LOCUS       NM_053924               5744 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus ATP binding cassette subfamily C member 5
            (Abcc5), mRNA.
ACCESSION   NM_053924
VERSION     NM_053924.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5744)
  AUTHORS   Umapathy,A., Li,B., Donaldson,P.J. and Lim,J.C.
  TITLE     Identification and Functional Characterization of a GSH Conjugate
            Efflux Pathway in the Rat Lens
  JOURNAL   Invest Ophthalmol Vis Sci 56 (9), 5256-5268 (2015)
   PUBMED   26244301
  REMARK    GeneRIF: Multidrug resistance-associated proteins 1, 4, 5, and
            Oatp1a4 were present at the transcript level, but only Mrp1, 4, and
            5 were detected at the protein level.
REFERENCE   2  (bases 1 to 5744)
  AUTHORS   Thiebaud,N., Menetrier,F., Belloir,C., Minn,A.L., Neiers,F.,
            Artur,Y., Le Bon,A.M. and Heydel,J.M.
  TITLE     Expression and differential localization of xenobiotic transporters
            in the rat olfactory neuro-epithelium
  JOURNAL   Neurosci Lett 505 (2), 180-185 (2011)
   PUBMED   22015764
  REMARK    GeneRIF: In olfactory epithelium, high levels of expression of
            xenobiotic transporters Mrp1, Mrp3, Mrp5, Mdr1a, Oatp2 and Oat6 are
            expressed.
REFERENCE   3  (bases 1 to 5744)
  AUTHORS   Roberts,L.M., Black,D.S., Raman,C., Woodford,K., Zhou,M.,
            Haggerty,J.E., Yan,A.T., Cwirla,S.E. and Grindstaff,K.K.
  TITLE     Subcellular localization of transporters along the rat blood-brain
            barrier and blood-cerebral-spinal fluid barrier by in vivo
            biotinylation
  JOURNAL   Neuroscience 155 (2), 423-438 (2008)
   PUBMED   18619525
REFERENCE   4  (bases 1 to 5744)
  AUTHORS   Schafer,C., Gehrmann,T., Richter,L., Keitel,V., Kohrer,K.,
            Haussinger,D. and Schliess,F.
  TITLE     Modulation of gene expression profiles by hyperosmolarity and
            insulin
  JOURNAL   Cell Physiol Biochem 20 (5), 369-386 (2007)
   PUBMED   17762165
  REMARK    Erratum:[Cell Physiol Biochem. 2008;21(5-6):499]
REFERENCE   5  (bases 1 to 5744)
  AUTHORS   Dazert,P., Suofu,Y., Grube,M., Popa-Wagner,A., Kroemer,H.K.,
            Jedlitschky,G. and Kessler,C.
  TITLE     Differential regulation of transport proteins in the periinfarct
            region following reversible middle cerebral artery occlusion in
            rats
  JOURNAL   Neuroscience 142 (4), 1071-1079 (2006)
   PUBMED   16997484
REFERENCE   6  (bases 1 to 5744)
  AUTHORS   Jedlitschky,G., Tirschmann,K., Lubenow,L.E., Nieuwenhuis,H.K.,
            Akkerman,J.W., Greinacher,A. and Kroemer,H.K.
  TITLE     The nucleotide transporter MRP4 (ABCC4) is highly expressed in
            human platelets and present in dense granules, indicating a role in
            mediator storage
  JOURNAL   Blood 104 (12), 3603-3610 (2004)
   PUBMED   15297306
REFERENCE   7  (bases 1 to 5744)
  AUTHORS   Xu,H.L., Gavrilyuk,V., Wolde,H.M., Baughman,V.L. and
            Pelligrino,D.A.
  TITLE     Regulation of rat pial arteriolar smooth muscle relaxation in vivo
            through multidrug resistance protein 5-mediated cGMP efflux
  JOURNAL   Am J Physiol Heart Circ Physiol 286 (5), H2020-H2027 (2004)
   PUBMED   14715514
  REMARK    GeneRIF: important role for MRP5-mediated cGMP efflux in the
            regulation of NO-induced cerebral arteriolar relaxation
REFERENCE   8  (bases 1 to 5744)
  AUTHORS   Donner,M.G., Warskulat,U., Saha,N. and Haussinger,D.
