LOCUS       NM_012623               3889 bp    mRNA    linear   ROD 15-JUN-2024
DEFINITION  Rattus norvegicus ATP-binding cassette, sub-family B member 1B
            (Abcb1b), mRNA.
ACCESSION   NM_012623
VERSION     NM_012623.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3889)
  AUTHORS   Yin,H., Shao,H., Liu,J., Qin,Y. and Deng,W.
  TITLE     Sex-specific and concentration-dependent influence of Cremophor RH
            40 on ampicillin absorption via its effect on intestinal membrane
            transporters in rats
  JOURNAL   PLoS One 17 (2), e0263692 (2022)
   PUBMED   35226682
  REMARK    GeneRIF: Sex-specific and concentration-dependent influence of
            Cremophor RH 40 on ampicillin absorption via its effect on
            intestinal membrane transporters in rats.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3889)
  AUTHORS   Duan,Y., Bai,X., Yang,J., Zhou,Y., Gu,W., Liu,G., Wang,Q., Zhu,J.,
            La,L. and Li,X.
  TITLE     Exposure to High-Altitude Environment Is Associated with Drug
            Transporters Change: microRNA-873-5p-Mediated Alteration of
            Function and Expression Levels of Drug Transporters under Hypoxia
  JOURNAL   Drug Metab Dispos 50 (2), 174-186 (2022)
   PUBMED   34844996
  REMARK    GeneRIF: Exposure to High-Altitude Environment Is Associated with
            Drug Transporters Change: microRNA-873-5p-Mediated Alteration of
            Function and Expression Levels of Drug Transporters under Hypoxia.
REFERENCE   3  (bases 1 to 3889)
  AUTHORS   Ge,C., Xu,D., Yu,P., Fang,M., Guo,J., Xu,D., Qiao,Y., Chen,S.,
            Zhang,Y. and Wang,H.
  TITLE     P-gp expression inhibition mediates placental glucocorticoid
            barrier opening and fetal weight loss
  JOURNAL   BMC Med 19 (1), 311 (2021)
   PUBMED   34876109
  REMARK    GeneRIF: P-gp expression inhibition mediates placental
            glucocorticoid barrier opening and fetal weight loss.
            Erratum:[BMC Med. 2022 Mar 27;20(1):126. doi:
            10.1186/s12916-022-02307-2. PMID: 35346196]
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3889)
  AUTHORS   Wu,T., Sheng,Y., Qin,Y.Y., Kong,W.M., Jin,M.M., Yang,H.Y.,
            Zheng,X.K., Dai,C., Liu,M., Liu,X.D. and Liu,L.
  TITLE     Bile duct ligation causes opposite impacts on the expression and
            function of BCRP and P-gp in rat brain partly via affecting
            membrane expression of ezrin/radixin/moesin proteins
  JOURNAL   Acta Pharmacol Sin 42 (11), 1942-1950 (2021)
   PUBMED   33558655
  REMARK    GeneRIF: Bile duct ligation causes opposite impacts on the
            expression and function of BCRP and P-gp in rat brain partly via
            affecting membrane expression of ezrin/radixin/moesin proteins.
REFERENCE   5  (bases 1 to 3889)
  AUTHORS   Wang,P., Chen,Y., Zhang,L.M., Yuan,S.Q., Lu,S.A. and Zhang,Y.J.
  TITLE     Effect of MicroRNA145 on the multidrug resistance gene of
            ulcerative colitis in rats
  JOURNAL   Life Sci 278, 119603 (2021)
   PUBMED   33984358
  REMARK    GeneRIF: Effect of MicroRNA145 on the multidrug resistance gene of
            ulcerative colitis in rats.
REFERENCE   6  (bases 1 to 3889)
  AUTHORS   Vos,T.A., Hooiveld,G.J., Koning,H., Childs,S., Meijer,D.K.,
            Moshage,H., Jansen,P.L. and Muller,M.
  TITLE     Up-regulation of the multidrug resistance genes, Mrp1 and Mdr1b,
            and down-regulation of the organic anion transporter, Mrp2, and the
            bile salt transporter, Spgp, in endotoxemic rat liver
  JOURNAL   Hepatology 28 (6), 1637-1644 (1998)
   PUBMED   9828229
REFERENCE   7  (bases 1 to 3889)
  AUTHORS   Teeter,L.D., Estes,M., Chan,J.Y., Atassi,H., Sell,S., Becker,F.F.
            and Kuo,M.T.
