LOCUS       NM_001007796            2850 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus ATP binding cassette subfamily B member 8
            (Abcb8), mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_001007796 XM_342614
VERSION     NM_001007796.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2850)
  AUTHORS   Paggio,A., Checchetto,V., Campo,A., Menabo,R., Di Marco,G., Di
            Lisa,F., Szabo,I., Rizzuto,R. and De Stefani,D.
  TITLE     Identification of an ATP-sensitive potassium channel in
            mitochondria
  JOURNAL   Nature 572 (7771), 609-613 (2019)
   PUBMED   31435016
REFERENCE   2  (bases 1 to 2850)
  AUTHORS   Ichikawa,Y., Bayeva,M., Ghanefar,M., Potini,V., Sun,L.,
            Mutharasan,R.K., Wu,R., Khechaduri,A., Jairaj Naik,T. and
            Ardehali,H.
  TITLE     Disruption of ATP-binding cassette B8 in mice leads to
            cardiomyopathy through a decrease in mitochondrial iron export
  JOURNAL   Proc Natl Acad Sci U S A 109 (11), 4152-4157 (2012)
   PUBMED   22375032
  REMARK    GeneRIF: These results indicate that ABCB8 is essential for normal
            cardiac function, maintenance of mitochondrial iron homeostasis and
            maturation of cytosolic Fe/S proteins.
REFERENCE   3  (bases 1 to 2850)
  AUTHORS   Melaine,N., Satie,A.P., Lassurguere,J., Desmots,S., Jegou,B. and
            Samson,M.
  TITLE     Molecular cloning of several rat ABC transporters including a new
            ABC transporter, Abcb8, and their expression in rat testis
  JOURNAL   Int J Androl 29 (3), 392-399 (2006)
   PUBMED   16390497
  REMARK    GeneRIF: In the testis, rat abcb8 was expressed both in the somatic
            Sertoli cells and peritubular cells and in the germline
            (spermatogonia and pachytene spermatocytes).
REFERENCE   4  (bases 1 to 2850)
  AUTHORS   Hogue,D.L., Liu,L. and Ling,V.
  TITLE     Identification and characterization of a mammalian mitochondrial
            ATP-binding cassette membrane protein
  JOURNAL   J Mol Biol 285 (1), 379-389 (1999)
   PUBMED   9878413
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000004.1.
            
            On Oct 6, 2022 this sequence version replaced NM_001007796.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC085781.1, DQ233644.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-168               JAXUCZ010000004.1  11675835-11676002   c
            169-478             JAXUCZ010000004.1  11671192-11671501   c
            479-634             JAXUCZ010000004.1  11670694-11670849   c
            635-729             JAXUCZ010000004.1  11670524-11670618   c
            730-835             JAXUCZ010000004.1  11670296-11670401   c
            836-997             JAXUCZ010000004.1  11669441-11669602   c
            998-1083            JAXUCZ010000004.1  11669114-11669199   c
            1084-1181           JAXUCZ010000004.1  11668910-11669007   c
            1182-1287           JAXUCZ010000004.1  11668140-11668245   c
            1288-1321           JAXUCZ010000004.1  11665556-11665589   c
            1322-1458           JAXUCZ010000004.1  11665137-11665273   c
            1459-1553           JAXUCZ010000004.1  11664888-11664982   c
            1554-1687           JAXUCZ010000004.1  11664570-11664703   c
            1688-1835           JAXUCZ010000004.1  11663922-11664069   c
            1836-2086           JAXUCZ010000004.1  11662126-11662376   c
            2087-2850           JAXUCZ010000004.1  11660716-11661479   c
FEATURES             Location/Qualifiers
     source          1..2850
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q11"
     gene            1..2850
                     /gene="Abcb8"
                     /gene_synonym="MITOSUR"
                     /note="ATP binding cassette subfamily B member 8"
                     /db_xref="GeneID:362302"
                     /db_xref="RGD:1307655"
     exon            1..168
                     /gene="Abcb8"
                     /gene_synonym="MITOSUR"
