LOCUS       NM_001107721            7163 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus ATP binding cassette subfamily A member 4
            (Abca4), mRNA.
ACCESSION   NM_001107721 XM_001074129 XM_241525
VERSION     NM_001107721.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 7163)
  AUTHORS   Huang,J., Zhao,Q., Wei,X., Ma,W., Luo,W., Gu,H., Liu,D., He,Y.,
            Huang,T., Liu,Y., Wang,C. and Yuan,Z.
  TITLE     miR-351-3p promotes rat amniotic fluid-derived mesenchymal stromal
            cell proliferation via targeting the coding sequence of Abca4
  JOURNAL   Stem Cells 39 (9), 1192-1206 (2021)
   PUBMED   33970551
  REMARK    GeneRIF: miR-351-3p promotes rat amniotic fluid-derived mesenchymal
            stromal cell proliferation via targeting the coding sequence of
            Abca4.
REFERENCE   2  (bases 1 to 7163)
  AUTHORS   Zhang,Y., Seo,S., Bhattarai,S., Bugge,K., Searby,C.C., Zhang,Q.,
            Drack,A.V., Stone,E.M. and Sheffield,V.C.
  TITLE     BBS mutations modify phenotypic expression of CEP290-related
            ciliopathies
  JOURNAL   Hum Mol Genet 23 (1), 40-51 (2014)
   PUBMED   23943788
REFERENCE   3  (bases 1 to 7163)
  AUTHORS   Quazi,F. and Molday,R.S.
  TITLE     Differential phospholipid substrates and directional transport by
            ATP-binding cassette proteins ABCA1, ABCA7, and ABCA4 and
            disease-causing mutants
  JOURNAL   J Biol Chem 288 (48), 34414-34426 (2013)
   PUBMED   24097981
REFERENCE   4  (bases 1 to 7163)
  AUTHORS   Chouchene,I., Largueche,L., Ouechtati,F., Derouiche,K., Turki,A.,
            Abdelhak,S. and El Matri,L.
  TITLE     [Clinical characterization of the Stargardt disease and molecular
            exploration of the c.2041C>T mutation (ABCA4 gene) in Tunisian
            patients]
  JOURNAL   Ann Biol Clin (Paris) 71 (6), 645-651 (2013)
   PUBMED   24342785
REFERENCE   5  (bases 1 to 7163)
  AUTHORS   Daiger,S.P., Sullivan,L.S. and Bowne,S.J.
  TITLE     Genes and mutations causing retinitis pigmentosa
  JOURNAL   Clin Genet 84 (2), 132-141 (2013)
   PUBMED   23701314
  REMARK    Review article
REFERENCE   6  (bases 1 to 7163)
  AUTHORS   Bhongsatiern,J., Ohtsuki,S., Tachikawa,M., Hori,S. and Terasaki,T.
  TITLE     Retinal-specific ATP-binding cassette transporter (ABCR/ABCA4) is
            expressed at the choroid plexus in rat brain
  JOURNAL   J Neurochem 92 (5), 1277-1280 (2005)
   PUBMED   15715676
  REMARK    GeneRIF: Glycosylated ABCA4 protein is expressed in rat choroid
            plexus epithelial cells. ABCA4 may play a role in the function of
            the blood-cerebrospinal fluid barrier and affect CSF conditions.
REFERENCE   7  (bases 1 to 7163)
  AUTHORS   Mata,N.L., Tzekov,R.T., Liu,X., Weng,J., Birch,D.G. and Travis,G.H.
  TITLE     Delayed dark-adaptation and lipofuscin accumulation in abcr+/-
            mice: implications for involvement of ABCR in age-related macular
            degeneration
  JOURNAL   Invest Ophthalmol Vis Sci 42 (8), 1685-1690 (2001)
   PUBMED   11431429
REFERENCE   8  (bases 1 to 7163)
  AUTHORS   Weng,J., Mata,N.L., Azarian,S.M., Tzekov,R.T., Birch,D.G. and
            Travis,G.H.
