LOCUS       NM_012690               3910 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus ATP binding cassette subfamily B member 4
            (Abcb4), mRNA.
ACCESSION   NM_012690
VERSION     NM_012690.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3910)
  AUTHORS   Aronson,S.J., Bakker,R.S., Shi,X., Duijst,S., Ten Bloemendaal,L.,
            de Waart,D.R., Verheij,J., Ronzitti,G., Oude Elferink,R.P.,
            Beuers,U., Paulusma,C.C. and Bosma,P.J.
  TITLE     Liver-directed gene therapy results in long-term correction of
            progressive familial intrahepatic cholestasis type 3 in mice
  JOURNAL   J Hepatol 71 (1), 153-162 (2019)
   PUBMED   30935993
REFERENCE   2  (bases 1 to 3910)
  AUTHORS   Degiorgio,D., Crosignani,A., Colombo,C., Bordo,D., Zuin,M.,
            Vassallo,E., Syren,M.L., Coviello,D.A. and Battezzati,P.M.
  TITLE     ABCB4 mutations in adult patients with cholestatic liver disease:
            impact and phenotypic expression
  JOURNAL   J Gastroenterol 51 (3), 271-280 (2016)
   PUBMED   26324191
REFERENCE   3  (bases 1 to 3910)
  AUTHORS   Jirsa,M., Bronsky,J., Dvorakova,L., Sperl,J., Smajstrla,V.,
            Horak,J., Nevoral,J. and Hrebicek,M.
  TITLE     ABCB4 mutations underlie hormonal cholestasis but not pediatric
            idiopathic gallstones
  JOURNAL   World J Gastroenterol 20 (19), 5867-5874 (2014)
   PUBMED   24914347
REFERENCE   4  (bases 1 to 3910)
  AUTHORS   Andress,E.J., Nicolaou,M., Romero,M.R., Naik,S., Dixon,P.H.,
            Williamson,C. and Linton,K.J.
  TITLE     Molecular mechanistic explanation for the spectrum of cholestatic
            disease caused by the S320F variant of ABCB4
  JOURNAL   Hepatology 59 (5), 1921-1931 (2014)
   PUBMED   24806754
REFERENCE   5  (bases 1 to 3910)
  AUTHORS   Degiorgio,D., Corsetto,P.A., Rizzo,A.M., Colombo,C., Seia,M.,
            Costantino,L., Montorfano,G., Tomaiuolo,R., Bordo,D.,
            Sansanelli,S., Li,M., Tavian,D., Rastaldi,M.P. and Coviello,D.A.
  TITLE     Two ABCB4 point mutations of strategic NBD-motifs do not prevent
            protein targeting to the plasma membrane but promote MDR3
            dysfunction
  JOURNAL   Eur J Hum Genet 22 (5), 633-639 (2014)
   PUBMED   24045840
REFERENCE   6  (bases 1 to 3910)
  AUTHORS   Furuya,K.N., Gebhardt,R., Schuetz,E.G. and Schuetz,J.D.
  TITLE     Isolation of rat pgp3 cDNA: evidence for gender and zonal
            regulation of expression in the liver
  JOURNAL   Biochim Biophys Acta 1219 (3), 636-644 (1994)
   PUBMED   7948020
REFERENCE   7  (bases 1 to 3910)
  AUTHORS   Smit,J.J., Schinkel,A.H., Oude Elferink,R.P., Groen,A.K.,
            Wagenaar,E., van Deemter,L., Mol,C.A., Ottenhoff,R., van der
            Lugt,N.M., van Roon,M.A. et al.
  TITLE     Homozygous disruption of the murine mdr2 P-glycoprotein gene leads
            to a complete absence of phospholipid from bile and to liver
            disease
  JOURNAL   Cell 75 (3), 451-462 (1993)
   PUBMED   8106172
REFERENCE   8  (bases 1 to 3910)
  AUTHORS   Brown,P.C., Thorgeirsson,S.S. and Silverman,J.A.
  TITLE     Cloning and regulation of the rat mdr2 gene
  JOURNAL   Nucleic Acids Res 21 (16), 3885-3891 (1993)
   PUBMED   8103593
REFERENCE   9  (bases 1 to 3910)
  AUTHORS   Deuchars,K.L., Duthie,M. and Ling,V.