  TITLE     Enhanced expression of basolateral multidrug resistance protein
            isoforms Mrp3 and Mrp5 in rat liver by LPS
  JOURNAL   Biol Chem 385 (3-4), 331-339 (2004)
   PUBMED   15134348
REFERENCE   9  (bases 1 to 5744)
  AUTHORS   Jedlitschky,G., Burchell,B. and Keppler,D.
  TITLE     The multidrug resistance protein 5 functions as an ATP-dependent
            export pump for cyclic nucleotides
  JOURNAL   J Biol Chem 275 (39), 30069-30074 (2000)
   PUBMED   10893247
REFERENCE   10 (bases 1 to 5744)
  AUTHORS   Wijnholds,J., Mol,C.A., van Deemter,L., de Haas,M., Scheffer,G.L.,
            Baas,F., Beijnen,J.H., Scheper,R.J., Hatse,S., De Clercq,E.,
            Balzarini,J. and Borst,P.
  TITLE     Multidrug-resistance protein 5 is a multispecific organic anion
            transporter able to transport nucleotide analogs
  JOURNAL   Proc Natl Acad Sci U S A 97 (13), 7476-7481 (2000)
   PUBMED   10840050
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AB020209.1.
            
            [WARNING] On Oct 8, 2024 this sequence was replaced by NM_053924.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB020209.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..5744
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11q23"
     gene            1..5744
                     /gene="Abcc5"
                     /gene_synonym="Abcc5a; Mrp5"
                     /note="ATP binding cassette subfamily C member 5"
                     /db_xref="GeneID:116721"
                     /db_xref="RGD:70913"
     exon            1..96
                     /gene="Abcc5"
                     /gene_synonym="Abcc5a; Mrp5"
                     /inference="alignment:Splign:2.1.0"
     exon            97..274
                     /gene="Abcc5"
                     /gene_synonym="Abcc5a; Mrp5"
                     /inference="alignment:Splign:2.1.0"
     exon            275..432
                     /gene="Abcc5"
                     /gene_synonym="Abcc5a; Mrp5"
                     /inference="alignment:Splign:2.1.0"
     exon            433..588
                     /gene="Abcc5"
                     /gene_synonym="Abcc5a; Mrp5"
                     /inference="alignment:Splign:2.1.0"
     exon            589..736
                     /gene="Abcc5"
                     /gene_synonym="Abcc5a; Mrp5"
                     /inference="alignment:Splign:2.1.0"
     exon            737..970
                     /gene="Abcc5"
                     /gene_synonym="Abcc5a; Mrp5"
                     /inference="alignment:Splign:2.1.0"
     exon            971..1144
                     /gene="Abcc5"
                     /gene_synonym="Abcc5a; Mrp5"
                     /inference="alignment:Splign:2.1.0"
     exon            1145..1292
                     /gene="Abcc5"
                     /gene_synonym="Abcc5a; Mrp5"
                     /inference="alignment:Splign:2.1.0"
     exon            1293..1441
                     /gene="Abcc5"
                     /gene_synonym="Abcc5a; Mrp5"
                     /inference="alignment:Splign:2.1.0"
     exon            1442..1549
                     /gene="Abcc5"
                     /gene_synonym="Abcc5a; Mrp5"
                     /inference="alignment:Splign:2.1.0"
     exon            1550..1906
                     /gene="Abcc5"
                     /gene_synonym="Abcc5a; Mrp5"
                     /inference="alignment:Splign:2.1.0"
     exon            1907..1978
                     /gene="Abcc5"
                     /gene_synonym="Abcc5a; Mrp5"