  TITLE     Insights into the function of Rim protein in photoreceptors and
            etiology of Stargardt's disease from the phenotype in abcr knockout
            mice
  JOURNAL   Cell 98 (1), 13-23 (1999)
   PUBMED   10412977
REFERENCE   9  (bases 1 to 7163)
  AUTHORS   Cremers,F.P., van de Pol,D.J., van Driel,M., den Hollander,A.I.,
            van Haren,F.J., Knoers,N.V., Tijmes,N., Bergen,A.A.,
            Rohrschneider,K., Blankenagel,A., Pinckers,A.J., Deutman,A.F. and
            Hoyng,C.B.
  TITLE     Autosomal recessive retinitis pigmentosa and cone-rod dystrophy
            caused by splice site mutations in the Stargardt's disease gene
            ABCR
  JOURNAL   Hum Mol Genet 7 (3), 355-362 (1998)
   PUBMED   9466990
REFERENCE   10 (bases 1 to 7163)
  AUTHORS   Allikmets,R., Shroyer,N.F., Singh,N., Seddon,J.M., Lewis,R.A.,
            Bernstein,P.S., Peiffer,A., Zabriskie,N.A., Li,Y., Hutchinson,A.,
            Dean,M., Lupski,J.R. and Leppert,M.
  TITLE     Mutation of the Stargardt disease gene (ABCR) in age-related
            macular degeneration
  JOURNAL   Science 277 (5333), 1805-1807 (1997)
   PUBMED   9295268
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473952.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_241525.4, XM_001074129.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: partial sample support SAMEA5760433, SAMN13663597
                              [ECO:0000350]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..7163
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q42"
     gene            1..7163
                     /gene="Abca4"
                     /gene_synonym="ABCR"
                     /note="ATP binding cassette subfamily A member 4"
                     /db_xref="GeneID:310836"
                     /db_xref="RGD:1309445"
     exon            1..150
                     /gene="Abca4"
                     /gene_synonym="ABCR"
                     /inference="alignment:Splign:2.1.0"
     CDS             85..6957
                     /gene="Abca4"
                     /gene_synonym="ABCR"
                     /EC_number="7.6.2.1"
                     /note="retinal-specific ATP-binding cassette transporter;
                     ATP-binding cassette, sub-family A (ABC1), member 4;
                     ATP-binding cassette, subfamily A (ABC1), member 4"
                     /codon_start=1
                     /product="retinal-specific phospholipid-transporting
                     ATPase ABCA4"
                     /protein_id="NP_001101191.1"
                     /db_xref="GeneID:310836"
                     /db_xref="RGD:1309445"
                     /translation="MGFLRQIQLLLWKNWTLRKRQKIRFVVELVWPLSLFLVLIWLRN
                     ANPLYSQHECHFPNKAMPSAGMLPWLQGIFCNMNNPCFQNPTPGESPGTVSNYNNSIL
                     ARLYRDFQELFMDTPEVQRLGRVWTELRTLSQLMDTLRTHPERFTGRGLPIRDILKDE
                     ETLTLFLKKNIGLSDSVAYLLVNSQVRMEQFAYGVPDLELKDIACSEALLQRFIIFSQ
                     RWGAQAVRGALCPLSQVTLQWIEDTLYADVDFFKLFRVLPTLLDSSSQGINLRFWGEI
                     LSDLSPRVQKFIHRPSVQDLLWVTRPLLQNSGPETFTQLMGILSDLLCGYPEGGGSRV
                     FSFNWYEDNNYKAFLGIDSTRRDPTYSYDKRTTWRATKPLLMGKILFTPDSPAARRLL
                     KNANSTFEELDRVRKLVKAWEEVGPQIWYFFEKSTQMAVIRDTLQHPTVKDFINRQLG