  TITLE     Activation of distinct multidrug-resistance (P-glycoprotein) genes
            during rat liver regeneration and hepatocarcinogenesis
  JOURNAL   Mol Carcinog 8 (2), 67-73 (1993)
   PUBMED   8104413
REFERENCE   8  (bases 1 to 3889)
  AUTHORS   Trezise,A.E., Romano,P.R., Gill,D.R., Hyde,S.C., Sepulveda,F.V.,
            Buchwald,M. and Higgins,C.F.
  TITLE     The multidrug resistance and cystic fibrosis genes have
            complementary patterns of epithelial expression
  JOURNAL   EMBO J 11 (12), 4291-4303 (1992)
   PUBMED   1385112
REFERENCE   9  (bases 1 to 3889)
  AUTHORS   Deuchars,K.L., Duthie,M. and Ling,V.
  TITLE     Identification of distinct P-glycoprotein gene sequences in rat
  JOURNAL   Biochim Biophys Acta 1130 (2), 157-165 (1992)
   PUBMED   1348630
REFERENCE   10 (bases 1 to 3889)
  AUTHORS   Silverman,J.A., Raunio,H., Gant,T.W. and Thorgeirsson,S.S.
  TITLE     Cloning and characterization of a member of the rat multidrug
            resistance (mdr) gene family
  JOURNAL   Gene 106 (2), 229-236 (1991)
   PUBMED   1682220
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000004.1.
            
            [WARNING] On Jan 4, 2025 this sequence was replaced by NM_012623.4.
            
            On Nov 27, 2020 this sequence version replaced NM_012623.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY082609.1, M81855.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760389,
                                           SAMEA5760400 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-30                JAXUCZ010000004.1  26280000-26280029   c
            31-101              JAXUCZ010000004.1  26279494-26279564   c
            102-147             JAXUCZ010000004.1  26277716-26277761   c
            148-310             JAXUCZ010000004.1  26276191-26276353   c
            311-368             JAXUCZ010000004.1  26271511-26271568   c
            369-560             JAXUCZ010000004.1  26269438-26269629   c
            561-732             JAXUCZ010000004.1  26268600-26268771   c
            733-857             JAXUCZ010000004.1  26267497-26267621   c
            858-1029            JAXUCZ010000004.1  26259750-26259921   c
            1030-1143           JAXUCZ010000004.1  26253452-26253565   c
            1144-1254           JAXUCZ010000004.1  26253197-26253307   c
            1255-1380           JAXUCZ010000004.1  26252869-26252994   c
            1381-1584           JAXUCZ010000004.1  26252575-26252778   c
            1585-1755           JAXUCZ010000004.1  26252143-26252313   c
            1756-1917           JAXUCZ010000004.1  26251754-26251915   c
            1918-2091           JAXUCZ010000004.1  26250376-26250549   c
            2092-2238           JAXUCZ010000004.1  26248851-26248997   c
            2239-2346           JAXUCZ010000004.1  26247763-26247870   c
            2347-2424           JAXUCZ010000004.1  26238247-26238324   c
            2425-2508           JAXUCZ010000004.1  26236394-26236477   c
            2509-2712           JAXUCZ010000004.1  26235036-26235239   c
            2713-2813           JAXUCZ010000004.1  26220130-26220230   c
            2814-2954           JAXUCZ010000004.1  26214595-26214735   c
            2955-3111           JAXUCZ010000004.1  26212530-26212686   c
            3112-3309           JAXUCZ010000004.1  26210610-26210807   c
            3310-3516           JAXUCZ010000004.1  26202355-26202561   c
            3517-3663           JAXUCZ010000004.1  26199751-26199897   c
