LOCUS       NM_031760               5036 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus ATP binding cassette subfamily B member 11
            (Abcb11), mRNA.
ACCESSION   NM_031760 XM_346681
VERSION     NM_031760.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5036)
  AUTHORS   He,X., Song,Y., Wang,L. and Xu,J.
  TITLE     Protective effect of pyrrolidine dithiocarbamate on
            isoniazid/rifampicin-induced liver injury in rats
  JOURNAL   Mol Med Rep 21 (1), 463-469 (2020)
   PUBMED   31746430
  REMARK    GeneRIF: Protective effect of pyrrolidine dithiocarbamate on
            isoniazid/rifampicininduced liver injury in rats.
REFERENCE   2  (bases 1 to 5036)
  AUTHORS   Besheer,T., Arafa,M., El-Maksoud,M.A., Elalfy,H., Hasson,A.,
            Zalata,K., Elkashef,W., Elshahawy,H., Raafat,D., Elemshaty,W.,
            Elsayed,E., Zaghloul,H., Razek,A.A. and El-Bendary,M.
  TITLE     Diagnosis of cirrhosis in patients with chronic hepatitis C
            genotype 4: Role of ABCB11 genotype polymorphism and plasma bile
            acid levels
  JOURNAL   Turk J Gastroenterol 29 (3), 299-307 (2018)
   PUBMED   29755014
REFERENCE   3  (bases 1 to 5036)
  AUTHORS   Takahashi,T., Deuschle,U., Taira,S., Nishida,T., Fujimoto,M.,
            Hijikata,T. and Tsuneyama,K.
  TITLE     Tsumura-Suzuki obese diabetic mice-derived hepatic tumors closely
            resemble human hepatocellular carcinomas in metabolism-related
            genes expression and bile acid accumulation
  JOURNAL   Hepatol Int 12 (3), 254-261 (2018)
   PUBMED   29651702
REFERENCE   4  (bases 1 to 5036)
  AUTHORS   Qu,X., Zhang,Y., Zhang,S., Zhai,J., Gao,H., Tao,L. and Song,Y.
  TITLE     Dysregulation of BSEP and MRP2 May Play an Important Role in
            Isoniazid-Induced Liver Injury via the SIRT1/FXR Pathway in Rats
            and HepG2 Cells
  JOURNAL   Biol Pharm Bull 41 (8), 1211-1218 (2018)
   PUBMED   30068870
  REMARK    GeneRIF: In conclusion, our data supports the hypothesis that
            isoniazid can induce liver injury via the down-regulation of
            hepatic efflux transporters BSEP and MRP2, and the SIRT1/FXR
            pathway may be the primary regulator with regard to the expression
            of transporters and the biosynthesis of bile acids in the liver.
REFERENCE   5  (bases 1 to 5036)
  AUTHORS   Cusato,J., De Nicolo,A., Boglione,L., Favata,F., Ariaudo,A.,
            Mornese Pinna,S., Guido,F., Avataneo,V., Carcieri,C., Cariti,G., Di
            Perri,G. and D'Avolio,A.
  TITLE     Influence of ABCB11 and HNF4alpha genes on daclatasvir plasma
            concentration: preliminary pharmacogenetic data from the Kineti-C
            study
  JOURNAL   J Antimicrob Chemother 72 (10), 2846-2849 (2017)
   PUBMED   29091211
REFERENCE   6  (bases 1 to 5036)
  AUTHORS   Kipp,H., Pichetshote,N. and Arias,I.M.
  TITLE     Transporters on demand: intrahepatic pools of canalicular ATP
            binding cassette transporters in rat liver
  JOURNAL   J Biol Chem 276 (10), 7218-7224 (2001)
   PUBMED   11113123
REFERENCE   7  (bases 1 to 5036)
  AUTHORS   Kipp,H. and Arias,I.M.
  TITLE     Newly synthesized canalicular ABC transporters are directly
            targeted from the Golgi to the hepatocyte apical domain in rat
            liver
  JOURNAL   J Biol Chem 275 (21), 15917-15925 (2000)
   PUBMED   10748167
REFERENCE   8  (bases 1 to 5036)
  AUTHORS   Vos,T.A., Hooiveld,G.J., Koning,H., Childs,S., Meijer,D.K.,
            Moshage,H., Jansen,P.L. and Muller,M.
