LOCUS       NM_173307               5170 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus ATP binding cassette subfamily A member 5
            (Abca5), mRNA.
ACCESSION   NM_173307
VERSION     NM_173307.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5170)
  AUTHORS   Ye,D., Meurs,I., Ohigashi,M., Calpe-Berdiel,L., Habets,K.L.,
            Zhao,Y., Kubo,Y., Yamaguchi,A., Van Berkel,T.J., Nishi,T. and Van
            Eck,M.
  TITLE     Macrophage ABCA5 deficiency influences cellular cholesterol efflux
            and increases susceptibility to atherosclerosis in female LDLr
            knockout mice
  JOURNAL   Biochem Biophys Res Commun 395 (3), 387-394 (2010)
   PUBMED   20382126
REFERENCE   2  (bases 1 to 5170)
  AUTHORS   Petry,F., Ritz,V., Meineke,C., Middel,P., Kietzmann,T.,
            Schmitz-Salue,C. and Hirsch-Ernst,K.I.
  TITLE     Subcellular localization of rat Abca5, a rat ATP-binding-cassette
            transporter expressed in Leydig cells, and characterization of its
            splice variant apparently encoding a half-transporter
  JOURNAL   Biochem J 393 (Pt 1), 79-87 (2006)
   PUBMED   16162093
  REMARK    GeneRIF: Expression of rAbca5 mRNA in Leydig cells, intracellular
            localization of rAbca5-EGFP/rAbca5-V5 and involvement of
            rAbca5-related proteins in lipid transport suggest that rAbca5 may
            participate in intracellular sterol/steroid trafficking.
REFERENCE   3  (bases 1 to 5170)
  AUTHORS   Kubo,Y., Sekiya,S., Ohigashi,M., Takenaka,C., Tamura,K., Nada,S.,
            Nishi,T., Yamamoto,A. and Yamaguchi,A.
  TITLE     ABCA5 resides in lysosomes, and ABCA5 knockout mice develop
            lysosomal disease-like symptoms
  JOURNAL   Mol Cell Biol 25 (10), 4138-4149 (2005)
   PUBMED   15870284
  REMARK    Erratum:[Mol Cell Biol. 2005 Jul;25(13):5786]
REFERENCE   4  (bases 1 to 5170)
  AUTHORS   Petry,F., Kotthaus,A. and Hirsch-Ernst,K.I.
  TITLE     Cloning of human and rat ABCA5/Abca5 and detection of a human
            splice variant
  JOURNAL   Biochem Biophys Res Commun 300 (2), 343-350 (2003)
   PUBMED   12504089
  REMARK    GeneRIF: Molecular cloning of Abca5.
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AJ426052.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ426052.2 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..5170
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="W"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q32.1"
     gene            1..5170
                     /gene="Abca5"
                     /note="ATP binding cassette subfamily A member 5"
                     /db_xref="GeneID:286970"
                     /db_xref="RGD:628661"
     exon            1..17
                     /gene="Abca5"
                     /inference="alignment:Splign:2.1.0"
     exon            18..137
                     /gene="Abca5"
                     /inference="alignment:Splign:2.1.0"
     CDS             36..4964
                     /gene="Abca5"
                     /function="transporter"
                     /note="ATP-binding cassette sub-family A member 5;
                     ATP-binding cassette, sub-family A (ABC1), member 5;
                     ATP-binding cassette, subfamily A (ABC1), member 5"
                     /codon_start=1
                     /product="cholesterol transporter ABCA5"
