LOCUS       NM_031013               5775 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus ATP binding cassette subfamily C member 6
            (Abcc6), mRNA.
ACCESSION   NM_031013
VERSION     NM_031013.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5775)
  AUTHORS   Szeri,F., Niaziorimi,F., Donnelly,S., Orndorff,J. and van de
            Wetering,K.
  TITLE     Generation of fully functional fluorescent fusion proteins to gain
            insights into ABCC6 biology
  JOURNAL   FEBS Lett 595 (6), 799-810 (2021)
   PUBMED   33058196
REFERENCE   2  (bases 1 to 5775)
  AUTHORS   Li,Q., Kingman,J., van de Wetering,K., Tannouri,S., Sundberg,J.P.
            and Uitto,J.
  TITLE     Abcc6 Knockout Rat Model Highlights the Role of Liver in PPi
            Homeostasis in Pseudoxanthoma Elasticum
  JOURNAL   J Invest Dermatol 137 (5), 1025-1032 (2017)
   PUBMED   28111129
  REMARK    GeneRIF: This study suggests a critical role of hepatic ABCC6 in
            contributing to plasma inorganic pyrophosphate levels, identifying
            liver as a target of molecular correction to counteract ectopic
            mineralization in pseudoxanthoma elasticum
REFERENCE   3  (bases 1 to 5775)
  AUTHORS   Jansen,R.S., Duijst,S., Mahakena,S., Sommer,D., Szeri,F.,
            Varadi,A., Plomp,A., Bergen,A.A., Oude Elferink,R.P., Borst,P. and
            van de Wetering,K.
  TITLE     ABCC6-mediated ATP secretion by the liver is the main source of the
            mineralization inhibitor inorganic pyrophosphate in the systemic
            circulation-brief report
  JOURNAL   Arterioscler Thromb Vasc Biol 34 (9), 1985-1989 (2014)
   PUBMED   24969777
  REMARK    GeneRIF: In the absence of transfected rat ABCC6, HeLa and HEK293
            cells released almost no ATP, but on induction of rat ABCC6, they
            released substantial amounts of ATP into the cell culture medium.
REFERENCE   4  (bases 1 to 5775)
  AUTHORS   Lau,W.L., Liu,S. and Vaziri,N.D.
  TITLE     Chronic kidney disease results in deficiency of ABCC6, the novel
            inhibitor of vascular calcification
  JOURNAL   Am J Nephrol 40 (1), 51-55 (2014)
   PUBMED   24994603
  REMARK    GeneRIF: In a rat model of CKD, ABCC6 protein expression was
            decreased in liver and kidney, however mRNA levels were unchanged.
REFERENCE   5  (bases 1 to 5775)
  AUTHORS   Hanafy,S., El-Kadi,A.O. and Jamali,F.
  TITLE     Effect of inflammation on molecular targets and drug transporters
  JOURNAL   J Pharm Pharm Sci 15 (3), 361-375 (2012)
   PUBMED   22974786
REFERENCE   6  (bases 1 to 5775)
  AUTHORS   Cai,L., Lumsden,A., Guenther,U.P., Neldner,S.A., Zach,S.,
            Knoblauch,H., Ramesar,R., Hohl,D., Callen,D.F., Neldner,K.H.,
            Lindpaintner,K., Richards,R.I. and Struk,B.
  TITLE     A novel Q378X mutation exists in the transmembrane transporter
            protein ABCC6 and its pseudogene: implications for mutation
            analysis in pseudoxanthoma elasticum
  JOURNAL   J Mol Med (Berl) 79 (9), 536-546 (2001)
   PUBMED   11692167
REFERENCE   7  (bases 1 to 5775)
  AUTHORS   Ringpfeil,F., Pulkkinen,L. and Uitto,J.
  TITLE     Molecular genetics of pseudoxanthoma elasticum
  JOURNAL   Exp Dermatol 10 (4), 221-228 (2001)
   PUBMED   11493310
  REMARK    Review article
REFERENCE   8  (bases 1 to 5775)
  AUTHORS   Bergen,A.A., Plomp,A.S., Schuurman,E.J., Terry,S., Breuning,M.,
            Dauwerse,H., Swart,J., Kool,M., van Soest,S., Baas,F., ten
            Brink,J.B. and de Jong,P.T.