            3664-3889           JAXUCZ010000004.1  26198031-26198256   c
FEATURES             Location/Qualifiers
     source          1..3889
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q12"
     gene            1..3889
                     /gene="Abcb1b"
                     /gene_synonym="Abcb1; Mdr1; mdr1b; Pgy1; Pgy2"
                     /note="ATP-binding cassette, sub-family B member 1B"
                     /db_xref="GeneID:24646"
                     /db_xref="RGD:3318"
     exon            1..30
                     /gene="Abcb1b"
                     /gene_synonym="Abcb1; Mdr1; mdr1b; Pgy1; Pgy2"
                     /inference="alignment:Splign:2.1.0"
     exon            31..101
                     /gene="Abcb1b"
                     /gene_synonym="Abcb1; Mdr1; mdr1b; Pgy1; Pgy2"
                     /inference="alignment:Splign:2.1.0"
     CDS             37..3864
                     /gene="Abcb1b"
                     /gene_synonym="Abcb1; Mdr1; mdr1b; Pgy1; Pgy2"
                     /EC_number="7.6.2.2"
                     /EC_number="7.6.2.1"
                     /note="ATP-binding cassette, subfamily B, member 1B;
                     multidrug resistance protein 1; P-glycoprotein 1;
                     ATP-binding cassette, subfamily B (MDR/TAP), member 1B;
                     ATP-binding cassette sub-family B member 1; ATP-binding
                     cassette, sub-family B (MDR/TAP), member 1B;
                     P-glycoprotein/multidrug resistance 1; ATP-binding
                     cassette sub-family B (MDR/TAP) member 1
                     (P-glycoprotein/multidrug resistance 1); ATP-binding
                     cassette, sub-family B (MDR/TAP), member 1
                     (P-glycoprotein/multidrug resistance 1); phospholipid
                     transporter ABCB1; P-glycoprotein 2/ multidrug resistance
                     1b"
                     /codon_start=1
                     /product="ATP-dependent translocase ABCB1"
                     /protein_id="NP_036755.3"
                     /db_xref="GeneID:24646"
                     /db_xref="RGD:3318"
                     /translation="MEFEEGLNGTADKNFSKMGKKSKKEKEKKPAVGIFGMFRYADWL
                     DKLCMALGTLAAIIHGTLLPLLMLVFGYMTDSFTQAETRILPSVTNQSEINSTQTVSD
                     SSLEEDMAMYAYYYTGIGAGVLIVAYIQVSLWCLAAGRQIHKIRQKFFHAIMNQEIGW
                     FDVNDAGELNTRLTDDVSKINDGIGDKLGMFFQSITTFSAGFIIGFISGWKLTLVILA
                     VSPLIGLSSAMWAKVLTSFTNKELQAYAKAGAVAEEVLAAIRTVIAFGGQKKELERYN
                     KNLEEAKRVGIKKAITANISIGIAYLLVYASYALAFWYGTSLVLSNEYSIGQVLTVFF
                     SILLGTFSIGHLAPNIEAFANARGAAYEIFKIIDNEPSIDSFSTKGHKPDSIMGNLEF
                     KNVYFNYPSRSEVKILKGLNLKVKSGQTVALVGNSGCGKSTTVQLLQRLYDPIEGEVS
                     IDGQDIRTINVRYLREIIGVVSQEPVLFATTIAENIRYGRENVTMDEIEKAVKEANAY
                     DFIMKLPHKFNTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAV
                     VQAALDKAREGRTTIVIAHRLSTVRNADVIAGFDGGVIVEQGNHEELMKEKGIYFKLV
                     MTQTRGNEIEPGNNAYESQSDTGASELTSEKSKSPLIRRSIRRSIHRRQDQERRLSSK
                     EDVDEDVPMVSFWQILKLNISEWPYLVVGVLCAVINGCIQPVFAIVFSKIVGVFSRDD
                     DHETKQRNCNLFSLLFLVMGMISFVTYFFQGFTFGKAGEILTKRLRYMVFKSMLRQDI
                     SWFDDHKNTTGSLTTRLASDASNVKGAMGSRLAVVTQNVANLGTGIILSLVYGWQLTL
                     LLVVIIPLIVLGGIIEMKLLSGQALKDKKELEISGKIATEAIENFRTVVSLTREQKFE