                     /protein_id="NP_775429.1"
                     /db_xref="GeneID:286970"
                     /db_xref="RGD:628661"
                     /translation="MATAIRDVGVWRQTRTLLLKNYLVKCRTKKSSVQEILFPLFFLF
                     WLILISMMHPNKKYEEVSDIELSPMDKSILSNLILGYTPVTNTTSSVMQRVSTDHLPD
                     VLVTEEYASEKELLASSLSKPSNFVGVVFKDVMSYELRFFPDMVPVSSVYMDSRAGCS
                     KSCDAAQYWSSGFTALQASIDAAIIQLKTNVSLWRELESTKAVIMGEAAVVEIDTFPR
                     GVILIYLVIAFSPFGYFLAIHIVAEKEKRLKEFLKIMGLHDTAFWLSWVLLYTSLIFL
                     MSLLMAVIATASSLFPQSSSIVIFLLFFLYGLSSVFFALMLTPLFKKSKHVGVVEFFV
                     TVVFGFVGLLIVLVESFPRSLVWLFSPLCQCAFLIGIAQVMHLEDFNEGALFSSLTEG
                     PYPLIITLTMLALDSVFYALLAVYLDQVIPGEFGLRRSSLYFLKPSYWSKNKRNYKEL
                     SEGNINGNISLNEIVEPVSSEFIGKEAIRISGIQKAYRKKNETVEALRNLSFDIYEGQ
                     ITALLGHSGTGKSTLMNILCGLCPPSDGFASIYGHRVSEIDEMFEARKMIGICPQSDM
                     NFDVLTVEENLSILASVKGIPANNIIQEVQKVLLDLDMQAIKDNQAKKLSGGQKRKLS
                     LGIAVLGNPKILLLDEPTAGMDPCSRHIVWNLLKYRKANRVTVFSTHFMDEADILADR
                     KAVISQGMLKCVGSSIFLKSKWGIGYRLSMYIDRYCATESLSSLVRQHIPAAALLQQN
                     DQQIVYSLPFKDMDKFSGLFSALDIHSNLGVISYGVSMTTLEDVFLKLEVEAEIDQAD
                     YSVFTQQPREEETDSKSFDEMEQSLLILSETKASLVSTMSLWKQQVSTIAKFHFLSLK
                     RESKSVRSVLLLLLIFFAVQIFMFLVHHSFKNAVVPIKLVPDLYFLKPGDKPHKYKTS
                     LLLQNSTDSDINDLIDFFTQQNIIVAMFNDSDYVSAAPHSAALNVVQSEKDYVFTAVF
                     NSTMVYSLPVMMNIISNYYLYHLNVTDTIQIWSTPFIQEITDIVFKVELYFQAALLGI
                     IVTAMPPYFAMENAENHKIKAYTQLKLSGLLPSAYWIGQAVVDIPLFFVVLTLMLGSL
                     FAFHHGLYFYPVKFLAVVFCLIAYVPSVILFTYIASFTFKKILNTKEFWSFIYSVTAL
                     ACVAVTEITFFLGYGVTAVFHYTFCIAIPIYPLLGCLISFIKGSWKNIPKTENAYNPW
                     DRLLVAVIMPYLQCVLWIFLLQHYEKKHGGRSIRKDPLFRALSQKAKHKKFPEPPINE
                     DEDEDVKAERLKVKELMGCQCCEEKPAIMVYNLHKEYDDKKDFLHSRKTTKVATKYVS
                     FCVKKGEILGLLGPNGAGKSTIINILVGDVEPTSGKIFLGDYGSHSNEDDESTKCMGY
                     CPQTNPLWPDITLQEHFEIYGAVKGMSSGDMKEVISRITKALDLKEHLQKTVKKLPAG
                     IKRKLCFALSMLGNPQVTLLDEPSTGMDPRAKQHMWRAIRTAFKNKKRAALLTTHYME
                     EAEAVCDRVAIMVSGQLRCIGTVQHLKSKFGKGYFLEIKLKDWIENLEIDRLQREIQY
                     IFPNASRQESFSSILAYKIPKEDVQSLSQSFAKLEEAKHTFAIEEYSFSQATLEQVFV
                     ELTKEQEEEDNSCGTLNSTLWWERRQEDRVVF"
     exon            138..342
                     /gene="Abca5"
                     /inference="alignment:Splign:2.1.0"
     exon            343..504
                     /gene="Abca5"
                     /inference="alignment:Splign:2.1.0"
     exon            505..593
                     /gene="Abca5"
                     /inference="alignment:Splign:2.1.0"
     exon            594..823
                     /gene="Abca5"
                     /inference="alignment:Splign:2.1.0"
     exon            824..965
                     /gene="Abca5"
                     /inference="alignment:Splign:2.1.0"
     exon            966..1154
                     /gene="Abca5"
                     /inference="alignment:Splign:2.1.0"
     exon            1155..1302
                     /gene="Abca5"
                     /inference="alignment:Splign:2.1.0"
     exon            1303..1471
                     /gene="Abca5"
                     /inference="alignment:Splign:2.1.0"