  TITLE     Mutations in ABCC6 cause pseudoxanthoma elasticum
  JOURNAL   Nat Genet 25 (2), 228-231 (2000)
   PUBMED   10835643
REFERENCE   9  (bases 1 to 5775)
  AUTHORS   Madon,J., Hagenbuch,B., Landmann,L., Meier,P.J. and Stieger,B.
  TITLE     Transport function and hepatocellular localization of mrp6 in rat
            liver
  JOURNAL   Mol Pharmacol 57 (3), 634-641 (2000)
   PUBMED   10692506
REFERENCE   10 (bases 1 to 5775)
  AUTHORS   Hirohashi,T., Suzuki,H., Ito,K., Ogawa,K., Kume,K., Shimizu,T. and
            Sugiyama,Y.
  TITLE     Hepatic expression of multidrug resistance-associated protein-like
            proteins maintained in eisai hyperbilirubinemic rats
  JOURNAL   Mol Pharmacol 53 (6), 1068-1075 (1998)
   PUBMED   9614210
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from U73038.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U73038.1, AB010466.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760400, SAMEA5760494
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..5775
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q22"
     gene            1..5775
                     /gene="Abcc6"
                     /gene_synonym="Mrp6"
                     /note="ATP binding cassette subfamily C member 6"
                     /db_xref="GeneID:81642"
                     /db_xref="RGD:620268"
     exon            1..125
                     /gene="Abcc6"
                     /gene_synonym="Mrp6"
                     /inference="alignment:Splign:2.1.0"
     CDS             72..4580
                     /gene="Abcc6"
                     /gene_synonym="Mrp6"
                     /EC_number="7.6.2.3"
                     /note="multidrug resistance-associated protein 6; MLP-1;
                     MRP-like protein 1; ATP-binding cassette, sub-family C
                     (CFTR/MRP), member 6; liver multidrug
                     resistance-associated protein 6; ATP-binding cassette,
                     subfamily C (CFTR/MRP), member 6"
                     /codon_start=1
                     /product="ATP-binding cassette sub-family C member 6"
                     /protein_id="NP_112275.1"
                     /db_xref="GeneID:81642"
                     /db_xref="RGD:620268"
                     /translation="MNGEHSMATPGESCAGLRVWNQTEQEPVAYHLLNLCFLRAAGSW
                     VPPMYLWVLGPIYLLYIHRHGCCYLRMSRLFKIKMVLGFALILLYTFNAAVPLWRIHR
                     GMPQAPELLIHPTVWLTTMSFATFLIHMERKKGVRASGLLFGYWLLCCLVPAIDTVQQ
                     ASAGSFRQEPLHHLATYLCLSLVVAELVLSCLVDQPPFFSEDSKPLNPCPEAEASFPS
                     KAMFWWASGLLWKGYRKLLGPKDLWSLERENSSEELVSQLEREWRRNFSELPGHKGHS
                     GMGTPETEAFLQPERSQRGPLLRAIWRVFRSTFLLGTLSLVISDAFRFAVPKLLSLFL
                     EFMGDLESSAWTGWLLAVLMFLSACLQTLFEQQYMYRVKVLQMRLRTAITGLVYRKVL
                     VLSSGSRKSSAAGDVVNLVSVDVQRLVESILHLNGLWLLFLWIIVCFVYLWQLLGPSA
                     LTAVAVFLSLLPLNFFITKKRSFHQEEQMRQKASRARLTSSMLRTVRTIKSHGWECAF
                     LERLLHIRGQELGALKTSAFLFSVSLVSFQVSTFLVALVVFAVHTLVAEDNAMDAEKA
                     FVTLTVLSILNKAQAFLPFSVHCLVQARVSFDRLAAFLCLEEVDPNGMVLSPSRCSSK
                     DRISIHNGTFAWSQESPPCLHGINLTVPQGCLLAVVGPVGAGKSSLLSALLGELLKVE
                     GSVSIEGSVAYVPQEAWVQNTSVVENVCFRQELDLPWLQEVLEACALGSDVASFPAGV