                     TMYAQSLQIPYRNALKKAHVFGITFAFTQAMIYFSYAACFRFGAYLVARELMTFENVM
                     LVFSAVVFGAMAAGNTSSFAPDYAKAKVSASHIIRIIEKIPEIDSYSTEGLKPNWLEG
                     NVKFNGVMFNYPTRPNIPVLQGLSFEVKKGQTLALVGSSGCGKSTVVQLLERFYNPMA
                     GTVFLDGKEIKQLNVQWLRAHLGIVSQEPILFDCSITENIAYGDNSRVVSHEEIVRAA
                     REANIHQFIDSLPEKYNTRVGDKGTQLSGGQKQRIAIARALVRQPHILLLDEATSALD
                     TESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVIQNGQVKEHGTHQQLLAQKG
                     IYFSMVQAGAKRS"
     exon            102..147
                     /gene="Abcb1b"
                     /gene_synonym="Abcb1; Mdr1; mdr1b; Pgy1; Pgy2"
                     /inference="alignment:Splign:2.1.0"
     exon            148..310
                     /gene="Abcb1b"
                     /gene_synonym="Abcb1; Mdr1; mdr1b; Pgy1; Pgy2"
                     /inference="alignment:Splign:2.1.0"
     exon            311..368
                     /gene="Abcb1b"
                     /gene_synonym="Abcb1; Mdr1; mdr1b; Pgy1; Pgy2"
                     /inference="alignment:Splign:2.1.0"
     exon            369..560
                     /gene="Abcb1b"
                     /gene_synonym="Abcb1; Mdr1; mdr1b; Pgy1; Pgy2"
                     /inference="alignment:Splign:2.1.0"
     exon            561..732
                     /gene="Abcb1b"
                     /gene_synonym="Abcb1; Mdr1; mdr1b; Pgy1; Pgy2"
                     /inference="alignment:Splign:2.1.0"
     exon            733..857
                     /gene="Abcb1b"
                     /gene_synonym="Abcb1; Mdr1; mdr1b; Pgy1; Pgy2"
                     /inference="alignment:Splign:2.1.0"
     exon            858..1029
                     /gene="Abcb1b"
                     /gene_synonym="Abcb1; Mdr1; mdr1b; Pgy1; Pgy2"
                     /inference="alignment:Splign:2.1.0"
     exon            1030..1143
                     /gene="Abcb1b"
                     /gene_synonym="Abcb1; Mdr1; mdr1b; Pgy1; Pgy2"
                     /inference="alignment:Splign:2.1.0"
     exon            1144..1254
                     /gene="Abcb1b"
                     /gene_synonym="Abcb1; Mdr1; mdr1b; Pgy1; Pgy2"
                     /inference="alignment:Splign:2.1.0"
     exon            1255..1380
                     /gene="Abcb1b"
                     /gene_synonym="Abcb1; Mdr1; mdr1b; Pgy1; Pgy2"
                     /inference="alignment:Splign:2.1.0"
     exon            1381..1584
                     /gene="Abcb1b"
                     /gene_synonym="Abcb1; Mdr1; mdr1b; Pgy1; Pgy2"
                     /inference="alignment:Splign:2.1.0"
     exon            1585..1755
                     /gene="Abcb1b"
                     /gene_synonym="Abcb1; Mdr1; mdr1b; Pgy1; Pgy2"
                     /inference="alignment:Splign:2.1.0"
     exon            1756..1917
                     /gene="Abcb1b"
                     /gene_synonym="Abcb1; Mdr1; mdr1b; Pgy1; Pgy2"
                     /inference="alignment:Splign:2.1.0"
     exon            1918..2091
                     /gene="Abcb1b"
                     /gene_synonym="Abcb1; Mdr1; mdr1b; Pgy1; Pgy2"
                     /inference="alignment:Splign:2.1.0"
     exon            2092..2238
                     /gene="Abcb1b"
                     /gene_synonym="Abcb1; Mdr1; mdr1b; Pgy1; Pgy2"
                     /inference="alignment:Splign:2.1.0"
     exon            2239..2346
                     /gene="Abcb1b"