  TITLE     Identification of distinct P-glycoprotein gene sequences in rat
  JOURNAL   Biochim Biophys Acta 1130 (2), 157-165 (1992)
   PUBMED   1348630
REFERENCE   10 (bases 1 to 3910)
  AUTHORS   Buschman,E. and Gros,P.
  TITLE     Functional analysis of chimeric genes obtained by exchanging
            homologous domains of the mouse mdr1 and mdr2 genes
  JOURNAL   Mol Cell Biol 11 (2), 595-603 (1991)
   PUBMED   1990275
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from L15079.1.
            
            On Aug 31, 2012 this sequence version replaced NM_012690.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: L15079.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132264 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3910              L15079.1           3-3912
FEATURES             Location/Qualifiers
     source          1..3910
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="F344"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q12"
     gene            1..3910
                     /gene="Abcb4"
                     /gene_synonym="Mdr2; Pgy3"
                     /note="ATP binding cassette subfamily B member 4"
                     /db_xref="GeneID:24891"
                     /db_xref="RGD:620248"
     exon            1..24
                     /gene="Abcb4"
                     /gene_synonym="Mdr2; Pgy3"
                     /inference="alignment:Splign:2.1.0"
     exon            25..101
                     /gene="Abcb4"
                     /gene_synonym="Mdr2; Pgy3"
                     /inference="alignment:Splign:2.1.0"
     CDS             31..3867
                     /gene="Abcb4"
                     /gene_synonym="Mdr2; Pgy3"
                     /EC_number="7.6.2.1"
                     /function="unknown"
                     /note="ATP-binding cassette, sub-family B (MDR/TAP),
                     member 4 (P-glycoprotein 3/ multidrug resistance 2);
                     ATP-binding cassette sub-family B (MDR/TAP) member 4
                     (P-glycoprotein 3/ multidrug resistance 2); multidrug
                     resistance protein 2; P-glycoprotein 2; ATP-binding
                     cassette sub-family B member 4; multidrug resistance
                     protein 3; ATP-binding cassette, subfamily B (MDR/TAP),
                     member 4"
                     /codon_start=1
                     /product="phosphatidylcholine translocator ABCB4"
                     /protein_id="NP_036822.1"
                     /db_xref="GeneID:24891"
                     /db_xref="RGD:620248"
                     /translation="MDLEAARNGTARRLDGDFELGSISNQSREKKKKVNLIGPLTLFR
                     YSDWQDKLFMLLGTAMAIAHGSGLPLMMIVFGEMTDKFVDNAGNFSLPVNFSLSMLNP
                     GRILEEEMTRYAYYYSGLGGGVLLAAYIQVSFWTLAAGRQIRKIRQKFFHAILRQEMG
                     WFDIKGTTELNTRLTDDISKISEGIGDKVGMFFQAIATFFAGFIVGFIRGWKLTLVIM
                     AITAILGLSTAVWAKILSTFSDKELAAYAKAGAVAEEALGAIRTVIAFGGQNKELERY
                     QKHLENAKKIGIKKAISANISMGIAFLLIYASYALAFWYGSTLVISKEYTIGNAMTVF
                     FSILIGAFSVGQAAPCIDAFPNARGAAYVIFDIIDNNPKIDSFSERGHKPDSIKGNLE
                     FSDVHFSYPSRANIKILKGLNLKVKSGQTVALVGNSGCGKSTTVQLLQRLYDPTEGTI
                     SIDGQDIRNFNVRCLREFIGVVSQEPVLFSTTIAENIRYGRGNVTMDEIKKAVKEANA
                     YDFIMKLPQKFDTLVGDRGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEA
                     EVQAALDKAREGRTTIVIAHRLSTVRNADVIAGFEDGVIVEQGSHSELIKKEGIYFRL