                     /inference="alignment:Splign:2.1.0"
     CDS             74..2218
                     /gene="Abcb8"
                     /gene_synonym="MITOSUR"
                     /note="ATP-binding cassette sub-family B member 8,
                     mitochondrial; ABC transporter 8; ATP-binding cassette,
                     sub-family B (MDR/TAP), member 8; ATP-binding cassette,
                     sub-family B, member 8; ATP-binding cassette, subfamily B
                     (MDR/TAP), member 8; mitochondrial sulfonylurea-receptor;
                     mitochondrial potassium channel ATP-binding subunit"
                     /codon_start=1
                     /product="mitochondrial potassium channel ATP-binding
                     subunit precursor"
                     /protein_id="NP_001007797.1"
                     /db_xref="GeneID:362302"
                     /db_xref="RGD:1307655"
                     /translation="MLVHLFRVGIRGGPVPRWSLQSLRFQTFSAARSSDDQFSSCLLR
                     AVAQLRSQLRAHLPRSPPASHRSTSAWCWVGGTLVVPAVLWQHPRFCLIALCEAKGSP
                     PAQPTRARELRFKWKLFWHFLHPHLLALGLAIVLALGAALVNVQIPLLLGQLVEIVAK
                     YTREHVGSFVSESRRLSIQLLLLYGVQGLLTFGYLVLLSHMGERMAMDMRKALFSSLL
                     RQDIAFFDAKKTGQLVSRLTTDVQEFKSSFKLVISQGLRSSTQVIGSLMTLSILSPRL
                     TLMLAVVTPALMGVGTLMGSGLRKLSRQCQEQIARATGVADEALGSVRTVRAFAMEKR
                     EEERYQAELESCCCKAEELGRGIALFQGLSNIAFNCMVLGTLFIGGSLVAGQQLKGGD
                     LMSFLVASQTVQRSMASLSVLFGQVVRGLSAGARVFEYMSLSPVIPLTGGYSIPSKDL
                     RGSITFQNVSFSYPCRPGFNVLKNFTLKLPPGKIVALVGQSGGGKTTVASLLERFYDP
                     TAGVVTLDGHDLRTLDPSWLRGQVIGFISQEPVLFATTIMENIRFGKLDASDEEVYTA
                     ARKANAHEFISSFPDGYSTVVGERGTTLSGGQKQRLAIARALIKRPTVLILDEATSAL
                     DAESERIVQEALDRASAGRTVLVIAHRLSTVRAAHSIIVMANGQVCEAGTHEELLQKG
                     GLYAELIRRQALDASLPSAPPAEKPEDHRSCQ"
     exon            169..478
                     /gene="Abcb8"
                     /gene_synonym="MITOSUR"
                     /inference="alignment:Splign:2.1.0"
     exon            479..634
                     /gene="Abcb8"
                     /gene_synonym="MITOSUR"
                     /inference="alignment:Splign:2.1.0"
     exon            635..729
                     /gene="Abcb8"
                     /gene_synonym="MITOSUR"
                     /inference="alignment:Splign:2.1.0"
     exon            730..835
                     /gene="Abcb8"
                     /gene_synonym="MITOSUR"
                     /inference="alignment:Splign:2.1.0"
     exon            836..997
                     /gene="Abcb8"
                     /gene_synonym="MITOSUR"
                     /inference="alignment:Splign:2.1.0"
     exon            998..1083
                     /gene="Abcb8"
                     /gene_synonym="MITOSUR"
                     /inference="alignment:Splign:2.1.0"
     exon            1084..1181
                     /gene="Abcb8"
                     /gene_synonym="MITOSUR"
                     /inference="alignment:Splign:2.1.0"
     exon            1182..1287
                     /gene="Abcb8"
                     /gene_synonym="MITOSUR"
                     /inference="alignment:Splign:2.1.0"
     exon            1288..1321
                     /gene="Abcb8"
                     /gene_synonym="MITOSUR"
                     /inference="alignment:Splign:2.1.0"
     exon            1322..1458
                     /gene="Abcb8"
                     /gene_synonym="MITOSUR"
                     /inference="alignment:Splign:2.1.0"
     exon            1459..1553
                     /gene="Abcb8"
                     /gene_synonym="MITOSUR"
                     /inference="alignment:Splign:2.1.0"
     exon            1554..1687
                     /gene="Abcb8"
                     /gene_synonym="MITOSUR"
                     /inference="alignment:Splign:2.1.0"
     exon            1688..1835
                     /gene="Abcb8"
