LOCUS       NM_212518               2368 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Rattus norvegicus ATP binding cassette subfamily B member 7
            (Abcb7), mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_212518 XM_217569
VERSION     NM_212518.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2368)
  AUTHORS   Kumar,V., A,A.K., Sanawar,R., Jaleel,A., Santhosh Kumar,T.R. and
            Kartha,C.C.
  TITLE     Chronic Pressure Overload Results in Deficiency of Mitochondrial
            Membrane Transporter ABCB7 Which Contributes to Iron Overload,
            Mitochondrial Dysfunction, Metabolic Shift and Worsens Cardiac
            Function
  JOURNAL   Sci Rep 9 (1), 13170 (2019)
   PUBMED   31511561
  REMARK    GeneRIF: Chronic Pressure Overload Results in Deficiency of
            Mitochondrial Membrane Transporter ABCB7 Which Contributes to Iron
            Overload, Mitochondrial Dysfunction, Metabolic Shift and Worsens
            Cardiac Function.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2368)
  AUTHORS   Maio,N. and Rouault,T.A.
  TITLE     Iron-sulfur cluster biogenesis in mammalian cells: New insights
            into the molecular mechanisms of cluster delivery
  JOURNAL   Biochim Biophys Acta 1853 (6), 1493-1512 (2015)
   PUBMED   25245479
  REMARK    Review article
REFERENCE   3  (bases 1 to 2368)
  AUTHORS   Boultwood,J., Pellagatti,A., Nikpour,M., Pushkaran,B., Fidler,C.,
            Cattan,H., Littlewood,T.J., Malcovati,L., Della Porta,M.G.,
            Jadersten,M., Killick,S., Giagounidis,A., Bowen,D.,
            Hellstrom-Lindberg,E., Cazzola,M. and Wainscoat,J.S.
  TITLE     The role of the iron transporter ABCB7 in refractory anemia with
            ring sideroblasts
  JOURNAL   PLoS One 3 (4), e1970 (2008)
   PUBMED   18398482
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2368)
  AUTHORS   Krishnamurthy,P.C., Du,G., Fukuda,Y., Sun,D., Sampath,J.,
            Mercer,K.E., Wang,J., Sosa-Pineda,B., Murti,K.G. and Schuetz,J.D.
  TITLE     Identification of a mammalian mitochondrial porphyrin transporter
  JOURNAL   Nature 443 (7111), 586-589 (2006)
   PUBMED   17006453
REFERENCE   5  (bases 1 to 2368)
  AUTHORS   Clarke,S.L., Vasanthakumar,A., Anderson,S.A., Pondarre,C.,
            Koh,C.M., Deck,K.M., Pitula,J.S., Epstein,C.J., Fleming,M.D. and
            Eisenstein,R.S.
  TITLE     Iron-responsive degradation of iron-regulatory protein 1 does not
            require the Fe-S cluster
  JOURNAL   EMBO J 25 (3), 544-553 (2006)
   PUBMED   16424901
REFERENCE   6  (bases 1 to 2368)
  AUTHORS   Da Cruz,S., Xenarios,I., Langridge,J., Vilbois,F., Parone,P.A. and
            Martinou,J.C.
  TITLE     Proteomic analysis of the mouse liver mitochondrial inner membrane
  JOURNAL   J Biol Chem 278 (42), 41566-41571 (2003)
   PUBMED   12865426
REFERENCE   7  (bases 1 to 2368)
  AUTHORS   Taketani,S., Kakimoto,K., Ueta,H., Masaki,R. and Furukawa,T.
  TITLE     Involvement of ABC7 in the biosynthesis of heme in erythroid cells:
            interaction of ABC7 with ferrochelatase
  JOURNAL   Blood 101 (8), 3274-3280 (2003)
   PUBMED   12480705
REFERENCE   8  (bases 1 to 2368)
  AUTHORS   Maguire,A., Hellier,K., Hammans,S. and May,A.
  TITLE     X-linked cerebellar ataxia and sideroblastic anaemia associated
            with a missense mutation in the ABC7 gene predicting V411L
  JOURNAL   Br J Haematol 115 (4), 910-917 (2001)
   PUBMED   11843825
REFERENCE   9  (bases 1 to 2368)
  AUTHORS   Bekri,S., Kispal,G., Lange,H., Fitzsimons,E., Tolmie,J., Lill,R.
            and Bishop,D.F.
  TITLE     Human ABC7 transporter: gene structure and mutation causing
            X-linked sideroblastic anemia with ataxia with disruption of
            cytosolic iron-sulfur protein maturation
  JOURNAL   Blood 96 (9), 3256-3264 (2000)
   PUBMED   11050011
REFERENCE   10 (bases 1 to 2368)
  AUTHORS   Allikmets,R., Raskind,W.H., Hutchinson,A., Schueck,N.D., Dean,M.
            and Koeller,D.M.