                     VNMQTSGSQILSEEFEVELSDEKAAGGVAPNGWKARIFRNSTKKSLKSSRAHQNRLDV
                     ETNELDANVPPVSFLKVLRLNKTEWPYFVVGTLCAIANGALQPAFSIILSEMIAIFGP
                     GDDTVKQQKCNMFSLVFLGLGVHSFFTFFLQGFTFGKAGEILTTRLRSMAFKAMLRQD
                     MSWFDDHKNSTGALSTRLATDAAQVQGATGTRLALIAQNTANLGTGIIISFIYGWQLT
                     LLLLSVVPFIAVAGIVEMKMLAGNAKRDKKEMEAAGKIATEAIENIRTVVSLTQERKF
                     ESMYVEKLHGPYRNSVRKAHIYGITFSISQAFMYFSYAGCFRFGSYLIVNGHMRFKDV
                     ILVFSAIVLGAVALGHASSFAPDYAKAKLSAAYLFSLFERQPLIDSYSREGMWPDKFE
                     GSVTFNEVVFNYPTRANVPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPM
                     AGTVLLDGQEAKKLNVQWLRAQLGIVSQEPILFDCSIAKNIAYGDNSRVVSQDEIVRA
                     AKEANIHPFIETLPQKYETRVGDKGTQLSGGQKQRIAIARALIRQPRVLLLDEATSAL
                     DTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVIDNGKVKEHGTHQQLLAQK
                     GIYFSMVNIQAGTQNL"
     exon            102..156
                     /gene="Abcb4"
                     /gene_synonym="Mdr2; Pgy3"
                     /inference="alignment:Splign:2.1.0"
     exon            157..307
                     /gene="Abcb4"
                     /gene_synonym="Mdr2; Pgy3"
                     /inference="alignment:Splign:2.1.0"
     exon            308..365
                     /gene="Abcb4"
                     /gene_synonym="Mdr2; Pgy3"
                     /inference="alignment:Splign:2.1.0"
     exon            366..557
                     /gene="Abcb4"
                     /gene_synonym="Mdr2; Pgy3"
                     /inference="alignment:Splign:2.1.0"
     exon            558..729
                     /gene="Abcb4"
                     /gene_synonym="Mdr2; Pgy3"
                     /inference="alignment:Splign:2.1.0"
     exon            730..854
                     /gene="Abcb4"
                     /gene_synonym="Mdr2; Pgy3"
                     /inference="alignment:Splign:2.1.0"
     exon            855..1026
                     /gene="Abcb4"
                     /gene_synonym="Mdr2; Pgy3"
                     /inference="alignment:Splign:2.1.0"
     exon            1027..1140
                     /gene="Abcb4"
                     /gene_synonym="Mdr2; Pgy3"
                     /inference="alignment:Splign:2.1.0"
     exon            1141..1251
                     /gene="Abcb4"
                     /gene_synonym="Mdr2; Pgy3"
                     /inference="alignment:Splign:2.1.0"
     exon            1252..1377
                     /gene="Abcb4"
                     /gene_synonym="Mdr2; Pgy3"
                     /inference="alignment:Splign:2.1.0"
     exon            1378..1581
                     /gene="Abcb4"
                     /gene_synonym="Mdr2; Pgy3"
                     /inference="alignment:Splign:2.1.0"
     exon            1582..1752
                     /gene="Abcb4"
                     /gene_synonym="Mdr2; Pgy3"
                     /inference="alignment:Splign:2.1.0"
     exon            1753..1914
                     /gene="Abcb4"
                     /gene_synonym="Mdr2; Pgy3"
                     /inference="alignment:Splign:2.1.0"
     exon            1915..2091
                     /gene="Abcb4"
                     /gene_synonym="Mdr2; Pgy3"
                     /inference="alignment:Splign:2.1.0"
     exon            2092..2238
                     /gene="Abcb4"
                     /gene_synonym="Mdr2; Pgy3"
