LOCUS       NM_080581               5175 bp    mRNA    linear   ROD 28-MAR-2024
DEFINITION  Rattus norvegicus ATP binding cassette subfamily C member 3
            (Abcc3), mRNA.
ACCESSION   NM_080581
VERSION     NM_080581.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5175)
  AUTHORS   Bartholomae,S., Gruhn,B., Debatin,K.M., Zimmermann,M., Creutzig,U.,
            Reinhardt,D. and Steinbach,D.
  TITLE     Coexpression of Multiple ABC-Transporters is Strongly Associated
            with Treatment Response in Childhood Acute Myeloid Leukemia
  JOURNAL   Pediatr Blood Cancer 63 (2), 242-247 (2016)
   PUBMED   26512967
REFERENCE   2  (bases 1 to 5175)
  AUTHORS   Carrasco-Torres,G., Fattel-Fazenda,S., Lopez-Alvarez,G.S.,
            Garcia-Roman,R., Villa-Trevino,S. and Vasquez-Garzon,V.R.
  TITLE     The transmembrane transporter ABCC3 participates in liver cancer
            progression and is a potential biomarker
  JOURNAL   Tumour Biol 37 (2), 2007-2014 (2016)
   PUBMED   26337276
  REMARK    GeneRIF: This report is the first to describe liver overexpression
            of Abcc3 during the cancer initiation, promotion, and progression
            periods in rat hepatocarcinogenesis model and in human
            hepatocellular carcinoma
REFERENCE   3  (bases 1 to 5175)
  AUTHORS   Zuniga-Garcia,V., Chavez-Lopez Mde,G., Quintanar-Jurado,V.,
            Gabino-Lopez,N.B., Hernandez-Gallegos,E., Soriano-Rosas,J.,
            Perez-Carreon,J.I. and Camacho,J.
  TITLE     Differential Expression of Ion Channels and Transporters During
            Hepatocellular Carcinoma Development
  JOURNAL   Dig Dis Sci 60 (8), 2373-2383 (2015)
   PUBMED   25842354
REFERENCE   4  (bases 1 to 5175)
  AUTHORS   McGill,M.R. and Jaeschke,H.
  TITLE     Metabolism and disposition of acetaminophen: recent advances in
            relation to hepatotoxicity and diagnosis
  JOURNAL   Pharm Res 30 (9), 2174-2187 (2013)
   PUBMED   23462933
  REMARK    Review article
REFERENCE   5  (bases 1 to 5175)
  AUTHORS   Aleksandrova,M.I., Kushnareva,N.S. and Smirnova,O.V.
  TITLE     Manifestation of multidrug resistance protein 3 (MRP3) in liver and
            kidney cells in cholestasis: effects of hyperprolactinemia
  JOURNAL   Bull Exp Biol Med 154 (4), 508-511 (2013)
   PUBMED   23486593
REFERENCE   6  (bases 1 to 5175)
  AUTHORS   Akita,H., Suzuki,H., Hirohashi,T., Takikawa,H. and Sugiyama,Y.
  TITLE     Transport activity of human MRP3 expressed in Sf9 cells:
            comparative studies with rat MRP3
  JOURNAL   Pharm Res 19 (1), 34-41 (2002)
   PUBMED   11837698
REFERENCE   7  (bases 1 to 5175)
  AUTHORS   Hirohashi,T., Suzuki,H., Takikawa,H. and Sugiyama,Y.
  TITLE     ATP-dependent transport of bile salts by rat multidrug
            resistance-associated protein 3 (Mrp3)
  JOURNAL   J Biol Chem 275 (4), 2905-2910 (2000)
   PUBMED   10644759
REFERENCE   8  (bases 1 to 5175)
  AUTHORS   Ortiz,D.F., Li,S., Iyer,R., Zhang,X., Novikoff,P. and Arias,I.M.
  TITLE     MRP3, a new ATP-binding cassette protein localized to the
            canalicular domain of the hepatocyte
  JOURNAL   Am J Physiol 276 (6), G1493-G1500 (1999)
   PUBMED   10362653
REFERENCE   9  (bases 1 to 5175)
  AUTHORS   Konig,J., Rost,D., Cui,Y. and Keppler,D.
  TITLE     Characterization of the human multidrug resistance protein isoform
            MRP3 localized to the basolateral hepatocyte membrane
  JOURNAL   Hepatology 29 (4), 1156-1163 (1999)
   PUBMED   10094960
REFERENCE   10 (bases 1 to 5175)
  AUTHORS   Hirohashi,T., Suzuki,H., Ito,K., Ogawa,K., Kume,K., Shimizu,T. and
            Sugiyama,Y.