                     /inference="alignment:Splign:2.1.0"
     exon            1979..2103
                     /gene="Abcc5"
                     /gene_synonym="Abcc5a; Mrp5"
                     /inference="alignment:Splign:2.1.0"
     exon            2104..2176
                     /gene="Abcc5"
                     /gene_synonym="Abcc5a; Mrp5"
                     /inference="alignment:Splign:2.1.0"
     exon            2177..2380
                     /gene="Abcc5"
                     /gene_synonym="Abcc5a; Mrp5"
                     /inference="alignment:Splign:2.1.0"
     exon            2381..2524
                     /gene="Abcc5"
                     /gene_synonym="Abcc5a; Mrp5"
                     /inference="alignment:Splign:2.1.0"
     exon            2525..2624
                     /gene="Abcc5"
                     /gene_synonym="Abcc5a; Mrp5"
                     /inference="alignment:Splign:2.1.0"
     exon            2625..2809
                     /gene="Abcc5"
                     /gene_synonym="Abcc5a; Mrp5"
                     /inference="alignment:Splign:2.1.0"
     exon            2810..2956
                     /gene="Abcc5"
                     /gene_synonym="Abcc5a; Mrp5"
                     /inference="alignment:Splign:2.1.0"
     exon            2957..3086
                     /gene="Abcc5"
                     /gene_synonym="Abcc5a; Mrp5"
                     /inference="alignment:Splign:2.1.0"
     exon            3087..3240
                     /gene="Abcc5"
                     /gene_synonym="Abcc5a; Mrp5"
                     /inference="alignment:Splign:2.1.0"
     exon            3241..3369
                     /gene="Abcc5"
                     /gene_synonym="Abcc5a; Mrp5"
                     /inference="alignment:Splign:2.1.0"
     exon            3370..3556
                     /gene="Abcc5"
                     /gene_synonym="Abcc5a; Mrp5"
                     /inference="alignment:Splign:2.1.0"
     exon            3557..3646
                     /gene="Abcc5"
                     /gene_synonym="Abcc5a; Mrp5"
                     /inference="alignment:Splign:2.1.0"
     exon            3647..3836
                     /gene="Abcc5"
                     /gene_synonym="Abcc5a; Mrp5"
                     /inference="alignment:Splign:2.1.0"
     exon            3837..3996
                     /gene="Abcc5"
                     /gene_synonym="Abcc5a; Mrp5"
                     /inference="alignment:Splign:2.1.0"
     exon            3997..4075
                     /gene="Abcc5"
                     /gene_synonym="Abcc5a; Mrp5"
                     /inference="alignment:Splign:2.1.0"
     exon            4076..4189
                     /gene="Abcc5"
                     /gene_synonym="Abcc5a; Mrp5"
                     /inference="alignment:Splign:2.1.0"
     exon            4190..4354
                     /gene="Abcc5"
                     /gene_synonym="Abcc5a; Mrp5"
                     /inference="alignment:Splign:2.1.0"
     exon            4355..5744
                     /gene="Abcc5"
                     /gene_synonym="Abcc5a; Mrp5"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      5744
                     /gene="Abcc5"
                     /gene_synonym="Abcc5a; Mrp5"
                     /note="19 a nucleotides"
ORIGIN      
        1 gggattatgc cgctataaag gcttgttttg ctccgggtcc gatgttcgcg agcgtgcccg
       61 ggctgtttgc tttcgtgtgg ggaggctggg atgcagaaat tctaaagtga gaggagcctg
      121 agccctggtc ctgtgtggag tgaagatgaa ggatattgac atgggaaaag aatacatcat