                     EEGITTEAILNFFPNGPRENQADDMTSFDWRDIFNITDRFLRLANQYLECLVLDKFES
                     YDDEVQLTQRALSLLEENRFWAGVVFPDMYPWTSSLPPHVKYKIRMDIDVVEKTNKIK
                     DRYWDSGPRADPVEDFRYIWGGFAYLQDMVEQGIVRSQTPAEPPIGVYLQQMPYPCFV
                     DDSFMIILNRCFPIFMVLAWIYSVSMTVKGIVLEKELRLKETLKNQGVSNAVIWCTWF
                     LDSFSIMSMSIFLLTLFIMHGRILHYSDPFILFLFLLAFATATIMQCFLFSTFFSKAS
                     LAAACSGVIYFTLYLPHILCFAWQDRMTADLKTTVSLLSPVAFGFGTEYLVRFEEQGL
                     GLQWSNIGKSPLEGDEFSFLLSMKMMLLDAALYGLLAWYLDQVFPGDYGTPLPWYFLL
                     QESYWLGGEGCSTREERALEKTEPLTEEIEDPEYPEDSFFERELPGLVPGVCVKNLVK
                     VFEPGSRPAVDRLNITFYENQITAFLGHNGAGKTTTLSILTGLLPPTSGTVLIGGKDI
                     EISLDAVRQSLGMCPQHNILFHHLTVAEHILFYAQLKGRSWEEARLEMEAMLEDTGLH
                     HKRNEEAQDLSGGMQRKLSVAIAFVGDSKVVVLDEPTSGVDPYSRRSIWDLLLKYRSG
                     RTIIMSTHHMDEADLLGDRIAIISQGRLYCSGTPLFLKNCFGTGFYLTLVRKMKNIQS
                     QRCGCEGACSCTSKGFSARCPARVDEITEEQVLDGDVKELTDLVYHHVPEAKLVECIG
                     QELIFLLPNKNFKQRAYASLFRELEETLADLGLSSFGISDTPLEEIFLKVTEDSESGS
                     KFVGGTQQKREHTGLRHPCSAPVEKHRQHAQASHTCSPGQVDPPKGQPSPEPEDPGIP
                     FNTGARLILQHVQALLVKRFHHAVRSRKDFVAQIVLPATFVFLALMLSIIVPPFGEFP
                     ALTLHPWMYGHQFTFFSMDEPNNEHLEVLADVLLNRPGFGNRCLKEEWLPEYPCGNAT
                     SWKTPSVSPNITHLFQKQKWTAAHPSPACKCSTREKLIMLPECPEGAGGLPPPQRIQR
                     STEVLQDLTNRNISDYLVKTYPALIRSSLKSKFWVNEQRYGGISIGGKLPDIPISGEA
                     LVGFLSDLGQMMNVSGGPVTRESSREMLDFLKHLETKDNIKVWFNNKGWHALVSFLNV
                     AHNAILRASLPKDRDPEEYGITVISQPLNLTKEQLSEITVLTTSIDAVVAICVIFAMS
                     FVPASFVLYLIQERVTKAKHLQFISGVSPTTYWMTNFLWDIMNYAVSAGLVVGIFIGF
                     QKKAYTSTDNLPALVTLLMLYGWAVIPMMYPASFLFDVPSTAYVALSCANLFIGINSS
                     AITFVLELFENNRMLLRFSATLRELLIVFPHFCLGRGLIDLALSQAVTDIYAQFGEEY
                     SANPFQWDLIGKNLVAMAIEGVVYFLLTLLIQHHFFLTRWIAEPAREPVFDEDDDVAE
                     ERQRVMSGGSKSDILKLNELTKVYSGSSSPAVDRLCVGVHPGECFGLLGVNGAGKTTT
                     FKMLTGDTTVTSGDATIAGKSILTNISDVHQNMGYCPQFDAIDDLLTGREHLYLYARL
                     RGVPSKEIEKVANWGIQSLGLSLYADRLAGTYSGGNKRKLSTAIALTGCPPLLLLDEP
                     TTGMDPQARRMLWNTIVNIIRQGRAVVLTSHSMEECEALCTRLAIMVKGTFQCMGTIQ
                     HLKYKFGDGYIVTMKIKSPKDDLLPDLNPVEQFFQGNFPGSVQRERHHSMLQFQVPSS
                     SLARIFQLLISHKDSLLIEEYSVTQTTLDQVFVNFAKQQTETYDLPLHPRAAGASWQA
                     KLEGKSGRLETQEPLPAGSSEHLANINNPTAVADNKHTRSPQ"
     exon            151..244
                     /gene="Abca4"
                     /gene_synonym="ABCR"
                     /inference="alignment:Splign:2.1.0"
     exon            245..386
                     /gene="Abca4"
                     /gene_synonym="ABCR"
                     /inference="alignment:Splign:2.1.0"
     exon            387..526
                     /gene="Abca4"
                     /gene_synonym="ABCR"
                     /inference="alignment:Splign:2.1.0"
     exon            527..654
                     /gene="Abca4"
                     /gene_synonym="ABCR"
                     /inference="alignment:Splign:2.1.0"
     exon            655..852
                     /gene="Abca4"
                     /gene_synonym="ABCR"