  TITLE     Hepatic expression of multidrug resistance-associated protein-like
            proteins maintained in eisai hyperbilirubinemic rats
  JOURNAL   Mol Pharmacol 53 (6), 1068-1075 (1998)
   PUBMED   9614210
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On Nov 27, 2020 this sequence version replaced NM_080581.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB010467.1, AF072816.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-93                JAXUCZ010000010.1  79839392-79839484   c
            94-270              JAXUCZ010000010.1  79823566-79823742   c
            271-396             JAXUCZ010000010.1  79823109-79823234   c
            397-534             JAXUCZ010000010.1  79822759-79822896   c
            535-660             JAXUCZ010000010.1  79821780-79821905   c
            661-722             JAXUCZ010000010.1  79821535-79821596   c
            723-854             JAXUCZ010000010.1  79820742-79820873   c
            855-1043            JAXUCZ010000010.1  79819450-79819638   c
            1044-1221           JAXUCZ010000010.1  79816231-79816408   c
            1222-1383           JAXUCZ010000010.1  79815972-79816133   c
            1384-1476           JAXUCZ010000010.1  79815499-79815591   c
            1477-1680           JAXUCZ010000010.1  79813612-79813815   c
            1681-1827           JAXUCZ010000010.1  79813360-79813506   c
            1828-1915           JAXUCZ010000010.1  79812947-79813034   c
            1916-1982           JAXUCZ010000010.1  79812628-79812694   c
            1983-2109           JAXUCZ010000010.1  79812286-79812412   c
            2110-2286           JAXUCZ010000010.1  79812022-79812198   c
            2287-2454           JAXUCZ010000010.1  79809534-79809701   c
            2455-2635           JAXUCZ010000010.1  79809062-79809242   c
            2636-2747           JAXUCZ010000010.1  79807972-79808083   c
            2748-2895           JAXUCZ010000010.1  79807672-79807819   c
            2896-3103           JAXUCZ010000010.1  79807383-79807590   c
            3104-3414           JAXUCZ010000010.1  79806908-79807218   c
            3415-3614           JAXUCZ010000010.1  79805247-79805446   c
            3615-3741           JAXUCZ010000010.1  79805011-79805137   c
            3742-3843           JAXUCZ010000010.1  79803037-79803138   c
            3844-3990           JAXUCZ010000010.1  79800664-79800810   c
            3991-4149           JAXUCZ010000010.1  79800395-79800553   c
            4150-4316           JAXUCZ010000010.1  79799523-79799689   c
            4317-4511           JAXUCZ010000010.1  79796849-79797043   c
            4512-5175           JAXUCZ010000010.1  79793583-79794246   c
FEATURES             Location/Qualifiers
     source          1..5175
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q26"
     gene            1..5175
                     /gene="Abcc3"
                     /gene_synonym="Mlp2; Mrp3"
                     /note="ATP binding cassette subfamily C member 3"
                     /db_xref="GeneID:140668"
                     /db_xref="RGD:71101"
     exon            1..93
                     /gene="Abcc3"
                     /gene_synonym="Mlp2; Mrp3"
                     /inference="alignment:Splign:2.1.0"
     CDS             49..4620
                     /gene="Abcc3"
                     /gene_synonym="Mlp2; Mrp3"
                     /EC_number="7.6.2.2"
                     /EC_number="7.6.2.3"
                     /note="ATP-binding cassette, sub-family C (CFTR/MRP),
