference="alignment:Splign:2.1.0"
     exon            4617..4679
                     /gene="Abcc8"
                     /gene_synonym="Sur; Sur1"
                     /inference="alignment:Splign:2.1.0"
     exon            4680..4912
                     /gene="Abcc8"
                     /gene_synonym="Sur; Sur1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agggtgctgc gagggacaga ggcgcgggag gcgcgcggag ccggagccga gcccgtgcgc
       61 gcgccaccat gcctttggcc ttctgcggca ccgagaacca ctcggccgcc taccgggtgg
      121 accaaggcgt cctcaacaac ggctgcttcg tggacgcgct caatgtggtg ccacatgtct
      181 ttctgctctt catcaccttc cccatcctct tcatcggatg gggcagccag agctccaagg
      241 tgcacattca ccacagcacc tggctccatt tcccggggca caacctgcgc tggatcctga
      301 ccttcatact gctcttcgtc ctcgtgtgtg agatcgctga gggtatcctg tctgacgggg
      361 tgacagaatc ccgccacctc cacttataca tgccagctgg gatggcattc atggctgcca
      421 tcacctctgt ggtctactac cataacattg agacctctaa ctttcccaag ctgctgattg
      481 ctctgctcat ctactggacc ctggccttca tcacgaagac catcaagttc gtcaagttct
      541 acgaccacgc cattggcttc tctcagctgc gcttctgcct cacggggctt ctggtgatcc
      601 tctacgggat gctgctgctt gtggaggtca atgtcatccg ggtgaggaga tacgtcttct
      661 tcaagacacc aagggaagta aagccccccg aggacctaca ggacctgggt gtgcgctttc
      721 tgcagccctt cgttaacctg ctatcaaagg ggacctactg gtggatgaat gccttcatca
      781 agactgctca caagaagccc atcgacctgc gggccatcgg gaagctgccc attgccatga
      841 gagccctcac caactaccag cgactctgct tggccttcga tgcccaggcg cggaaggaca
      901 cacagagcca gcagggtgcc cgggccatct ggagggctct ctgtcatgcc tttgggagac
      961 ggctggtcct cagcagcaca ttccgtatcc tggccgacct cctgggcttt gctgggccac
     1021 tctgcatctt cgggatcgtg gaccacctcg ggaaggagaa ccacgtcttc cagcccaaga
     1081 cacagtttct tggagtttac tttgtctcat cccaagagtt cctcggcaat gcctatgtct
     1141 tggctgttct tctgttcctt gccctcctgc tgcaaaggac ctttctacaa gcctcgtact
     1201 acgttgccat tgaaactggg atcaacctga gaggagcaat ccagaccaag atttacaata
     1261 agatcatgca cttgtctact tccaacctgt ccatggggga aatgactgct gggcagatct
     1321 gcaacctggt ggccatcgac accaaccagc tcatgtggtt tttcttctta tgcccaaacc
     1381 tctgggctat gccggtacag atcattgtgg gcgtgatcct cctctactac atccttgggg
     1441 tcagcgcctt gattggagcg gctgtcatca ttctgctggc tcctgtacag tactttgtgg
     1501 ccaccaagct gtcccaggca cagcggagca ccctggaata ttccaatgag aggctgaagc
     1561 agaccaatga gatgctccgg ggcatcaagt tgctcaagct ctatgcgtgg gagaacatct
     1621 tctgctccag ggtggagaag acacgcagga aggaaatgac cagcctcagg gccttcgctg
     1681 tctacacctc catctccatc ttcatgaaca cagctatccc catcgctgct gtcctcatca
     1741 ccttcgtggg ccacgtcagc ttcttcaaag agtcggactt ctcgccctcg gtggcctttg
     1801 cctctctctc tctcttccac atcctggtca caccgctgtt cctgctgtct agtgtggttc
     1861 ggtccactgt caaggccctg gtgagcgtgc aaaagctgag tgagttcctg tccagtgcag
     1921 agatccgtga ggaacagtgt gccccccgag agcccgcacc ccaaggccaa gcgggcaagt
     1981 accaggcggt gcccctcaag gtcgtaaacc gcaagcgccc agcccgagaa gaagtccggg
     2041 acctcttggg cccactgcag aggctgactc ccagcacgga tggagacgct gacaacttct
     2101 gtgtccagat catcggaggc ttcttcacct ggacccctga tggaatcccc accctgtcca
     2161 acatcaccat ccgtatcccc cgaggtcagc tgaccatgat cgtggggcag gtgggctgtg
     2221 gcaagtcctc gctccttctg gccaccctgg gggagatgca gaaggtctct ggagctgtct
     2281 tctggaacag cagccttcca gacagcgagg gagaagaccc cagcaaccca gagcgggaga
