LOCUS       NM_133401               4915 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus ATP binding cassette subfamily B member 1A
            (Abcb1a), mRNA.
ACCESSION   NM_133401 XM_346683
VERSION     NM_133401.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4915)
  AUTHORS   Gericke,B., Wienboker,I., Brandes,G. and Loscher,W.
  TITLE     Is P-Glycoprotein Functionally Expressed in the Limiting Membrane
            of Endolysosomes? A Biochemical and Ultrastructural Study in the
            Rat Liver
  JOURNAL   Cells 11 (9), 1556 (2022)
   PUBMED   35563868
  REMARK    GeneRIF: Is P-Glycoprotein Functionally Expressed in the Limiting
            Membrane of Endolysosomes? A Biochemical and Ultrastructural Study
            in the Rat Liver.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4915)
  AUTHORS   Wang,P., Chen,Y., Zhang,L.M., Yuan,S.Q., Lu,S.A. and Zhang,Y.J.
  TITLE     Effect of MicroRNA145 on the multidrug resistance gene of
            ulcerative colitis in rats
  JOURNAL   Life Sci 278, 119603 (2021)
   PUBMED   33984358
  REMARK    GeneRIF: Effect of MicroRNA145 on the multidrug resistance gene of
            ulcerative colitis in rats.
REFERENCE   3  (bases 1 to 4915)
  AUTHORS   Ganguly,S., Finkelstein,D., Shaw,T.I., Michalek,R.D., Zorn,K.M.,
            Ekins,S., Yasuda,K., Fukuda,Y., Schuetz,J.D., Mukherjee,K. and
            Schuetz,E.G.
  TITLE     Metabolomic and transcriptomic analysis reveals endogenous
            substrates and metabolic adaptation in rats lacking Abcg2 and
            Abcb1a transporters
  JOURNAL   PLoS One 16 (7), e0253852 (2021)
   PUBMED   34255797
  REMARK    GeneRIF: Metabolomic and transcriptomic analysis reveals endogenous
            substrates and metabolic adaptation in rats lacking Abcg2 and
            Abcb1a transporters.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4915)
  AUTHORS   Hammad,A.M., Alasmari,F., Sari,Y., Scott Hall,F. and Tiwari,A.K.
  TITLE     Alcohol and Cocaine Exposure Modulates ABCB1 and ABCG2 Transporters
            in Male Alcohol-Preferring Rats
  JOURNAL   Mol Neurobiol 56 (3), 1921-1932 (2019)
   PUBMED   29978425
REFERENCE   5  (bases 1 to 4915)
  AUTHORS   Allegra,S., Di Paolo,A., Cusato,J., Fatiguso,G., Arrigoni,E.,
            Danesi,R., Corcione,S. and D'Avolio,A.
  TITLE     A Common mdr1 Gene Polymorphism is Associated With Changes in
            Linezolid Clearance
  JOURNAL   Ther Drug Monit 40 (5), 602-609 (2018)
   PUBMED   29979333
REFERENCE   6  (bases 1 to 4915)
  AUTHORS   Eid,H., Geczi,L., Magori,A., Bodrogi,I., Institoris,E. and Bak,M.
  TITLE     Drug resistance and sensitivity of germ cell testicular tumors:
            evaluation of clinical relevance of MDR1/Pgp, p53, and
            metallothionein (MT) proteins
  JOURNAL   Anticancer Res 18 (4C), 3059-3064 (1998)
   PUBMED   9713510
REFERENCE   7  (bases 1 to 4915)
  AUTHORS   van Helvoort,A., Smith,A.J., Sprong,H., Fritzsche,I.,
            Schinkel,A.H., Borst,P. and van Meer,G.
  TITLE     MDR1 P-glycoprotein is a lipid translocase of broad specificity,
            while MDR3 P-glycoprotein specifically translocates
            phosphatidylcholine
  JOURNAL   Cell 87 (3), 507-517 (1996)
   PUBMED   8898203
REFERENCE   8  (bases 1 to 4915)
  AUTHORS   Hardy,S.P., Goodfellow,H.R., Valverde,M.A., Gill,D.R., Sepulveda,V.
            and Higgins,C.F.