  TITLE     Mutation of a putative mitochondrial iron transporter gene (ABC7)
            in X-linked sideroblastic anemia and ataxia (XLSA/A)
  JOURNAL   Hum Mol Genet 8 (5), 743-749 (1999)
   PUBMED   10196363
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AJ621255.1.
            
            On Aug 30, 2004 this sequence version replaced XM_217569.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ621255.1, SRR8487226.196826.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2368
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="W"
                     /db_xref="taxon:10116"
                     /chromosome="X"
                     /map="Xq22"
     gene            1..2368
                     /gene="Abcb7"
                     /note="ATP binding cassette subfamily B member 7"
                     /db_xref="GeneID:302395"
                     /db_xref="RGD:1303086"
     exon            1..180
                     /gene="Abcb7"
                     /inference="alignment:Splign:2.1.0"
     CDS             13..2271
                     /gene="Abcb7"
                     /function="transporter"
                     /note="ABC transporter 7 protein; ATP-binding cassette
                     transporter 7; ATP-binding cassette, sub-family B, member
                     7, mitochondrial; ATP-binding cassette, subfamily B
                     (MDR/TAP), member 7; ATP-binding cassette, sub-family B
                     (MDR/TAP), member 7"
                     /codon_start=1
                     /product="iron-sulfur clusters transporter ABCB7,
                     mitochondrial"
                     /protein_id="NP_997683.1"
                     /db_xref="GeneID:302395"
                     /db_xref="RGD:1303086"
                     /translation="MALLAIHSWRWAAAAVAFEKHKHSAVLTRSLVSICGSGLRWSSY
                     QSGASGSARLSQTTESLRNSTQQRWEKNNSRQLLDASKVLQAWPLIEKRTCWHGHAGG
                     GLHTDPKEGLKDVDTRKIIKAMLSYVWPKDRPDLRARVAISLGFLGGAKAMNIVVPFM
                     FKYAVDSLNQMSGNMLNLSDAPNTVATMATAVLIGYGVSRAGAAFFNEVRNAVFGKVA
                     QNSIRRIAKNVFLHLHNLDLGFHLSRQTGALSKAIDRGTRGISFVLSALVFNLLPIVF
                     EMTLVSSVLYYKCGAQFALVTLGTLGAYTAFTVAVTRWRTRFRIEMNKADNDAGNAAI
                     DSLLNYETVKYFNNEKYEAQRYDGFLKTYETASLKSTSTLAMLNFGQSAIFSVGLTAI
                     MVLASQGIVAGALTVGDLVMVNGLLFQLSLPLNFLGTVYRETRQALIDMNTLFTLLKV
                     DTRIKDKAMASPLQITPQTATVAFDNVHFEYIEGQKVLSGVSFEVPAGKKVAIVGGSG
                     SGKSTIVRLLFRFYEPQKGSIYLAGQNIQDVSLESLRRAVGVVPQDAVLFHNTIYYNL
                     LYGNINASPEEVYAVAKLAGLHDAILRMPHGYDTQVGERGLKLSGGEKQRVAIARAIL
                     KDPPVILYDEATSSLDSITEETILGAMRDVVKHRTSIFIAHRLSTVVDADEIIVLSQG
                     KVAERGTHYGLLANSSSIYSEMWHTQSTRIQNHDNLGWDAKKESLSKEEERKKLQEEI
                     VNSVKGCGNCSC"
     exon            181..258
                     /gene="Abcb7"
                     /inference="alignment:Splign:2.1.0"
     exon            259..345
                     /gene="Abcb7"
                     /inference="alignment:Splign:2.1.0"
     exon            346..465
                     /gene="Abcb7"
                     /inference="alignment:Splign:2.1.0"
     exon            466..598
                     /gene="Abcb7"
                     /inference="alignment:Splign:2.1.0"
     exon            599..867
                     /gene="Abcb7"
                     /inference="alignment:Splign:2.1.0"
     exon            868..956
                     /gene="Abcb7"
                     /inference="alignment:Splign:2.1.0"
     exon            957..1044
                     /gene="Abcb7"
                     /inference="alignment:Splign:2.1.0"
     exon            1045..1219
                     /gene="Abcb7"
                     /inference="alignment:Splign:2.1.0"
     exon            1220..1377