                     /inference="alignment:Splign:2.1.0"
     exon            853..942
                     /gene="Abca4"
                     /gene_synonym="ABCR"
                     /inference="alignment:Splign:2.1.0"
     exon            943..1183
                     /gene="Abca4"
                     /gene_synonym="ABCR"
                     /inference="alignment:Splign:2.1.0"
     exon            1184..1266
                     /gene="Abca4"
                     /gene_synonym="ABCR"
                     /inference="alignment:Splign:2.1.0"
     exon            1267..1383
                     /gene="Abca4"
                     /gene_synonym="ABCR"
                     /inference="alignment:Splign:2.1.0"
     exon            1384..1581
                     /gene="Abca4"
                     /gene_synonym="ABCR"
                     /inference="alignment:Splign:2.1.0"
     exon            1582..1787
                     /gene="Abca4"
                     /gene_synonym="ABCR"
                     /inference="alignment:Splign:2.1.0"
     exon            1788..1964
                     /gene="Abca4"
                     /gene_synonym="ABCR"
                     /inference="alignment:Splign:2.1.0"
     exon            1965..2187
                     /gene="Abca4"
                     /gene_synonym="ABCR"
                     /inference="alignment:Splign:2.1.0"
     exon            2188..2409
                     /gene="Abca4"
                     /gene_synonym="ABCR"
                     /inference="alignment:Splign:2.1.0"
     exon            2410..2614
                     /gene="Abca4"
                     /gene_synonym="ABCR"
                     /inference="alignment:Splign:2.1.0"
     exon            2615..2680
                     /gene="Abca4"
                     /gene_synonym="ABCR"
                     /inference="alignment:Splign:2.1.0"
     exon            2681..2761
                     /gene="Abca4"
                     /gene_synonym="ABCR"
                     /inference="alignment:Splign:2.1.0"
     exon            2762..2936
                     /gene="Abca4"
                     /gene_synonym="ABCR"
                     /inference="alignment:Splign:2.1.0"
     exon            2937..3068
                     /gene="Abca4"
                     /gene_synonym="ABCR"
                     /inference="alignment:Splign:2.1.0"
     exon            3069..3208
                     /gene="Abca4"
                     /gene_synonym="ABCR"
                     /inference="alignment:Splign:2.1.0"
     exon            3209..3346
                     /gene="Abca4"
                     /gene_synonym="ABCR"
                     /inference="alignment:Splign:2.1.0"
     exon            3347..3540
                     /gene="Abca4"
                     /gene_synonym="ABCR"
                     /inference="alignment:Splign:2.1.0"
     exon            3541..3625
                     /gene="Abca4"
                     /gene_synonym="ABCR"
                     /inference="alignment:Splign:2.1.0"
     exon            3626..3831
                     /gene="Abca4"
                     /gene_synonym="ABCR"
                     /inference="alignment:Splign:2.1.0"
     exon            3832..3880
                     /gene="Abca4"