                     /gene_synonym="Abcb1; Mdr1; mdr1b; Pgy1; Pgy2"
                     /inference="alignment:Splign:2.1.0"
     exon            2347..2424
                     /gene="Abcb1b"
                     /gene_synonym="Abcb1; Mdr1; mdr1b; Pgy1; Pgy2"
                     /inference="alignment:Splign:2.1.0"
     exon            2425..2508
                     /gene="Abcb1b"
                     /gene_synonym="Abcb1; Mdr1; mdr1b; Pgy1; Pgy2"
                     /inference="alignment:Splign:2.1.0"
     exon            2509..2712
                     /gene="Abcb1b"
                     /gene_synonym="Abcb1; Mdr1; mdr1b; Pgy1; Pgy2"
                     /inference="alignment:Splign:2.1.0"
     exon            2713..2813
                     /gene="Abcb1b"
                     /gene_synonym="Abcb1; Mdr1; mdr1b; Pgy1; Pgy2"
                     /inference="alignment:Splign:2.1.0"
     exon            2814..2954
                     /gene="Abcb1b"
                     /gene_synonym="Abcb1; Mdr1; mdr1b; Pgy1; Pgy2"
                     /inference="alignment:Splign:2.1.0"
     exon            2955..3111
                     /gene="Abcb1b"
                     /gene_synonym="Abcb1; Mdr1; mdr1b; Pgy1; Pgy2"
                     /inference="alignment:Splign:2.1.0"
     exon            3112..3309
                     /gene="Abcb1b"
                     /gene_synonym="Abcb1; Mdr1; mdr1b; Pgy1; Pgy2"
                     /inference="alignment:Splign:2.1.0"
     exon            3310..3516
                     /gene="Abcb1b"
                     /gene_synonym="Abcb1; Mdr1; mdr1b; Pgy1; Pgy2"
                     /inference="alignment:Splign:2.1.0"
     exon            3517..3663
                     /gene="Abcb1b"
                     /gene_synonym="Abcb1; Mdr1; mdr1b; Pgy1; Pgy2"
                     /inference="alignment:Splign:2.1.0"
     exon            3664..3889
                     /gene="Abcb1b"
                     /gene_synonym="Abcb1; Mdr1; mdr1b; Pgy1; Pgy2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgcgaaggaa acccggaggt gtcacgtgag gtcgtgatgg agtttgaaga gggccttaac
       61 ggaacagcag acaagaactt ctcaaagatg ggcaaaaaga gtaaaaagga gaaggagaag
      121 aaacctgctg ttggcatatt cgggatgttt cgctatgcag attggcttga caagctgtgc
      181 atggctctgg gaactctcgc tgctatcatc cacggaaccc tgcttcccct cctgatgctg
      241 gtgttcggat acatgacaga tagttttacc caagcagaga cccgcattct gccgagcgtt
      301 actaatcaaa gtgaaatcaa cagtacacag accgtcagcg acagcagtct ggaggaggac
      361 atggccatgt acgcctacta ttacacgggc attggtgccg gtgtgctcat cgttgcctac
      421 atccaggttt cactttggtg cctggcagct gggagacaaa tacacaagat taggcagaag
      481 tttttccatg ccatcatgaa tcaggagata ggctggtttg acgtgaatga cgctggggag
      541 ctcaacaccc ggctcacaga tgacgtctcc aaaattaatg acggaattgg tgacaaactt
      601 ggaatgttct ttcagtccat aacgacattt tcagccggtt ttataatagg atttataagt
      661 ggttggaagc taacccttgt aattttggcc gtcagccctc ttattgggtt gtcatctgcc
      721 atgtgggcaa aggtactgac ttcatttact aataaggaac tccaggctta tgcgaaagct
      781 ggagcagttg ccgaagaagt cttagcagcc atcagaactg tgattgcatt tggaggacaa
      841 aagaaggaac ttgaaaggta caataaaaat ttagaagaag ctaaaagagt tggcataaag
      901 aaagccatca cggccaacat ttccataggt attgcctacc tgttggtcta tgcgtcttat
      961 gcactggcat tctggtatgg gacctccttg gtcctctcaa atgaatattc tattggacaa
     1021 gtgcttaccg tcttcttctc tattttattg gggactttca gtattggaca tttagcccca
     1081 aacatagaag cctttgcaaa tgcaagaggg gcagcctatg aaatcttcaa gataattgat