                     /gene="Abcb7"
                     /inference="alignment:Splign:2.1.0"
     exon            1378..1541
                     /gene="Abcb7"
                     /inference="alignment:Splign:2.1.0"
     exon            1542..1671
                     /gene="Abcb7"
                     /inference="alignment:Splign:2.1.0"
     exon            1672..1843
                     /gene="Abcb7"
                     /inference="alignment:Splign:2.1.0"
     exon            1844..1947
                     /gene="Abcb7"
                     /inference="alignment:Splign:2.1.0"
     exon            1948..2055
                     /gene="Abcb7"
                     /inference="alignment:Splign:2.1.0"
     exon            2056..2368
                     /gene="Abcb7"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccctcgctca agatggcgct gctcgcgata cattcttggc gctgggcagc cgcggcggtc
       61 gctttcgaaa agcacaagca ttcggcagtt ctgacccggt ctctagtctc catctgcggc
      121 tcaggcctgc ggtggagttc gtaccagagc ggcgcgtcag gaagcgctcg gctgtcccag
      181 actacagaat cattaagaaa ttctacacag cagagatggg aaaaaaacaa ctcaagacag
      241 ttactagatg cttcaaaggt tcttcaggca tggccattga tagaaaagag aacatgttgg
      301 catgggcacg caggaggagg actccacaca gacccaaaag aagggttaaa ggatgttgat
      361 actagaaaaa tcattaaagc catgctttct tatgtgtggc ccaaagacag gcctgatctg
      421 cgagccagag ttgccatttc cctgggattt ctgggtggtg caaaggccat gaatattgtg
      481 gttcctttca tgtttaaata tgctgtagac agcctcaacc agatgtcggg aaacatgctg
      541 aacctgagtg atgcaccaaa tacagttgca accatggcaa cagcagttct gattggctat
      601 ggtgtatcaa gagccggggc tgcctttttc aatgaagtcc gaaatgcagt atttggcaaa
      661 gtagcacaaa attcaatccg aagaatagcc aaaaatgtat ttctccatct tcacaacttg
      721 gatctgggtt tccatctgag cagacagaca ggagccttat ctaaggctat tgacagaggg
      781 acaaggggca ttagttttgt cctcagtgct ttagtattta atcttctccc tattgtgttt
      841 gagatgacgc ttgtcagtag tgttttgtat tacaaatgtg gggcccagtt tgcattggta
      901 accctgggaa cacttggtgc atatacagca ttcacagttg cagttacacg gtggagaact
      961 agatttagaa tagaaatgaa caaagctgat aacgatgcag ggaacgctgc tattgactca
     1021 ctgctgaatt atgaaactgt gaagtatttt aacaatgaaa aatatgaagc acaaagatat
     1081 gatggattct tgaagacata tgagactgct tcattgaaaa gtacctctac tctggctatg
     1141 ctgaattttg gccaaagtgc tattttcagt gttggattaa cagctatcat ggtgcttgcc
     1201 agtcagggaa ttgtggcagg tgcccttact gttggagatc tagtaatggt gaatggactg
     1261 ctttttcaac tttcattacc ccttaacttc ttgggaactg tatatagaga gacacggcaa
     1321 gcactcatag atatgaatac cttgtttact ctgctcaagg tagacacgcg gattaaagac
     1381 aaagcgatgg catctcccct tcaaataaca ccacagacag ccacggtggc ctttgataat
     1441 gtgcattttg agtacattga aggacagaaa gtccttagcg gagtatcttt tgaagtccct
     1501 gcaggaaaga aagtggccat tgtaggaggt agtgggtcag gaaaaagcac gatagtgagg
     1561 ctgctgtttc gcttctatga gcctcaaaag ggtagcattt accttgctgg tcaaaatatt
     1621 caagatgtga gcctggaaag tcttcggcgt gcagtgggag tagtacctca ggatgctgtc
     1681 ctcttccata atactatcta ctacaacctc ttatatggaa acatcaatgc gtcaccagag
     1741 gaagtatatg cagtcgcaaa attggctggt cttcatgatg caattcttcg aatgccacat
     1801 ggatatgaca cacaagtagg agaacgagga ctcaagttat caggaggaga aaagcagagg
     1861 gtagcgattg caagagccat tttgaaggat cccccagtta ttctctatga tgaagctact
     1921 tcatcattag attcgattac tgaagagact attcttggtg ccatgaggga tgtggtgaag
     1981 cacagaactt ctattttcat cgcacataga ttgtcaacag tggttgatgc agatgaaatc
     2041 attgtcctga gccagggaaa agtagctgaa cgtggtaccc actatggtct gcttgctaac
     2101 tctagcagta tctattcaga gatgtggcat acacagagca cccgcataca gaaccatgat
     2161 aaccttggat gggatgcaaa gaaagagagt ctctctaaag aggaggagag aaagaagctc
     2221 caagaagaga ttgtcaacag cgtgaaaggc tgtggaaatt gctcctgcta aggaacacag
     2281 acattttctc gtctttcttt ttgttgtctt gtttggtttt gaaatatgca tttgcactga
     2341 agtaaaacca gttcacaaaa acacaaat
//