                     HTPVGEQGMNLSGGQKQRLSLARAVYRRAAVYLMDDPLAALDAHVSQEVFKQVIGPSG
                     LLQGTTRILVTHTLHVLPQADQILVLANGTIAEMGSYQDLLHRNGALVGLLDGARQPA
                     GEGEGEAHAAATSDDLGGFSGGGTPTRRPERPRPSDAAPVKGSTSEAQMEPSLDDVEV
                     TGLTAGEDSVQYGRVKSATYLSYLRAVGTPLCTYTLFLFLCQQVASFCQGYWLSLWAD
                     DPVVDGKQMHSALRGSIFGLLGCLQAIGLFASMAAVFLGGARASCLLFRSLLWDVARS
                     PIGFFERTPVGNLLNRFSKETDIVDVDIPDKMRTLLTYAFGLLEVGLAVSMATPLAIV
                     AILPLMLLYAGFQSLYVATCCQLRRLESASYSSVCSHLAETFQGSQVVRAFQAQGPFT
                     AQHDALMDENQRISFPRLVADRWLAANLELLGNGLVFVAATCAVLSKAHLSAGLAGFS
                     VSAALQVTQTLQWVVRSWTDLENSMVAVERVQDYVHTPKEAPWRLPSSAAQPLWPCGG
                     QIEFRDFGLRHRPELPMAVQGVSLKIHAGEKVGIVGRTGAGKSSLTWGLLRLQEATEG
                     GIWIDGVPITDMGLHTLRSRITIIPQDPVLFPGSLRMNLDLLQENTDEGIWAALETVQ
                     LKAFVTSLPGQLQYECSGQGDDLSVGQKQLLCLARALLRKTQILILDEATASVDPGTE
                     IQMQAALERWFAQCTVLLIAHRLRSVMNCARVLVMDEGQVAESGSPAQLLAQKGLFYR
                     LAQESGLA"
     exon            126..308
                     /gene="Abcc6"
                     /gene_synonym="Mrp6"
                     /inference="alignment:Splign:2.1.0"
     exon            309..434
                     /gene="Abcc6"
                     /gene_synonym="Mrp6"
                     /inference="alignment:Splign:2.1.0"
     exon            435..563
                     /gene="Abcc6"
                     /gene_synonym="Mrp6"
                     /inference="alignment:Splign:2.1.0"
     exon            564..689
                     /gene="Abcc6"
                     /gene_synonym="Mrp6"
                     /inference="alignment:Splign:2.1.0"
     exon            690..751
                     /gene="Abcc6"
                     /gene_synonym="Mrp6"
                     /inference="alignment:Splign:2.1.0"
     exon            752..883
                     /gene="Abcc6"
                     /gene_synonym="Mrp6"
                     /inference="alignment:Splign:2.1.0"
     exon            884..1063
                     /gene="Abcc6"
                     /gene_synonym="Mrp6"
                     /inference="alignment:Splign:2.1.0"
     exon            1064..1241
                     /gene="Abcc6"
                     /gene_synonym="Mrp6"
                     /inference="alignment:Splign:2.1.0"
     exon            1242..1403
                     /gene="Abcc6"
                     /gene_synonym="Mrp6"
                     /inference="alignment:Splign:2.1.0"
     exon            1404..1496
                     /gene="Abcc6"
                     /gene_synonym="Mrp6"
                     /inference="alignment:Splign:2.1.0"
     exon            1497..1700
                     /gene="Abcc6"
                     /gene_synonym="Mrp6"
                     /inference="alignment:Splign:2.1.0"
     exon            1701..1847
                     /gene="Abcc6"
                     /gene_synonym="Mrp6"
                     /inference="alignment:Splign:2.1.0"
     exon            1848..1935
                     /gene="Abcc6"
                     /gene_synonym="Mrp6"
                     /inference="alignment:Splign:2.1.0"
     exon            1936..2008
                     /gene="Abcc6"
                     /gene_synonym="Mrp6"
                     /inference="alignment:Splign:2.1.0"