                     member 3; canalicular multispecific organic anion
                     transporter 2; multidrug resistance protein 3; MLP-2;
                     ATP-binding cassette, subfamily C (CFTR/MRP), member 3;
                     MRP-like protein 2; multidrug resistance-associated
                     protein 3"
                     /codon_start=1
                     /product="ATP-binding cassette sub-family C member 3"
                     /protein_id="NP_542148.2"
                     /db_xref="GeneID:140668"
                     /db_xref="RGD:71101"
                     /translation="MDRLCGSGELGSKFWDSNLTVYTNTPDLTPCFQNSLLAWVPCIY
                     LWAALPCYLFYLRHHRLGYIVLSCLSRLKTALGVLLWCISWVDLFYSFHGLVHGSSPA
                     PVFFITPLLVGITMLLATLLIQYERLRGVRSSGVLIIFWLLCVICAIIPFRSKILLAL
                     AEGKILDPFRFTTFYIYFALVLCAFILSCFQEKPPLFSPENLDTNPCPEASAGFFSRL
                     SFWWFTKLAILGYRRPLEDSDLWSLSEEDCSHKVVQRLLEAWQKQQTQASGPQTAALE
                     PKIAGEDEVLLKARPKTKKPSFLRALVRTFTSSLLMGACFKLIQDLLSFINPQLLSIL
                     IRFISDPTAPTWWGFLLAGLMFVSSTMQTLILHQHYHCIFVMALRIRTAIIGVIYRKA
                     LTITNSVKREYTVGEMVNLMSVDAQRFMDVSPFINLLWSAPLQVILAIYFLWQILGPS
                     ALAGVAVIVLLIPLNGAVSMKMKTYQVQQMKFKDSRIKLMSEILNGIKVLKLYAWEPT
                     FLEQVEGIRQSELQLLRKGAYLQAISTFIWVCTPFMVTLITLGVYVCVDKNNVLDAEK
                     AFVSLSLFNILKIPLNLLPQLISGMTQTSVSLKRIQDFLNQDELDPQCVERKTISPGR
                     AITIHNGTFSWSKDLPPTLHSLNIQIPKGALVAVVGPVGCGKSSLVSALLGEMEKLEG
                     AVSVKGSVAYVPQQAWIQNCTLQENVLFGQPMNPKRYQQALETCALLADLDVLPGGDQ
                     TEIGEKGINLSGGQRQRVSLARAVYSDANIFLLDDPLSAVDSHVAKHIFDQVIGPEGV
                     LAGKTRVLVTHGISFLPQTDFIIVLADGQITEMGHYSELLQHDGSFANFLRNYAPDEN
                     QEANEGVLQHANEEVLLLEDTLSTHTDLTDTEPAIYEVRKQFMREMSSLSSEGEGQNR
                     PVLKRYTSSLEKEVPATQTKETGALIKEEIAETGNVKLSVYWDYAKSVGLCTTLFICL
                     LYAGQNAVAIGANVWLSAWTNDVEEHGQQNNTSVRLGVYATLGILQGLLVMLSAFTMV
                     VGAIQAARLLHTALLHNQIRAPQSFFDTTPSGRILNRFSKDIYVIDEVLAPTILMLFN
                     SFYTSISTIVVIVASTPLFCVVVLPLAVFYGFVQRFYVATSRQLKRLESVSRSPIFSH
                     FSETVTGTSVIRAYGRVQDFKVLSDAKVDSNQKTTYPYIASNRWLGVHVEFVGNCVVL
                     FSALFAVIGRNSLNPGLVGLSVSYALQVTLSLNWMIRTLSDLESNIIAVERVKEYSKT
                     ETEAPWVLESNRAPEGWPRSGVVEFRNYSVRYRPGLELVLKNLTLHVQGGEKVGIVGR
                     TGAGKSSMTLCLFRILEAAEGEIFIDGLNVAHIGLHDLRSQLTIIPQDPILFSGTLRM
                     NLDPFGRYSDEDIWRTLELSHLSAFVSSQPTGLDFQCSEGGDNLSVGQRQLVCLARAL
                     LRKSRVLVLDEATAAIDLETDDLIQGTIRTQFEDCTVLTIAHRLNTIMDYNRVLVLDK
                     GVVAEFDSPVNLIAAGGIFYGMAKDAGLA"
     exon            94..270
                     /gene="Abcc3"
                     /gene_synonym="Mlp2; Mrp3"
                     /inference="alignment:Splign:2.1.0"
     exon            271..396
                     /gene="Abcc3"
                     /gene_synonym="Mlp2; Mrp3"
                     /inference="alignment:Splign:2.1.0"
     exon            397..534
                     /gene="Abcc3"
                     /gene_synonym="Mlp2; Mrp3"
                     /inference="alignment:Splign:2.1.0"
     exon            535..660
                     /gene="Abcc3"
                     /gene_synonym="Mlp2; Mrp3"
                     /inference="alignment:Splign:2.1.0"
     exon            661..722
                     /gene="Abcc3"
                     /gene_synonym="Mlp2; Mrp3"
                     /inference="alignment:Splign:2.1.0"