  TITLE     Protein kinase C-mediated phosphorylation of the human multidrug
            resistance P-glycoprotein regulates cell volume-activated chloride
            channels
  JOURNAL   EMBO J 14 (1), 68-75 (1995)
   PUBMED   7828597
  REMARK    Erratum:[EMBO J 1995 Apr 18;14(8):1844]
REFERENCE   9  (bases 1 to 4915)
  AUTHORS   Teeter,L.D., Estes,M., Chan,J.Y., Atassi,H., Sell,S., Becker,F.F.
            and Kuo,M.T.
  TITLE     Activation of distinct multidrug-resistance (P-glycoprotein) genes
            during rat liver regeneration and hepatocarcinogenesis
  JOURNAL   Mol Carcinog 8 (2), 67-73 (1993)
   PUBMED   8104413
REFERENCE   10 (bases 1 to 4915)
  AUTHORS   Deuchars,K.L., Duthie,M. and Ling,V.
  TITLE     Identification of distinct P-glycoprotein gene sequences in rat
  JOURNAL   Biochim Biophys Acta 1130 (2), 157-165 (1992)
   PUBMED   1348630
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000004.1.
            
            On Nov 27, 2020 this sequence version replaced NM_133401.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF257746.1, SRR26643429.15349.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-79                JAXUCZ010000004.1  26397570-26397648   c
            80-150              JAXUCZ010000004.1  26397065-26397135   c
            151-199             JAXUCZ010000004.1  26393602-26393650   c
            200-347             JAXUCZ010000004.1  26383258-26383405   c
            348-399             JAXUCZ010000004.1  26371841-26371892   c
            400-591             JAXUCZ010000004.1  26369735-26369926   c
            592-763             JAXUCZ010000004.1  26368876-26369047   c
            764-888             JAXUCZ010000004.1  26360769-26360893   c
            889-1060            JAXUCZ010000004.1  26356779-26356950   c
            1061-1174           JAXUCZ010000004.1  26353717-26353830   c
            1175-1285           JAXUCZ010000004.1  26353467-26353577   c
            1286-1411           JAXUCZ010000004.1  26353160-26353285   c
            1412-1615           JAXUCZ010000004.1  26352866-26353069   c
            1616-1786           JAXUCZ010000004.1  26352435-26352605   c
            1787-1948           JAXUCZ010000004.1  26350285-26350446   c
            1949-2125           JAXUCZ010000004.1  26348449-26348625   c
            2126-2272           JAXUCZ010000004.1  26347658-26347804   c
            2273-2380           JAXUCZ010000004.1  26344354-26344461   c
            2381-2458           JAXUCZ010000004.1  26336079-26336156   c
            2459-2542           JAXUCZ010000004.1  26333294-26333377   c
            2543-2746           JAXUCZ010000004.1  26329403-26329606   c
            2747-2847           JAXUCZ010000004.1  26325536-26325636   c
            2848-2988           JAXUCZ010000004.1  26324180-26324320   c
            2989-3145           JAXUCZ010000004.1  26320040-26320196   c
            3146-3343           JAXUCZ010000004.1  26319453-26319650   c
            3344-3550           JAXUCZ010000004.1  26317526-26317732   c
            3551-3697           JAXUCZ010000004.1  26314324-26314470   c
            3698-4915           JAXUCZ010000004.1  26312409-26313626   c
FEATURES             Location/Qualifiers
     source          1..4915
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q12"
     gene            1..4915
                     /gene="Abcb1a"
                     /gene_synonym="Abcb1; Mdr1a"