     exon            2009..2135
                     /gene="Abcc6"
                     /gene_synonym="Mrp6"
                     /inference="alignment:Splign:2.1.0"
     exon            2136..2312
                     /gene="Abcc6"
                     /gene_synonym="Mrp6"
                     /inference="alignment:Splign:2.1.0"
     exon            2313..2480
                     /gene="Abcc6"
                     /gene_synonym="Mrp6"
                     /inference="alignment:Splign:2.1.0"
     exon            2481..2655
                     /gene="Abcc6"
                     /gene_synonym="Mrp6"
                     /inference="alignment:Splign:2.1.0"
     exon            2656..2731
                     /gene="Abcc6"
                     /gene_synonym="Mrp6"
                     /inference="alignment:Splign:2.1.0"
     exon            2732..2855
                     /gene="Abcc6"
                     /gene_synonym="Mrp6"
                     /inference="alignment:Splign:2.1.0"
     exon            2856..3063
                     /gene="Abcc6"
                     /gene_synonym="Mrp6"
                     /inference="alignment:Splign:2.1.0"
     exon            3064..3374
                     /gene="Abcc6"
                     /gene_synonym="Mrp6"
                     /inference="alignment:Splign:2.1.0"
     exon            3375..3574
                     /gene="Abcc6"
                     /gene_synonym="Mrp6"
                     /inference="alignment:Splign:2.1.0"
     exon            3575..3701
                     /gene="Abcc6"
                     /gene_synonym="Mrp6"
                     /inference="alignment:Splign:2.1.0"
     exon            3702..3803
                     /gene="Abcc6"
                     /gene_synonym="Mrp6"
                     /inference="alignment:Splign:2.1.0"
     exon            3804..3950
                     /gene="Abcc6"
                     /gene_synonym="Mrp6"
                     /inference="alignment:Splign:2.1.0"
     exon            3951..4109
                     /gene="Abcc6"
                     /gene_synonym="Mrp6"
                     /inference="alignment:Splign:2.1.0"
     exon            4110..4276
                     /gene="Abcc6"
                     /gene_synonym="Mrp6"
                     /inference="alignment:Splign:2.1.0"
     exon            4277..4471
                     /gene="Abcc6"
                     /gene_synonym="Mrp6"
                     /inference="alignment:Splign:2.1.0"
     exon            4472..5775
                     /gene="Abcc6"
                     /gene_synonym="Mrp6"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcccgggtcc cgcctcttcc tcagcttgga gctgggctcc gaaggctgct ctgggacaga
       61 gtctcatact gatgaacgga gagcactcaa tggccacgcc tggagagtcc tgcgcaggcc
      121 tgagggtctg gaaccagaca gaacaggagc ctgtggccta tcacttgctc aacctgtgct
      181 tcctgcgagc cgccgggagc tgggtgcccc ccatgtacct ctgggtcctt ggccccatct
      241 acctcctcta catccatcgc catggctgct gctacctccg gatgtcccgc ctcttcaaaa
      301 tcaaaatggt gctcggcttt gccctcatcc ttctctacac cttcaacgcg gccgtgcctc
      361 tctggaggat ccaccggggc atgccccagg ccccagagct tctcattcac cctaccgtgt
      421 ggctcaccac catgagcttc gccaccttcc tgatccacat ggagagaaag aagggggtcc
      481 gtgcatctgg gttgttgttc gggtactggc tgctctgctg cctcgtgcca gccatcgaca