                     /gene_synonym="ABCR"
                     /inference="alignment:Splign:2.1.0"
     exon            3881..4143
                     /gene="Abca4"
                     /gene_synonym="ABCR"
                     /inference="alignment:Splign:2.1.0"
     exon            4144..4268
                     /gene="Abca4"
                     /gene_synonym="ABCR"
                     /inference="alignment:Splign:2.1.0"
     exon            4269..4367
                     /gene="Abca4"
                     /gene_synonym="ABCR"
                     /inference="alignment:Splign:2.1.0"
     exon            4368..4554
                     /gene="Abca4"
                     /gene_synonym="ABCR"
                     /inference="alignment:Splign:2.1.0"
     exon            4555..4649
                     /gene="Abca4"
                     /gene_synonym="ABCR"
                     /inference="alignment:Splign:2.1.0"
     exon            4650..4682
                     /gene="Abca4"
                     /gene_synonym="ABCR"
                     /inference="alignment:Splign:2.1.0"
     exon            4683..4788
                     /gene="Abca4"
                     /gene_synonym="ABCR"
                     /inference="alignment:Splign:2.1.0"
     exon            4789..4863
                     /gene="Abca4"
                     /gene_synonym="ABCR"
                     /inference="alignment:Splign:2.1.0"
     exon            4864..5033
                     /gene="Abca4"
                     /gene_synonym="ABCR"
                     /inference="alignment:Splign:2.1.0"
     exon            5034..5211
                     /gene="Abca4"
                     /gene_synonym="ABCR"
                     /inference="alignment:Splign:2.1.0"
     exon            5212..5327
                     /gene="Abca4"
                     /gene_synonym="ABCR"
                     /inference="alignment:Splign:2.1.0"
     exon            5328..5475
                     /gene="Abca4"
                     /gene_synonym="ABCR"
                     /inference="alignment:Splign:2.1.0"
     exon            5476..5599
                     /gene="Abca4"
                     /gene_synonym="ABCR"
                     /inference="alignment:Splign:2.1.0"
     exon            5600..5729
                     /gene="Abca4"
                     /gene_synonym="ABCR"
                     /inference="alignment:Splign:2.1.0"
     exon            5730..5850
                     /gene="Abca4"
                     /gene_synonym="ABCR"
                     /inference="alignment:Splign:2.1.0"
     exon            5851..5913
                     /gene="Abca4"
                     /gene_synonym="ABCR"
                     /inference="alignment:Splign:2.1.0"
     exon            5914..6020
                     /gene="Abca4"
                     /gene_synonym="ABCR"
                     /inference="alignment:Splign:2.1.0"
     exon            6021..6162
                     /gene="Abca4"
                     /gene_synonym="ABCR"
                     /inference="alignment:Splign:2.1.0"
     exon            6163..6297
                     /gene="Abca4"
                     /gene_synonym="ABCR"
                     /inference="alignment:Splign:2.1.0"
     exon            6298..6401