                     /note="ATP binding cassette subfamily B member 1A"
                     /db_xref="GeneID:170913"
                     /db_xref="RGD:619951"
     exon            1..79
                     /gene="Abcb1a"
                     /gene_synonym="Abcb1; Mdr1a"
                     /inference="alignment:Splign:2.1.0"
     exon            80..150
                     /gene="Abcb1a"
                     /gene_synonym="Abcb1; Mdr1a"
                     /inference="alignment:Splign:2.1.0"
     CDS             86..3904
                     /gene="Abcb1a"
                     /gene_synonym="Abcb1; Mdr1a"
                     /note="ATP-binding cassette, sub-family B (MDR/TAP),
                     member 1; ATP-binding cassette, subfamily B (MDR/TAP),
                     member 1A; multiple drug resistant 1a; ATP-binding
                     cassette, sub-family B (MDR/TAP), member 1A; ATP binding
                     cassette subfamily B member 1"
                     /codon_start=1
                     /product="ATP binding cassette subfamily B member 1A"
                     /protein_id="NP_596892.1"
                     /db_xref="GeneID:170913"
                     /db_xref="RGD:619951"
                     /translation="MELEEDLNGRADKNFSKMGKKSKKEKKEKKPAVSVLTMFRYAGW
                     LDRFYMLLGTLAAIIHGIALPLMMLVFGDMTDSFANVGNNRSMSFYNATDIYAKLEDE
                     MTTYAYYYTGIGAGVLIVAYIQVSLWCLAAGRQIHKIRQKFFHAIMNQEIGWFDVHDV
                     GELNTRLTDDVSKINEGIGDKIGMFFQAMATFFGGFIIGFTRGWKLTLVILAISPVLG
                     LSAGIWAKILSSFTDKELQAYAKAGAVAEEVLAAIRTVIAFGGQKKELERYNNNLEEA
                     KRLGIKKAITANISMGAAFLLIYASYALAFWYGTSLVISKEYTIGQVLTVFFSVLIGA
                     FSVGQASPNIEAFANARGAAYEVFSIIDNKPSIDSFSKSGHKPDNIQGNLEFKNIHFS
                     YPSRKDVQILKGLNLKVKSGQTVALVGNSGCGKSTTVQLLQRLYDPIEGEVSIDGQDI
                     RTINVRYLREIIGVVSQEPVLFATTIAENIRYGRENVTMDEIEKAVKEANAYDFIMKL
                     PHKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQAALD
                     KAREGRTTIVIAHRLSTVRNADVIAGFDGGVIVEQGNHDELMREKGIYFKLVMTQTAG
                     NEIELGNEACESKDGIDNVDMSSKDSGSSLIRRRSTRKSIRGPHDQDGELSTKEALDD
                     DVPPASFWRILKLNSTEWPYFVVGVFCAIINGGLQPAFSIIFSKVVGVFTKNDTPEIQ
                     RQNSNLFSLLFLILGIISFITFFLQGFTFGKAGEILTKRLRYMVFKSMLRQDISWFDD
                     PKNTTGALTTRLANDAAQVKGATGSRLAVITQNIANLGTGIIISLIYGWQLTLLLLAI
                     VPIIAIAGVVEMKMLSGQALKDKKELEGSGKIATEAIENFRTVVSLTREQKFETMYAQ
                     SLQIPYRNALKKAHVFGITFSFTQAMMYFSYAACFRFGAYLVARELMTFENVLLVFSA
                     IVFGAMAVGQVSSFAPDYAKAKVSASHIIRIIEKIPEIDSYSTEGLKPNMLEGNVKFN
                     GVMFNYPTRPNIPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPMAGTVFL
                     DGKEIKQLNVQWLRAHLGIVSQEPILFDCSIAENIAYGDNSRVVSHEEIVKAAKEANI
                     HQFIDSLPEKYNTRVGDKGTQLSGGQKQRIAIARALVRQPHILLLDEATSALDTESEK
                     VVQEALDKAREGRTCIVIAHRLSTIQNADLIVVIQNGQVKEHGTHQQLLAQKGIYFSM
                     VSVQAGAKRS"
     exon            151..199
                     /gene="Abcb1a"
                     /gene_synonym="Abcb1; Mdr1a"
                     /inference="alignment:Splign:2.1.0"
     exon            200..347
                     /gene="Abcb1a"
                     /gene_synonym="Abcb1; Mdr1a"
                     /inference="alignment:Splign:2.1.0"
     exon            348..399
                     /gene="Abcb1a"