     exon            1472..1530
                     /gene="Abca5"
                     /inference="alignment:Splign:2.1.0"
     exon            1531..1641
                     /gene="Abca5"
                     /inference="alignment:Splign:2.1.0"
     exon            1642..1817
                     /gene="Abca5"
                     /inference="alignment:Splign:2.1.0"
     exon            1818..1937
                     /gene="Abca5"
                     /inference="alignment:Splign:2.1.0"
     exon            1938..2076
                     /gene="Abca5"
                     /inference="alignment:Splign:2.1.0"
     exon            2077..2167
                     /gene="Abca5"
                     /inference="alignment:Splign:2.1.0"
     exon            2168..2307
                     /gene="Abca5"
                     /inference="alignment:Splign:2.1.0"
     exon            2308..2427
                     /gene="Abca5"
                     /inference="alignment:Splign:2.1.0"
     exon            2428..2629
                     /gene="Abca5"
                     /inference="alignment:Splign:2.1.0"
     exon            2630..2799
                     /gene="Abca5"
                     /inference="alignment:Splign:2.1.0"
     exon            2800..2927
                     /gene="Abca5"
                     /inference="alignment:Splign:2.1.0"
     exon            2928..3065
                     /gene="Abca5"
                     /inference="alignment:Splign:2.1.0"
     exon            3066..3179
                     /gene="Abca5"
                     /inference="alignment:Splign:2.1.0"
     exon            3180..3350
                     /gene="Abca5"
                     /inference="alignment:Splign:2.1.0"
     exon            3351..3464
                     /gene="Abca5"
                     /inference="alignment:Splign:2.1.0"
     exon            3465..3599
                     /gene="Abca5"
                     /inference="alignment:Splign:2.1.0"
     exon            3600..3674
                     /gene="Abca5"
                     /inference="alignment:Splign:2.1.0"
     exon            3675..3766
                     /gene="Abca5"
                     /inference="alignment:Splign:2.1.0"
     exon            3767..3893
                     /gene="Abca5"
                     /inference="alignment:Splign:2.1.0"
     exon            3894..4011
                     /gene="Abca5"
                     /inference="alignment:Splign:2.1.0"
     exon            4012..4103
                     /gene="Abca5"
                     /inference="alignment:Splign:2.1.0"
     exon            4104..4279
                     /gene="Abca5"
                     /inference="alignment:Splign:2.1.0"
     exon            4280..4355
                     /gene="Abca5"
                     /inference="alignment:Splign:2.1.0"
     exon            4356..4450
                     /gene="Abca5"
                     /inference="alignment:Splign:2.1.0"
     exon            4451..4570
                     /gene="Abca5"
                     /inference="alignment:Splign:2.1.0"
     exon            4571..4720
                     /gene="Abca5"
                     /inference="alignment:Splign:2.1.0"
     exon            4721..4800
                     /gene="Abca5"
                     /inference="alignment:Splign:2.1.0"
     exon            4801..4856