      181 ccccagtccc ggatacagaa gcgtcaggga cagaagcact atcccgggac aacacggcga
      241 tcgtgaagaa cccaggttcc ggagaacaag atcattggaa tgccaagatg ccctagaaac
      301 agcagcccga gttgagggtc tttccctgga catctctgtg cattctcatc tccaaattct
      361 ggacgaggaa catacgaagg ggaaatacca ccatggttta agcgccctga agcccttccg
      421 gaccaccacc aagcaccagc acccagtgga caatgctggc cttttctcct acatgacctt
      481 ttcatggctc tctcctctgg cccaagtggt tcacaagaag ggggagctgt taatggagga
      541 tgtgtggcct ttgtccaagt atgagtcttc tgatgtgaac tgcagaagac tagagagact
      601 gtggcaagaa gagctgaatg aagtcgggcc agacgccgcc tccctgcgaa gggttgtgtg
      661 gatcttttgc cgcaccaggc tcatcctgtc catcgtgtgc ctgatgatca cgcagttggc
      721 tggcttcagt ggaccagcct tcgtggtgaa gcacctcttg gagtacaccc aggcaacaga
      781 gtctaacctg cagtacagct tgctgttggt actaggcctc ctcctgacag aggttgtacg
      841 ctcctggtca ctcgcactga cttgggcatt gaattatcgc actggtgtcc ggctgcgggg
      901 ggctgtcctg accatggcat tcaagaagat cctgaagcta aagaacatta aggaaaagtc
      961 cctgggggag cttatcaata tctgctccaa cgatgggcag aggatgtttg aagcagccgc
     1021 tgtgggcagc ttgctggccg gaggacccgt tgtcgccatc ttgggcatga tttataatgt
     1081 aatcattcta ggaccaacgg gcttcctggg atcggctgtc tttatcctct tttatccggc
     1141 aatgatgttc gtgtcacggc taaccgcgta tttcaggaga aagtgtgtag ccgccacaga
     1201 cgaccgtgtc cagaagatga atgaagttct tacctacatt aaatttatta aaatgtatgc
     1261 ctgggtcaaa gcgttttctc agtgtgttca aaaaatccga gaggaggagc gtcggatcct
     1321 ggagaaggcc gggtactttc agagcatcac cgttggagtg gctcccattg tcgtagtgat
     1381 cgccagcgtg gtgacgttct ccgtccacat gaccctgggc ttcgacctga cagcggcgca
     1441 ggccttcaca gtggtgactg tcttcaattc catgactttt gctttaaaag taacaccatt
     1501 ctcagtgaag tccctctctg aagcatccgt tgctgttgac agatttaaga gtttgtttct
     1561 aatggaagag gttcacatga taaagaacaa accggccagt cctcacatca agatagagat
     1621 gaaaaatgcc accttggcat gggactcctc ccactccagt acacagagct cgcccaagct
     1681 gacccccaaa gtgaaaaaag acaagagggc tcccaagggc aagaaagaga agtcgaggca
     1741 gctgcaacat actgagcacc aggcggtgct ggcagagcag aaaggacacc tcctcctgga
     1801 cagtgatgag cggcccagtc cggaagagga agaaggcaag cagatccacg cagggagcat
     1861 gcgtctgcag aggacactct acaacattga cttagagatt gaagagggca aactggttgg
     1921 aatctgtggc agtgtgggaa gtggaaaaac ctctctgatt tccgccattt taggccagat
     1981 gacgcttttg gagggcagca ttgccgtcag tgggaccttt gcttacgtgg cccaacaggc
     2041 ctggattctc aacgccacgc tgagagacaa cattctcttt gggaaggaat ttgatgaaga
     2101 gagatacaac tcagtgctga acagttgctg cctgcggcct gacttggcca ttctccccaa
     2161 cagcgacctg actgagattg gagagcgagg agccaacctg agtggtgggc agcgccagcg
     2221 aatcagcctt gctcgagccc tgtacagtga cagaagcatc tatatcttgg atgatcccct
     2281 cagtgcctta gatgcccatg tgggcaacca catcttcaac agtgctatcc ggaagcgtct
     2341 caagtctaag acggtcctgt ttgtcacaca ccagttacag tacctggtcg attgtgatga
     2401 ggtgatcttc atgaaagaag gctgtatcac agagagaggt acccacgagg agctgatgaa
     2461 cttaaatgga gactacgcta ccatttttaa taacctgttg ctgggagaga cacccccggt
     2521 cgagattaat tcaaaaaagg aagctagtgg ttcacaaaaa tcacaagaca agggccctaa
     2581 gccagggtca gtgaagaagg agaaggcagt gaagtcggag gaagggcagc tcgtgcaggt
     2641 ggaggagaaa gggcagggct ccgtgccttg gtcagtttac tgggtctaca tccaggctgc
     2701 agggggtccc ttggctttcc tggtcatcat ggtcctcttc atgctcaatg tgggcagcac
     2761 tgccttcagc acctggtggc taagctactg gatcaagcaa ggaagcggga acagcacggt
     2821 gtttgaaggg aacagaagct ctgtgagtga cagcatgagg gacaacccct tcctgcagta
     2881 ctatgccagc atctacgctc tctccatggc agtcatgctg atcctgaagg ccatccgagg