      541 ctgtccagca ggcctccgca gggagcttcc gccaggagcc cctccaccac ctggccacct
      601 acctgtgctt gtccctggtg gtggcagagc tggtgctgtc ttgtctggta gaccagccac
      661 ccttcttctc ggaagactcc aagccattga atccatgtcc agaggccgag gcctcttttc
      721 cctccaaggc catgttctgg tgggcctctg gactgctatg gaagggctac aggaaactgc
      781 tggggccaaa agacctctgg tcacttgaga gagaaaactc ttcagaagaa cttgtttccc
      841 agctggaaag agaatggagg aggaacttca gtgagctgcc ggggcacaaa gggcacagtg
      901 gtatggggac ccccgagaca gaggccttcc tgcagccaga gaggagccag cggggcccgc
      961 tgctcagggc tatctggcgt gtgttccggt ccactttcct gctggggacc ctcagcctgg
     1021 tcattagcga tgccttcagg tttgctgttc ccaagctcct cagtctgttt ctggagttca
     1081 tgggcgacct cgagtcctcg gcttggacgg gctggctcct ggctgtgctg atgttcttgt
     1141 cggcctgcct acagacactg tttgaacagc agtacatgta cagagtcaag gtcctgcaga
     1201 tgaggctgcg aacagccatc actggcctgg tgtacagaaa ggtcctggtc ctgtccagtg
     1261 gttccagaaa gtccagtgca gcaggggacg tggtcaacct ggtgtcagtg gacgtacagc
     1321 ggctggtcga gagcatcctc cacctcaacg ggctgtggct gctcttcctg tggatcattg
     1381 tgtgctttgt ctacctgtgg cagctccttg ggccctctgc cctcacagcc gttgctgtct
     1441 tcctgagcct tctccccctg aacttcttca ttaccaagaa gaggagcttc catcaggaag
     1501 aacagatgag gcagaaggcc tcccgagcac ggctcaccag ctccatgctc agaactgtga
     1561 gaaccatcaa gtcccacggc tgggagtgtg ccttcctgga gcgactcctg catatccggg
     1621 gccaggagct aggtgccctg aagacctccg ccttcctctt ctctgtgtct ctcgtgtcct
     1681 tccaagtgtc tacatttctg gtggcgctgg ttgtgtttgc tgtccacacc ctggtggcag
     1741 aggacaacgc catggatgcg gagaaggcgt ttgtgacgct cacggtgctc agcatcctta
     1801 acaaagccca ggccttcctc cccttctctg tgcactgcct cgttcaggct cgggtgtcct
     1861 ttgaccgcct agctgctttc ctgtgcctgg aagaagtaga ccccaatggc atggtcttga
     1921 gtccctccag atgctcctcg aaggatcgaa tttctataca caatggcacc ttcgcttggt
     1981 cccaggagag cccgccctgc ctgcacggga tcaacctcac cgtgccccag ggctgtctgc
     2041 tggctgttgt gggtccagtg ggggctggaa agtcctccct gctgtctgcc ctgcttgggg
     2101 agctgttgaa ggtagaaggg tctgtgagca ttgagggttc cgtggcctac gtgcctcagg
     2161 aggcttgggt ccagaatacc tctgtggtgg agaatgtgtg cttcaggcag gagctggatc
     2221 tgccatggtt gcaggaagtt ctagaagcct gtgccttggg gtctgatgtg gccagcttcc
     2281 ctgcaggagt tcacacccca gtaggggagc agggcatgaa tctttctggg ggccagaagc
     2341 agcggctgag cttggctcgg gctgtgtaca gaagggctgc tgtgtacctg atggatgacc
     2401 ccctagcagc cctggatgcg catgtcagcc aggaagtctt caaacaggtc attggcccca
     2461 gtggacttct ccaaggtacg actcggatcc ttgtaacaca cacgctgcat gtcctgcccc
     2521 aagctgacca gatcctggtg ctggccaatg ggaccatcgc agagatgggc tcctaccaag
     2581 accttctgca taggaacgga gccctggtgg gtcttctgga tggagccaga cagcctgcag
     2641 gcgaaggaga aggagaagca catgctgcag ccaccagtga tgaccttgga ggcttttctg
     2701 gaggtgggac gcccacgcgc agaccagaga ggcccagacc cagtgacgca gcccctgtga
     2761 agggcagtac ttcagaggca cagatggagc cttctctgga tgacgttgag gtcactggac
     2821 tgacagcagg agaggacagt gtgcagtatg gccgggtgaa gagcgccaca tacctgagct
     2881 acctgcgggc ggtgggcaca ccgctctgca cctacaccct gttcctcttc ctctgccagc
     2941 aagtggcgtc cttctgccaa ggctactggc tgagcctctg ggccgacgac ccggtcgtgg
     3001 atgggaagca gatgcattca gccctgcgtg gctccatctt tggactcctt ggctgtctgc
     3061 aagccatcgg actgtttgcc tccatggctg cggtgttcct gggtggagcc cgagcttcat
     3121 gcctgctttt ccggagcctc ctctgggacg tggctcgctc tcccattggc ttctttgagc
