LOCUS       NM_080582               2848 bp    mRNA    linear   ROD 02-APR-2024
DEFINITION  Rattus norvegicus ATP binding cassette subfamily B member 6
            (Abcb6), mRNA.
ACCESSION   NM_080582
VERSION     NM_080582.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2848)
  AUTHORS   Zhang,C., Li,D., Zhang,J., Chen,X., Huang,M., Archacki,S., Tian,Y.,
            Ren,W., Mei,A., Zhang,Q., Fang,M., Su,Z., Yin,Y., Liu,D., Chen,Y.,
            Cui,X., Li,C., Yang,H., Wang,Q., Wang,J., Liu,M. and Deng,Y.
  TITLE     Mutations in ABCB6 cause dyschromatosis universalis hereditaria
  JOURNAL   J Invest Dermatol 133 (9), 2221-2228 (2013)
   PUBMED   23519333
REFERENCE   2  (bases 1 to 2848)
  AUTHORS   Wang,L., He,F., Bu,J., Zhen,Y., Liu,X., Du,W., Dong,J.,
            Cooney,J.D., Dubey,S.K., Shi,Y., Gong,B., Li,J., McBride,P.F.,
            Jia,Y., Lu,F., Soltis,K.A., Lin,Y., Namburi,P., Liang,C.,
            Sundaresan,P., Paw,B.H., Li,W., Li,D.Y., Phillips,J.D. and Yang,Z.
  TITLE     ABCB6 mutations cause ocular coloboma
  JOURNAL   Am J Hum Genet 90 (1), 40-48 (2012)
   PUBMED   22226084
  REMARK    Erratum:[Am J Hum Genet. 2012 Aug 10;91(2):397. Zhen, Yuanli
            [added]; Li, Wei [added]; Wang, Lejing [corrected to Wang, Lejin];
            Liu, Xiaqi [corrected to Liu, Xiaoqui]]
REFERENCE   3  (bases 1 to 2848)
  AUTHORS   Aldahmesh,M.A., Mohamed,J.Y., Alkuraya,H.S., Verma,I.C., Puri,R.D.,
            Alaiya,A.A., Rizzo,W.B. and Alkuraya,F.S.
  TITLE     Recessive mutations in ELOVL4 cause ichthyosis, intellectual
            disability, and spastic quadriplegia
  JOURNAL   Am J Hum Genet 89 (6), 745-750 (2011)
   PUBMED   22100072
REFERENCE   4  (bases 1 to 2848)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   5  (bases 1 to 2848)
  AUTHORS   Tsuchida,M., Emi,Y., Kida,Y. and Sakaguchi,M.
  TITLE     Human ABC transporter isoform B6 (ABCB6) localizes primarily in the
            Golgi apparatus
  JOURNAL   Biochem Biophys Res Commun 369 (2), 369-375 (2008)
   PUBMED   18279659
REFERENCE   6  (bases 1 to 2848)
  AUTHORS   Krishnamurthy,P.C., Du,G., Fukuda,Y., Sun,D., Sampath,J.,
            Mercer,K.E., Wang,J., Sosa-Pineda,B., Murti,K.G. and Schuetz,J.D.
  TITLE     Identification of a mammalian mitochondrial porphyrin transporter
  JOURNAL   Nature 443 (7111), 586-589 (2006)
   PUBMED   17006453
REFERENCE   7  (bases 1 to 2848)
  AUTHORS   Melaine,N., Satie,A.P., Lassurguere,J., Desmots,S., Jegou,B. and
            Samson,M.
  TITLE     Molecular cloning of several rat ABC transporters including a new
            ABC transporter, Abcb8, and their expression in rat testis
  JOURNAL   Int J Androl 29 (3), 392-399 (2006)
   PUBMED   16390497
REFERENCE   8  (bases 1 to 2848)
  AUTHORS   Mitsuhashi,N., Miki,T., Senbongi,H., Yokoi,N., Yano,H.,
            Miyazaki,M., Nakajima,N., Iwanaga,T., Yokoyama,Y., Shibata,T. and
            Seino,S.