                     /inference="alignment:Splign:2.1.0"
     exon            2239..2343
                     /gene="Abcb4"
                     /gene_synonym="Mdr2; Pgy3"
                     /inference="alignment:Splign:2.1.0"
     exon            2344..2421
                     /gene="Abcb4"
                     /gene_synonym="Mdr2; Pgy3"
                     /inference="alignment:Splign:2.1.0"
     exon            2422..2505
                     /gene="Abcb4"
                     /gene_synonym="Mdr2; Pgy3"
                     /inference="alignment:Splign:2.1.0"
     exon            2506..2709
                     /gene="Abcb4"
                     /gene_synonym="Mdr2; Pgy3"
                     /inference="alignment:Splign:2.1.0"
     exon            2710..2810
                     /gene="Abcb4"
                     /gene_synonym="Mdr2; Pgy3"
                     /inference="alignment:Splign:2.1.0"
     exon            2811..2951
                     /gene="Abcb4"
                     /gene_synonym="Mdr2; Pgy3"
                     /inference="alignment:Splign:2.1.0"
     exon            2952..3108
                     /gene="Abcb4"
                     /gene_synonym="Mdr2; Pgy3"
                     /inference="alignment:Splign:2.1.0"
     exon            3109..3306
                     /gene="Abcb4"
                     /gene_synonym="Mdr2; Pgy3"
                     /inference="alignment:Splign:2.1.0"
     exon            3307..3513
                     /gene="Abcb4"
                     /gene_synonym="Mdr2; Pgy3"
                     /inference="alignment:Splign:2.1.0"
     exon            3514..3660
                     /gene="Abcb4"
                     /gene_synonym="Mdr2; Pgy3"
                     /inference="alignment:Splign:2.1.0"
     exon            3661..3910
                     /gene="Abcb4"
                     /gene_synonym="Mdr2; Pgy3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggccaacacg cgcgtgaagt tcaggctgag atggatcttg aggcagcaag aaacggaaca
       61 gcgcggcgcc tggacggcga ctttgaacta ggcagcatca gcaaccagag cagagaaaaa
      121 aagaagaaag tgaatttaat tggcccgttg acactgttcc gatactctga ttggcaggat
      181 aaattgttta tgctcctggg caccgccatg gccatagctc acggatcagg tcttcccctt
      241 atgatgatag tctttggaga aatgacagat aagtttgtag ataatgctgg gaacttttcc
      301 ttgccagtga atttttcatt gtcaatgcta aatccaggaa gaattctgga agaagaaatg
      361 actagatatg catactacta ttcgggacta ggtggtggag ttcttttggc tgcctatatc
      421 caagtctcct tctggacttt ggcagctggc cgacaaataa ggaaaatcag gcaaaaattt
      481 tttcacgcca tccttcgaca agaaatgggc tggtttgata tcaagggcac caccgaactc
      541 aacacgcggc tgacagatga catctccaaa atcagtgaag gaattggtga caaggttgga
      601 atgttctttc aagcaatagc cacgtttttt gcaggattca tagtggggtt catcagaggc
      661 tggaaactca ccctcgtgat catggccatc accgccatct tggggctctc tacagccgtt
      721 tgggcaaaga tactctcaac attcagtgac aaagaactag ctgcctatgc aaaagcaggt
      781 gccgtggcgg aagaggctct gggagccatc aggaccgtga tagctttcgg gggccagaac
      841 aaagagctag aaaggtatca gaagcattta gaaaatgcca aaaagattgg aattaaaaag
      901 gctatctcgg ccaacatctc catgggcatt gcctttttgt taatatatgc atcctatgca
      961 ctggccttct ggtatggatc cactctggtt atatcaaaag aatatacaat tggaaatgcc
     1021 atgacagtgt tcttctcaat cctcattggg gccttcagtg tggggcaggc tgccccctgt
     1081 attgatgctt tccccaatgc tagaggagca gcctatgtga tctttgacat tattgataat
     1141 aatcctaaaa ttgacagttt ttcagagaga ggacacaagc cagacagcat caaaggaaat