  TITLE     Up-regulation of the multidrug resistance genes, Mrp1 and Mdr1b,
            and down-regulation of the organic anion transporter, Mrp2, and the
            bile salt transporter, Spgp, in endotoxemic rat liver
  JOURNAL   Hepatology 28 (6), 1637-1644 (1998)
   PUBMED   9828229
REFERENCE   9  (bases 1 to 5036)
  AUTHORS   Strautnieks,S.S., Bull,L.N., Knisely,A.S., Kocoshis,S.A., Dahl,N.,
            Arnell,H., Sokal,E., Dahan,K., Childs,S., Ling,V., Tanner,M.S.,
            Kagalwalla,A.F., Nemeth,A., Pawlowska,J., Baker,A.,
            Mieli-Vergani,G., Freimer,N.B., Gardiner,R.M. and Thompson,R.J.
  TITLE     A gene encoding a liver-specific ABC transporter is mutated in
            progressive familial intrahepatic cholestasis
  JOURNAL   Nat Genet 20 (3), 233-238 (1998)
   PUBMED   9806540
REFERENCE   10 (bases 1 to 5036)
  AUTHORS   Gerloff,T., Stieger,B., Hagenbuch,B., Madon,J., Landmann,L.,
            Roth,J., Hofmann,A.F. and Meier,P.J.
  TITLE     The sister of P-glycoprotein represents the canalicular bile salt
            export pump of mammalian liver
  JOURNAL   J Biol Chem 273 (16), 10046-10050 (1998)
   PUBMED   9545351
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from U69487.1.
            
            [WARNING] On Jul 17, 2024 this sequence was replaced by
            NM_031760.2.
            
            On Dec 17, 2003 this sequence version replaced XM_346681.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U69487.1, AF010597.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760476, SAMEA5760494
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..5036
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q21"
     gene            1..5036
                     /gene="Abcb11"
                     /gene_synonym="Bsep; Spgp"
                     /note="ATP binding cassette subfamily B member 11"
                     /db_xref="GeneID:83569"
                     /db_xref="RGD:619930"
     exon            1..84
                     /gene="Abcb11"
                     /gene_synonym="Bsep; Spgp"
                     /inference="alignment:Splign:2.1.0"
     exon            85..239
                     /gene="Abcb11"
                     /gene_synonym="Bsep; Spgp"
                     /inference="alignment:Splign:2.1.0"
     exon            240..338
                     /gene="Abcb11"
                     /gene_synonym="Bsep; Spgp"
                     /inference="alignment:Splign:2.1.0"
     CDS             263..4228
                     /gene="Abcb11"
                     /gene_synonym="Bsep; Spgp"
                     /note="ATP-binding cassette sub-family B member 11; sister
                     of P-glycoprotein; ATP-binding cassette, sub-family B
                     (MDR/TAP), member 11; ATP-binding cassette, subfamily B
                     (MDR/TAP), member 11"
                     /codon_start=1
                     /product="bile salt export pump"
                     /protein_id="NP_113948.1"
                     /db_xref="GeneID:83569"
                     /db_xref="RGD:619930"
                     /translation="MSDSVILRSVKKFGEENHAFESDGSHNNDKKSRLQDKMKEGDIR