                     /gene="Abca4"
                     /gene_synonym="ABCR"
                     /inference="alignment:Splign:2.1.0"
     exon            6402..6494
                     /gene="Abca4"
                     /gene_synonym="ABCR"
                     /inference="alignment:Splign:2.1.0"
     exon            6495..6744
                     /gene="Abca4"
                     /gene_synonym="ABCR"
                     /inference="alignment:Splign:2.1.0"
     exon            6745..6831
                     /gene="Abca4"
                     /gene_synonym="ABCR"
                     /inference="alignment:Splign:2.1.0"
     exon            6832..7163
                     /gene="Abca4"
                     /gene_synonym="ABCR"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gctggacgcg gtcccagtgg cctttgtgtc tggtgcttgc ctgagcccca gttggggtga
       61 tccccgggtg ctgggtggtc cagcatgggc ttcctcagac agatacagct tttgctttgg
      121 aagaactgga ctctgaggaa aaggcaaaag attcgctttg tagtggaact cgtgtggcct
      181 ttgtctttgt ttttggtgtt aatctggctg aggaatgcca accccctcta cagtcaacat
      241 gaatgccact ttcccaacaa ggcgatgcct tcagcaggaa tgttaccatg gctccagggg
      301 attttctgca atatgaacaa cccttgtttt caaaacccca cccctggaga atctcccgga
      361 actgtatcaa actataataa ttccatcttg gcaagactat atcgagattt tcaagagctc
      421 ttcatggaca caccggaggt ccagcgtctt ggccgggttt ggacagagct ccgcacctta
      481 tctcagctca tggacaccct gcggactcac cctgagagat ttacaggaag aggattacca
      541 atccgagaca tcctgaaaga tgaagagaca ctgacactat ttctcaagaa aaacattggc
      601 ctgtctgact cagttgccta tcttctggtc aactcccaag ttcgtatgga acagtttgct
      661 tatggagtcc cagacttgga actgaaagac attgcctgca gcgaggccct gttgcaacgc
      721 ttcatcatct tcagccagcg ttggggggca caggcggtac gcggtgccct gtgtcccctc
      781 tcccaggtca ccctacagtg gatagaagac actctgtatg ccgacgtgga cttcttcaaa
      841 ctcttccgtg tgctccccac actccttgac agcagctctc aaggaatcaa cttgagattt
      901 tggggagaaa tactgtctga tctgtcacca agagtgcaaa agtttatcca tcggccaagt
      961 gttcaagact tgctgtgggt aaccagacct cttctgcaga acagtggtcc cgagaccttc
     1021 acacagttga tgggcatcct gtctgacctc ctgtgtgggt acccagaggg aggaggctct
     1081 cgagtgttct ccttcaactg gtatgaagac aataactata aggccttcct ggggattgat
     1141 tccacaagga gagaccccac ctattcttat gacaaaagaa caacctggag ggcaacaaag
     1201 ccattgctga tgggaaaaat cctctttact ccagattccc ctgctgctcg aaggctgctg
     1261 aagaacgcca actcaacttt tgaagaactg gatcgagtta ggaagctggt caaagcctgg
     1321 gaggaagtag ggccccagat ttggtacttc tttgagaaga gcacacagat ggccgtgatc
     1381 agagataccc tgcagcaccc aacagtaaaa gacttcataa ataggcagct tggagaagaa
     1441 ggcattacca ctgaagccat attaaatttc ttccctaatg gtccccgaga gaaccaagct
     1501 gatgacatga ccagctttga ctggagggat atattcaaca tcactgaccg cttcctgcgc
     1561 ctggctaatc aatacctgga gtgtctggtc ctggataagt ttgaaagtta cgatgatgaa
     1621 gttcagctca cccagcgagc cctgtctctc ctggaggaga acaggttctg ggctggagtg
     1681 gtattccctg acatgtatcc gtggaccagc tccctacctc cccatgtgaa gtacaagatt
     1741 cggatggaca ttgatgtggt ggagaagacc aataagatca aagacaggta ctgggattct
     1801 ggtcccaggg cagatcctgt cgaagatttc cggtacatct ggggaggctt tgcctatcta
     1861 caggacatgg ttgagcaagg aatcgtgagg agtcagaccc cggcagagcc tccaattgga
     1921 gtctatctcc agcagatgcc ttacccctgc tttgtggatg actccttcat gatcatcctg