     2341 cagcggccga ttcggatgcc aggagcagag gccctgtggc ctacgcatct cagaaaccat
     2401 ggctgctaaa tgccactgtg gaggagaaca tcaccttcga gagtcccttc aataagcaac
     2461 ggtacaagat ggtcatcgaa gcctgctccc tgcagccaga catagacatc ctgccccatg
     2521 gagaccagac tcagattggg gaacggggca tcaacttgtc tggtggtcag cgtcagcgaa
     2581 tcagtgtagc ccgagccctc taccagcaca ccaatgttgt ctttttggat gaccctttct
     2641 cggctctgga tgtccatctg agtgaccacc taatgcaggc tggcatcctc gagctgctcc
     2701 gggatgacaa gaggacagtg gtcttggtga cccacaagct acagtacctg cctcatgctg
     2761 actggatcat tgctatgaag gatggcacca ttcagaggga ggggacactc aaggacttcc
     2821 agaggtctga gtgccagctc tttgagcatt ggaagaccct catgaaccgg caggaccaag
     2881 agctggagaa ggagacagtc atggagagaa aagccccaga gccatctcag ggcctgcccc
     2941 gtgccatgtc ctcaagagat ggccttctgc tggatgagga tgaggaggaa gaggaggcag
     3001 ccgagagcga ggaagatgac aacttatcct ctgtgctgca tcagcgagcc aagatcccat
     3061 ggcgagcctg caccaagtat ttgtcctctg ctggcatcct gctcctgtcc ctgcttgtct
     3121 tctcccagct gctcaagcac atggtcttgg tggccattga ctactggctg gccaagtgga
     3181 cggacagtgc cctggtcctg agccccgccg ccaggaactg ctccctcagc caggaatgtg
     3241 ccctggacca atctgtctat gccatggtat tcaccgtgct ctgcagcctg ggtatcgcgc
     3301 tgtgccttgt cacctctgtc actgtggagt ggacgggact gaaggtggcc aagaggctgc
     3361 atcgcagcct gctcaaccgt atcatcctgg ctcccatgag gttctttgag accacgcccc
     3421 tggggagtat cctgaacaga ttttcatctg actgtaacac cattgaccag catatcccgt
     3481 ccacgctgga gtgcctgagc agatccacct tactctgtgt ctccgccctg gctgtcatct
     3541 cctacgtcac gcctgtgttc ctagtggccc tcttacccct cgccgtcgtg tgctacttca
     3601 tccagaagta cttccgagtg gcgtccaggg acctgcagca gctggacgac acaacacagc
     3661 tccctctgct ctcacacttt gctgaaactg tggaaggact caccaccatc cgtgccttca
     3721 ggtacgaggc ccggttccag cagaagctcc tagagtacac cgactccaac aacattgcct
     3781 ctctcttcct cacagcagcc aacaggtggc tggaagtccg catggagtac atcggagcat
     3841 gcgtggtact catcgccgct gccacctcca tctccaactc cctacacagg gagctctcag
     3901 ccggcctagt aggcctgggc ctcacctatg ccttgatggt ctccaactac ctcaactgga
     3961 tggtgaggaa cctggcagac atggagatcc aactgggagc tgtgaagcgt atccacacac
     4021 tcctgaaaac tgaggcagag agctatgagg ggctcctggc accatcgctg atccccaaga
     4081 actggccaga ccaagggaag atccaaattc aaaacctgag tgtacgctat gacagctccc
     4141 tgaagcccgt gctgaagcac gtcaacgccc tcatctcccc aggacagaag attgggatct
     4201 gcggccgcac aggcagtgga aaatcctcct tctctctcgc ctttttccga atggtggata
     4261 tgtttgaagg gcgtatcatc atcgatggca ttgacatcgc caagctgccg ctgcacacgc
     4321 tccgctcacg cctgtctatc atcctacagg accctgttct cttcagtggt accatcagat
     4381 tcaacctgga cccagagaag aaatgctcag acagcacgct gtgggaggct ctggagatcg
     4441 ctcagctgaa gctggtggtg aaggccctgc caggaggcct ggatgccatc atcacggaag
     4501 gaggggagaa ttttagccag ggccagaggc agctgttctg cctggcccgg gcctttgtga
     4561 ggaagaccag catcttcatc atggatgaag caactgcctc catcgacatg gctacggaaa
     4621 atatcctcca gaaggtggtg atgacagcct tcgcagaccg caccgtggtc accatcgcgc
     4681 accgcgtgca caccatcctg agtgcagacc tagtgatggt cctgaagagg ggcgcgatcc
     4741 tggagttcga caagccggaa aagcttctca gccagaagga cagcgtcttt gcctcctttg
     4801 tccgcgcgga caaatgacca gccagcgcca aagtgccacc ccacacctca cctgcttgcc
     4861 taggatttct tactgtaaat cacttgtaaa taaagaaact aattctttgc ta
//