     1201 ttggagttca gtgacgttca cttttcctac ccatctcggg ctaatatcaa gatcttgaag
     1261 ggcctcaacc tgaaggtgaa gagcgggcag acggtagccc tggttggcaa cagtggctgt
     1321 gggaaaagca caactgtcca gctgctgcag aggctctacg accccacaga gggtacgatt
     1381 agcatcgatg ggcaggacat ccggaacttt aacgtcaggt gtctaaggga attcatcggc
     1441 gtggtgagtc aagagccggt actgttctct accacgattg ctgaaaatat ccgctatggc
     1501 cgtgggaatg taacaatgga tgagattaaa aaagctgtca aagaggctaa tgcctatgac
     1561 ttcatcatga aactgccaca gaaatttgac accctggttg gtgacagagg ggcgcagctg
     1621 agcgggggac agaaacagag gatcgccatt gctcgtgcct tggtccgcaa ccccaagatc
     1681 ctcctgctgg acgaggccac gtcagccttg gacacagaaa gcgaagctga ggtgcaggcc
     1741 gctctggata aggccagaga aggccggacc accatcgtga tagctcaccg actgtcaact
     1801 gtccggaatg cagatgtcat cgctgggttt gaggatggcg tcatcgtgga gcaaggaagc
     1861 cacagtgagc tgataaagaa ggaagggatc tacttcagac ttgttaacat gcagacatca
     1921 ggaagccaga tcctgtcaga agaatttgaa gttgagctaa gtgatgaaaa ggctgctgga
     1981 ggtgtggccc caaatggctg gaaagcacgc atatttagga attctacgaa gaaaagtctg
     2041 aaaagttcac gggcgcatca aaataggctg gatgtggaaa ccaatgaact tgatgcaaac
     2101 gtgccaccag tgtcttttct gaaggtctta agactgaata aaacagagtg gccctacttt
     2161 gtggtgggga cactctgtgc cattgccaac ggggccctcc agccggcatt ctccatcatc
     2221 ctgtcagaga tgatagctat ctttggccct ggggatgaca cagtaaagca acagaagtgt
     2281 aacatgttct cgctggtctt cttgggccta ggagtccact ccttctttac tttcttcctt
     2341 cagggtttca cattcgggaa agctggcgag atcctcacca caaggctccg gtccatggcc
     2401 ttcaaagcaa tgctaagaca ggacatgagc tggtttgacg atcataaaaa cagtactggt
     2461 gccctctcta caagactcgc cacagacgct gcgcaggtcc aaggagccac aggaaccagg
     2521 ttggctttaa ttgcacagaa cacagccaac cttggaacgg gtattattat atcatttatt
     2581 tacggttggc aactgacact tctgctctta tcagttgttc cattcattgc tgtagcggga
     2641 attgttgaaa tgaaaatgtt ggctggcaac gccaagagag ataaaaagga gatggaagct
     2701 gctggaaaga ttgcaacaga ggcaatagaa aatattcgga ctgttgtatc cttgacccaa
     2761 gagagaaaat ttgagtcaat gtatgttgaa aaattacacg gaccttacag gaattcagtg
     2821 cggaaggctc acatctacgg catcactttt agcatctcac aagcattcat gtacttttct
     2881 tatgctggct gctttcgatt tggttcttac ctcattgtga atggacacat gcgcttcaag
     2941 gatgtcatcc tggtgttctc agcaatcgtg cttggtgcag tggctctagg acatgccagc
     3001 tcatttgctc cagactatgc aaaagccaag ctgtctgcag catacttatt cagtctgttt
     3061 gaaagacaac ctctgattga cagctacagc agagaaggaa tgtggccgga taagtttgaa
     3121 ggaagcgtga cattcaatga agttgtgttc aattatccca cccgggccaa tgtgccagtg
     3181 cttcaggggc tgagcctcga ggtgaagaag gggcagaccc tggccctggt gggcagtagt
     3241 ggctgcggga agagcaccgt ggtccagctg ctcgagcgct tctacgaccc catggccgga
     3301 acagtgctcc tcgatggtca ggaagcaaag aaactcaatg tccagtggct ccgagctcaa
     3361 cttggcattg tgtcccagga gcccatcctg tttgactgca gcatcgccaa gaacatcgcc
     3421 tacggagaca acagccgtgt cgtgtctcag gatgagattg tgagggcggc caaggaggcc
     3481 aacatccacc ccttcattga gacactgccc caaaagtatg aaacaagagt aggagacaag
     3541 gggacacagc tctctggagg ccagaaacag aggattgcta tcgcccgagc cctcatcaga
     3601 cagcctcggg tcctactgct ggatgaagcc acgtcggctt tggacactga gagtgaaaag
     3661 gtcgtccagg aagcgctgga caaagccagg gaaggccgca cctgcattgt gatcgcgcac
     3721 cgcctgtcca ccatccagaa cgcagacttg atcgtggtga tcgacaacgg caaggtcaag
     3781 gagcacggca cccaccagca gctgctggcc cagaaaggca tctatttctc catggtcaac
     3841 attcaagctg gcacacagaa cttatgaact tgttacagta tatttttaaa ataaattcca
     3901 atcgtttttt
//