  TITLE     MTABC3, a novel mitochondrial ATP-binding cassette protein involved
            in iron homeostasis
  JOURNAL   J Biol Chem 275 (23), 17536-17540 (2000)
   PUBMED   10837493
REFERENCE   9  (bases 1 to 2848)
  AUTHORS   Hirsch-Ernst,K.I., Gaini-Rahimi,S., Ernst,B.P., Schmitz-Salue,C.,
            Blume,S. and Kahl,G.F.
  TITLE     Molecular cDNA cloning and tissue distribution of mRNA encoding a
            novel ATP-binding cassette (ABC) half-transporter
  JOURNAL   Biochem Biophys Res Commun 249 (1), 151-155 (1998)
   PUBMED   9705847
REFERENCE   10 (bases 1 to 2848)
  AUTHORS   Furuya,K.N., Bradley,G., Sun,D., Schuetz,E.G. and Schuetz,J.D.
  TITLE     Identification of a new P-glycoprotein-like ATP-binding cassette
            transporter gene that is overexpressed during hepatocarcinogenesis
  JOURNAL   Cancer Res 57 (17), 3708-3716 (1997)
   PUBMED   9288777
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AJ003004.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ003004.1, BC085712.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760476 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2848
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q33"
     gene            1..2848
                     /gene="Abcb6"
                     /gene_synonym="MTABC3"
                     /note="ATP binding cassette subfamily B member 6"
                     /db_xref="GeneID:140669"
                     /db_xref="RGD:71077"
     exon            1..703
                     /gene="Abcb6"
                     /gene_synonym="MTABC3"
                     /inference="alignment:Splign:2.1.0"
     CDS             155..2665
                     /gene="Abcb6"
                     /gene_synonym="MTABC3"
                     /EC_number="7.6.2.5"
                     /note="ATP-binding cassette, sub-family B (MDR/TAP),
                     member 6; ATP-binding cassette sub-family B member 6,
                     mitochondrial; ABC-type heme transporter ABCB6;
                     ubiquitously-expressed mammalian ABC half transporter;
                     mammalian mitochondrial ABC protein 3; ATP-binding
                     cassette, subfamily B (MDR/TAP), member 6"
                     /codon_start=1
                     /product="ATP-binding cassette sub-family B member 6"
                     /protein_id="NP_542149.1"
                     /db_xref="GeneID:140669"
                     /db_xref="RGD:71077"
                     /translation="MVTVGNYCEAEGPAGPAWTQNGLSPCFFYTLVPSTLMTLGVLAL
                     VLVLPCRRREVPAGTEELSWAAGPRVAPYALQLSLAILQMALPLASLAGRVGTARGVR
                     LPGYLLLASVLESLASACGLWLLVVERSQARQSLAMGVWMKFRHSLGLLLLWTVTFAA
                     ENLVLVSWNSPQWWWSRADLGQQVQFGLWVLRYMTSGGLFILGLWAPGLRPQSYTLHV
                     NEEDQDGGRNQGRSTDPRSTWRDLGRKLRLLSGYLWPRGSPSLQLTVLLCMGLMGLDR
                     ALNVLVPIFYRDIVNLLTSKAPWSSLAWTVTTYVFLKFLQGGGTGSTGFVSNLRTFLW
                     IRVQQFTSRGVELRLFSHLHELSLRWHLGRRTGEVLRIVDRGTSSVTGLLSYLVFNII
                     PTLADIIIGIIYFSMFFNAWFGLIVFLCMSLYLILTIMVTEWRAKFRRDMNTQENATR
                     ARAVDSLLNFETVKYYNAEGYELERYREAILKFQGLEWKSTASLVLLNQTQNMVIGFG
                     LLAGSLLCAYFVSERRLQVGDFVLFGTYITQLYMPLNWFGTYYRMIQTNFIDMENMFD
                     LLKEETEVKDVPGAGPLRFHKGRVEFENVHFSYADGRETLQDVSFTVMPGQTVALVGP
                     SGAGKSTILRLLFRFYDISSGCIRIDGQDISQVTQISLRSHIGVVPQDTVLFNDTIAN