                     VGFFELFRFSSSKDIWLMLMGGVCALLHGMAQPGILIIFGIMTDIFIKYDIERQELEI
                     PGKACVNNTIVWINSSFHQNMTNGTVCGLVDIESEMIKFSGIYAGVGMTVLILGYFQI
                     RLWVITGARQIRRMRKIYFRRIMRMEIGWFDCTSVGELNSRFADDIEKINDAIADQLA
                     HFLQRMSTAMCGLLLGFYRGWKLTLVILAVSPLIGIGAAVIGLSIAKFTELELKAYAK
                     AGSIADEVLSSIRTVAAFGGENKEVERYEKNLVFAQRWGIWKGMVMGFFTGYMWCLIF
                     FCYALAFWYGSTLVLDEEEYTPGTLVQIFLCVILAAMNIGHASSCLEIFSTGCSAATN
                     IFQTIDRQPVIDCMSGDGYKLDRIKGEIEFHNVTFHYPSRPDVKILDNLSMVIKPGET
                     TALVGSSGAGKSTALQLIQRFYDPCEGMVTLDGHDIRSLNIRWLRDQIGIVEQEPVLF
                     STTIAENIRFGREDATMEDIVQAAKDANAYNFIMALPQQFDTLVGEGGGQMSGGQKQR
                     VAIARALIRNPKILLLDMATSALDNESEARVQEALNKIQHGHTIISVAHRLSTVRAAD
                     VIIGFEHGVAVERGTHEELLERKGVYFMLVTLQSQGDNAHKETSIMGKDATEGGTLER
                     TFSRGSYRDSLRASIRQRSKSQLSLLTHDPPLAVADHKSSYKDSKDNDVLVEEVEPAP
                     VRRILKYNIPEWHYILVGSLSAAINGAVTPIYSLLFSQLLGTFSLLDKEQQRSEIHSM
                     CLFFVILGCVSIFTQFLQGYTFAKSGELLTKRLRKFGFKAMLGQDIGWFDDLRNNPGV
                     LTTRLATDASQVQGATGSQVGMMVNSFTNIIAALLIAFFFSWKLSLIITIFFPFLALS
                     GAVQTKMLTGFASQDKQALEKAGQITSEALSNIRTVAGIGVEGRFIKAFEVELQTSYK
                     TAVRKANIYGLCFAFSQGIAFLANSAAYRYGGYLIAYEGLGFSHVFRVVSSVALSATA
                     VGRTFSYTPSYAKAKISAARFFQLLDRKPPINVYSEAGEKWDNFQGKIDFIDCKFTYP
                     SRPDIQVLNGLSVSVNPGQTLAFVGSSGCGKSTSIQLLERFYDPDQGTVMIDGHDSKK
                     VNIQFLRSNIGIVSQEPVLFDCSIMDNIKYGDNTKEISVERAIAAAKQAQLHDFVMSL
                     PEKYETNVGIQGSQLSRGEKQRIAIARAIVRDPKILLLDEATSALDTESEKTVQTALD
                     KAREGRTCIVIAHRLSTIQNSDIIAVVSQGVVIEKGTHEKLMAQKGAYYKLVITGAPI
                     S"
     exon            339..360
                     /gene="Abcb11"
                     /gene_synonym="Bsep; Spgp"
                     /inference="alignment:Splign:2.1.0"
     exon            361..412
                     /gene="Abcb11"
                     /gene_synonym="Bsep; Spgp"
                     /inference="alignment:Splign:2.1.0"
     exon            413..651
                     /gene="Abcb11"
                     /gene_synonym="Bsep; Spgp"
                     /inference="alignment:Splign:2.1.0"
     exon            652..739
                     /gene="Abcb11"
                     /gene_synonym="Bsep; Spgp"
                     /inference="alignment:Splign:2.1.0"
     exon            740..873
                     /gene="Abcb11"
                     /gene_synonym="Bsep; Spgp"
                     /inference="alignment:Splign:2.1.0"
     exon            874..1045
                     /gene="Abcb11"
                     /gene_synonym="Bsep; Spgp"
                     /inference="alignment:Splign:2.1.0"
     exon            1046..1170
                     /gene="Abcb11"
                     /gene_synonym="Bsep; Spgp"
                     /inference="alignment:Splign:2.1.0"
     exon            1171..1345
                     /gene="Abcb11"
                     /gene_synonym="Bsep; Spgp"
                     /inference="alignment:Splign:2.1.0"