     1981 aatcgctgtt tccccatctt catggtgctg gcatggatct actctgtctc catgactgtt
     2041 aagggcattg tcttggaaaa ggagctgagg ctgaaggaga ccttgaagaa ccaaggtgtc
     2101 tctaacgctg tgatttggtg tacttggttc ctggacagct tctccattat gtcaatgagt
     2161 atcttcctcc tgacgctgtt catcatgcac gggagaattc tccattacag cgatcccttc
     2221 attctcttcc tgttcctatt ggcctttgcc accgcgacca tcatgcagtg cttcctgttc
     2281 agtactttct tttccaaggc cagcctcgcc gcagcctgca gcggggtcat ctacttcacc
     2341 ctctacctgc cacacattct gtgctttgcg tggcaagacc ggatgaccgc cgacctgaag
     2401 accactgtga gcctgctttc tccggtggca tttgggtttg gcaccgagta cctggtccgc
     2461 tttgaagagc aaggcctggg actgcagtgg agcaacattg ggaagagtcc cctggaaggg
     2521 gatgagttca gtttcctgtt gtctatgaag atgatgctcc tcgatgctgc tctgtacggc
     2581 ttgcttgctt ggtatcttga ccaggttttc ccaggagact atggcacccc acttccctgg
     2641 tacttccttc tacaggagtc ttactggctt ggaggtgaag gttgttcgac cagagaagaa
     2701 agggcactgg aaaagactga acccttaaca gaggaaatag aggatccgga gtacccagaa
     2761 gactcctttt ttgaacgtga gcttccaggg ttggtgcctg gagtgtgtgt gaagaacctg
     2821 gtgaaggtgt ttgagcccgg tagccggcca gccgtggacc gccttaacat cactttctat
     2881 gagaaccaaa tcactgcatt cctgggtcac aatggagccg gaaaaaccac caccttgtcc
     2941 atcctcacgg gtctgttgcc gccaacatca ggaactgtgc ttattggggg aaaagacatt
     3001 gaaatcagcc tggatgcagt acgccagagc ctgggcatgt gtccccaaca caacatcctg
     3061 ttccatcacc tcacggtggc tgagcatatc ttgttctatg cccagctgaa agggaggtcc
     3121 tgggaggagg cccggcttga gatggaagcc atgttagaag acacgggcct tcaccacaag
     3181 agaaacgaag aagctcagga cctttcaggg ggcatgcaga ggaagctgtc tgttgccatt
     3241 gcttttgtgg gagattccaa ggtggtggtc ctggatgagc ccacctctgg ggtggaccct
     3301 tactctagac gctccatctg ggacctgctc ctgaagtatc gctcaggtag aaccatcatc
     3361 atgtccactc accacatgga tgaggcagac ctccttggtg accgcattgc catcatttct
     3421 cagggaaggc tctactgctc tgggacgcca ctcttcctga agaactgctt tggcacaggc
     3481 ttctacttga ccttagttcg caagatgaaa aacatccaga gccaaagatg tggctgtgag
     3541 ggggcctgca gctgtacatc aaagggtttc tctgccaggt gtccagcccg agtcgatgag
     3601 ataacggaag aacaagtctt ggatggggat gtgaaggagc tgacagattt ggtgtaccac
     3661 catgttccag aggcaaagct ggtggaatgc attggccaag aacttatctt cctcctccca
     3721 aacaagaatt tcaagcagag agcatatgcc agcctcttcc gagagctgga ggagactctg
     3781 gctgacctgg ggctcagcag ctttggaatt tctgacactc ccctggaaga gattttcctg
     3841 aaggtcacgg aggattctga atcaggttct aagtttgtag gtggcacaca gcagaagaga
     3901 gagcatactg gtcttcggca tccttgttcg gctcccgtcg agaagcacag gcagcatgcc
     3961 caggcctcac atacctgttc cccaggacaa gtggatcctc ccaagggcca gccttcccca
     4021 gagccagagg accccggtat cccattcaac acaggtgctc ggctgatcct tcagcatgtg
     4081 caggcactgc tggtcaagcg attccatcat gctgtccgca gccgcaagga ttttgtggct
     4141 cagattgttc tccctgccac ttttgtgttc ttggctctga tgctttccat catcgtgcct
     4201 ccgtttggtg aattcccagc tttgaccctt cacccctgga tgtatgggca tcaatttacc
     4261 ttcttcagca tggatgaacc caacaatgaa caccttgaag tactggcaga tgtccttttg
     4321 aacaggccag gttttggcaa ccgttgtcta aaggaagagt ggcttccgga gtacccctgc
     4381 ggcaacgcaa cctcctggaa gacgccttcc gtgtccccaa acatcaccca cctgttccag
     4441 aagcagaaat ggacagcagc ccacccttcg cccgcctgca agtgcagcac cagagagaag
     4501 ctcatcatgc tccccgaatg ccccgagggt gctggggggc tcccaccccc acagaggata