                     /gene_synonym="Abcb1; Mdr1a"
                     /inference="alignment:Splign:2.1.0"
     exon            400..591
                     /gene="Abcb1a"
                     /gene_synonym="Abcb1; Mdr1a"
                     /inference="alignment:Splign:2.1.0"
     exon            592..763
                     /gene="Abcb1a"
                     /gene_synonym="Abcb1; Mdr1a"
                     /inference="alignment:Splign:2.1.0"
     exon            764..888
                     /gene="Abcb1a"
                     /gene_synonym="Abcb1; Mdr1a"
                     /inference="alignment:Splign:2.1.0"
     exon            889..1060
                     /gene="Abcb1a"
                     /gene_synonym="Abcb1; Mdr1a"
                     /inference="alignment:Splign:2.1.0"
     exon            1061..1174
                     /gene="Abcb1a"
                     /gene_synonym="Abcb1; Mdr1a"
                     /inference="alignment:Splign:2.1.0"
     exon            1175..1285
                     /gene="Abcb1a"
                     /gene_synonym="Abcb1; Mdr1a"
                     /inference="alignment:Splign:2.1.0"
     exon            1286..1411
                     /gene="Abcb1a"
                     /gene_synonym="Abcb1; Mdr1a"
                     /inference="alignment:Splign:2.1.0"
     exon            1412..1615
                     /gene="Abcb1a"
                     /gene_synonym="Abcb1; Mdr1a"
                     /inference="alignment:Splign:2.1.0"
     exon            1616..1786
                     /gene="Abcb1a"
                     /gene_synonym="Abcb1; Mdr1a"
                     /inference="alignment:Splign:2.1.0"
     exon            1787..1948
                     /gene="Abcb1a"
                     /gene_synonym="Abcb1; Mdr1a"
                     /inference="alignment:Splign:2.1.0"
     exon            1949..2125
                     /gene="Abcb1a"
                     /gene_synonym="Abcb1; Mdr1a"
                     /inference="alignment:Splign:2.1.0"
     exon            2126..2272
                     /gene="Abcb1a"
                     /gene_synonym="Abcb1; Mdr1a"
                     /inference="alignment:Splign:2.1.0"
     exon            2273..2380
                     /gene="Abcb1a"
                     /gene_synonym="Abcb1; Mdr1a"
                     /inference="alignment:Splign:2.1.0"
     exon            2381..2458
                     /gene="Abcb1a"
                     /gene_synonym="Abcb1; Mdr1a"
                     /inference="alignment:Splign:2.1.0"
     exon            2459..2542
                     /gene="Abcb1a"
                     /gene_synonym="Abcb1; Mdr1a"
                     /inference="alignment:Splign:2.1.0"
     exon            2543..2746
                     /gene="Abcb1a"
                     /gene_synonym="Abcb1; Mdr1a"
                     /inference="alignment:Splign:2.1.0"
     exon            2747..2847
                     /gene="Abcb1a"
                     /gene_synonym="Abcb1; Mdr1a"
                     /inference="alignment:Splign:2.1.0"
     exon            2848..2988
                     /gene="Abcb1a"
                     /gene_synonym="Abcb1; Mdr1a"
                     /inference="alignment:Splign:2.1.0"
     exon            2989..3145
                     /gene="Abcb1a"
                     /gene_synonym="Abcb1; Mdr1a"
                     /inference="alignment:Splign:2.1.0"
     exon            3146..3343