     3181 gcacaccagt cgggaacctg ctgaaccgtt tttccaagga gacggacata gtggatgtgg
     3241 acatcccaga caagatgagg accctgctga cctatgcctt tggactcctg gaggttggcc
     3301 tggcagtgtc gatggccaca ccactggcta ttgtggccat cctacctctt atgctccttt
     3361 atgctgggtt tcagagcctc tacgtggcca catgttgcca gctgagacgc ctggagtcgg
     3421 ccagttactc ctcagtgtgt tcccatctgg ctgagacctt ccagggcagt caggtggtca
     3481 gggccttcca ggcccagggg cccttcacag ctcagcacga tgccctcatg gatgagaacc
     3541 agaggatcag tttcccgagg ctggtggctg acaggtggct ggctgccaac ctggagctcc
     3601 tggggaatgg cctggtgttt gtggccgcta catgtgctgt gctgagcaag gctcacctga
     3661 gtgctggcct cgcgggcttc tcggtttctg ctgccctcca ggtaacacag actctgcagt
     3721 gggtggtccg cagctggaca gatctggaga acagcatggt ggccgtggag cgagtacagg
     3781 actacgttca cacccccaag gaggctccct ggaggctgcc ctcctctgca gcccagcctc
     3841 tctggccctg tgggggacag attgagttcc gagactttgg gctcagacac cgaccagagc
     3901 tgcccatggc tgtgcagggt gtgtccctga agatccatgc aggggagaag gtgggcatcg
     3961 tgggcaggac aggggccggg aagtcctccc tgacttgggg cctgctgcgg cttcaggagg
     4021 ccactgaggg tggtatttgg atcgatgggg tccccatcac cgacatgggg ctgcacacac
     4081 tgcggtccag aatcaccatc atccctcagg accctgtcct gttcccgggc tcgctgcgga
     4141 tgaacctgga cctgcttcag gagaacacag atgagggcat ctgggcagcg ctggagacgg
     4201 tgcagctcaa ggccttcgtg accagcctgc ctggccagct gcagtatgag tgctcaggcc
     4261 agggagatga cctgagtgtg ggtcagaagc agctcctgtg tctggcacgt gcccttctcc
     4321 ggaaaaccca gatcctcatc ctggatgaag ccactgcctc cgtggaccca gggacggaga
     4381 tacagatgca ggcggccctc gagcgctggt ttgcacagtg tacagtgctg ctcattgctc
     4441 accgcctgcg ctccgtgatg aactgcgcca gggttctagt catggatgag gggcaggtgg
     4501 cagagagtgg cagtccagca cagctgctgg cccagaaagg cctgttttac aggctagccc
     4561 aggagtcggg cctagcctga gtcaggactc ttcccaaacc tcctggagcc agccacagag
     4621 cctgcagtag ctggagatgc cagagactca ggggccacat gatgcccaat ctaaactcct
     4681 ttttgggagg aagatagcag agagagtgac agagtattgg aataccagac ccagaagaac
     4741 ccagcatgcc caggttggct tgagcaaggc cacacccacc ccaggccaaa aagaacagtg
     4801 actctcagcc caagctgtct acttcaaggc catacccacc ccaggccatt caggttggat
     4861 gccctggacc ggggtgatgg cgtgcacata tcccctaact ccttattttg aggtcattgt
     4921 agagttcact cacagtttta agaagccaca tggagagaag ccgcaaaccc tctgccctgt
     4981 ttattccggg ggtgacacct tgtccaaccc taggacaaga tgaagcatca cactgactcc
     5041 gactgacttg tctttacctc tgctgcgtgt gcatcagtgt ttggactccg tgctttgtgc
     5101 tctcattggt ttttgagaca ggatttcaca tagcccaggc tggccctgaa ctcactttgt
     5161 tgctgaggat ggccttgaac atctgatgct cctgccttcc ctcccaagtg ctgggattat
     5221 ggcctgtgtc accacgccct gtgtgggggt ctcaaacaag gctttgtgtg tgcttgacag
     5281 gcactcactc taaaaactgt gttacagccc cggctctgga ttcggttcta ctcctgttta
     5341 aaattgtagt ggtgaagggt ctcttgctca aactggcctc aaactcgaga tgctcctgtc
     5401 tcggtctcca gagtgctgga atgacagacg tgtgccacta cacctgcctt gactcaccac
     5461 agctaagtag tgacatcccc atgggccagg gctggtgagt cccgtgcgtg acagtgtgct
     5521 gagcagtacc cttcgcttct gctcagagat gcccttctaa agctgtggca aagagatttc
     5581 cacacactgc cgtgcccccc caggactgca tcatgaattg atccgcccta atagcaccca
     5641 tgactccctg agcagtgata tgttgggttc aggagaggat tcctgcttgc ttcttggaca
     5701 gggcttgctc ttccctcgac cctgaggctt ctctgattgg ctacccttaa taaaggattt
     5761 acgggatttc ctttc
//