     exon            1346..1459
                     /gene="Abcb11"
                     /gene_synonym="Bsep; Spgp"
                     /inference="alignment:Splign:2.1.0"
     exon            1460..1570
                     /gene="Abcb11"
                     /gene_synonym="Bsep; Spgp"
                     /inference="alignment:Splign:2.1.0"
     exon            1571..1696
                     /gene="Abcb11"
                     /gene_synonym="Bsep; Spgp"
                     /inference="alignment:Splign:2.1.0"
     exon            1697..1900
                     /gene="Abcb11"
                     /gene_synonym="Bsep; Spgp"
                     /inference="alignment:Splign:2.1.0"
     exon            1901..2071
                     /gene="Abcb11"
                     /gene_synonym="Bsep; Spgp"
                     /inference="alignment:Splign:2.1.0"
     exon            2072..2273
                     /gene="Abcb11"
                     /gene_synonym="Bsep; Spgp"
                     /inference="alignment:Splign:2.1.0"
     exon            2274..2343
                     /gene="Abcb11"
                     /gene_synonym="Bsep; Spgp"
                     /inference="alignment:Splign:2.1.0"
     exon            2344..2443
                     /gene="Abcb11"
                     /gene_synonym="Bsep; Spgp"
                     /inference="alignment:Splign:2.1.0"
     exon            2444..2605
                     /gene="Abcb11"
                     /gene_synonym="Bsep; Spgp"
                     /inference="alignment:Splign:2.1.0"
     exon            2606..2710
                     /gene="Abcb11"
                     /gene_synonym="Bsep; Spgp"
                     /inference="alignment:Splign:2.1.0"
     exon            2711..2872
                     /gene="Abcb11"
                     /gene_synonym="Bsep; Spgp"
                     /inference="alignment:Splign:2.1.0"
     exon            2873..3076
                     /gene="Abcb11"
                     /gene_synonym="Bsep; Spgp"
                     /inference="alignment:Splign:2.1.0"
     exon            3077..3318
                     /gene="Abcb11"
                     /gene_synonym="Bsep; Spgp"
                     /inference="alignment:Splign:2.1.0"
     exon            3319..3475
                     /gene="Abcb11"
                     /gene_synonym="Bsep; Spgp"
                     /inference="alignment:Splign:2.1.0"
     exon            3476..3673
                     /gene="Abcb11"
                     /gene_synonym="Bsep; Spgp"
                     /inference="alignment:Splign:2.1.0"
     exon            3674..3880
                     /gene="Abcb11"
                     /gene_synonym="Bsep; Spgp"
                     /inference="alignment:Splign:2.1.0"
     exon            3881..4027
                     /gene="Abcb11"
                     /gene_synonym="Bsep; Spgp"
                     /inference="alignment:Splign:2.1.0"
     exon            4028..5036
                     /gene="Abcb11"
                     /gene_synonym="Bsep; Spgp"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tgaacttgaa aactggtgta caatcctgac tttccacagt ggggtctctc tcttctcctg