     2941 agttgtcttt gtcaagggta cactgagagc ctcctcccgg ctccatgatg agctcttccg
     3001 gaggatcctg agaagcccca tgaagttttt tgatactacc ccaacaggaa ggattctcaa
     3061 caggttttcc aaagacatgg atgaagtgga cgtgcgtctg ccattccagg ctgagatgtt
     3121 tatccagaat gtgatcctgg tgttcttctg tgttggaatg atcgcagggg tcttcccatg
     3181 gttccttgtg gcagtggggc ctctcctcat cctcttctca gttctacaca ttgtctccag
     3241 ggtcctgatt cgggagctga agcgcttgga caatatcacg caatctcctt tcctctccca
     3301 tatcacgtcc agcattcagg gcctcgccac catccatgcc tataacaaaa ggcaggagtt
     3361 tctacacagg tatcaggagc ttctggatga caaccaagcc cccttcttct tgttcacctg
     3421 tgcaatgagg tggctggcag tgcggctgga cctcatcagc atcgccctga tcaccaccac
     3481 ggggctcatg attgttctca tgcacgggca gatcccttca gcgtacgcgg gcctcgccat
     3541 ctcctacgct gtgcagttaa ccggactctt ccagtttacc gttagactgg cgtcggagac
     3601 agaagcacgg ttcacctcag tggagaggat caaccactac ataaagactc tctctttgga
     3661 agcacctgcc agaatcaaga acaaggctcc tccccatgac tggccccagg agggagaaat
     3721 aacctttgag aatgcggaaa tgagataccg ggaaaatctc cctctggtcc ttaagaaagt
     3781 gtccttcacc atcaagccca aggaaaagat aggcattgtg ggacgaacag ggtcagggaa
     3841 gtcctctcta gggatggccc tcttccgcct ggtggagtta tctggaggct gcatcaagat
     3901 cgatggagta agaatcagtg acattggcct ggccgacctc cgaagcaaac tgaccatcat
     3961 ccctcaggag ccagtgctgt tcagcggcac agtcagatca aacctggacc ctttcaacca
     4021 gtacacagaa gagcagatct gggatgccct agagagaaca cacatgaagg aatgtattgc
     4081 ccagctacct ctgaaactgg aatctgaagt aatggagaac ggggacaact tctctgttgg
     4141 ggaacggcag ttgttatgca tagcaagggc cctgctacgt cactgtaaga ttctgatttt
     4201 agatgaagct acagccgcta tggacacaga gacagactta ctgatccaag agaccatccg
     4261 ggaagcattt gctgactgca ccatgctgac cattgcccat cgcctgcaca cagttctggg
     4321 ctctgatagg atcatggtgc tggcccaggg acaggtggtg gagtttgaca ccccgtcggt
     4381 ccttctgtcc aacgacagct caagattcta tgccatgtgt gctgctgcag agaacaaggt
     4441 ggctgtcaag ggctgactcc tcccacgctg gaagtctctt ccttggagcg ttgccattct
     4501 cttcctggtt gggccctcat cctgtcctgc tgaaacctcg cctttcctgg ttttctctct
     4561 cacgacagtt cagggttagc tgtgtgtctc acttttaagg aaaatcatat tttgattatt
     4621 gtatttattc cctattcact taaatgaaat ttagtttttg ttcttaattg cactcttaag
     4681 aggttcaggg aaccattact ataacgtatc agtggcctat aacgaagctt tatacgtgta
     4741 gctatgtcta tatataattc tgtacatagc ctatatttac agtaaatgta agtggtttat
     4801 tttctattaa agcgagcact gtgctaacac agtgcgcttt catttctatt gtttttgtac
     4861 agctgactgc actacagatc tcatttgctc ttagctgtag gaaaggcagt gtttccttct
     4921 ccagctggtc gtttcacggt gctgggctcc ctaggtgtcc agggggagac acttggcagc
     4981 agcgggccct ccatggcctg ctccgtgggc tccccagtgg aaacccagta cagtgggctg
     5041 caggaggcct tgcagagcac cgtgaattct cagggctcct gctttcctgt ctccctgtca
     5101 gttgccattt atgttagagc agcgggcaaa gccccacccc cttcccctct caggaatgag
     5161 aactccagca ttcctcagag gggagagctt ctttctgcct cccttcttct gctgtcattt
     5221 ctaagcaagg tccagtctgc tgccagtgtt ccgtgcttca ggttcctgag gctggccacc
     5281 gcagagctcc caagctcccc ggccagttgg ttcccagccc ccacccgggc tccactgctg
     5341 ctgctgttgt aggtggcgtt ttcatttgcc tgaccccaca gctccagagc tcagcaacag
     5401 ggctcaggag tgtggggtcc gttcttcctc acttcagtct cctctgcaaa gtctgcaccc
     5461 ctcagcagct cttgctaatc agtgtctcac actggtgtag aagttttttg tactgtaaag
     5521 agacctacct caggttgctg attgctgtgt ggtttggtgc gctcctgcag accccctgtg
     5581 ttgtggggct cttagcttgg gtgggtgtgg ttgccactgt caccagttga gtggtcagcg
     5641 ttgcatgtcg tgaccaatta gacattctat cgccttagca tgtttgctaa acaccttatg
     5701 aaagcaaaaa tctgaaaaag tgaataaaat tattttggat ttat
//