     1141 aatgagccaa gcattgacag cttctcaacc aagggacaca aaccagacag tataatggga
     1201 aatttggaat ttaaaaatgt ttacttcaac tacccatcac gaagtgaagt taagatcttg
     1261 aagggcctca acctgaaggt gaagagcggg cagacggtag ccctggttgg caacagtggc
     1321 tgtgggaaaa gcacaactgt ccagctgctg cagaggctct acgaccccat agagggcgag
     1381 gtcagtatcg acggacagga catcaggacc atcaatgtga ggtatctgcg ggaaatcatt
     1441 ggggtggtga gtcaggaacc cgtgctgttt gccaccacga ttgccgaaaa cattcgctat
     1501 ggccgagaaa acgtcaccat ggatgagata gagaaagctg tcaaggaagc caatgcctat
     1561 gacttcatca tgaaactgcc ccacaaattt aacaccctgg ttggtgagag aggggcgcag
     1621 ctgagtgggg gacagaaaca gaggatcgcc attgcccggg ccctggtccg caaccccaag
     1681 atccttttgt tggatgaggc cacgtcagcc ttggacacag aaagcgaagc cgtggttcag
     1741 gccgctctgg ataaggctag agaaggccgg accaccattg tgatagctca ccgcttgtct
     1801 acagtgcgca atgctgacgt cattgctggt tttgatggtg gtgtcattgt ggagcaagga
     1861 aatcatgaag agctcatgaa agagaagggc atttacttca aacttgtcat gacacagact
     1921 agaggaaatg aaattgaacc aggaaataat gcttatgaat cccaaagtga cactggtgcc
     1981 tctgagttga cttcagaaaa atcaaaatct cctttaataa ggagatcaat tcgcagaagt
     2041 atccacagaa gacaagacca ggagagaaga cttagttcga aagaggatgt ggatgaagat
     2101 gtgcctatgg tttccttttg gcagatccta aagctaaata ttagtgaatg gccctattta
     2161 gttgtgggtg tactttgtgc tgttataaat gggtgcatac aaccagtgtt tgccatagtg
     2221 ttttcaaaga ttgtaggggt tttttcaaga gacgacgacc atgaaaccaa acaacggaat
     2281 tgtaacttgt tttcccttct ctttctggtc atgggaatga tttcttttgt tacgtacttc
     2341 tttcaaggct tcacatttgg caaagctgga gagatcctca ccaagcgact ccgatacatg
     2401 gtcttcaaat ccatgctgcg acaggatata agctggtttg atgaccataa aaacaccact
     2461 ggctcgctga ctaccaggct cgctagtgac gcttctaatg ttaaaggggc tatgggctcc
     2521 aggcttgctg tagttaccca gaatgtagca aaccttggca caggaattat cttatcctta
     2581 gtctatggct ggcagcttac acttttactt gtagtaatta taccactcat tgtcttgggt
     2641 ggaattattg aaatgaaact gttgtctggt caagccttga aggacaagaa agagctagag
     2701 atctctggga agatcgctac agaagcaatt gaaaacttcc gcactgttgt ctctttgact
     2761 cgggagcaga agtttgaaac tatgtatgcc cagagcttgc agataccata cagaaatgct
     2821 ttgaagaaag cacacgtctt tgggatcacc ttcgccttca cccaggccat gatttatttc
     2881 tcctatgctg cttgtttccg gttcggtgcc tacttggtgg cacgagaact catgacattt
     2941 gaaaatgtta tgttggtatt ttctgctgtt gtctttggtg ccatggcagc agggaatacc
     3001 agttcattcg ctcctgacta cgcgaaggcc aaagtctcag catcccacat catcaggatc
     3061 attgagaaaa tccccgagat tgacagctac agcacggagg gcttgaagcc taattggtta
     3121 gaaggaaatg tgaaatttaa tggagtcatg ttcaactatc ccacccgacc caacatccca
     3181 gtgcttcagg gactgagctt cgaggtgaag aaggggcaga cgctcgccct ggtgggcagc
     3241 agtggctgcg ggaagagcac ggtggtccag ctgctcgagc gcttctacaa ccccatggct
     3301 ggaacagtgt ttctagatgg caaagaaata aaacaactca acgtccagtg gctccgcgcc
     3361 cacctgggca ttgtgtccca ggagcccatc ctgtttgact gcagcatcac cgagaacatc
     3421 gcctacggag acaacagccg tgtcgtgtct catgaggaga tcgtgagggc cgccagggag
     3481 gccaacatcc accagttcat cgactcactg cctgagaaat acaacaccag agtgggagac
     3541 aaagggactc agctgtcggg cgggcagaag cagcgcatcg ccatcgcgcg cgccctcgtc
     3601 agacagcctc acatcttact tctggatgaa gcgacatcag ctctggatac ggagagtgaa
     3661 aaggtcgtcc aggaagcgct ggacaaagcc agggaaggcc gcacctgcat tgtgatcgcg
     3721 caccgcctgt ccaccatcca gaacgcagac ttgatcgtgg tgattcagaa cggccaggtc
     3781 aaggagcacg gcacccacca gcagctgctg gcccagaaag gcatctattt ctcgatggtt
     3841 caggctggag caaagcgctc atgagctggg agtatttgag gtgctaagt
//