       61 gctccgtcaa gttcacatct gtagggtcca acttggatgg catggtgtag gctgctggta
      121 cctgatgaac ctgaatttgg aagactgaag aaagttgtac tgtagcctcc tctgagccaa
      181 aagctgaaaa gcaagtaaac cgttctcaac tgggctaagt ttttgaaaag ctggcaaagg
      241 gttgttgagt gcagattctg caatgtctga ctcagtgatt cttcgcagcg tgaagaaatt
      301 tggagaggag aatcatgctt tcgaatcaga tggatcacat aacaatgata agaaatcaag
      361 gttacaagat aagatgaagg agggagacat tcgagttggc ttctttgaac tgtttcgatt
      421 ttcttcatca aaagacatct ggctgatgct tatgggaggc gtatgcgcat tgctacatgg
      481 aatggcccag ccaggcatac ttattatttt tggtataatg acagatattt ttattaaata
      541 tgacattgaa aggcaagaac tcgagatacc aggaaaagcg tgtgtgaata acaccattgt
      601 atggatcaac agctccttcc accagaacat gacaaacgga acagtctgtg ggttggtgga
      661 cattgaaagt gaaatgatca aattctctgg catctacgca ggagtcggca tgaccgtact
      721 tatccttgga tactttcaaa taaggttatg ggtcatcact ggggctcgtc agataaggag
      781 aatgaggaaa atttacttcc ggagaataat gagaatggaa attgggtggt tcgactgcac
      841 ttctgtggga gagctgaatt caaggtttgc tgatgatatt gaaaaaatca atgacgccat
      901 tgccgaccag ttggctcatt tcctccagcg catgtcgacg gctatgtgtg ggttactttt
      961 agggttctac aggggttgga aactaacctt ggtgattctt gctgtcagcc ctctcattgg
     1021 cattggggca gccgtcatag gtctgagtat agccaagttc acggagcttg agttgaaggc
     1081 ttatgccaaa gcggggtcta ttgctgatga agtcctctca tctattcgaa cagtggccgc
     1141 ttttggtggt gagaacaaag aggttgaaag gtatgagaaa aatcttgtgt ttgcccagcg
     1201 ctggggaatt tggaaaggaa tggtgatggg cttcttcact gggtacatgt ggtgtctcat
     1261 tttcttctgt tatgcactgg ccttctggta tggttccaca cttgtcctag atgaagaaga
     1321 gtatacacca gggacactgg tccagatttt cctctgtgtc atattagcag ctatgaatat
     1381 tggccatgca tcttcttgct tggaaatctt ctccactggg tgttcagcag ctaccaatat
     1441 ttttcaaaca atagacaggc aacctgtcat tgactgcatg tcaggagacg gctacaagct
     1501 agaccgaatc aagggtgaaa ttgagttcca caatgtgacc ttccattatc cttctagacc
     1561 ggacgtgaag attttagata acctcagcat ggtcataaag ccaggggaaa cgacggctct
     1621 ggtgggatcc agtggggctg ggaagagtac agcattacag ctcattcaga gattctatga
     1681 cccctgtgaa ggcatggtga ctctggacgg ccatgacatt cgctctctta acatccggtg
     1741 gctgagagat caaatcggga tcgtggaaca ggagcccgtt ctgttctcca ccactatcgc
     1801 agaaaacatc cgttttggca gagaagatgc aacaatggaa gacatagtcc aagctgccaa
     1861 ggatgctaat gcatacaact tcattatggc cctgccgcag caatttgaca cccttgttgg
     1921 agaaggagga ggccagatga gtggtggtca gaagcaaaga gtagccattg cccgagccct
     1981 catacggaat cccaagatct tgcttctgga tatggctacc tcagcactgg acaatgagag
     2041 tgaagctaga gtacaagaag cattgaataa gatccaacat gggcatacaa tcatctcagt
     2101 tgcccatcgc ctgtcaacag tcagagctgc agatgtgatc attgggtttg agcatggagt
     2161 agctgtggaa agaggcaccc atgaagagct gctagaaaga aaaggtgtct acttcatgct
     2221 tgtgaccctg caaagccaag gagataatgc tcacaaagaa acgagcataa tggggaaaga
     2281 tgcgacggaa ggtggcaccc ttgagaggac cttttccaga ggcagctatc gggatagttt
     2341 aagagcttcg atccggcaac gctccaagtc tcagctgtct cttctgacac atgaccctcc
     2401 actggctgtt gctgatcaca aatcctctta caaagacagc aaggacaatg acgtgcttgt
     2461 ggaagaagtt gaacctgccc cagttaggag gattctaaaa tacaacattc cagaatggca