     4561 cagcgcagca cagaagtcct acaagacctc acgaacagga acatctctga ctacttggta
     4621 aaaacgtatc ctgctctcat acgaagcagc ttaaagagca aattctgggt caatgaacag
     4681 aggtatggag gaatttccat tggagggaag ctccctgaca tccccatcag cggggaagca
     4741 cttgtgggct tcttaagtga cctgggccag atgatgaatg tgagcggggg tcctgtcacc
     4801 agagagtctt ccagagagat gttagatttc ctcaaacacc tcgaaaccaa agacaacatt
     4861 aaggtgtggt ttaacaacaa gggctggcat gccctggtca gcttcctgaa cgtggctcac
     4921 aacgccatct tgcgggccag cctgcccaag gacagggacc cggaagaata tggaatcacc
     4981 gttatcagcc agcctctgaa cctgaccaag gagcagctct cagagatcac agtgctgact
     5041 acttccatcg atgccgtggt tgccatatgt gtgattttcg ccatgtcctt cgttccagcc
     5101 agctttgtcc tctacctgat ccaggagaga gtgacgaaag ccaaacattt gcagtttatc
     5161 agtggtgtga gccccaccac ctactggatg accaacttcc tctgggacat tatgaattat
     5221 gctgtgagtg cgggactagt ggtgggtatc ttcattggat ttcaaaagaa agcctacaca
     5281 tccacagaca accttcctgc gcttgtcact ctgctcatgc tgtatggatg ggcagtcatc
     5341 ccaatgatgt atccagcgtc cttcctgttt gacgtcccca gcacagccta tgtggctttg
     5401 tcttgtgcta acctgttcat cggcatcaac agcagcgcaa tcacatttgt cctggaacta
     5461 tttgagaata accggatgct gctcaggttc agtgccacgc tgagggagtt gctcattgtc
     5521 ttcccacact tctgcctggg caggggcctc atcgacctgg cactcagcca agctgtgaca
     5581 gacatctacg cccagtttgg tgaggagtac tctgcaaacc cattccagtg ggacctgatt
     5641 gggaagaacc tggttgctat ggcaatagaa ggggtggtgt acttccttct gaccctgctc
     5701 atccaacacc actttttcct cacccggtgg atcgctgagc ctgctagaga gcccgttttt
     5761 gatgaagatg atgatgtggc tgaagaaagg caaagagtta tgagtggagg aagtaaaagt
     5821 gacatcttaa agctaaacga actaaccaag gtttactcag gctcctccag tccagcagta
     5881 gatcggttat gtgtcggcgt ccaccctggg gagtgctttg gcctcctggg agtgaatggt
     5941 gcaggcaaaa ccaccacatt caagatgctc actggggaca ccacagtgac atcaggggat
     6001 gctaccatag caggcaagag cattttaact aatatttctg atgttcatca aaacatgggc
     6061 tactgtcctc aattcgatgc aattgatgac ctactcacag gccgggaaca tctctacctc
     6121 tatgccaggc tgcggggtgt gccatcgaag gaaattgaga aggttgccaa ctggggcatc
     6181 caaagcctgg gcttgtctct ctacgctgac cgcctagcgg gcacctacag tggaggcaat
     6241 aagaggaaac tctccacggc catagcactc accggctgcc cgcccctgct gctgctggat
     6301 gagcccacaa cagggatgga tccacaggcc cgccgcatgc tgtggaatac cattgtgaac
     6361 atcatcagac aagggagagc cgtggtgctc acctcccaca gcatggaaga gtgtgaagca
     6421 ctgtgcacga ggctggccat catggtgaag ggcacctttc agtgcatggg caccattcaa
     6481 cacctcaagt acaagtttgg agacggctac attgtcacaa tgaaaatcaa atccccaaag
     6541 gacgacttgc ttcctgattt gaatcctgtg gagcagttct tccagggcaa ctttcctggc
     6601 agcgtgcaga gggagagaca ccacagcatg ctccagttcc aggtcccctc gtcctccctg
     6661 gccaggatct tccagctgct catttcccac aaggacagcc tgctcatcga ggagtactca
     6721 gttacccaga ccacactgga ccaggtattt gtaaacttcg ccaaacagca gactgagacc
     6781 tatgacctcc ctctgcaccc tcgggctgcc ggagccagct ggcaagccaa gctggaaggg
     6841 aaatccggac ggctagagac acaggagcct ttacccgctg gatcatctga acacctggct
     6901 aacataaaca accccactgc agtagcagat aataagcaca cgaggagtcc gcagtgagct
     6961 ggaggaaacc aaaatattca ccggctcacc cgaactcccg atggcaaaac tggaacacag
     7021 tcaccttttc atccagaccc ctgactagtg gctttggcct tagcgattat tttcattctg
     7081 agtggatcta cttttgtgga gtgggagggg tatggatgtg tgggtgttat ttgggaggaa
     7141 gaataaaaag cagcttcctg atg
//