                     NIRYGRVTAGDSEIQAAAQAAGIHDAILSFPEGYETQVGERGLKLSGGEKQRVAIART
                     ILKAPDIILLDEATSALDTSNERAIQASLAKVCTNRTTIVVAHRLSTVVNADQILVIK
                     DGCIIERGRHEALLSRGGVYAEMWQLQQQGQETVPEDS"
     exon            704..841
                     /gene="Abcb6"
                     /gene_synonym="MTABC3"
                     /inference="alignment:Splign:2.1.0"
     exon            842..1022
                     /gene="Abcb6"
                     /gene_synonym="MTABC3"
                     /inference="alignment:Splign:2.1.0"
     exon            1023..1124
                     /gene="Abcb6"
                     /gene_synonym="MTABC3"
                     /inference="alignment:Splign:2.1.0"
     exon            1125..1308
                     /gene="Abcb6"
                     /gene_synonym="MTABC3"
                     /inference="alignment:Splign:2.1.0"
     exon            1309..1430
                     /gene="Abcb6"
                     /gene_synonym="MTABC3"
                     /inference="alignment:Splign:2.1.0"
     exon            1431..1540
                     /gene="Abcb6"
                     /gene_synonym="MTABC3"
                     /inference="alignment:Splign:2.1.0"
     exon            1541..1606
                     /gene="Abcb6"
                     /gene_synonym="MTABC3"
                     /inference="alignment:Splign:2.1.0"
     exon            1607..1732
                     /gene="Abcb6"
                     /gene_synonym="MTABC3"
                     /inference="alignment:Splign:2.1.0"
     exon            1733..1809
                     /gene="Abcb6"
                     /gene_synonym="MTABC3"
                     /inference="alignment:Splign:2.1.0"
     exon            1810..1873
                     /gene="Abcb6"
                     /gene_synonym="MTABC3"
                     /inference="alignment:Splign:2.1.0"
     exon            1874..1959
                     /gene="Abcb6"
                     /gene_synonym="MTABC3"
                     /inference="alignment:Splign:2.1.0"
     exon            1960..2017
                     /gene="Abcb6"
                     /gene_synonym="MTABC3"
                     /inference="alignment:Splign:2.1.0"
     exon            2018..2122
                     /gene="Abcb6"
                     /gene_synonym="MTABC3"
                     /inference="alignment:Splign:2.1.0"
     exon            2123..2297
                     /gene="Abcb6"
                     /gene_synonym="MTABC3"
                     /inference="alignment:Splign:2.1.0"
     exon            2298..2410
                     /gene="Abcb6"
                     /gene_synonym="MTABC3"
                     /inference="alignment:Splign:2.1.0"
     exon            2411..2505
                     /gene="Abcb6"
                     /gene_synonym="MTABC3"
                     /inference="alignment:Splign:2.1.0"
     exon            2506..2574
                     /gene="Abcb6"
                     /gene_synonym="MTABC3"
                     /inference="alignment:Splign:2.1.0"
     exon            2575..2843
                     /gene="Abcb6"
                     /gene_synonym="MTABC3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cagtgtagca ggtccacgtg cgtcccttcc cgcgacccca ccgtcttagc tccatgtccc
       61 aggacaccct ggcatctgcg gccctctctg aatggccagc ccgactcttt gatcctgcag
      121 tgacctcaag ttcaaccagc agccacagat cgccatggtg actgtgggca actactgcga