     2521 ctacattctg gtaggatctt tgagtgcagc cattaatggg gcagtcacac ccatctactc
     2581 ccttttattc agccagctcc ttgggacttt ttcactcctc gataaagaac aacaaaggtc
     2641 agagattcac agcatgtgtc tgttctttgt catcctgggc tgtgtatcca ttttcacaca
     2701 atttctgcag ggttacactt ttgccaaatc cggagagctc ctcacaaaga ggctgcggaa
     2761 atttggtttc aaggcaatgt taggacaaga tatcggctgg ttcgatgacc tcagaaataa
     2821 tcctggagta ctgacgacta ggcttgctac agatgcttcc caagttcaag gggctactgg
     2881 ctctcaagtt ggaatgatgg tcaattcctt cactaacatc attgcggcct tgctgattgc
     2941 cttcttcttt agctggaagc tcagtctgat tataacgatc ttcttcccct ttctggcttt
     3001 atcgggagct gtacagacaa aaatgttgac gggattcgct tctcaagaca agcaagctct
     3061 ggagaaggct ggtcagatca ccagcgaagc cctcagcaat atccgcacag ttgctgggat
     3121 tggagtggag ggaagattta ttaaagcatt tgaggttgag ctccagacat catacaagac
     3181 tgctgtcagg aaggcgaata tctatggact ctgctttgcc ttttcccagg ggatagcatt
     3241 tcttgcaaat tccgctgcct atagatatgg aggttactta atagcctacg aaggtctggg
     3301 cttcagccac gttttcaggg tggtctcttc agttgcattg agtgcaacag ccgttggaag
     3361 aacattctct tatactccga gctatgccaa agctaaaata tcagctgcac gcttttttca
     3421 actgctagat cggaaacctc caattaatgt gtacagtgaa gcaggtgaaa aatgggacaa
     3481 cttccaaggg aagattgatt ttattgactg taaatttacg tatccttctc gacccgatat
     3541 tcaagttctg aatggtctct cagtatctgt taatcctggg cagacgctgg catttgttgg
     3601 aagcagtggg tgtggcaaaa gcaccagcat tcagctgttg gaacggttct atgatcccga
     3661 tcagggaact gtgatgatag atggtcatga cagcaaaaaa gtcaacattc agttcctccg
     3721 ttccaacatc gggattgtct cccaggagcc agtgctgttt gactgtagca taatggacaa
     3781 catcaagtac ggggacaaca ctaaagagat ctccgtggag agagccatag ctgctgcaaa
     3841 gcaggctcag ctgcatgact tcgtcatgtc gctcccagag aaatatgaaa ctaatgttgg
     3901 gatccagggc tctcagctct ctcgtggaga gaaacaacgc attgctattg ctcgggccat
     3961 tgtgcgagat cctaaaatct tactactgga tgaagctacg tctgccctag acacagaaag
     4021 tgaaaagaca gtgcagactg ctctggacaa agccagagag ggtcggacct gcattgtcat
     4081 tgctcatcgt ttgtccacca tccagaactc agatatcatt gctgtcgtgt cacaaggagt
     4141 ggtgattgaa aaagggaccc atgagaaact gatggcccag aagggagcct actacaagct
     4201 ggtcatcact ggagccccca tcagttgacc tgactggaga cttcacacag ataatgatgt
     4261 gctgagtaca ggagggctgt gggtttttgt agtcatatag agaattatta atgctttaca
     4321 gacagaagta tccactggga tccaaagtaa ttttgagtga ctttcagtaa taatttcagt
     4381 ttgaaatgtc tatgtagaaa ggagagagcc cagagtcagc atgagtcaaa gttcaaagtc
     4441 caaggtcaag tagctgctta tctgccggcc agtgctgctc tgggtagaaa ctggtcactg
     4501 tctccatcga ggacgccgcg gtgagagcaa ggagtcctcc ttcaggacag agggttatct
     4561 cttgcatctg ggaaagctcc ctgcgcactg agcctgctct gtaatctgca ctcaactgtt
     4621 tgagccagtt caaggccaag agctaaggac ccaaggctac tggtatttct taactaagtt
     4681 tagtttgttt actataagga agcaaattta tttaccttta actcctgtga gtagggtggg
     4741 gagccctttc ctattctggc atctcccagg ctcagggagg ccaaggtgac aaaaggagaa
     4801 gtagaggtcg ctggtcaggt gtgttgattg taccgaaggc tcagggtatt ggtgtcactg
     4861 tacactacag tggatctgcc agtgtgaagc aggggctctc taccaggact tcgacttttc
     4921 attccctgcc accatgtcac ctgatgtccc ttactcttag gaaattctat gcatggaatg
     4981 gaaatgcatc cgaatcttaa gttgttacat aaaaaaatct agtaaaacat agtagg
//