                     /gene_synonym="MITOSUR"
                     /inference="alignment:Splign:2.1.0"
     exon            1836..2086
                     /gene="Abcb8"
                     /gene_synonym="MITOSUR"
                     /inference="alignment:Splign:2.1.0"
     exon            2087..2850
                     /gene="Abcb8"
                     /gene_synonym="MITOSUR"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agctaacatg gaaccctcgg taggataagt gtgagattgc cgttgctggc tgtccctgtt
       61 ttattgcctc aacatgttgg tgcacttatt tcgggtcgga attcggggtg gcccagttcc
      121 aagatggtcg ctacaatccc tgcgcttcca gacgttctca gccgccaggt cctcagatga
      181 ccagttcagc tcatgcctcc tgcgggctgt agcccagctc cggtcacaac tccgcgctca
      241 cctccctcga tccccaccag cttcccaccg gagtacctct gcctggtgtt gggttggggg
      301 gactttggtg gtccccgctg tgctgtggca gcatccccgt ttctgcctta tagcactatg
      361 tgaggccaaa gggtcccctc ctgcccagcc cacacgtgcc cgggagctgc gctttaagtg
      421 gaagctattc tggcatttcc ttcaccccca cctgctggcc ctggggctag ccattgtgct
      481 ggccttgggt gcggcactag tgaatgtgca gatccccttg ctcctcggcc aactggtgga
      541 gatcgtcgcc aagtacacga gggagcatgt ggggagtttc gtgtctgagt cccgtaggct
      601 cagtatccag ctgctcctac tctatggtgt tcagggacta ctgacctttg gatacctagt
      661 gctgctgtcc cacatgggtg agcgcatggc catggacatg cggaaagccc ttttcagctc
      721 cctgctccgg caagacattg ctttctttga tgccaaaaag acagggcagc tagtgagccg
      781 cttgactact gatgtgcaag agttcaagtc atccttcaag cttgtcatct cccagggact
      841 gcgcagctcc acccaggtga tcggtagcct gatgaccctg tctattctgt ccccgcgcct
      901 tacactgatg ctggctgttg tcacacctgc cctcatggga gtgggcaccc tgatgggctc
      961 aggcctccga aagctttctc gacagtgtca ggagcagatt gccagggcga caggtgtagc
     1021 agacgaggcc cttggcagtg ttcggactgt tcgggccttc gcaatggaga agagggagga
     1081 ggaacgctat caagcagaac tggagtcatg ctgctgtaaa gcagaggagc tgggcagggg
     1141 catcgccttg ttccaggggc tctcaaacat cgctttcaac tgtatggtct tgggcaccct
     1201 gttcattgga ggctcccttg tggctggaca gcagctgaaa gggggagacc tcatgtcctt
     1261 cctggtggct tcccagacag tacagaggtc tatggccagc ctctctgtcc tgtttggtca
     1321 ggtggtgcgt gggctgagtg caggagcccg agtctttgag tacatgtccc tgagccccgt
     1381 catccccttg accgggggct actctatccc cagcaaggac cttcgtggtt ctatcacctt
     1441 ccagaatgtc agcttcagct acccctgccg acctggcttc aatgtgctca agaacttcac
     1501 cctgaagctg ccccctggca agattgtggc tctcgttggc cagtctgggg gaggaaagac
     1561 cacagttgct tccctgctgg aacgcttcta tgaccccaca gctggcgtgg tgacgctgga
     1621 tgggcatgac ctgcgtactc tcgacccctc ctggctccgg ggccaggtca taggtttcat
     1681 cagccaggag ccagtcctgt ttgcaacaac catcatggag aatatccgat ttgggaagct
     1741 agatgcttcc gatgaagagg tgtatacagc tgcacggaaa gccaatgccc acgagttcat
     1801 cagcagcttc cctgatggct acagcactgt ggttggtgaa cggggcacaa ccttgtccgg
     1861 tggtcagaag cagcgcctag ccatcgcacg tgccctcatc aagaggccca cagtgttgat
     1921 cctggatgaa gccaccagtg cgctggacgc agagtctgag aggatagtac aggaggcact
     1981 ggaccgggcc agtgctggtc gcaccgtgtt ggtcattgcc caccggctca gtactgttcg
     2041 tgccgcccac tccatcatcg tcatggccaa tggccaagtc tgtgaggctg ggacccacga
     2101 agaactcctt caaaaaggcg ggctctacgc agagcttatc cggagacaag ccctggatgc
     2161 ctcactgccc tcagccccac ctgcagagaa gcctgaagac cacagaagct gccagtgagg
     2221 ccccctgggg tcagtctgag gctggagctc tgctggggac agagcccttg agggccagtg
     2281 tgctggagtg tggcctggac tactactccc ttaaaggagc tgggacccaa ccactggggt
     2341 gggagactgg ctttcctccc acctgctcct acgatcctaa ctcagctctg tggtcacagg
     2401 atgtatacgg tgaggcagag tccctgaaca cctctgcttg accctctcag gctggcccag
     2461 ttctgcccaa cactcagttg tttaggcccc aactccaggg aactggctgg gcctggtaga
     2521 atgggctgaa gtcccagcac ttgggagaca gaagtgggag gaggatcaag agttcaaggc
     2581 cggggctgga gagatggctc agatgttaag agcactgtct gctcatccag aggtcacgag
     2641 ttcaattccc agcaaccaca tggtggctca caaccatata taatgagatc tggtgccctc
     2701 ttctggcctg catgtataca tgcaggtgca atgctgtata cataataaat aaatctttaa
     2761 aaaaaaaaaa gttcaaggcc atcctgggct acatagtgag actgtatctt aaaaaaggag
     2821 aacctaaata aaaagacaat tttaaaagag
//