                     /gene="Abca5"
                     /inference="alignment:Splign:2.1.0"
     exon            4857..5170
                     /gene="Abca5"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgcttcagcg gagagagtaa gctgacctag aaaacatggc tactgcaatt agggatgtgg
       61 gcgtttggag acagaccaga acacttcttc tgaagaatta cctcgtcaaa tgcaggacta
      121 aaaagagtag tgttcaggaa attctttttc ctctattttt cttattttgg ctgatattaa
      181 ttagcatgat gcatccaaat aagaaatatg aagaagtatc tgatatagaa ctcagcccta
      241 tggacaaatc catcctttcc aaccttatcc tggggtacac tccagtgact aatactacaa
      301 gcagcgtcat gcagagagtt tctaccgatc atcttcccga cgttctagtt actgaagaat
      361 acgccagtga gaaggagctg ctggcatcca gtttgtctaa gcccagcaac ttcgtgggtg
      421 tggttttcaa agacgtcatg tcctatgaac tgcggttttt tcctgatatg gttccagtgt
      481 cttctgttta tatggattca agagcaggct gttcaaagtc atgtgatgct gctcagtact
      541 ggtcttcagg gtttacagct ttacaggcct caatagatgc tgccattata cagttgaaga
      601 ccaatgtttc tctgtggagg gagctggagt caaccaaagc tgtcatcatg ggggaagctg
      661 cggtcgtgga gattgacacc ttcccacgag gggtcatcct catctacctc gtcatagcct
      721 tctcgccctt cgggtacttt ctggcaattc acattgtagc agaaaaggaa aagaggttaa
      781 aggagttttt aaagataatg ggacttcacg acactgcttt ttggctgtcc tgggttcttc
      841 tgtacacgag tttgatcttc cttatgtccc ttcttatggc cgtcattgca acagcgtcct
      901 cgttattccc tcagagtagc agcatcgtga tttttctgct cttcttcctg tacggattgt
      961 catctgtgtt ttttgcttta atgttgacgc ctctttttaa aaaatcaaag cacgtgggag
     1021 tcgttgagtt ttttgtcacc gtggtgtttg gctttgtcgg cctgttgata gtcctcgtag
     1081 aaagtttccc caggtcgcta gtgtggctct tcagtccttt gtgtcagtgc gcctttctga
     1141 ttgggattgc acaggtcatg catttagaag atttcaatga aggagcctta ttttctagtt
     1201 tgactgaagg cccctacccg ctaattatca cccttaccat gctcgctctg gacagtgtgt
     1261 tctatgccct gctggctgtg taccttgatc aggtcatccc aggggaattt ggcttgagga
     1321 ggtcatcttt gtacttccta aagccatcat attggtcaaa aaacaaaagg aactataagg
     1381 agctatcaga gggcaacatc aatgggaata ttagtctcaa tgaaattgtt gagcccgttt
     1441 cttcagaatt tataggaaaa gaagctataa gaataagtgg tattcagaaa gcctatagga
     1501 agaagaatga gaccgtggag gctttgagaa atttgtcgtt tgacatctat gaaggccaga
     1561 ttactgctct gctgggccac agtggaacag gaaaaagcac actaatgaat attctgtgtg
     1621 gactgtgccc accttctgat gggtttgctt ctatatatgg acacagagtc tctgaaatag
     1681 atgaaatgtt tgaagcgagg aaaatgattg gcatatgtcc acagtcagat atgaactttg
     1741 atgttctgac agtagaagaa aatttatcaa ttttggcttc agtcaaagga ataccagcca
     1801 acaacataat tcaggaagta cagaaagttt tactggattt ggacatgcaa gccatcaaag
     1861 ataatcaagc gaaaaaacta agtggtggcc aaaagagaaa gctgtcttta ggaattgcag
     1921 ttcttgggaa tccaaagatc ctcctgctag atgagccgac agcaggaatg gacccctgct
     1981 ctcgccacat tgtttggaat cttctcaagt acaggaaggc taaccgagtg acagtcttca
     2041 gcactcactt catggatgag gccgacattc ttgccgacag gaaagctgtc atatcacaag
     2101 gaatgctgaa atgtgttggt tcttcaattt tcctgaaaag taaatgggga atcggctacc
     2161 gtctgagcat gtatatagac aggtactgtg ccacagagtc gctctcgtcg ctggttagac
     2221 agcacatccc tgcggccgct ctgctgcagc agaatgacca gcagattgtc tatagcttgc
     2281 ccttcaaaga catggacaaa ttttcaggct tgttttctgc tctagacatt cattcaaacc
     2341 tgggtgtaat ttcttatggt gtttccatga cgacattgga agacgtgttt ttaaagctag
     2401 aagttgaagc agaaattgac caagcagatt atagtgtatt tacccagcag ccacgggagg
     2461 aagaaacaga ttcaaagtct tttgatgaaa tggaacagag tttacttatt ctctctgaaa