     exon            723..854
                     /gene="Abcc3"
                     /gene_synonym="Mlp2; Mrp3"
                     /inference="alignment:Splign:2.1.0"
     exon            855..1043
                     /gene="Abcc3"
                     /gene_synonym="Mlp2; Mrp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1044..1221
                     /gene="Abcc3"
                     /gene_synonym="Mlp2; Mrp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1222..1383
                     /gene="Abcc3"
                     /gene_synonym="Mlp2; Mrp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1384..1476
                     /gene="Abcc3"
                     /gene_synonym="Mlp2; Mrp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1477..1680
                     /gene="Abcc3"
                     /gene_synonym="Mlp2; Mrp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1681..1827
                     /gene="Abcc3"
                     /gene_synonym="Mlp2; Mrp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1828..1915
                     /gene="Abcc3"
                     /gene_synonym="Mlp2; Mrp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1916..1982
                     /gene="Abcc3"
                     /gene_synonym="Mlp2; Mrp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1983..2109
                     /gene="Abcc3"
                     /gene_synonym="Mlp2; Mrp3"
                     /inference="alignment:Splign:2.1.0"
     exon            2110..2286
                     /gene="Abcc3"
                     /gene_synonym="Mlp2; Mrp3"
                     /inference="alignment:Splign:2.1.0"
     exon            2287..2454
                     /gene="Abcc3"
                     /gene_synonym="Mlp2; Mrp3"
                     /inference="alignment:Splign:2.1.0"
     exon            2455..2635
                     /gene="Abcc3"
                     /gene_synonym="Mlp2; Mrp3"
                     /inference="alignment:Splign:2.1.0"
     exon            2636..2747
                     /gene="Abcc3"
                     /gene_synonym="Mlp2; Mrp3"
                     /inference="alignment:Splign:2.1.0"
     exon            2748..2895
                     /gene="Abcc3"
                     /gene_synonym="Mlp2; Mrp3"
                     /inference="alignment:Splign:2.1.0"
     exon            2896..3103
                     /gene="Abcc3"
                     /gene_synonym="Mlp2; Mrp3"
                     /inference="alignment:Splign:2.1.0"
     exon            3104..3414
                     /gene="Abcc3"
                     /gene_synonym="Mlp2; Mrp3"
                     /inference="alignment:Splign:2.1.0"
     exon            3415..3614
                     /gene="Abcc3"
                     /gene_synonym="Mlp2; Mrp3"
                     /inference="alignment:Splign:2.1.0"
     exon            3615..3741
                     /gene="Abcc3"
                     /gene_synonym="Mlp2; Mrp3"
                     /inference="alignment:Splign:2.1.0"
     exon            3742..3843
                     /gene="Abcc3"
                     /gene_synonym="Mlp2; Mrp3"
                     /inference="alignment:Splign:2.1.0"
     exon            3844..3990
                     /gene="Abcc3"
                     /gene_synonym="Mlp2; Mrp3"
                     /inference="alignment:Splign:2.1.0"
     exon            3991..4149
                     /gene="Abcc3"
                     /gene_synonym="Mlp2; Mrp3"
                     /inference="alignment:Splign:2.1.0"