      181 ggccgaaggg ccggcggggc cggcatggac tcagaatggc ttgagtccct gcttcttcta
      241 cactctagtg ccctcgacac tcatgacttt gggggtactg gccttggtgc tggttcttcc
      301 ctgcaggcgt cgggaggtgc ctgctggcac agaggagcta tcttgggcgg ctggccctcg
      361 ggtcgctccc tatgcgctgc agctgtctct ggcgatactt cagatggcac tgcccctggc
      421 cagtctggct ggccgagtgg gcactgctcg gggggtccgc ctgccaggtt acctactgct
      481 ggcttctgtg ctggagagtc tagccagtgc ctgtggcttg tggctgctcg tggtggaacg
      541 gagccaggca cggcagagtc tggcaatggg cgtctggatg aagttcaggc atagcttggg
      601 tcttctgctc ctctggactg tgacatttgc agccgagaac ttggtcctgg tatcttggaa
      661 cagcccacag tggtggtggt ccagggcaga tctgggccag caggttcaat ttggcctatg
      721 ggtcctgcgt tatatgacct ctggagggct atttatcctg gggctctggg cccctggact
      781 tcgcccccag tcttataccc tacatgttaa tgaagaagac caagatggag gaaggaacca
      841 gggccgctca acagacccac gatccacttg gagagacctc ggcaggaagc ttcgactgct
      901 gagtggctac ttgtggcctc gggggagtcc atctctgcag ctgactgtgc tcctatgcat
      961 gggcctcatg gggttggacc gagcactcaa tgtgttggtc cccatcttct atagggacat
     1021 tgtgaactta ctgacttcga aggctccttg gagctccctg gcctggaccg ttaccaccta
     1081 tgtcttcctc aagttcctgc aggggggtgg cactggcagt acaggttttg tgagcaacct
     1141 tcgaaccttc ctgtggatcc gggtgcagca gttcacgtcc cgaggtgtgg aactccgtct
     1201 cttctctcat ctgcatgaac tctcactgcg ctggcacctg ggccgtcgga ctggggaggt
     1261 gcttcggatt gtggaccggg gaacatccag tgtcacagga ctgctcagct acctggtgtt
     1321 caacatcatc cccaccctgg ccgacatcat cattggcatc atctacttca gcatgttctt
     1381 caatgcctgg tttggcctca ttgtgttcct gtgcatgagt ctttacctca tcctcactat
     1441 tatggtcact gagtggagag ccaagtttcg ccgtgatatg aacacacagg aaaatgccac
     1501 ccgggcacga gcagtagact ctctgctaaa ctttgagacg gtgaaatact acaatgcgga
     1561 gggttatgag ttagaacgct atcgagaggc catcctcaag tttcagggtt tggagtggaa
     1621 gtcaacggct tcactggttt tactgaatca gacccagaac atggtgattg gatttgggct
     1681 ccttgctggc tccttgcttt gtgcatactt cgtcagcgag cgacggctac aggttgggga
     1741 ctttgtgctt tttggcactt atatcaccca actgtacatg cctctcaact ggttcggcac
     1801 ctactacaga atgatccaga ctaacttcat tgacatggag aacatgtttg acttgttgaa
     1861 agaggaaaca gaggtgaagg acgtccctgg agcagggccc cttcgttttc ataagggccg
     1921 ggttgagttt gaaaatgtgc acttcagcta cgctgatggg cgggagacct tacaagatgt
     1981 gtccttcact gtgatgcctg gacagacggt ggctctggta ggcccatctg gggcaggaaa
     2041 gagcacaatt ttacgcctgc tgtttcgctt ctatgacatc agctctggct gcatccgaat
     2101 agatggacag gacatttcac aggtaaccca gatctctctc cggtctcaca ttggagttgt
     2161 gccccaggac actgtcctct tcaacgacac cattgccaac aatatccgct atggccgtgt
     2221 tacagctggg gacagtgaga tacaggctgc tgctcaggct gcgggcatcc atgatgccat
     2281 cttgtctttc cctgaagggt atgagacaca ggttggggag cggggtctga agctgagtgg
     2341 tggcgagaag cagcgagtgg ccattgcccg caccatcctt aaggctcctg acatcattct
     2401 gctggatgag gcaacatcag cactggatac atctaatgag agagccatcc aggcctctct
     2461 ggccaaagtc tgcaccaacc gcaccaccat cgtagtagca cacaggctct caactgtggt
     2521 caatgctgac cagattcttg tcatcaagga tggctgcatc atagagagag gaaggcacga
     2581 agccctgcta tcccgaggtg gcgtgtatgc tgagatgtgg cagctgcagc agcaaggaca
     2641 agaaactgtc cctgaagact cttaacctca ggacatggcg tagtaataaa agggatgacc
     2701 tctttccttc taaaggctaa ctcaggagaa aaagatgtcc cctctccttg gcttcagttc
     2761 attctggtat aggagtttgg tgctagctat tgtaatggga ctgtgcagaa agcaccaaag
     2821 gaaataaatg gcctgtgtaa ggaaaaaa
//