     2521 ccaaagcttc tctagtgagc accatgagtc tctggaagca gcaagtatct acaatagcaa
     2581 agtttcattt cctctcactg aagcgagaaa gcaaatcagt gcgctctgtg ttgcttctgc
     2641 ttttaatttt ttttgcagtt cagattttta tgtttttggt ccatcattct tttaaaaatg
     2701 ctgtggttcc catcaagctc gttccagact tgtattttct aaaacctgga gataaacctc
     2761 ataaatacaa aacaagcctg ctgcttcaaa attctactga ttcagatatc aatgatctta
     2821 ttgacttttt cacacagcag aacataattg tggccatgtt taatgacagt gactatgtgt
     2881 ctgctgctcc tcatagtgcg gctctcaatg tggtgcagtc agaaaaggac tatgttttta
     2941 ctgctgtttt caacagtact atggtttatt ctttgccagt aatgatgaac atcattagta
     3001 actactatct ctatcattta aatgtgactg acactatcca gatctggagt accccgttca
     3061 ttcaggaaat tactgacatt gtttttaaag ttgagctata ttttcaagca gctttgcttg
     3121 gaatcattgt tactgcaatg ccaccttact ttgccatgga aaatgcagag aatcataaga
     3181 tcaaagctta cactcagctt aaactttcag gtcttttgcc atccgcctac tggattggac
     3241 aggctgtggt ggacattccc ctgttttttg ttgttctgac tttgatgctg ggaagtttat
     3301 ttgcctttca tcacggactg tatttttatc ctgtaaagtt tcttgctgtg gttttttgcc
     3361 tcattgctta tgtgccctcg gttattctgt tcacttatat agcttcgttc acctttaaga
     3421 aaattttaaa taccaaggaa ttttggtcat ttatctattc tgtgacagca ttggcttgtg
     3481 tcgcagtcac ggaaataact ttctttctgg ggtatggagt tacggctgtt tttcattaca
     3541 ccttctgcat agccatccca atctacccgc tcctgggttg tctgatttct ttcataaagg
     3601 gttcttggaa gaatatacca aaaactgaga atgcctacaa tccctgggac agacttttag
     3661 ttgctgtaat catgccctac ctgcagtgtg tactgtggat tttcctctta caacactatg
     3721 agaaaaaaca tggaggcaga tcaataagaa aggatccgct tttcagggcc ctctcacaaa
     3781 aagccaaaca taagaagttt ccagaaccac ccatcaatga ggatgaagat gaagatgtca
     3841 aagcggaaag gttgaaggtt aaagagctga tgggttgcca gtgttgtgag gagaaaccgg
     3901 ccattatggt atacaatttg cataaagaat atgatgacaa gaaagatttc cttcactcaa
     3961 ggaaaacaac aaaagtagca acaaaatacg tctctttctg tgtgaaaaaa ggagagatct
     4021 tgggactgtt gggtccaaat ggtgctggca aaagcacgat tattaatatt cttgttgggg
     4081 atgttgaacc aacttcaggc aagatatttc taggagatta tggttcacat tcaaatgaag
     4141 atgatgaatc caccaagtgt atgggttact gcccccagac aaacccactc tggccagata
     4201 ttactctgca agaacatttt gaaatttatg gagctgtgaa agggatgagt tcaggtgaca
     4261 tgaaggaagt aatcagtcga ataacaaaag cccttgattt gaaagaacat cttcagaaaa
     4321 ctgtaaagaa actccctgca gggatcaagc gaaagctgtg ttttgctctc agtatgctgg
     4381 ggaatcctca ggtgacactg ctggatgagc cgtctacagg tatggacccc agagccaaac
     4441 agcacatgtg gcgagccatt cgaactgcgt ttaaaaacaa gaagcgggct gccctcctca
     4501 ctacgcatta catggaagag gcggaggctg tctgtgacag ggtggccatc atggtgtccg
     4561 ggcagctaag atgcattgga acagtacaac atctaaagag caagtttggc aaaggctact
     4621 ttttagaaat taaactaaag gactggatag aaaacctgga aatagatcgc cttcaaagag
     4681 aaattcaata tattttccca aatgcaagcc gccaagagag cttctcttct attctggctt
     4741 ataaaattcc aaaagaagat gtccagtctc tctcacagtc ctttgctaag ttggaggaag
     4801 caaaacacac ttttgccatt gaagaataca gcttttctca agcaaccctg gaacaggttt
     4861 ttgtagaact tactaaggag caggaggagg aagataatag ctgcgggact ttaaacagca
     4921 cgctctggtg ggaaagaagg caggaagaca gagtcgtgtt ctgaatgtct gcgctcaccc
     4981 cgcctgctga ccctgaactt actctttttt attttgtttt tccttctttt atcttaactt
     5041 tgattttaaa agtttattac ttgaatagtc acaaaacatg aaagcacttg gaaatttcct
     5101 aaactcctta atttatgcac catggttatt tatgtgtctg ggttttcttt aaataaatgt
     5161 gtgtgtagtt
//