     exon            4150..4316
                     /gene="Abcc3"
                     /gene_synonym="Mlp2; Mrp3"
                     /inference="alignment:Splign:2.1.0"
     exon            4317..4511
                     /gene="Abcc3"
                     /gene_synonym="Mlp2; Mrp3"
                     /inference="alignment:Splign:2.1.0"
     exon            4512..5175
                     /gene="Abcc3"
                     /gene_synonym="Mlp2; Mrp3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggttgagct gaactgagat cccaagacca gcggtgcacc agagccacat ggaccgcttg
       61 tgcggctccg gggagctggg ctccaagttc tgggactcca acctgactgt atataccaac
      121 actccagacc tcacaccctg tttccagaac tccttgctgg cctgggttcc ctgcatctat
      181 ctgtgggctg ccttgccctg ctacctgttc tacctgaggc accatcggct tggctacata
      241 gtcctctcat gcttatccag gctcaagacg gccctcggtg ttctgctgtg gtgtatctca
      301 tgggtggacc tgttctactc cttccatggc ctggttcacg gctcatcccc tgctcctgtc
      361 ttctttatca cacccttgtt ggtggggatc accatgctgc tggccacatt gctaatccag
      421 tatgagcggc ttcggggcgt gcggtcttca ggtgtgctca tcatcttctg gctcctgtgt
      481 gtgatctgtg ccatcatccc cttccgttcc aagatcctct tggctttggc agagggtaaa
      541 atcttggatc cgttccgatt caccactttc tacatctact tcgccctcgt gctgtgtgcc
      601 ttcatcctgt cctgcttcca ggagaagccg cctttgtttt ccccagagaa tcttgacaca
      661 aatccttgcc cagaggccag cgctggcttc ttctcccgtc tgtctttctg gtggttcaca
      721 aagcttgcca tccttggcta ccgacgtccc ctggaggaca gtgacctctg gtctctgtct
      781 gaggaggact gctctcacaa ggtggtgcaa cggctactgg aagcatggca aaagcagcag
      841 acccaagcat cagggcccca gactgcagcc cttgagccaa agatcgcagg tgaggatgag
      901 gtcctgctga aggcccgccc caagaccaag aagccttcct ttctgagggc tttggtgaga
      961 accttcacct ccagcttgct catgggtgcc tgcttcaagc tgatccagga cctgctctcc
     1021 ttcatcaacc cacagctgct cagcatcctc atcaggttta tttctgaccc cacggcccct
     1081 acctggtggg gcttcttgct ggccggactg atgttcgtga gctccaccat gcagacattg
     1141 atcttacacc aacattacca ctgcatcttt gtgatggcct tgaggatacg gactgctatc
     1201 ataggcgtca tctacaggaa ggctctgacc atcaccaact cagtcaaacg tgagtacact
     1261 gtgggagaaa tggtcaacct catgtcggtg gacgcccagc gcttcatgga tgtctcccca
     1321 ttcatcaacc tgctgtggtc tgcacctttg caggtcatcc tggcgatata cttcctctgg
     1381 cagatcttag gcccatcagc cctggctggg gtggctgtga tagtcttgct gataccactc
     1441 aatggagctg tgtccatgaa aatgaagacc taccaggtac agcaaatgaa gttcaaagac
     1501 tcccgcatca aactgatgag tgagatcctg aatggcatca aagttctgaa gctgtacgct
     1561 tgggagccca ccttcttgga gcaggtagaa ggaatcaggc agagtgagct ccagctactg
     1621 cggaagggcg cctacctgca ggctatctct accttcatct gggtctgcac cccgtttatg
     1681 gtgaccctga tcaccctcgg ggtgtacgtg tgtgtggaca agaacaatgt gctggatgct
     1741 gagaaggcct tcgtgtccct gtccttgttc aatatcttaa agatccccct caacctgctg
     1801 cctcagttaa tcagtggcat gacccagacc agcgtgtctc tgaaacggat ccaggatttc
     1861 ctgaaccaag atgaacttga cccccagtgt gtggaaagaa agaccatctc cccaggccgt
     1921 gccatcacca tacacaacgg caccttctcc tggtccaagg acctgcctcc cacccttcac
     1981 agcctaaaca ttcaaatccc gaagggggca ttggtggctg tggtgggacc tgtgggctgt
     2041 gggaagtctt ccctggtgtc tgccttgctc ggagagatgg agaagctgga aggtgcagtg
     2101 tctgtaaagg gctctgtggc ctacgtgccc cagcaggcgt ggatccagaa ctgcacactt
     2161 caggaaaatg tgctatttgg ccaacccatg aaccccaagc gctaccaaca ggctctggag
     2221 acgtgtgccc tgctagctga cctagatgtg cttcctggtg gggaccagac agagattgga
     2281 gagaagggca ttaacctatc tggaggccag cgacaacggg tgagtttggc ccgagctgtt
     2341 tatagtgacg ccaacatttt tttgctggat gacccactgt cggctgtgga ctctcacgtg