                     /gene="Abcb1a"
                     /gene_synonym="Abcb1; Mdr1a"
                     /inference="alignment:Splign:2.1.0"
     exon            3344..3550
                     /gene="Abcb1a"
                     /gene_synonym="Abcb1; Mdr1a"
                     /inference="alignment:Splign:2.1.0"
     exon            3551..3697
                     /gene="Abcb1a"
                     /gene_synonym="Abcb1; Mdr1a"
                     /inference="alignment:Splign:2.1.0"
     exon            3698..4915
                     /gene="Abcb1a"
                     /gene_synonym="Abcb1; Mdr1a"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aactcagagc cgctgcttct tccaaagtgt acatcttggc ggaccttacg gaggaaatcg
       61 gaaagtagag acacgtgagg tcgtgatgga gctcgaagaa gaccttaacg gaagagcaga
      121 caagaacttc tcaaagatgg gcaaaaagag taaaaaggag aagaaagaaa agaaaccagc
      181 ggtcagtgtg ctcacaatgt ttcgctatgc aggttggctg gacagatttt acatgctgct
      241 gggaactctg gcggccatta tccatggaat tgcgctccca cttatgatgc tggtctttgg
      301 agacatgaca gatagctttg caaatgtagg aaacaaccgt agtatgagtt tctacaatgc
      361 tacagacata tatgccaagc tggaggacga aatgaccacg tacgcctact attacacggg
      421 cattggtgcc ggtgtgctca tcgttgccta catccaggtt tcactttggt gcctggcagc
      481 tgggagacaa atacacaaga ttaggcagaa gtttttccat gccatcatga atcaggagat
      541 aggctggttt gacgtgcatg acgttgggga gctcaacacc cggctcacag atgacgtctc
      601 caaaattaat gaaggaattg gtgacaaaat tggaatgttc tttcaggcaa tggcaacatt
      661 ttttggtggt tttataatag gatttactcg cggctggaag ctaactcttg tgattttggc
      721 catcagccct gttcttggac tgtcagctgg tatttgggca aagatattgt cttcatttac
      781 tgataaggaa ctccaggctt atgcaaaagc tggagcagtt gctgaagaag tcttagcagc
      841 catcagaact gtgattgcct ttggaggaca aaagaaggaa cttgaaaggt acaataacaa
      901 tttggaagaa gctaaaaggc ttgggataaa gaaagctatc acggccaaca tttccatggg
      961 tgcagctttt ctgcttatct atgcatcata tgctctggca ttctggtatg ggacttcctt
     1021 ggtcatctca aaagaataca ctattggaca agtgctcact gtcttttttt ctgtattaat
     1081 tggagcattc agtgttgggc aggcatctcc aaatattgaa gccttcgcca atgctagagg
     1141 agcagcttat gaagtcttca gtataattga taataagccc agtatagaca gcttctcaaa
     1201 gagtgggcac aaacccgaca acatacaagg aaatttggaa ttcaaaaata ttcacttcag
     1261 ttacccgtct cgaaaagacg ttcagatctt gaagggcctc aacctgaagg tgaagagcgg
     1321 gcagacggta gccctggttg gcaacagtgg ctgtgggaaa agcacaactg tccagctgct
     1381 gcagaggctc tacgacccca tagagggcga ggtcagtatc gacggacagg acatcaggac
     1441 catcaatgtg aggtatctgc gggaaatcat tggggtggtg agtcaggaac ccgtgctgtt
     1501 tgccaccaca attgccgaaa acattcgcta tggccgagaa aacgtcacca tggatgagat
     1561 agagaaagct gtcaaggaag ccaatgccta tgatttcatc atgaaactgc cccacaaatt
     1621 tgacaccctg gttggtgaga gaggggcgca gctgagtggg ggacagaaac agaggatcgc
     1681 cattgcccgg gccctggtcc gcaaccccaa gatccttttg ttggatgagg ccacgtcagc
     1741 cttggacaca gaaagcgaag ccgtggttca ggccgctctg gataaggcta gagaaggccg
     1801 gaccaccatt gtgatagctc accgcttgtc tacagttcgc aatgctgatg tcattgctgg
     1861 ttttgatggt ggtgtcattg tggagcaagg aaatcatgat gagctcatga gagagaaagg
     1921 aatttacttc aaacttgtca tgactcagac agcaggaaat gaaattgaat taggaaatga
     1981 agcttgtgaa tctaaagacg gaattgataa tgtggacatg tcttcaaaag attcgggatc
     2041 cagtctaata agaagaagat caactcgcaa aagcatccgt gggccacatg atcaagacgg
     2101 ggaacttagc accaaagagg ctctggatga cgacgtacct ccagcttcct tttggcggat
     2161 cctgaagttg aattcaactg aatggcctta ttttgtggtt ggtgtatttt gtgccataat
     2221 aaatggaggc ttgcaaccag cattctccat aatattttca aaggttgtag gggtttttac
     2281 aaaaaatgac acccctgaaa tccagcggca gaacagcaac ttgttttctt tattgttcct
     2341 gatccttggg atcatctctt tcattacgtt tttccttcag ggcttcacat ttggcaaagc
     2401 tggagagatc ctcaccaagc gactccgata catggtcttc aaatccatgc tgagacagga
     2461 cataagctgg tttgatgacc ctaaaaacac cacaggagcg ctgaccacca ggcttgccaa
     2521 tgacgctgct caagtgaaag gggctacagg gtctaggctt gctgttatta cccagaacat
     2581 agcaaatctt gggacaggca tcatcatatc cctgatctac ggctggcaat tgacactttt
     2641 actcctagca attgttccca tcattgctat agcaggagtg gttgaaatga aaatgttgtc
     2701 tggacaagcg ctgaaagata agaaggaact agaaggttct gggaagatcg ctacagaagc
     2761 aattgaaaac tttcgcactg tcgtctcttt gactcgggag cagaagtttg aaactatgta
     2821 tgcccagagc ttgcagatac catacagaaa tgctttgaag aaagcgcacg tctttgggat
     2881 cactttctcc ttcacccagg ccatgatgta tttctcctat gctgcttgtt tccggtttgg
     2941 tgcctacttg gtggcacgag aactcatgac atttgaaaat gttctgttag tattctcagc
     3001 tattgtcttt ggtgccatgg cagtggggca ggtcagttca ttcgctcctg actacgcgaa
     3061 agccaaagtc tcggcatccc acatcatcag gatcattgag aaaatccctg agattgacag
     3121 ctacagcacg gagggcttga agcctaatat gttggaagga aatgtgaaat ttaatggagt
     3181 catgttcaac tatcctaccc gacccaacat cccagtgctt caggggctga gcctagaggt
     3241 gaagaaaggg cagacgctgg ccctcgtggg cagcagtggc tgcgggaaga gtacagtggt
     3301 ccagctgctt gagcgcttct atgaccccat ggccggaaca gtgtttctag atggcaaaga
     3361 aataaagcaa ctcaatgtcc agtggctccg cgcccacctg ggcattgtgt cccaggagcc
     3421 catcctgttt gactgcagca tcgccgagaa cattgcctac ggagacaaca gccgtgtcgt
     3481 gtctcatgag gagatcgtga aggcagccaa ggaggccaac atccaccagt tcatcgactc
     3541 actgcctgag aaatacaaca ccagagtggg agacaaaggg actcagctgt cgggcgggca
     3601 gaagcagcgc atcgccatcg cgcgcgccct cgtcagacag cctcacatct tacttctgga
     3661 tgaagcgaca tcagctctgg atacggagag tgaaaaggtc gtccaggaag cgctggacaa
     3721 agccagggaa ggccgcacct gcattgtgat cgcgcaccgc ctgtccacca tccagaacgc
     3781 agacttgatc gtggtgattc agaacggcca ggtcaaggag cacggcaccc accagcagct
     3841 gctggcccag aaaggcatct atttctccat ggtcagtgtg caggctggag caaagcgctc
     3901 atgaactgtg accatgcgag atgttaaata tttttaatgt ttgtattaat atatgacact
     3961 taatcaaagt caaaaggaaa acacttacta gaatagtcag ttatctattt cctgtcacaa
     4021 aggaaagcat ttagtccatt ttagagtctt cagagacttt gtaattaaaa gaacaaaaat
     4081 agatacatca tcaagtggag agtaatagtt taaaatgcac tataaaattt acaaaagagt
     4141 taaaagtaaa tatttgataa tatatacttt tatttatact ttctcatttg taactataac
     4201 tgatttcctt gcttaacaaa ttatgtatgt atcaaaacta ctgaaatgtt tgtataaagt
     4261 atatatatat agtgaaactg aatgtttata ttttttgact tgttttgctc aaaatgcatg
     4321 tgaaattata tattctacca actggagtat tgtacataat tttagccttt aaaacttagt
     4381 ctatggggga ggggtcactc tatgggtaat gtgcctgata atacacaaac atgagtacct
     4441 gagtccagat ccctagcacc tatgtaagca gaaaggtgtg gtatgtttgt aatgccaggg
     4501 ctagaggcag aaacagacag atcctatggg ctccgtggtc agctagccta gccagcatag
     4561 ggagctccag gttcagtgag aagacttgcc tcaaaaataa gagggaaaaa gcaaatgagg
     4621 ttgtcacaaa tgtgtactcg tcatacaaat gccatccatg caaatgtata cacacacaca
     4681 ctcacacaca cacacacata cacacacaca cacacacaca cacacacaca cacacacaca
     4741 cacattaaca gaggactagc aaggaaaagg aaggggatta acaggagtgg gaccaggaca
     4801 aaggaggtta cttggatgaa tatgactgaa ggatgttatg tacatgtatg aaaatgccgt
     4861 actgaaacac tatgatgtat acttaatata tgctaataaa catttttaaa aggaa
//