     2401 gctaagcata tcttcgacca agtgattgga ccagaaggtg tgctggcagg caagactcgg
     2461 gtgctggtaa cccatggcat cagcttcctg ccccagacgg actttatcat tgtgcttgct
     2521 gacggacaga ttactgagat gggtcactac tccgaactcc tgcagcacga tggctccttt
     2581 gccaacttcc tccgaaacta tgcaccagat gaaaaccagg aggccaatga aggagtcttg
     2641 caacatgcaa atgaggaggt gctcctgctt gaagacacac tcagcaccca cacagacctg
     2701 acagacaccg agccagccat atacgaggtc cgcaagcagt tcatgagaga gatgagctcc
     2761 ttgtcttctg aaggagaggg ccagaaccgg cctgtgctca agagatatac gagttcactg
     2821 gagaaggagg tgccggcgac acagactaaa gagactggtg cattaatcaa agaggagatc
     2881 gcagagacag gcaatgtgaa gctgagcgtg tactgggatt atgccaagtc tgtggggctc
     2941 tgcaccacgc tgtttatctg cctcctgtat gctggccaaa atgcggttgc tatcggagcc
     3001 aatgtgtggc tcagtgcctg gaccaatgat gtggaggaac atggccagca gaacaacacc
     3061 tccgtaaggc tgggagtcta cgccacccta ggaatactgc aagggctcct ggtcatgctg
     3121 tcggccttca ccatggtggt tggcgctatc caggctgccc gcctgctgca cacagctctg
     3181 ttgcacaacc agatccgtgc gcctcagtcc ttctttgaca cgacgccctc aggccgcatc
     3241 ctcaatcgtt tctccaagga catatacgtc atcgatgagg ttctggcccc caccatcctc
     3301 atgctgttca attcattcta cacatccatc tccaccattg tggtcatcgt ggccagcacg
     3361 ccactcttct gcgtggttgt tcttcctctg gctgtgttct atggcttcgt gcagcgcttc
     3421 tatgtggcca catcgaggca gctgaagaga ctggaatccg ttagccgctc gcccatcttc
     3481 tcccacttct cggagacagt aactggcacc agtgtcattc gggcctacgg ccgagtccaa
     3541 gacttcaagg tcctcagtga tgctaaggtg gatagcaacc agaagaccac ttatccttac
     3601 atcgcctcca accggtggct gggtgtccac gtggagtttg tggggaactg cgtggtgctc
     3661 ttctccgcgc tgtttgcagt gatcgggaga aacagcttga atccagggct tgtgggtctt
     3721 tccgtgtcct atgccttaca ggtgaccttg agtttgaatt ggatgatacg gacgctatcc
     3781 gacctggagt ctaatatcat agccgtggag agagtcaagg agtactctaa gacggagact
     3841 gaggctccct gggtgttgga gagcaaccgt gctccagaag gctggcccag gagtggggtg
     3901 gtagagttcc ggaactattc ggtgcggtac cgcccgggcc tcgagttggt gctgaagaat
     3961 ttgactctgc atgtgcaggg tggggagaag gtaggcatcg tgggccgcac tggggctggc
     4021 aaatcttcca tgactctttg cctattccga atcctggagg ccgcagaggg tgagatcttc
     4081 attgacgggc tcaatgtggc acacattggc ctccatgacc tgcgttcaca actcaccatc
     4141 atccctcagg accccatcct gttctcgggc acgctgcgca tgaacctcga tccctttggc
     4201 cgttactcgg acgaggacat ctggaggacc ctggagctat cccacctgag tgcatttgtg
     4261 agcagccagc cgacaggcct ggattttcag tgctctgagg gtggggataa tctcagtgtt
     4321 ggccagaggc agctcgtgtg cctagcccga gccctgctcc gaaagagccg tgtcctggtt
     4381 ttagacgagg ccaccgctgc cattgacctg gagactgatg acctcatcca gggtaccatc
     4441 cgtacccagt ttgaagactg cactgtactg accatcgccc accggctcaa cacaatcatg
     4501 gactacaacc gggtcctggt cttggacaaa ggagtagtag ctgaatttga ttctccagta
     4561 aacctcattg cagctggagg catcttctat gggatggcca aagatgcagg actcgcctag
     4621 aatctgcatt ccaaaggttt cttccttgtc tgaatcggac agcaagtagc tgcagcatgg
     4681 atttgatggc aacgagtggg gacatttgag ttggttttgg tttttttttg ttttttgttt
     4741 tttttttttt ttttaaattc tgcaaattgc cttacagact agccatactt aacagtggaa
     4801 tgaggaagtg ggtccttgga ggtcacagcc agttcacagc caagttcaga ccagtccctg
     4861 ggtctcctag acctagtcta ccattattcc cgtactgcat ttttttttgg ttcttttttt
     4921 cagagctggg gaccgaaccc agggccttgc gcttcctagg taagcgctct accactgagc
     4981 taaatcccca gcccccgtac tgcagttttt aagagaccct gctcctgcct ctacatattc
     5041 atagtttcca attttttttt taaatgagcc tttctccttc tggaccaggg actgctaggt
     5101 cagtctgtcc ggggaacaga atccctggtt ggtgctgtct gaatccactg acgaaataaa
     5161 gccatgagca gcagc
//
